scholarly journals Gastric cancer in East Azerbaijan, Iran: Five-year survival analysis of population-based cancer registry results

2020 ◽  
Vol 7 (11) ◽  
pp. 4114-4121
Author(s):  
Pooneh Jabbaripour ◽  
Mohammad Hossein Somi ◽  
Hossein Mashhadi Abdolahi ◽  
Roya Dolatkhah
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Cancer Registry ◽  
Survival Data ◽  
Cox Regression ◽  
Survival Function ◽  
Population Based ◽  
Rank Test ◽  
Cancer Data ◽  
East Azerbaijan

Introduction: Gastric cancer is the most common cancer with significant increasing trends during the last decade in Iran. The aim of this study was to evaluate the epidemiologic profile of gastric cancer along with gastric cancer-specific survival analysis. Methods: This was an analytical cross-sectional study in which all gastric cancer data were analyzed using the database of the East Azerbaijan Population-Based Cancer Registry (EA-PBCR). The incidents of definitive gastric cancer diagnosis were between the period of March 20th, 2015 to March 19th, 2017 ( = 3 Iranian solar years). The survival analysis was performed using the Kaplan-Meier method and life tables for 1- to 5-year survival data. The Log-rank test and Cox regression were computed to test the equality of survival function and mortality hazard. Results: Overall, 2,631 newly diagnosed gastric cancer cases were registered for 3 years. Gastric cancer was 2.35 times more common in men than women. The most common age group was the 7th decade- with 531 (31.2%) gastric cancer cases. Most of the gastric cancer cases were non-cardia (n = 2,244, 85.29%) cancer, and the proportion of non-cardia to cardia gastric cancer was 5.8:1. Overall survival was 60.1%, and 1- to 5-year survival proportions were 91.61%, 64.21%, 58.53%, 30.14% and 24.77%, respectively. Cardia cancers had a worse survival rate than non-cardia cancers, and the hazard of mortality was 1.33 times higher in cardia than non-cardia cancers (hazard ratio or HR = 1.33; 95% CI: 1.05 - 1.68; P = 0.017). Conclusion: Non-cardia gastric cancer is still the most dominant subsite in East Azerbaijan, Iran. There was a higher 1- to 5- year survival proportion in East Azerbaijan, with lower overall mortality rates, compared to other regions of Iran.

scholarly journals Epidemiological aspects of colorectal cancer in East Azerbaijan, Northwest Iran: five year survival analysis

2021 ◽  
Vol 40 (3) ◽  
pp. 190-199
Author(s):  
Ramin Barnous ◽  
Mohammad Hossein Somi ◽  
Zohreh Sanaat ◽  
Pooneh Jabbaripoor ◽  
Neda Dolatkhah ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Analysis ◽  
Survival Analysis ◽  
Cox Regression ◽  
Survival Function ◽  
Rank Test ◽  
Female Ratio ◽  
Cox Regression Analysis ◽  
Common Cancer ◽  
East Azerbaijan

BackgroundColorectal cancer (CRC) is the third most common cancer and the second leading cause of death from cancer in the world. Currently, CRC is the fourth most common cancer in men and the second common cancer in women of all ages in Iran. The aim of this study was to determine the epidemiologic profile of CRC along with CRC specific survival analysis. MethodsThis was an analytical cross-sectional study using the East Azerbaijan Population Based Cancer Registry database (EA-PBCR) as a source for data related to patients with a diagnosis of CRC. Colorectal cancer specific 1- to 5-year survival analysis and mortality rates were calculated. Log-rank test and Cox regression analysis was performed to test the equality of survival function and mortality hazard. ResultsA total of 2,366 newly diagnosed CRCs were registered during 3 years, with a male: female ratio of 1.31. Overall survival rate was 49.8%. One- to 5-year survival rates were 96.21%, 56.94%, 48.62%, 47.88% and 46.76% respectively. At multivariate level, after adjusting for all variables, regression analysis showed that the hazard of mortality in stage IV cancers was 46.44 times higher than that in stage I cancers (HR=46.44, 95% CI: 14.86-145.14, p=0.000). However, differences in patients’ age group and sex and the subsite of cancer did not create any statistically significant variation between groups in regards to mortality hazards (p>0.05). ConclusionThis study demonstrated that the stage and grade of CRC were important prognostic factors and that early screening and diagnosis of CRC were essential.

scholarly journals Proportion and Prognosis of Bone Metastases from Gastric Cancer in SEER database

2019 ◽  
Author(s):  
zepang sun ◽  
Hao Chen ◽  
Zhen Han ◽  
Jiang Yu ◽  
Weicai Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Bone Metastases ◽  
Cox Regression ◽  
Cox Model ◽  
Population Based ◽  
Rank Test ◽  
Seer Database ◽  
Entire Cohort ◽  
Kaplan Meier

