Weight has a weak influence on calcium-phosphorus metabolism in HIV-patients with vitamin d deficiency

Hypothesis/aims of study. According to the literature, the prevalence of vitamin D deficiency and its deficiency in pregnant women reaches 6080%, which is a significant factor in reducing bone mineral density (BMD), osteopenia, and the risk of fractures after childbirth. Hormone-mediated changes in calcium-phosphorus metabolism during lactation are an independent factor in the reduction of BMD. Therefore, the study of the relationship between vitamin D deficiency and insufficiency after childbirth and the possibility of correction is relevant. The aim of this study was to evaluate the effect of prophylactic doses of cholecalciferol and calcium carbonate over time on calcium-phosphorus metabolism indicators after childbirth. Study design, materials and methods. A randomized controlled trial was conducted based on V.A. Almazov National Medical Research Center, Saint Petersburg. 64 puerperas, who lived in St. Petersburg from 2013 to 2014, were surveyed on the 35th day after childbirth. The age of women ranged from 20 to 35 years. Blood serum levels of calcium, phosphorus, magnesium, 25-hydroxycalciferol (25(OH)D), and parathyroid hormone (PTH) were determined for all the puerpera. Using the blind envelope method, the postpartum women were randomized into groups: group I received cholecalciferol 400 IU and calcium carbonate 1000 mg after delivery for 6 months; group II received cholecalciferol 900 IU and calcium carbonate 1000 mg after delivery for 6 months. Blood sampling was performed over time to assess the levels of 25(OH)D, PTH, calcium, phosphorus, and magnesium. Results. In group I after childbirth, the initial level of 25(OH)D in the blood serum was 22.46 4.35 ng/ml, which corresponds to vitamin D insufficiency. An increase in 25(OH)D level by 3.56 ng/ml was observed after 3 months from the start of taking cholecalciferol 400 IU. After 6 months, the level of 25(OH)D reached normal values in 20% of women (p = 0.0001). In group II after childbirth, the initial level of 25(OH)D in the blood serum was 20.64 5.37 ng/ml, which corresponds to vitamin D insufficiency. An increase in 25(OH)D level by 7.60 ng/ml was observed after 3 months from the start of taking cholecalciferol 900 IU. After 6 months, the level of 25(OH)D reached normal values in 56% of women, while the average level of 25(OH)D in these women corresponded to its normally low values. The levels of PTH, calcium, phosphorus, and magnesium remained within the reference values in both groups; however, there was an increase in PTH concentration 6 months after delivery, which may indicate that the cholecalciferol dose is insufficient to stabilize PTH. Conclusion. Vitamin D deficiency and insufficiency occurred in 80-97 % of those examined after delivery. The use of prophylactic doses of cholecalciferol has a positive effect on calcium-phosphorus metabolism; however, they are not sufficient to stabilize PTH level. The cholecalciferol dose of 400 IU is insufficient to normalize the level of 25(OH)D within 6 months of administration. The cholecalciferol dose of 900 IU leads to normally low values of 25(OH)D in 56 % of women after 6 months of administration, but this does not stabilize PTH level either.

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The level of vitamin D and parameters of calcium and phosphorus metabolism in primary school children living in the south of Bashkortostan

Kazan medical journal ◽

10.17750/kmj2015-752 ◽

2015 ◽

Vol 96 (5) ◽

pp. 752-756

Author(s):

E R Bikmetova ◽

I V Golovatskikh ◽

E V Kuznetsova ◽

V N Kozlov ◽

V G Ivanov

Keyword(s):

Vitamin D ◽

Primary School ◽

Vitamin D Deficiency ◽

School Children ◽

Calcium Intake ◽

Calcium Level ◽

Primary School Children ◽

Phosphorus Metabolism ◽

The South ◽

Calcium Phosphorus

Aim. Estimation of vitamin D level and calcium-phosphorus metabolism in urban and rural school children of 8-9 years old, living in the south of Bashkortostan. Methods. The study included two groups of 2-3 class pupils: 87 children living in Meleuz and 93 children of Meleuz Region (Zirgan village). The average age was 8.3±0.66 years. The following parameters were analyzed: serum levels of 25-hydroxyvitamin D, phosphorus, total calcium level, urine calcium level, and daily calcium intake. Results. 72.4% of children from Meleuz and 30.1% of rural children had vitamin D deficiency, subclinical vitamin D-deficiency was detected in 27.6 and 63% of primary school children, respectively. The average serum calcium level in schoolchildren living in town was somewhat lower than in rural residents (p=0.0012), and was close to the lower limit of the reference values. Serum phosphorus levels and urine calcium levels were within the physiological range in the examined children no matter of where they lived. The leading causes of calcium-phosphorus metabolism alterations are reduced calcium intake and vitamin D deficiency. Conclusion. The vast majority of primary school children on the south of Bashkortostan had vitamin D-deficiency or subclinical vitamin D-deficiency. Dietary calcium intake is 60 to 70% of the age norm, which is characterized as a moderate deficit.

