The role of vitamin D dificiency in the development of pathology in women of perimenopausal age

2018 ◽  
pp. 76-79
Author(s):  
Kh.V. Kozak ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Neurological Diseases ◽  
Research Direction ◽  
Literary Sources ◽  
Autoimmune Conditions ◽  
Calcium Phosphorus ◽  
The Relationship

The article presents an analysis of literary sources about contemporary views on the role of vitamin D deficiency in the health problems of women of the perimenopausal period. According to research data of recent years, vitamin D plays a role not only in the control of calcium-phosphorus metabolism, but also plays a role in the pathogenesis of cardiovascular and neurological diseases, insulin resistance and diabetes, in the development of cancer and autoimmune conditions, especially in women of perimenopausal age. It is important to continue the study of the relationship between vitamin D deficiency and menopausal and menopausal disorders. Currently, the existing principles and effectiveness of the correction of lack of vitamin D in improving the quality of life of women of perimenopausal age are ambiguously assessed, which determines the relevance of this research direction. Key words: perimenopausal period, insufficiency/deficiency of vitamin D.

scholarly journals Assessment of vitamin D among Sudanese Patients with Hypothyroidism

2021 ◽  
Vol 1 (2) ◽  
pp. 057-061
Author(s):  
Hasna Osman Fadalla Mohamed ◽  
Omer Fadol Edris ◽  
Gad Allah Modawe ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Control Hospital ◽  
Study Population ◽  
Thyroid Profile ◽  
Methods Analytical ◽  
The Relationship

Background: Vitamin D deficiency is a worldwide health issue and its role as an immune modulator has recently been emphasized. Evidence increasingly indicates the important role of vitamin D in reducing the incidence of autoimmune diseases. However, at this time the search for its role in autoimmune diseases and thyroid is not critical. Objectives: The study aimed to assess the relationship between vitamin D deficiency in Sudanese patients with hypothyroidism. Methods: Analytical case control hospital based study, conducted in Fadil Hospital and Police Hospital, Khartoum city, Khartoum state. The study carried out from March 2018 to September 2018. A total of 100 subjects were enrolled in the study. Vitamin D deficiency was set at levels below 20 ng / ml. Thyroid hormones (TSH, T3 and T4) were assessed in all participants using auto analyzer TOSOH AIA 313,while vitamin D was estimated using ELIZA. The data were analyzed using SPSS version (21). Results: The study included 76(76%) females and 24(24%) males, no significance differences between thyroid profile among study population.75 (75%) deficiency of vitamin D and 25(25%) normal vitamin D. vitamin D deficiency was significantly lower in female than male with( p =0.001). Conclusion: The results indicated that patients with hypothyroidism suffer from vitamin D deficiency significantly associated with the degree and severity of hypothyroidism. This encourages the desirability of vitamin D supplementation and recommends the detection of vitamin D deficiency for all hypothyroidism patients.

THE ROLE OF VITAMIN D IN THE PATHOGENESIS OF THE ARTERIAL HYPERTENSION

2020 ◽  
Vol 65 (1) ◽  
pp. 5-10
Author(s):  
N. L. Lystsova ◽  
Tatiana Ivanovna Petelina ◽  
L. I. Gapon ◽  
K. S. Avdeeva ◽  
S. G. Bucova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Hypertension ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Hormonal Status ◽  
Age Changes ◽  
Numerous Data ◽  
Mechanisms Of Development ◽  
The Relationship

In recent years, accumulated numerous data on the pathogenetic links of the formation of arterial hypertension. A number of studies have shown that vitamin D deficiency, associated with age, changes in sex hormonal status, increased tone of the renin-angiotensin-aldosterone system, endothelial dysfunction, and calcium metabolism, can be one of the mechanisms of development and progression of arterial hypertension. The purpose of the review was to summarize the results of the original domestic and foreign studies, prospective observations and meta-analyzes on the relationship between vitamin D deficiency and arterial hypertension.

scholarly journals Vitamin D Deficiency in Children with Chronic Renal Disease

2021 ◽  
Vol 9 (B) ◽  
pp. 1751-1757
Author(s):  
S. B. Dyussenova ◽  
M. Y. Gordiyenko ◽  
G. B. Serikova ◽  
S. A. Turlybekova ◽  
A. A. Issayeva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Growth ◽  
Chronic Renal Disease ◽  
Immune Disorders ◽  
Increased Risk ◽  
The Relationship ◽  
Increased Susceptibility