Abstract Purpose The purpose of this study was to analyze the proportion and prognosis of bone metastases at diagnosis of gastric cancer using population-based data from SEER. Patients and methods Patients with gastric cancer and bone metastases (GCBM) at the time of diagnosis in advanced gastric cancer were identified using the Surveillance, Epidemiology and End Result (SEER) database of the National Cancer Institute. Multivariable logistic and Cox regression were performed to identify predictors of the presence of GCBM at diagnosis and factors associated with all-cause mortality and gastric cancer-specific mortality. Survival curves were obtained according to the Kaplan-Meier method and compared using the log-rank test. Results We identified 975 patients with gastric cancer and bone metastases at the time of diagnosis, representing 5.31% of the entire cohort and 13.35% of the subset with metastatic disease to any distant site. Among entire cohort, multivariable logistic regression identified five factors (lower age, diffused-type, adverse pathology grade, N1 staging and presence of more extraosseous metastases to liver, lung and brain.) as positive predictors of the presence of bone metastases at diagnosis. Median survival among the entire cohort with GCBM was 4.0 months (interquartile range: 1.0-8.0mo). Multivariable Cox model in SEER cohort confirmed two factors (non-cardia stomach and absence of chemotherapy) as negative predictors for overall survival. We also found poor survival in non-surgical patients using Fine and Gray’s competing risk regression model. Conclusion The findings of this study provided population-based estimates of the proportion and prognosis for GCBM at time of diagnosis. These findings provided guidance for screening and treatment of GCBM patients. Chemotherapy may make benefit for overall survival, but the role of surgery remained to be determined by further research.

scholarly journals Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Bioinformatics Analysis

2021 ◽  
Author(s):  
Ya-zhen Zhu ◽  
Yi Liu ◽  
Xi-wen Liao ◽  
Shan-shan Luo
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Cox Regression ◽  
Gene Set Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Rank Test ◽  
Poor Overall Survival ◽  
Qrt Pcr ◽  
A Genome ◽  
A Disintegrin And Metalloproteinase

Objective: We aimed to explore the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes in gastric cancer (GC). Methods: The RNA-sequencing (RNA-seq) expression data for 351 GC patients and other relevant clinical data was acquired from The Cancer Genome Atlas (TCGA). Survival analysis and a genome-wide gene set enrichment analysis (GSEA) were performed to define the underlying molecular value of the ADAMTS genes in GC development. Besides, qRT-PCR and immunohistochemistry were all employed to validate the relationship between the expression of these genes and GC patient prognosis. Results: The Log rank test with both Cox regression and Kaplan–Meier survival analysis showed that ADAMTS6 expression profile correlated with the GC patients clinical outcome. Patients with a high expression of ADAMTS6 were associated with poor overall survival (OS). Comprehensive survival analysis of the ADAMTS genes suggests that ADAMTS6 might be an independent predictive factor for the OS in patients with GC. Besides, GSEA demonstrated that ADAMTS6 might be involved in multiple biological processes and pathways, such as the vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), tumor protein P53, c-Jun N-terminal kinase (JNK), cadherin (CDH1) or tumor necrosis factor (TNF) pathways. It was also confirmed by immunohistochemistry and qRT-PCR that ADAMTS6 is highly expressed in GC, which may be related to the prognosis of GC patients. Conclusions: In summary, our study demonstrated that ADAMTS6 gene could be used as a potential molecular marker for GC prognosis.

scholarly journals Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Integrating Analysis of Gene Expression Profile

2020 ◽  
Author(s):  
Ya-zhen Zhu ◽  
Yi Liu ◽  
Xi-wen Liao ◽  
Xian-wei Mo ◽  
Yuan Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Expression Profile ◽  
Cox Regression ◽  
Gene Set Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Rank Test ◽  
Poor Overall Survival ◽  
A Genome ◽  
A Disintegrin And Metalloproteinase

Abstract Objective: We aimed to explore the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes in gastric cancer (GC).Methods: The RNA-sequencing (RNA-seq) expression data for 351 GC patients and other relevant clinical data was acquired from The Cancer Genome Atlas (TCGA). Survival analysis and a genome-wide gene set enrichment analysis (GSEA) were performed to define the underlying molecular value of the ADAMTS genes in GC development.Results: The Log rank test with both Cox regression and Kaplan–Meier survival analysis showed that ADAMTS6 expression profile correlated with the GC patients’ clinical outcome. Patients with a high expression of ADAMTS6 were associated with poor overall survival (OS). Comprehensive survival analysis of the ADAMTS genes suggests that ADAMTS6 might be an independent predictive factor for the OS in patients with GC. Besides, GSEA demonstrated that ADAMTS6 might be involved in multiple biological processes and pathways, such as the vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), tumor protein P53, c-Jun N-terminal kinase (JNK), cadherin (CDH1) or tumor necrosis factor (TNF) pathways.Conclusions: In summary, our study demonstrated that ADAMTS6 gene could be used as a potential molecular marker for GC prognosis.

