BACTERIAL MENINGITIS

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 586-600
Author(s):  
David H. Smith ◽  
David L. Ingram ◽  
Arnold L. Smith ◽  
Floyd Gilles ◽  
M. J. Bresnan
Keyword(s):  
Bacterial Meningitis ◽  
Medical Care ◽  
Newborn Infant ◽  
Antibacterial Therapy ◽  
Tuberculous Meningitis ◽  
Current Knowledge ◽  
The Past ◽  
Meningococcal Group ◽  
Group A ◽  
Almost All

Prior to the introduction of specific antibacterial therapy, bacterial meningitis was a disease with a universally fatal or disastrous outcome. The introduction of typespecific antiserum, and then of the antibacterial drugs, improved this situation dramatically. Improvements in the general medical care of acutely ill children, and the introduction of a series of more potent antibiotics against its bacterial causes helped to generate an attitude that bacterial meningitis was, or soon would be, a disease of the past. The experience of the past two decades belies this thesis. Today, interest in many facets of this disease has been renewed by many physicians concerned with the health of children: the epidemiology, pathophysiology, diagnosis, and treatment. This symposium attempts to summarize for the practitioner the highlights of current knowledge in this area, and to outline certain areas in which recent advances can be anticipated, or will be studied. Tuberculous meningitis will be omitted for the sake of brevity, as will the special problems of meningitis in the newborn infant. There has been a resurgence of interest in developing vaccines to prevent Hemophilus influenzae b, pneumococcal, and meningococcal Group A, B, and C meningitis. These organisms cause almost all the bacterial meningitis after the first two months of life. If, as now seems possible, vaccines against most or all of these organisms will soon become available, those children having the greatest risk must be defined to determine who, and at what age should have priority in receiving the vaccine(s). A. THE CURRENT MAGNITUDE OF THE PROBLEM

scholarly journals Characteristics of the etiological structure of infection associated with the provision of medical care in a multi-specialty hospital

2020 ◽  
Vol 22 (1) ◽  
pp. 7-11
Author(s):  
B N Kotiv ◽  
B Yu Gumilevsky ◽  
E N Kolosovskaya ◽  
L A Kaftyreva ◽  
E S Orlova ◽  
...  
Keyword(s):  
Medical Care ◽  
Antibacterial Therapy ◽  
Lower Respiratory Tract ◽  
Surgical Intervention ◽  
Epidemiological Data ◽  
Epidemic Process ◽  
The Past ◽  
Surgical Infections ◽  
Klebsiella Spp ◽  
Russian Association

Epidemiological data on infections associated with medical care in surgical hospitals are presented. The features of the epidemic process of infections associated with Klebsiella spp. were studied among the patients of surgical profile. The study of the etiological structure in hemocultures in 33% of cases revealed the predominance of Klebsiella spp. In patients with a surgical profile, the incidence of Klebsiella spp. has increased over the past 10 years in wound content from 0,4 to 8,3% and in 7,7% of cases - in hemocultures. Significant resistance of Klebsiella spp. strains was detected currently used in the clinical practice of surgical hospitals antibacterial drugs. The highest sensitivity among Klebsiella spp. strains antimicrobial resistance was detected in the group of carbapenems. The structure of the epidemic process of infections caused by Klebsiella spp. is considered among patients of surgical clinics in 2018. In 32% of cases, the infectious process was localized in the lower respiratory tract, in 25% of cases - in the urinary tract, in 22% of cases - in the blood and in 21% of cases - in the area of surgical intervention. The results obtained do not differ significantly from the data obtained in other medical organizations in the country. The need for a comprehensive approach to microbiological monitoring and the appointment of antibacterial therapy for infections associated with the provision of medical care in surgical hospitals has been established. For example, the «Strategy for controlling antibacterial therapy» developed by the Russian Association of specialists in surgical infections, which is well-established in several dozen large hospitals in the country, is being more widely introduced into medical practice.

Increased Risks or Peace of Mind? Exploring Fear, Victimization, and Safety Strategies Among Women Planning to Get a Gun

2021 ◽  
pp. 088626052110358
Author(s):  
TK Logan ◽  
Kellie R. Lynch
Keyword(s):  
Interpersonal Violence ◽  
Depression Symptoms ◽  
Personal Safety ◽  
Peace Of Mind ◽  
The Past ◽  
Limited Experience ◽  
Safety Strategies ◽  
Group A ◽  
Self Harm ◽  
Almost All

Much of the research on firearm owners implies that the U.S. population can be divided into two groups—those that own guns and those that do not; however, there is a third group—those thinking of getting a gun and almost nothing is known about this group. A survey on gun ownership, experiences, and behaviors was deployed online via Prolific in June and July 2020 to recruit women from the general U.S. population who were planning on getting a gun ( n = 187), who owned a gun ( n = 288) and who did not own or plan to own guns ( n = 968). Results show that women planning on getting a gun worried more about their personal safety and more had experienced recent interpersonal violence victimization compared to the other two groups. Almost all of the women planning on getting a gun believed that carrying a gun would make them safer. Even though women planning on getting a gun had limited experience with guns, they expressed fewer gun related worries than nongun owners. Additionally, women planning on getting a gun had more depression symptoms and more of them indicated they had thoughts of self-harm in the past two weeks than current gun owners. Depression symptoms were significantly associated with plans to get a gun in the multivariate model. Given the risks associated with having firearms in the household, interventions could target those considering getting a gun as well as educating friends and family about what to say when someone close is considering obtaining a firearm for safety.

scholarly journals Hormone-mediated maternal effects in birds: mechanisms matter but what do we know of them?

