Comparison of hs-CRP and Fetuine-A levels before and after the treatment of subjects with subclinical hyperthyroidism

2013 ◽  
Author(s):  
Mehmet Calan ◽  
Oktay Bilgir ◽  
Ferda Bilgir ◽  
Tugba Topcuoglu ◽  
Ozlem Calan
Keyword(s):  
Subclinical Hyperthyroidism ◽  
Before And After ◽  
Hs Crp

scholarly journals Risk Factors of Acute Pancreatitis in Oral Double Balloon Enteroscopy

2016 ◽  
Vol 59 (3) ◽  
pp. 84-90 ◽  
Author(s):  
Marcela Kopáčová ◽  
Jan Bureš ◽  
Stanislav Rejchrt ◽  
Jaroslava Vávrová ◽  
Jolana Bártová ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Serum Amylase ◽  
Double Balloon Enteroscopy ◽  
Serum Lipase ◽  
Balloon Enteroscopy ◽  
Double Balloon ◽  
Laboratory Markers ◽  
Before And After ◽  
Hs Crp ◽  
Urine Amylase

Double balloon enteroscopy (DBE) was introduced 15 years ago. The complications of diagnostic DBE are rare, acute pancreatitis is most redoubtable one (incidence about 0.3%). Hyperamylasemia after DBE seems to be a rather common condition respectively. The most probable cause seems to be a mechanical straining of the pancreas. We tried to identify patients in a higher risk of acute pancreatitis after DBE. We investigated several laboratory markers before and after DBE (serum cathepsin B, lactoferrin, E-selectin, SPINK 1, procalcitonin, S100 proteins, alfa-1-antitrypsin, hs-CRP, malondialdehyde, serum and urine amylase and serum lipase). Serum amylase and lipase rose significantly with the maximum 4 hours after DBE. Serum cathepsin and procalcitonin decreased significantly 4 hours after DBE compared to healthy controls and patients values before DBE. Either serum amylase or lipase 4 hours after DBE did not correlate with any markers before DBE. There was a trend for an association between the number of push-and-pull cycles and procalcitonin and urine amylase 4 hours after DBE; between procalcitonin and alfa-1-antitrypsin, cathepsin and hs-CRP; and between E-selectin and malondialdehyde 4 hours after DBE. We found no laboratory markers determinative in advance those patients in a higher risk of acute pancreatitis after DBE.

scholarly journals Clinical Efficacy of Surgical Treatment in 40 Patients with Acute Hematogenous Osteomyelitis

2020 ◽  
pp. 1-7
Author(s):  
Wang Linan ◽  
Wang Xuewei ◽  
Liu Jian ◽  
Li Yongai ◽  
Wanghui Wanghui ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Diagnostic Methods ◽  
Pathological Examination ◽  
Blood Cell Count ◽  
Erythrocyte Sedimentation ◽  
Hematogenous Osteomyelitis ◽  
Acute Hematogenous Osteomyelitis ◽  
Before And After ◽  
Hs Crp ◽  
Esr Imaging

Objective: This study aimed to evaluate the diagnostic methods of acute hematogenous osteomyelitis and the clinical efficacy of fenestration decompression, focus debridement, and convective flushing. Methods: A retrospective analysis was performed on 40 patients with acute hematogenous osteomyelitis admitted to the Department of Orthopedics of our hospital from January 2011 to December 2018. There were 21 males and 19 females, aged 1–70 years, with an average age of 21.45 ± 15.23 years, including 27 children and adolescents. The pathogenic sites were as follows: femur 20 cases, tibia 16 cases, humerus 2 cases, ulna 1 case, and radius 1 case. The systemic and local symptoms of patients before and after surgery were evaluated. The results of white blood cell count (WBC), NEUT%, hs-CRP, erythrocyte sedimentation rate (ESR), imaging examination, bacteriology, and pathological examination were analyzed. Fenestration decompression, focus debridement, and convective flushing were used at the site of lesion in the surgery.

scholarly journals Cardiovascular risk and the possibility of its correction in women with premature ovarian insufficiency

2019 ◽  
Vol 12 (4) ◽  
pp. 37-46 ◽  
Author(s):  
A. A. Pozdnyakova ◽  
L. A. Marchenko ◽  
N. K. Runikhina
Keyword(s):  
Uric Acid ◽  
Cardiovascular Risk ◽  
Relative Risk ◽  
Brachial Artery ◽  
Premature Ovarian Insufficiency ◽  
Functional Markers ◽  
Ovarian Insufficiency ◽  
Apo B ◽  
Before And After ◽  
Hs Crp