scholarly journals EAST AZERBAIJAN POPULATION BASED CANCER REGISTRY DURING 2015 TO 2016: PRELIMINARY REPORT

2017 ◽  
Vol 2 (2) ◽  
pp. 179-179
Author(s):  
Mohammad Hossein Somi ◽  
Roya Dolatkhah ◽  
Sepideh Sepahi ◽  
Mina Belalzadeh ◽  
Leila Abdollahi ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Preliminary Report ◽  
Population Based ◽  
East Azerbaijan

scholarly journals Liver Metastases in Newly Diagnosed Pancreatic Ductal Adenocarcinoma: A Population Based Analysis

2020 ◽  
Author(s):  
Guoyi Wu ◽  
Xiaoben Pan ◽  
Baohua Wang ◽  
Xiaolei Zhu ◽  
Jing Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Metastases ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Tumor Size ◽  
Cox Regression ◽  
Population Based ◽  
The Body ◽  
Ductal Adenocarcinoma ◽  
Rank Test ◽  
Factors Associated

Abstract Background Estimates of the incidence and prognosis of developing liver metastases at the pancreatic ductal adenocarcinoma (PDAC) diagnosis are lacking.Methods In this study, we analyzed the association of liver metastases and the PDAC patients outcome. The risk factors associated with liver metastases in PDAC patients were analyzed using multivariable logistic regression analysis. The overall survival (OS) was estimated using Kaplan-Meier curves and log-rank test. Cox regression was performed to identify factors associated with OS.Results Patients with primary PDAC in the tail of the pancreas had a higher incidence of liver metastases (62.2%) than those with PDAC in the head (28.6%). Female gender, younger age, primary PDAC in the body or tail of the pancreas, and larger primary PDAC tumor size were positively associated with the occurrence of liver metastases. The median survival of patients with liver metastases was significantly shorter than that of patients without liver metastases. Older age, unmarried status, primary PDAC in the tail of the pancreas, and tumor size ≥4 cm were risk factors for OS in the liver metastases cohort.Conclusions Population-based estimates of the incidence and prognosis of PDAC with liver metastases may help decide whether diffusion-weighted magnetic resonance imaging should be performed in patients with primary PDAC in the tail or body of the pancreas. The location of primary PDAC should be considered during the diagnosis and treatment of primary PDAC.

scholarly journals Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
R. A. Snyder ◽  
E. T. Castaldo ◽  
C. E. Bailey ◽  
S. E. Phillips ◽  
A. B. Chakravarthy ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Radiation Therapy ◽  
Gastric Adenocarcinoma ◽  
Survival Benefit ◽  
Cox Regression ◽  
Population Based ◽  
Adjuvant Radiation ◽  
Extended Lymphadenectomy ◽  
Factors Affecting ◽  
Gastric Cancer Patients

Purpose. Although randomized trials suggest a survival benefit of adjuvant chemotherapy and radiation therapy (XRT) for gastric adenocarcinoma, its use in patients who undergo an extended lymphadenectomy is less clear. The purpose of this study was to determine if a survival benefit exists in gastric cancer patients who receive adjuvant XRT following resection with extended lymphadenectomy.Methods. The SEER registry was queried for records of patients with resected gastric adenocarcinoma from 1988 to 2007. Multivariable Cox regression models were used to assess independent prognostic factors affecting overall survival (OS) and disease-specific survival (DSS).Results. Of 15,060 patients identified, 3,208 (21%) received adjuvant XRT. Adjuvant XRT was independently associated with improved OS (HR 0.67, CI 0.64–0.71) and DSS (HR 0.69, CI 0.65–0.73) in stages IB through IV (M0). This OS and DSS benefit persisted regardless of the extent of lymphadenectomy. Furthermore, lymphadenectomy with >25 LN resected was associated with improved OS and DSS compared with <15 LN or 15–25 LN.Conclusion. This population-based study shows a survival benefit of adjuvant XRT following gastrectomy that persists in patients who have an extended lymphadenectomy. Furthermore, removal of >25 LNs results in improved OS and DSS compared with patients who have fewer LNs resected.

