Impact of air pollution on health has become an important social issue. Air pollution is closely related to the morbidity and death rate of cardiopulmonary disease, produces short-term acute and chronic hazards on health, and especially has long-term and profound impact on primary and secondary school students’ constitution. Long-term effects of air pollution on cardiopulmonary function of primary and secondary school students are represented as incidence increase of asthma, decrease of FEV1, MMEF, VO2max, MVV and other indicators and relation to NO, PM2.5 and CO. Students taking exercise in air pollution environment can cause acute cardiopulmonary reactions, such as abnormal changes of MVV, VC, FEV1, FVC and other indicators after exercise, which may relate to O3, PM10, PM2.5, SO2and NO2. Therefore, schools should strengthen the awareness of air pollution in implementing sports, and conduct development of control measures, to ensure the effect of physical exercise.