BACKGROUND: Vitamin D is essential for children and adults for healthy bone growth. Lack of this vitamin in children can cause rickets, and in adults, softening of the bones and an increased risk of fractures. Vitamin D deficiency can cause immune disorders, increased susceptibility to infections, the development of certain types of cancer, diabetes mellitus, and cardiovascular diseases. AIM: The article presents the literature data and the results of our own research on the analysis of the relationship between chronic kidney disease (CKD) and Vitamin D provision in children from 1 to 17 years old. The aim of the study was to establish the level of Vitamin D in children with different stages of CKD. METHODS: Between January 2020 and September 2020, we examined 40 children (16 boys and 24 girls). The patients’ age ranged from 1 to 17 years inclusive. RESULTS: Vitamin D deficiency was found in 62.5% of children with CKD. Vitamin D deficiency was noted in 25% of cases. The prevalence of Vitamin D deficiency correlates with a decrease in glomerular filtration rate. CONCLUSION: Determination of Vitamin D level in children with CKD is important for timely correction and prevention of further progression of CKD. Timely substitution therapy will improve the quality of life of a child with CKD and prevent the development of complications.

scholarly journals Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders

Folia Medica ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 5-10
Author(s):  
Presiyana V. Nyagolova ◽  
Mitko D. Mitkov ◽  
Maria M. Orbetsova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Abstract The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome. The goal of the review is to present contemporary concepts of the relationship between hormones affecting the metabolic body status, serum vitamin D levels and the reproductive function.

Analysis of the association of polymorphisms CASR and VDR with the development of nephrolithiasis in patients with primary hyperparathyroidism

2016 ◽  
Vol 61 (5) ◽  
pp. 4-8 ◽  
Author(s):  
Elena Viktorovna Peretokina ◽  
Ekaterina Aleksandrovna Pigarova ◽  
Natal'ya Georgievna Mokrysheva ◽  
Lyudmila Yakovlevna Rozhinskaya ◽  
Galina Viktorovna Baydakova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphisms ◽  
Restriction Analysis ◽  
Phosphorus Metabolism ◽  
Chain Reaction ◽  
Calcium Phosphorus ◽  
Polymerase Chain ◽  
Relationship Of ◽  
The Relationship

Pathogenesis of nephrolithiasis (NL) at PHPT is not fully understood. Meanwhile, the detection of NL patients with PHPT is an absolute indication for parathyroidectomy. Conducted various studies aimed at finding a predictor of NL patients with PHPT. Actively study the role of genetic markers, particularly genes that regulate calcium-phosphorus metabolism.Objective — to assess the relationship of polymorphisms CASR and VDR with the development of the NL at PHPТ.Material and methods. A study to include 203 patients with confirmed PHPT, out of which 114 patients had the NL and 87 patients without NL. All patients were studied indicators calcium-phosphorus metabolism, the study of the level of PTH, vitamin D, the filtration function of the kidneys. All patients were studied indicators calcium-phosphorus metabolism, the level of PTH, vitamin D, the filtration function of the kidneys. The study of gene polymorphisms VDR (FokI, TaqI, BsmI, ApaI, Cdx2) was performed in 169 patients (113 with NL, 56 without NL) by polymerase chain reaction followed by restriction analysis; Study 3 polymorphisms CASR (A986S, R990G, Q1011E) was performed in 187 patients (110 with NL, 77 without NL), by direct sequencing.Results. No significant differences in the frequency of genotypes and alleles studied genes between the two groups has been received. According to logistic regression analysis, the only predictor of NL is the level of ionized calcium.Conclusions. The studied genes can not be used as predictors of the NL. May need to investigate other genes.

scholarly journals Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1378
Author(s):  
Francesco Palmese ◽  
Rossella Del Toro ◽  
Giulia Di Marzio ◽  
Pierluigi Cataleta ◽  
Maria Giulia Sama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Nutrient Deficiencies ◽  
Pathological Conditions ◽  
High Prevalence ◽  
The Relationship

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions.