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Vitamina D e rachitismo carenziale

Medico e Bambino ◽

10.53126/meb39426 ◽

2020 ◽

Vol 39 (7) ◽

pp. 426-429

Author(s):

Anna Agrusti ◽

Sarah Contorno ◽

Irene Bruno ◽

Giulia Gortani ◽

Egidio Barbi

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Vitamin D Supplementation ◽

High Dose ◽

The Sun ◽

Phosphorus Metabolism ◽

Calcium Phosphorus ◽

Vitamin D3 Supplementation ◽

First Year Of Life

Mouhamed, a 7-year-old boy of African origin, presented with progressive fatigue and difficulty in walking. He was never treated with vitamin D supplementation. The evaluation of his calcium-phosphorus metabolism revealed a myopathy related to severe rickets. Therefore, he was treated with high-dose vitamin D3 and myopathy and fatigue progressively resolved. Vitamin D plays a crucial role in the calcium-phosphorus metabolism, by acting on enterocytes, osteoclasts and renal tubule. Vitamin D deficiency is defined when the 25OHD value is less than 20 ng/ml. In order to guarantee the assumption of the minimum daily dose of vitamin D, it is recommended to start vitamin D3 supplementation in all newborns and infants in their first year of life, regardless of the feeding modality. Exposure to the sun is essential for the activation of vitamin D, so dark-skinned children and mothers or those little exposed to the sun should start vitamin D3 supplementation. Vitamin D3 should also be supplemented in children with cerebral palsy and in patients treated with anti-epileptic drugs. Other conditions at risk of vitamin D deficiency are inflammatory bowel disease, celiac disease, cystic fibrosis, obesity, liver failure, cholestasis and vegetarian or vegan diets. Classic signs of rickets are the rickety rosary, the widening of the wrist and the arching of the tibia. Severe hypocalcaemia secondary to vitamin D deficiency can occur with dilated cardiomyopathy or convulsions, especially in dark-skinned infants. Vitamin D deficiency should be considered in children with progressive myopathy or muscular weakness, especially in dark-skinned ones or in those poorly exposed to the sun for cultural or religious reasons.

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PROGRAMMING OF SKELETAL DEVELOPMENT IN CHILDREN: THE ROLE OF VITAMIN D

Osteoporosis and Bone Diseases ◽

10.14341/osteo2014331-33 ◽

2014 ◽

Vol 17 (3) ◽

pp. 31-33

Author(s):

L A Scheplyagina

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Mineral ◽

Skeletal Development ◽

Phosphorus Metabolism ◽

Mineral Density ◽

Working Age ◽

Calcium Phosphorus

Well known that the lack of vitamin D in mother leads to its deficiency in the fetus. Vitamin D deficiency in the fetus significantly increases the risk of disorders of calcium/phosphorus metabolism, decreases of size of ante - and postnatal skeleton of the child, and affects the child ’s growth, bone mineral density and increases the risk of fractures in working age.

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Association of vitamin D and osteocalcin levels in post-menopausal women with osteoporosis

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20170936 ◽

2017 ◽

Vol 6 (4) ◽

pp. 1244

Author(s):

Yogiraj Vaijanathrao Chidre ◽

Amir Babansab Shaikh

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Vitamin D Deficiency ◽

Fragility Fractures ◽

Bone Fragility ◽

Vitamin D Supplementation ◽

Mineral Density ◽

Age Related ◽

Calcium Phosphorus ◽

Post Menopausal

Background: Osteoporosis is a common age related problem especially in women, with a consequent increase in bone fragility and susceptibility to fracture. Apart from Calcium, another nutrient that plays an important role in the mineralization of skeleton in Vitamin D. Osteocalcin, which is produced primarily by osteoblasts during bone formation, is considered to be one of the markers for osteoporosis.Methods: 314 women above the age of 40 were included into the study. A thorough physical and clinical examination, assessment of vital parameters, anthropometry evaluation was done for all patients. Bone mineral density was calculated using central DXA osteodensitometer at lumbar spine L1-L4, hip and ultradistal radius (in some cases.). Blood samples were taken for the detection of ionized calcium, phosphorus, alkaline phosphatase, 25hydroxivitamin D (25 ODH) and serum parathyroid hormone (PTH) by chemiluminiscent assay. Bone markers such as osteocalcin were measured as required.Results: Out of the 314 women attending our OPD, 96 of them were diagnosed as having osteoporosis. 24 out of them had fragility fractures, mainly of the hip, and 82 had ostepenia. Elevated levels of calcium (8.96 mg/dl), parathyroid hormone (58.76 pg/ml) and osteocalcin (24.46 ng/ml) were observed. Vitamin D deficiency of ≤ 20 was seen in 59 (63%) of the cases, insufficient in 23 (24%) and only 12 (13%) of these women had normal Vitamin D levels.Conclusions: Osteocalcin is a promising marker for the detection of osteoporosis. There is a considerable Vitamin D deficiency among the women with osteoporosis, and it is under-treated. It is essential to provide Vitamin D supplementation to these women especially those who are at high risk for fragility fractures.