Co-expression of CMTM6 and PD-L1: a novel prognostic indicator of gastric cancer

2020 ◽  
Author(s):  
Chao Zhang ◽  
Wen An ◽  
Yuen Tan ◽  
Huimian Xu
Keyword(s):  
Gastric Cancer ◽  
Survival Data ◽  
Transmembrane Domain ◽  
Prognostic Indicator ◽  
Clinicopathological Characteristics ◽  
High Expression ◽  
Rank Test ◽  
Chi Square ◽  
Borrmann Type ◽  
Chi Square Test

Abstract Background CKLF Like MARVEL Transmembrane Domain Containing 6 (CMTM6) is involved in the epigenetic regulation of genes and tumorigenesis. Programmed cell death ligand 1 (PD-L1) is closely related to the prognosis of some human cancers. CMTM6 is a key regulator of PD-L1 in many cancers. The purpose of this study was to investigate the expressions of these proteins in gastric cancer and the correlations with clinicopathological features and survival. Methods The expression levels of CMTM6 and PD-L1 were examined in 185 gastric cancer specimens by immunohistochemistry. Chi-square test was used to analyze the relationship between CMTM6 and PD-L1 expressions and clinicopathological characteristics. Kaplan-Meier method and log-rank test were used to analyze the survival data of patients.Results The positive expression rates of CMTM6 and PD-L1 were 78.38% (145/185) and 75.68% (140/185), respectively. High expression of CMTM6 and PD-L1 was correlated with Borrmann type ( P < 0.001), N stage ( P = 0.002), peritoneal metastasis ( P = 0.007) and TNM stage ( P = 0.038). The expression of CMTM6 and PD-L1 in gastric cancer tissues was positively correlated (Pearson's coefficient test, r = 0.260; P < 0.001). High expression of CMTM6 was correlated with poor prognosis (HR = 1.668; 95% CI = 1.032–2.695; P = 0.037). High expression of both CMTM6 and PD-L1 could be used as an independent factor for overall survival (HR = 1.554; 95% CI = 1.011–2.389; P = 0.044). Conclusions The combined detection of CMTM6 and PD-L1 may be used as an indicator for judging the prognosis of gastric cancer.

164 Hispanic Ethnicity and Socioeconomic Status are Independently Associated with Improved Prognosis in Glioblastoma Patients

Neurosurgery ◽  
2017 ◽  
Vol 64 (CN_suppl_1) ◽  
pp. 241-241
Author(s):  
Kevin J Moore ◽  
Angela Richardson ◽  
Tulay Koru-Sengul ◽  
Michael E Ivan
Keyword(s):  
Socioeconomic Status ◽  
Race And Ethnicity ◽  
Cox Regression ◽  
The United States ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Hispanic Ethnicity ◽  
Cancer Data ◽  
Hispanic Patients

Abstract INTRODUCTION Significant racial and social disparities have previously been identified in outcomes from glioblastoma. Although some epidemiologic studies have shown Hispanic ethnicity to be protective, other studies have not replicated this finding. As many studies do not consider race separately from ethnicity, the role of Hispanic ethnicity in glioblastoma survival is not well understood. Florida has one of the largest Hispanic populations in the United States. Using a population-based cancer database, this study examines sociodemographic and survival disparities in glioblastoma patients. METHODS Data from the Florida Cancer Data System (FCDS) and the US Census were linked for adult (>18 yrs) glioblastoma patients to determine disease burden and survival. A multivariable Cox regression model was used to model patient survival adjusting for sociodemographic, tumor, and clinical characteristics. Adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) were calculated for overall sample. All statistical analyses were completed with SAS v.9.4. RESULTS >In total, 16,180 Florida adults were diagnosed with glioblastoma between 1981 and 2013. The majority were male (56.0%) and white (93.0%), and 11.2% of glioblastoma patients identified as Hispanic with 2.4% self-identifying as Cuban. Hispanics had significantly better survival compared to non-Hispanics (aHR 0.84; 95% CI 0.78 0.90). Current smokers fared significantly worse (aHR 1.11; 95% CI 1.04 1.18). Higher socioeconomic status was also associated with increased survival (aHR 0.91, 95% CI 0.84 0.99). Younger age at diagnosis, surgical resection, chemotherapy, radiation therapy, and female sex were also associated with significantly improved outcomes. CONCLUSION This study demonstrates clear sociodemographic and survival disparities for glioblastoma patients. This analysis considers race and ethnicity as two distinct variables and shows improved survival outcomes for Hispanic patients. Additionally patients from neighborhoods with higher socioeconomic status have increased survival. Further analysis is needed to assess the role of histologic and molecular subtypes in these ethnic groups.

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