2007 ◽  
Vol 363 (1497) ◽  
pp. 1647-1661 ◽  
Author(s):  
Ton. G.G Groothuis ◽  
Hubert Schwabl
Keyword(s):  
Maternal Effects ◽  
Current Knowledge ◽  
Mechanistic Studies ◽  
Maternal Circulation ◽  
Apparent Lack ◽  
The Past ◽  
Trade Offs ◽  
Underlying Mechanisms ◽  
Almost All ◽  
Pleiotropic Actions

Over the past decade, birds have proven to be excellent models to study hormone-mediated maternal effects in an evolutionary framework. Almost all these studies focus on the function of maternal steroid hormones for offspring development, but lack of knowledge about the underlying mechanisms hampers further progress. We discuss several hypotheses concerning these mechanisms, point out their relevance for ecological and evolutionary interpretations, and review the relevant data. We first examine whether maternal hormones can accumulate in the egg independently of changes in hormone concentrations in the maternal circulation. This is important for Darwinian selection and female physiological trade-offs, and possible mechanisms for hormone accumulation in the egg, which may differ among hormones, are reviewed. Although independent regulation of plasma and yolk concentrations of hormones is conceivable, the data are as yet inconclusive for ovarian hormones. Next, we discuss embryonic utilization of maternal steroids, since enzyme and receptor systems in the embryo may have coevolved with maternal effect mechanisms in the mother. We consider dose–response relationships and action pathways of androgens and argue that these considerations may help to explain the apparent lack of interference of maternal steroids with sexual differentiation. Finally, we discuss mechanisms underlying the pleiotropic actions of maternal steroids, since linked effects may influence the coevolution of parent and offspring traits, owing to their role in the mediation of physiological trade-offs. Possible mechanisms here are interactions with other hormonal systems in the embryo. We urge endocrinologists to embark on suggested mechanistic studies and behavioural ecologists to adjust their interpretations to accommodate the current knowledge of mechanisms.

ESPE and PES International Survey of Centers and Clinicians Delivering Specialist Care for Children and Adolescents with Gender Dysphoria

2018 ◽  
Vol 90 (5) ◽  
pp. 326-331 ◽  
Author(s):  
Nicos Skordis ◽  
Gary Butler ◽  
Martine C. de Vries ◽  
Katharina Main ◽  
Sabine E. Hannema
Keyword(s):  
Medical Care ◽  
Children And Adolescents ◽  
Gender Dysphoria ◽  
International Survey ◽  
Specialist Care ◽  
Endocrine Society ◽  
Gnrh Analogues ◽  
The Past ◽  
Legal Restrictions ◽  
Almost All

Background/Aims: Increasing numbers of children and adolescents seek medical care because they experience incongruence between their physical sex and their gender identity. Methods: The ESPE working group on gender dysphoria (GD) undertook a survey to investigate the structure and the type of medical care in centers that offer specialist care for transgender adolescents. Results: The personnel of each center varied from country to country, and a nationally organized network or plan for managing GD did not exist in all centers. The majority of young people were transitioning from female to male, and the number of new referrals increased remarkably during the past 3 years. Almost all centers follow the guidelines issued by the Endocrine Society and World Professional Association for Transgender Health. GnRH analogues were used as the initial treatment in the majority of the centers. The age from which adolescents are treated with gender-affirming hormones varied between centers. Several legal restrictions that concern or influence the treatment of children and adolescents with GD were finally addressed. Conclusion: This first international survey examining the variations in availability and provisions of services for children and adolescents with GD serves as a starting block for further dialogue and future studies.

