TREATMENT OF MALIGNANT SYMPATHETIC TUMORS IN CHILDREN: CLINICOPATHOLOGICAL CORRELATION

PEDIATRICS ◽  
1968 ◽  
Vol 41 (2) ◽  
pp. 452-462
Author(s):  
Carlos A. Perez ◽  
Teresa J. Vietti ◽  
Lauren V. Ackerman ◽  
Panja Kulapongs ◽  
William E. Powers
Keyword(s):  
Distant Metastasis ◽  
Advanced Disease ◽  
Chemotherapeutic Agents ◽  
Primary Role ◽  
Clinicopathological Correlation ◽  
Cure Rate ◽  
Factors Affecting ◽  
Results Of Treatment ◽  
Methods Of Treatment

The results of treatment in a series of 46 children with malignant sympathetic tumors are reported with an absolute cure rate of 47% at 2 years and 46% at 5 years. Thirty-two percent of the patients with distant metastasis have survived tumor free 2 years or longer. Factors affecting the prognosis and the various methods of treatment are analyzed. Aggressive radiation therapy of these patients is advocated, depending on their clinical condition, even in the presence of distant metastasis. The primary role of irradiation in the sterilization of these malignant sympathetic tumors is postulated. Chemotherapy with cyclophosphamide and vincristine produced only transient regression of some of the tumors, with limited palliative results. The indication of chemotherapeutic agents is questioned in the treatment of patients with localized tumor because it is felt that this may impair the host resistance of the patient. Intensive chemotherapy may adversely affect survival, although admittedly all patients receiving this form of therapy had far advanced disease.

Treatment of Carcinoma of the Epiglottis

1981 ◽  
Vol 90 (5) ◽  
pp. 442-448 ◽  
Author(s):  
Joseph B. Nadol
Keyword(s):  
Squamous Cell Carcinoma ◽  
Thyroid Cartilage ◽  
Nodal Metastases ◽  
Primary Squamous Cell Carcinoma ◽  
Cure Rate ◽  
Results Of Treatment ◽  
Anterior Extension ◽  
Cure Rates ◽  
Initial Staging

One hundred five cases of primary squamous cell carcinoma of the epiglottis were reviewed and the results of treatment compared. The cure rate by radiation therapy for epiglottic carcinomas, both suprahyoid and infrahyoid, was poorer than previously reported cure rates for all supraglottic carcinomas (p<0.01). This may be due to unsuspected anterior extension of infrahyoid tumors into the preepiglottic space and thyroid cartilage. The cure rate (five years with no evidence of disease) for suprahyoid lesions was superior to that of infrahyoid lesions for all stages of primary size and nodal metastases and for all treatments. It is suggested that initial staging of primary epiglottic carcinomas should include the designation of suprahyoid or infrahyoid. The role of xeroradiography as an adjunct to staging and the implications for treatment are discussed.

scholarly journals Embryogenesis and Applications of Fingerprints- a review

2017 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Adamu LH ◽  
Taura MG
Keyword(s):  
Genetic Factors ◽  
In Utero ◽  
Personal Identification ◽  
Primary Role ◽  
Medical Sciences ◽  
Factors Affecting ◽  
Identification Processes ◽  
Diet And Lifestyle

Fingerprint is an impression made by the friction ridges that are almost parallel at constant crest to crest wavelength. The pattern is dominated by central features, such as whorls, loops, arches and triradii. Fingerprints have been used for several decades in forensic and medical sciences. The fingerprints characteristics such uniqueness, consistency and universality are the main features that are used by forensic experts in identification processes, are well developed during intra-uterine life. Understanding embryogenesis of fingerprints is essential in linking its features to some disease conditions. The purpose of this review was to highlight information regarding establishment, formation, hypotheses and factors affecting fingerprints. Applications of the fingerprints in forensic and medical sciences were also highlighted. Both environmental (in utero) and genetic factors have role to play in the formation of the fingerprints. The primary role of fingerprints is personal identification; these can be achieved through revealing sex, ethnicity, diet and lifestyle of an individual. In another perspective the fingerprints can be used as tools in diagnosis and ascertaining presence of disease conditions, however, this is population specific.

Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: relevance to redox signalling in apoptosis

2004 ◽  
Vol 71 ◽  
pp. 97-106 ◽  
Author(s):  
Mark Burkitt ◽  
Clare Jones ◽  
Andrew Lawrence ◽  
Peter Wardman
Keyword(s):  
Cytochrome C ◽  
Hydroxyl Radical ◽  
Redox Regulation ◽  
Chemotherapeutic Agents ◽  
Tyrosyl Radical ◽  
Compound I ◽  
Definitive Evidence ◽  
Enhanced Production ◽  
Physico Chemical

The release of cytochrome c from mitochondria during apoptosis results in the enhanced production of superoxide radicals, which are converted to H2O2 by Mn-superoxide dismutase. We have been concerned with the role of cytochrome c/H2O2 in the induction of oxidative stress during apoptosis. Our initial studies showed that cytochrome c is a potent catalyst of 2′,7′-dichlorofluorescin oxidation, thereby explaining the increased rate of production of the fluorophore 2′,7′-dichlorofluorescein in apoptotic cells. Although it has been speculated that the oxidizing species may be a ferryl-haem intermediate, no definitive evidence for the formation of such a species has been reported. Alternatively, it is possible that the hydroxyl radical may be generated, as seen in the reaction of certain iron chelates with H2O2. By examining the effects of radical scavengers on 2′,7′-dichlorofluorescin oxidation by cytochrome c/H2O2, together with complementary EPR studies, we have demonstrated that the hydroxyl radical is not generated. Our findings point, instead, to the formation of a peroxidase compound I species, with one oxidizing equivalent present as an oxo-ferryl haem intermediate and the other as the tyrosyl radical identified by Barr and colleagues [Barr, Gunther, Deterding, Tomer and Mason (1996) J. Biol. Chem. 271, 15498-15503]. Studies with spin traps indicated that the oxo-ferryl haem is the active oxidant. These findings provide a physico-chemical basis for the redox changes that occur during apoptosis. Excessive changes (possibly catalysed by cytochrome c) may have implications for the redox regulation of cell death, including the sensitivity of tumour cells to chemotherapeutic agents.

Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

Sports Photography and Historical Development

2018 ◽  
Vol 5 (1) ◽  
pp. 93-115
Author(s):  
Miloš Stamenković
Keyword(s):  
Historical Development ◽  
Emotional Reaction ◽  
Main Role ◽  
Primary Role

SummarySports photography undoubtedly has a significant place in sports press and publicism. It’s main and primary role is to present sports to the readers as art, which it is. Sport is characterized by dynamic and varied movements, and the main role of sports photography is reflected in the fact that it is in this way that sport shows its essence. Having in mind that photography tells more than a thousand words it sends a clear message to the reader as well to people who are informed about events via sports portals. Sports photography is a multidimensional art for many reasons. When we say “multi”, it primarily refers to a wider range that sports photography has to offer, which means sports photography is not only directed at presenting athletes on the move and the main actors who contribute to achieving the results by their engagement – it also has the role of sports “psychophotography” which is an analysis and capture of the emotional reaction of an athlete after winning or losing from the opposing team.