Since recently, the association of premature ovarian insufficiency (POI) with an increased risk of mortality and morbidity caused by cardiovascular diseases (CVD) has been extensively discussed in the context of early detection and prevention of CVD in these patients.Aim: to evaluate the relative cardiovascular risk (CV risk) before and after hormone replacement therapy (HRT) in women with POI.Materials and methods. The study included 170 women aged from 18 to 40; among them, 85 women with POI and 85 women with regular periods. We evaluated the usual CV risk factors: smoking habits, arterial blood pressure, total cholesterol (TC), low-density lipoproteins (LDL), high-density lipoproteins; in addition, we determined apolipoprotein B (Apo B), high-sensitivity C-reactive protein (hs-CRP), uric acid, and endotelin-1, as well as the functional markers: the right and left carotid intima-media thickness (CIMT) and the brachial artery flow-mediated dilatation (FMD). The CV risk was calculated using the relative risk SCORE scale before and after HRT lasted for 12 months.Results. In the POI group, there were 3.8 times more women with a moderate CV risk (per the SCORE scale), whereas in the POI-free group, women with a low CV risk dominated. In addition, the levels of CV risk markers were 4-fold higher in patients with POI (high levels of Apo B, hs-CRP and uric acid, increased CIMT bilaterally, decreased FMD in the brachial artery). Cyclic HRT during 12 months contributed to the lipid profile normalization, decrease in TC, LDL and FMD in the brachial artery as well as to the decrease of relative CV risk in general.Conclusion. The estrogen deficiency in patients with POI is an independent factor in the increased relative risk of CVD. The HRT has anti-atherogenic, antiinflammatory, and angioprotective effects, regulates the production of endothelium-dependent factors of vasoconstriction and vasodilation, leading to a reduction in the relative risk of CVD in general.

scholarly journals Morning pentraxin3 levels reflect obstructive sleep apnea–related acute inflammation

2014 ◽  
Vol 117 (10) ◽  
pp. 1141-1148 ◽  
Author(s):  
Yusuke Kobukai ◽  
Takashi Koyama ◽  
Hiroyuki Watanabe ◽  
Hiroshi Ito
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Acute Inflammation ◽  
High Sensitivity ◽  
Apnea Hypopnea Index ◽  
Cpap Therapy ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
Before And After ◽  
Hs Crp

This study investigated morning levels of pentraxin3 (PTX3) as a sensitive biomarker for acute inflammation in patients with obstructive sleep apnea (OSA). A total of 61 consecutive patients with OSA were divided into two groups: non-to-mild ( n = 20) and moderate-to-severe ( n = 41) OSA based on their apnea-hypopnea index (AHI) score. Those patients with moderate-to-severe OSA were further divided into continuous positive airway pressure (CPAP) treated ( n = 21) and non-CPAP-treated ( n = 20) groups. Morning and evening serum PTX3 and high-sensitivity (hs) C-reactive protein (CRP) levels were measured before and after 3 mo of CPAP therapy. The baseline hs-CRP and PTX3 levels were higher in patients with moderate-to-severe OSA than in those with non-to-mild OSA. Moreover, the serum PTX3 levels, but not the hs-CRP levels, were significantly higher after than before sleep in the moderate-to-severe OSA group (morning PTX3, 1.96 ± 0.52; evening PTX3, 1.71 ± 0.44 ng/ml). OSA severity as judged using the AHI was significantly correlated with serum PTX3 levels but not hs-CRP levels. The highest level of correlation was found between the AHI and morning PTX3 levels ( r = 0.563, P < 0.001). CPAP therapy reduced evening and morning serum hs-CRP and PTX3 levels in patients with moderate-to-severe OSA; however, the reduction in PTX3 levels in the morning was greater than that in the evening (morning −29.8 ± 16.7% vs. evening −12.6 ± 26.8%, P = 0.029). Improvement in the AHI score following CPAP therapy was strongly correlated with reduced morning PTX3 levels( r = 0.727, P < 0.001). Based on these results, morning PTX3 levels reflect OSA-related acute inflammation and are a useful marker for improvement in OSA following CPAP therapy.