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Craniotabes in Normal Newborns: The Earliest Sign of Subclinical Vitamin D Deficiency

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-2254 ◽

2008 ◽

Vol 93 (5) ◽

pp. 1784-1788 ◽

Cited By ~ 71

Author(s):

Junko Yorifuji ◽

Tohru Yorifuji ◽

Kenji Tachibana ◽

Shizuyo Nagai ◽

Masahiko Kawai ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Urinary Calcium ◽

University Hospital ◽

X Rays ◽

Intact Pth ◽

Calcium Phosphorus ◽

Serum Pth ◽

Normal Neonates ◽

Breast Fed

Abstract Context: Craniotabes in otherwise normal neonates has been regarded as physiological and left untreated. Objective: Our objective was to investigate the role of vitamin D deficiency in the development of craniotabes in normal neonates. Design and Setting: Newborn screening of craniotabes was conducted at the single largest obstetrical facility in Kyoto, Japan. Follow-up study at 1 month was conducted at Kyoto University Hospital. Subjects: A total of 1120 consecutive normal Japanese neonates born in May, 2006, through April, 2007, were included in the study. Main Outcome Measures: The incidence of craniotabes was scored each month. Neonates with craniotabes were followed up at 1 month with measurements of serum calcium, phosphorus, alkaline phosphatase (ALP), intact PTH, 25-OH vitamin D (25-OHD), urinary calcium, phosphorus, creatinine, and hand x-rays. Results: Craniotabes was present in 246 (22.0%) neonates, and the incidence had obvious seasonal variations, highest in April-May and lowest in November. At 1 month, infants with craniotabes had significantly higher serum ALP compared with normal neonates; 6.9% of them had elevated intact PTH over 60 pg/ml, and 37.3% had 25-OHD less than 10 ng/ml. When separately analyzed according to the method of feeding, 56.9% of breast-fed infants showed 25-OHD less than 10 ng/ml, whereas none of formula/mixed-fed infants did, and breast-fed infants had significantly higher serum PTH and ALP compared with formula/mixed-fed infants. Summary: These results suggest that craniotabes in normal neonates is associated with vitamin D deficiency in utero, and the deficiency persists at 1 month in many of them, especially when breast-fed.

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The role of vitamin D dificiency in the development of pathology in women of perimenopausal age

HEALTH OF WOMAN ◽

10.15574/hw.2018.131.76 ◽

2018 ◽

pp. 76-79

Author(s):

Kh.V. Kozak ◽

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Neurological Diseases ◽

Research Direction ◽

Literary Sources ◽

Autoimmune Conditions ◽

Calcium Phosphorus ◽

The Relationship

The article presents an analysis of literary sources about contemporary views on the role of vitamin D deficiency in the health problems of women of the perimenopausal period. According to research data of recent years, vitamin D plays a role not only in the control of calcium-phosphorus metabolism, but also plays a role in the pathogenesis of cardiovascular and neurological diseases, insulin resistance and diabetes, in the development of cancer and autoimmune conditions, especially in women of perimenopausal age. It is important to continue the study of the relationship between vitamin D deficiency and menopausal and menopausal disorders. Currently, the existing principles and effectiveness of the correction of lack of vitamin D in improving the quality of life of women of perimenopausal age are ambiguously assessed, which determines the relevance of this research direction. Key words: perimenopausal period, insufficiency/deficiency of vitamin D.

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Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects

Journal of Lipids ◽

10.1155/2013/623420 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 20

Author(s):

Jaydip Ray Chaudhuri ◽

K. Rukmini Mridula ◽

Alluri Anamika ◽

Demudu Babu Boddu ◽

Pradeep Kumar Misra ◽

...

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase ◽

Vitamin D Deficiency ◽

Serum Glucose ◽

C Reactive Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

Calcium Phosphorus ◽

25 Hydroxyvitamin D ◽

Chemiluminescent Microparticle Immunoassay

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia.Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects.Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP).Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P=0.0001), mean serum glucose (P=0.0002) mean CRP (P=0.04), and mean alkaline phosphatase (P=0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5).Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

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