Researching the factors influencing the satisfaction of master students at VNU School of Interdisciplinary Studies

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Do Huy Thuong ◽  
Nguyen Thi Phuong Hong
Keyword(s):  
Service Industry ◽  
Interdisciplinary Studies ◽  
Number Of Solutions ◽  
Factors Affecting ◽  
Training Institutions ◽  
Market Needs ◽  
Market Strategies ◽  
Students Satisfaction ◽  
Training Service

Improving the quality in order to keep up with the trend in the world is the vital task of training institutions today. Training institutions need to grasp market needs and satisfy the requirements of customers - learners. Nadiri, H., Kandampully, J & Hussain, K. (2009) argue that the managers in education need to apply market strategies that are being used by manufacturing and business enterprises and need to be aware that the role of training institutions is a service industry which is responsible for satisfying learner needs (Elliott & Shin, 2002). Currently, there have been many researches on students’ satisfaction. However, each research has its own objectives and is conducted on different scales. This study is implemented to provide information about the factors affecting master students’ satisfaction with the training service at VNU School of Interdisciplinary Studies (VNU SIS). Through it, the research offers a number of solutions to improving the satisfaction level of the master students at VNU SIS in the coming time.

OBOLESCENCE AND THE DIFFUSION OF INNOVATIONS

2020 ◽  
pp. 113-130
Author(s):  
A.V. GOLUBEV ◽  
Keyword(s):  
Diffusion Of Innovations ◽  
Time Lag ◽  
Practical Implementation ◽  
Primary Role ◽  
Innovation Development ◽  
Scientific Hypothesis ◽  
Scientific Papers ◽  
The Moment ◽  
Sociological Studies

The diffusion of innovations is described as a process in a number of scientific papers. At the same time, the causes of this process have not been sufficiently studied. The author’s goal is to consider the main regularities, under which the life cycle of innovations begins, and propose measures to enhance diffusion in modern conditions. As a scientific hypothesis, the author accepts the postulate about the primary role of the obolescence of attracted innovations in this process. The analysis revealed not only the economic proportions that initiate the start of innovation promotion, but also the influence on the diffusion rate of the obsolescence degree of innovations and the market share occupied by the new product. Methodological approaches have been developed to determine economic efficiency depending on the moment of technological change-over, as well as to determine the absolute and relative speed of innovation diffusion. Sociological studies were conducted to determine the state of innovation development and the time lag between obtaining information about an innovation and its practical implementation. The author presents his “Agroopyt” information system developed to disseminate knowledge in the agricultural sphere and ensure technology transfer in agriculture. Digital methods provide for significant accelerateion of the diffusion of innovations and expand its scope.

Business Aviation in Russia: Specific Features and Prospects of Development

2020 ◽  
Vol 26 (1) ◽  
pp. 86-93
Author(s):  
D. V. Slivinsky ◽  
I. A. Fomina ◽  
D. G. Menshikh
Keyword(s):  
Systems Approach ◽  
National Policy ◽  
Civil Aviation ◽  
Economic Growth Rate ◽  
Factors Affecting ◽  
Organization And Management ◽  
Transport Services ◽  
Business Aviation ◽  
Wide Range

The presented study determines the role of business aviation in the modern economy and examines the specific features of its development in Russia.Aim. The study aims to analyze the development of business aviation in Russia and its correlation with economic development in general.Tasks. The authors determine the benefits of business aviation as a business tool, examine the specific features of the Russian business aviation market and problems of its development, and identify factors that affect the development of business aviation in Russia.Methods. This study uses the methods of comparative and retrospective analysis, cross-country comparison, systems approach, and expert analytics.Results. Business aviation is a new segment of civil aviation for Russia. Therefore, it is advisable to rely on foreign practices in the management of its development. In many countries, business aviation is a separate industry that specializes in providing transport services to a wide range of corporate clients and/or individuals. The development of this industry is associated with the economic growth rate and the development level of the national economy, and also depends on the national institutional specifics. This study describes the specific features of development of business aviation in Russia and problems arising in the organization and management of this type of business.Conclusions. The authors develop a system of factors affecting the development of business aviation in Russia, describe the major problems of this industry, and propose solutions. The results of this study can be used in the development (adjustment) of business aviation development strategies in Russia both at the industrial and corporate level, and in the implementation of the national policy in this field.

Sign in / Sign up

Export Citation Format

Share Document