scholarly journals The Role of Vitamin D in Cognitive Disorders in Older Adults

US Neurology ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 41 ◽  
Author(s):  
Jake Gold ◽  
Abdullah Shoaib ◽  
Gopinath Gorthy ◽  
George T Grossberg
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cognitive Disorders ◽  
Normal Brain ◽  
Brain Functions ◽  
Synaptic Structure ◽  
Calcium Phosphorus ◽  
And Function

The physiological effects of vitamin D on calcium/phosphorus metabolism have been well studied since its discovery in the early 20th century. With recent advances in cellular and molecular biology, its role in maintaining normal brain functions and the protection of neurons via maintenance of cellular homeostasis, immune regulation, modulation of synaptic structure and function are more clearly known. Recently, its deficiency is increasingly implicated in major neurocognitive disorders including Alzheimer’s disease, Parkinson’s disease, and vascular dementia. Older adults are particularly vulnerable not only because vitamin D deficiency becomes more prevalent with aging, but they also are often complicated with other comorbid illnesses. This article reviews the role of vitamin D in maintaining normal brain functions, and implications for vitamin D deficiency in cognitive disorders.

scholarly journals PROGRAMMING OF SKELETAL DEVELOPMENT IN CHILDREN: THE ROLE OF VITAMIN D

2014 ◽  
Vol 17 (3) ◽  
pp. 31-33
Author(s):  
L A Scheplyagina
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Skeletal Development ◽  
Phosphorus Metabolism ◽  
Mineral Density ◽  
Working Age ◽  
Calcium Phosphorus

Well known that the lack of vitamin D in mother leads to its deficiency in the fetus. Vitamin D deficiency in the fetus significantly increases the risk of disorders of calcium/phosphorus metabolism, decreases of size of ante - and postnatal skeleton of the child, and affects the child ’s growth, bone mineral density and increases the risk of fractures in working age.

Vitamin D and chronic spontaneous urticaria: searching for algorithms of personalized therapy

2021 ◽  
Vol 17 (4) ◽  
pp. 95-101
Author(s):  
Ilya V. Kukes ◽  
Elena Yu. Borzova ◽  
Natalya M. Nenasheva ◽  
Dmitriy A. Sychev
Keyword(s):  
Vitamin D ◽  
Genetic Variability ◽  
Vitamin D Deficiency ◽  
Patient Management ◽  
Chronic Spontaneous Urticaria ◽  
Vitamin D Binding Protein ◽  
Vitamin D Metabolism ◽  
Vitamin D Levels

Today, we can see a great interest in vitamin D because it participates in the regulation of many metabolic processes, and its deficiency is associated with the development of various diseases. Chronic spontaneous urticaria (CSU) is the disease that affects the quality of patients life, and the existing strategy of patient management is not always sufficiently effective. Nowadays, there is enough information about the role of vitamin D deficiency and the severity of CSU. That is why it is important to study not only therapeutic schemes, but also a role of genetic variability that may have an impact on vitamin D levels. Such studies will help to personalize the treatment schemes for patients with CSU. At the same time, the focus of these studies should be not only on the receptor and vitamin D binding protein, but also on P450 system, which plays a key role in the vitamin D metabolism.

scholarly journals Vitamin D deficiency during late pregnancy mediates placenta-associated complications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tiphaine Raia-Barjat ◽  
Camille Sarkis ◽  
Florence Rancon ◽  
Lise Thibaudin ◽  
Jean-Christophe Gris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Late Onset ◽  
Late Pregnancy ◽  
Vitamin D Insufficiency ◽  
Multicenter Cohort Study ◽  
Vitamin D Levels ◽  
The One ◽  
The Relationship

AbstractDuring pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high risk. A prospective multicenter cohort study of 200 pregnant patients was conducted. The vitamin D level of patients with placenta-mediated complications was lower at 32 weeks compared to uncomplicated pregnancies (P = 0.001). At 32 weeks, the risk of occurrence of PMCs was five times higher in patients with vitamin D deficiency (RR: 5.14 95% CI (1.50–17.55)) compared to patients with normal vitamin D levels. There was a strong, inverse relationship between serum 25(OH)D levels at 32 weeks and the subsequent risk of PMCs (P = 0.001). At 32 weeks, the vitamin D level of patients with late-onset PMCs was lower than the one of patients with early-onset PMCs and of patients without PMCs (P < 0.0001). These results suggest a role of vitamin D in the maintenance of placental performance and therefore in the prevention of the onset of late PMC.

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