Effects of varying doses of testosterone on atherogenic markers in healthy younger and older men

2014 ◽  
Vol 306 (2) ◽  
pp. R118-R123 ◽  
Author(s):  
Christian K. Roberts ◽  
Brian H. Chen ◽  
Sandeep Pruthi ◽  
Martin L. Lee
Keyword(s):  
Dose Range ◽  
High Sensitivity ◽  
Older Men ◽  
Serum Markers ◽  
Double Blind ◽  
Atherosclerosis Progression ◽  
Before And After ◽  
Markers Of Oxidative Stress ◽  
Hs Crp ◽  
Long Acting

Whether exogenous testosterone is proatherogenic remains controversial. We assessed the effects of graded doses of testosterone on serum markers of oxidative stress, chemotaxis, adhesion, and inflammation in healthy younger and older men. In a double-blind, randomized trial, 121 eugonadal men ( n = 61, 18–35 years of age and n = 60, 60–75 years of age) were randomized to one of five groups to receive weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk, respectively, along with a long-acting gonadotropin-releasing hormone (GnRH) agonist. Energy and protein intakes were standardized and no resistance training was allowed. We measured plasma levels of the atherogenic biomarkers monocyte chemotactic protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1), 8-isoprostane-PGF2α (8-iso-PGF2α), and high-sensitivity C-reactive protein (hs-CRP) before and after the intervention. Administration of increasing doses of testosterone led to reduction in total 8-iso-PGF2α in the younger (p-trendYounger = 0.01), but not older (p-trendOlder = 0.79) men. No significant linear associations were observed between testosterone dose and MCP-1, sICAM-1, or hs-CRP (all p-trend >0.20). In apparently healthy men, over a wide dose range, testosterone did not adversely affect atherogenic biomarkers. Long-term studies with larger sample sizes are warranted to determine whether testosterone supplementation affects atherosclerosis progression and cardiovascular risk.

Effect of Moringa oleifera Leaf Extract on High Sensitivity C-Reactive Protein, ESR And MEX SLEDAI Score in Lupus Patients

2020 ◽  
Vol 4 (4) ◽  
pp. 291
Author(s):  
Arief Nurudhin ◽  
Nurhasan Agung Prabowo ◽  
Yulyani ◽  
Zainal Arifin Adnan ◽  
Adil
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
High Sensitivity ◽  
Definitive Treatment ◽  
Simple Method ◽  
Sledai Score ◽  
Novel Treatments ◽  
Before And After ◽  
Hs Crp ◽  
Clinical Changes

Introduction: No definitive treatment is available for SLE. Moringa oleifera Leaf Extract is one of promising novel treatments in SLE because of anti inflammatory and immunomodulatory effect. Our study aimed to identify the effect of Moringa oleifera Leaf Extract on the level of hs-CRP, ESR and MEX SLEDAI score in lupus patients. HsCRP and ESR levels are related to the pathogenesis of SLE and they are positively correlated with the disease activity. The MEX SLEDAI score is a simple method that is quite valid for finding the degree of SLE activity, and MEX SLEDAI has the ability to evaluate clinical changes in SLE patients.Methods: Experimental study consisted of 29 samples of SLE patients, divided into 2 groups, namely 13 SLE patients who received Moringa oleifera leaf extract as much as 40.5 mg / kg per day and 16 SLE patients who received placebo. The study was conducted for 28 days. MEX SLEDAI scores, hsCRP and ESR levels were measured before and after administration of therapy. Statistical analysis was applied using SPSS 23, with different t-test, Mann Whitney, and Will Coxon tests. P is significant if p <0.05.Result: Result of the study showed that before Moringa oleifera leaf extract was given, the average MEX SLEDAI score was (1.56 ± 2.16) for control, and (2.69 ± 3.01) for treatment, hsCRP (0.24 ± 0.22) for control and ( 0.76 ± 1.01) for treatment, ESR (25.56 ± 23.44) for control and (26.00 ± 25.27) for treatment. There was a significant decrease in MEX SLEDAI score in the treatment group. There was no significant reduction in hsCRP and ESR of SLE patients in both groups.Conclusion: This study showed that the effect of lowering the MEX SLEDAI score on the administration of Moringa leaf extract was significant and could not significantly reduce hsCRP and ESR levels.International Journal of Human and Health Sciences Vol. 04 No. 04 October’20 Page : 291-297

Assessment of cytokine levels and hs-CRP in bipolar I disorder before and after treatment