Blood Viscosity and Platelet Aggregation in Male and Female Patients with Transient Ischaemic Attacks (TIA)

1979 ◽  
Author(s):  
G. Palareti ◽  
M. Poggi ◽  
G. Fortunato ◽  
S. Coccheri
Keyword(s):  
Platelet Aggregation ◽  
Blood Viscosity ◽  
Indirect Evidence ◽  
Vascular Lesions ◽  
Transient Ischaemic Attacks ◽  
Group A ◽  
Circulating Platelet Aggregates ◽  
Male Patients ◽  
Group B ◽  
Almost All

A series of 40 patients with TIA (25 males and 15 females) was thoroughly investigated by means of angiography and computerized tomography, and divided into a group (A) of 15 “sine materia”, and a group (B) of 25 with direct or indirect evidence of vascular occlusive or stenotic changes. Blood viscosity at 230 sec-1 37° was cp 4.2 ± 0.3 in the controls, cp 4.7 ± 0.7 in all patients (p < 0.05) cp 4.98 ± 0.7 in all male patients (p < 0.01 versus male controls), and cp 4.75 ± 0.8 in group B (p < 0.02). Haematocrit and Fibrinogen were also significantly increased in all male patients and in group B. Circulating platelet aggregates (CPA) were increased in 40% of the patients. Almost all patients with elevated CPA were males, with a slight prevalence in group B. Changes in blood viscosity parameters and in platelet aggregation in TIA patients were therefore related both to evidence of vascular lesions, and to sex, since they were found to prevail in male patients of both groups.

BP Global Energy Outlook 2030

2013 ◽  
pp. 109-128 ◽  
Author(s):  
C. Rühl
Keyword(s):  
Emerging Economies ◽  
Energy Demand ◽  
Fossil Fuels ◽  
Net Energy ◽  
Global Energy ◽  
The Past ◽  
Market Shares ◽  
The Us ◽  
Almost All ◽  
Oil Gas

This paper presents the highlights of the third annual edition of the BP Energy Outlook, which sets out BP’s view of the most likely developments in global energy markets to 2030, based on up-to-date analysis and taking into account developments of the past year. The Outlook’s overall expectation for growth in global energy demand is to be 36% higher in 2030 than in 2011 and almost all the growth coming from emerging economies. It also reflects shifting expectations of the pattern of supply, with unconventional sources — shale gas and tight oil together with heavy oil and biofuels — playing an increasingly important role and, in particular, transforming the energy balance of the US. While the fuel mix is evolving, fossil fuels will continue to be dominant. Oil, gas and coal are expected to converge on market shares of around 26—28% each by 2030, and non-fossil fuels — nuclear, hydro and renewables — on a share of around 6—7% each. By 2030, increasing production and moderating demand will result in the US being 99% self-sufficient in net energy. Meanwhile, with continuing steep economic growth, major emerging economies such as China and India will become increasingly reliant on energy imports. These shifts will have major impacts on trade balances.

Building Research Teams

2017 ◽  
Author(s):  
Ken Peach
Keyword(s):  
Common Goal ◽  
Research Teams ◽  
Building Research ◽  
The Past ◽  
Collective Activity ◽  
Research Administrators ◽  
Working Together ◽  
Common Goals ◽  
Almost All ◽  
Century Science

This chapter discusses the process of building research teams. Increasingly over the past three-quarters of a century, science has become a collective activity, with teams of tens, hundreds or even thousands of scientists, engineers and technicians working together on a common goal. Consequently, almost all research involves building, motivating and maintaining a research team. Even a theoretical group is likely to have one or two postdocs, graduate students and visitors, but research teams will, in addition, have engineers and technicians, as well as, possibly, research administrators. The chapter also addresses the importance of creating and maintaining a good team and team spirit, as large projects are assembled from a large number of small teams working on common goals, usually in a loose federated structure with some overall coordination and leadership.

scholarly journals 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 287
Author(s):  
Ye Lin Park ◽  
Kiwon Park ◽  
Jae Min Cha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Critical Size ◽  
Current Knowledge ◽  
3D Bioprinting ◽  
The Past ◽  
Regeneration Processes

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

scholarly journals Improved PrEP Awareness and Use among Trans Women in San Francisco, California

2021 ◽  
Author(s):  
Erin C. Wilson ◽  
Christopher J. Hernandez ◽  
Susan Scheer ◽  
Dillon Trujillo ◽  
Sean Arayasirikul ◽  
...  
Keyword(s):  
San Francisco ◽  
Anal Intercourse ◽  
Receptive Anal Intercourse ◽  
The Past ◽  
National Hiv Behavioral Surveillance ◽  
Trans Women ◽  
Gender Based ◽  
Prep Awareness ◽  
Almost All ◽  
Exposure Prophylaxis

AbstractTransgender women face a serious risk of HIV infection. Despite this, there is limited knowledge and use of Pre-exposure prophylaxis (PrEP). We measured the continuity of prevention across services in the PrEP cascade and correlates of PrEP use among trans women in San Francisco enrolled in the 2019/20 National HIV Behavioral Surveillance Study. Knowledge and use of PrEP among trans women in San Francisco increased in recent years; almost all (94.0%) had heard about PrEP, 64.7% had discussed PrEP with a healthcare provider, and 44.8% had taken PrEP in the past 12 months. PrEP use was associated with participation in a PrEP demonstration project (aOR = 31.44, p = 0.001) and condomless receptive anal intercourse (aOR = 3.63, p = 0.024). Injection drug use was negatively associated (aOR = 0.19, p = 0.014). Efforts are needed to combat the gender-based stigma and discrimination faced by trans women, which can result in avoidance and mistrust of the medical system.

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