2015 ◽  
Vol 228 (3) ◽  
pp. 386-392 ◽  
Author(s):  
Vesile Uyanik ◽  
Cengiz Tuglu ◽  
Yasemin Gorgulu ◽  
Hakan Kunduracilar ◽  
Mehmet Sevki Uyanik
Keyword(s):  
Bipolar I Disorder ◽  
Cytokine Levels ◽  
Before And After ◽  
Hs Crp

scholarly journals Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Steven K. Malin ◽  
Nicole M. Gilbertson ◽  
Natalie Z. M. Eichner ◽  
Emily Heiston ◽  
Stephanie Miller ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Endothelial Function ◽  
Area Under The Curve ◽  
Bioelectrical Impedance ◽  
Short Term ◽  
Before And After ◽  
Hs Crp ◽  
The Impact

Introduction. The impact of interval (INT) vs. continuous (CONT) exercise training on endothelial function in relation to glucose metabolism prior to clinically meaningful weight loss is unknown in adults with prediabetes. Methods. Twenty-six subjects with prediabetes (60±1 y; 33±1 kg/m2; 2-hr-PG OGTT: 145±7 mg/dl) were randomized to 60 min of CONT (n=12; 70% of HRpeak) or work-matched INT exercise training (n=14; alternating 3 min at 90 and 50% HRpeak) for 2 weeks. Aerobic fitness (VO2peak) and body composition (bioelectrical impedance) were assessed before and after training. Flow-mediated dilation (FMD) was measured during a 2 h 75 g OGTT (0, 60, and 120 min) to assess endothelial function. Postprandial FMD was calculated as incremental area under the curve (iAUC). Glucose tolerance and insulin were also calculated by iAUC. Fasting plasma VCAM, ICAM, and hs-CRP were also assessed as indicators of vascular/systemic inflammation. Results. Both interventions increased VO2peak (P=0.002) but had no effect on body fat (P=0.20). Although both treatments improved glucose tolerance (P=0.06) and insulin iAUC (P=0.02), VCAM increased (P=0.01). There was no effect of either treatment on ICAM, hs-CRP, or fasting as well as postprandial FMD. However, 57% of people improved fasting and iAUC FMD following CONT compared with only 42% after INT exercise (each: P=0.04). Elevated VCAM was linked to blunted fasting FMD after training (r=−0.38, P=0.05). But, there was no correlation between fasting FMD or postprandial FMD with glucose tolerance (r=0.17, P=0.39 and r=0.02, P=0.90, respectively) or insulin iAUC following training (r=0.34, P=0.08 and r=0.04, P=0.83, respectively). Conclusion. Endothelial function is not improved consistently after short-term training, despite improvements in glucose and insulin responses to the OGTT in obese adults with prediabetes.

scholarly journals Endothelial Dysfunction Markers in Low Cardiovascular Risk Individuals: Comparison of Males and Females

2017 ◽  
Vol 36 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Zeynep B. Gungor ◽  
Nurver Sipahioglu ◽  
Huseyin Sonmez ◽  
Hakan Ekmekci ◽  
Sait Toprak ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Endothelial Dysfunction ◽  
Biochemical Markers ◽  
Nitrosative Stress ◽  
Scoring Systems ◽  
Before And After ◽  
Risk Scoring ◽  
Males And Females ◽  
Hs Crp ◽  
European Society Of Cardiology

Summary Background: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more attention. We hypothesized that differences in endothelial dysfunction biochemical markers among genders would aid to capture proatherogenic activity that was not diagnosed by conventional risk assessment scoring systems. Methods: We assessed the endothelial dysfuntion markers in 92 Turkish adults who were in the »low CV risk group« according to ESC (European Society of Cardiology)-Score Risk Charts. We compared the males and females. Results: We observed higher endothelial dysfunction rates in males, with higher median and mean levels of e-NOS, ox-LDL before and after adjustment for HDL lowness and obesity (P=0.018, P=0.036 for NOS; P=0.000, P=0.004 for ox-LDL, respectively). Men had higher hs-CRP levels than females before adjustment (P=0.021). Decreased e-NOS levels were related with FMD for females before adjustment for confounders (P=0.028). We also found significant correlation between e-NOS and ox-LDL levels both before (r=0.360, P<0.001) and after adjustment (r=0.366, P<0.01) for confounders which pointed out the nitrosative stress. In multivariate regression analyses, after adjusting for other endothelial dysfunction markers which were not included in the ESC-risk scoring system, decreased e-NOS levels were independently asssociated with impaired flow mediated dilatation for females (odds ratio 0.3; P=0.038). Conclusions: Our results underline the importance of gender in evaluating endothelial dysfunction biochemical markers to assess cardiovascular risk for low CV risk indivuals.

Sign in / Sign up

Export Citation Format

Share Document