Sternum Length, Torso Length, and Internipple Distance in Newborn Infants

In order to define standards for sternal length, torso length, and internipple distance in the newborn infant, 198 term and preterm infants (27 to 41 gestational weeks) were examined. In every case, the gestational age was determined chronologically and clinically. Sternal and torso length and internipple distance were measured by two observers using standard measurement techniques. Normal values are presented by plotting the mean ±2 SD for each gestational week v the gestational age.

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Serum Aldosterone Concentrations Related to Sodium Balance in the Newborn Infant

PEDIATRICS ◽

10.1542/peds.53.3.410 ◽

1974 ◽

Vol 53 (3) ◽

pp. 410-413

Author(s):

Sharon R. Siegel ◽

Delbert A. Fisher ◽

William Oh

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Newborn Infants ◽

Full Term ◽

Sodium Balance ◽

Term Infants ◽

Serum Aldosterone ◽

Sodium Load ◽

Sodium Dependent ◽

The Mean

Serum aldosterone concentrations and sodium (Na) balance were studied between 24 and 48 hours of life in 39 newborn infants of various gestational ages and in infants with or without respiratory distress syndrome (RDS) . The serum aldosterone levels in the neonatal period were high but not related to gestational age. The serum aldosterone levels of small-for-gestational-age (SGA) infants were similar to those of the full-term infants. In normal infants (preterm and full term) and in SGA infants, the mean oral Na intake was 1.0 mEq/kg/24 hr; in this group of infants, no correlation was observed between Na intake and excretion or between Na intake and serum aldosterone concentrations, probably due to the narrow range of Na intake. In preterm infants with RDS, Na was given in larger quantities and by the parenteral route. In this group, significant correlations were observed between Na intake and Na excretion and between Na intake and serum aldosterone concentrations. These data suggest that the expected sodium dependent regulatory mechanism for aldosterone secretion is functional 10 the preterm infants with RDS when given a large sodium load; and that the quantity of Na excretion is consistent with the variations in aldosterone concentrations.

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Reference Values for Transverse Cerebellar Diameter Throughout Gestation

Pediatric and Developmental Pathology ◽

10.1007/s10024-001-0262-4 ◽

2002 ◽

Vol 5 (5) ◽

pp. 489-494 ◽

Cited By ~ 7

Author(s):

Halit Pinar ◽

Sarah H. Burke ◽

Carol W. Huang ◽

Don B. Singer ◽

C. James Sung

Keyword(s):

Reference Values ◽

Growth Curve ◽

Gestational Age ◽

Normal Values ◽

Growth Restriction ◽

Reliable Indicator ◽

Transverse Diameter ◽

Reliable Parameter ◽

Gestational Week ◽

Duration Of Gestation

The transverse cerebellar diameter (TCD) is well established in the ultrasound literature as a reliable parameter for estimating the duration of gestation. In cases of growth restriction the cerebellum is usually spared, making TCD a reliable indicator of gestational age even when other parameters fall off the appropriate growth curve. The purpose of this study is to establish normal values for the transverse diameter of the cerebellum in pathology specimens, and to determine if these values correlate with those obtained by ultrasound. We examined 96 specimens ranging from 14 to 42 weeks gestational age and found that our values correlate well with those published in the ultrasound literature. Mean TCD with 2 standard deviations for each gestational week were determined as reference values.

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The Usefulness of Saliva in Therapeutic Drug Monitoring of Caffeine in Preterm Infants.

10.21203/rs.3.rs-236907/v1 ◽

2021 ◽

Author(s):

Ana García-Robles ◽

Álvaro Solaz-García ◽

Jorge Verdú-Andrés ◽

José Luis Poveda-Andrés ◽

Antonio José Cañada-Martínez ◽

...

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Solid Phase ◽

Newborn Infants ◽

Capillary Liquid Chromatography ◽

Therapeutic Drug ◽

Paired Samples ◽

Postmenstrual Age ◽

On Line ◽

Array Detection

Abstract Aim To verify if the concentrations of caffeine in saliva are comparable to the serum concentrations in preterm infants treated with caffeine for apnoea of prematurity. Methods Prospective observational study. Eligible patients were newborn infants < 37 weeks of gestational age treated with oral or intravenous caffeine for apnoea of prematurity. Two paired samples of saliva-blood were collected per patient. Tube solid phase microextraction coupled on-line to capillary liquid chromatography with diode array detection were used for analysis. Results A total of 47 newborns with a median gestational age 28 [26–30] weeks and mean of 1.11 ± 0.4 kg of birth weight. Median postmenstrual age, when samples were collected, was 31 [29–33] weeks. Serum caffeine median levels of 19.30 µg/mL [1.9–53.90]and salivary caffeine median levels of 16.36 µg/mL [2.20–56.90] were obtained. There was a strong positive Pearson’s correlation between the two variables r = 0.83 (p < 0.001). Conclusion The measurement of caffeine salivary concentrations after intravenous or oral administration offers an alternative to serum caffeine monitoring in apnoea of prematurity.

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Short Term Outcomes of Neonates Born after Prolonged Premature Rupture of Membranes < 34 Weeks Gestation

Research in Health Science ◽

10.22158/rhs.v4n2p83 ◽

2019 ◽

Vol 4 (2) ◽

pp. 83

Author(s):

Isam Bsisu ◽

Alaa Aldalaeen ◽

Rawan Elrajabi ◽

Ala AlZaatreh ◽

Rama Jadallah ◽

...

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Preterm Births ◽

University Hospital ◽

High Rate ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Gestational Week ◽

The Mean

Background: Preterm premature rupture of membranes (PPROM) is responsible for one?third of all preterm births worldwide. This aim of this study was to investigate the outcome of neonates born after prolonged PPROM with gestational age below 34 weeks. Materials and methods: This retrospective study included 65 patients who were born to mothers with Prolonged PPROM <34 weeks gestation between January 2011 and December 2015 and admitted to the neonatal intensive care unit (NICU) at Jordan University Hospital. Results: The mean gestational age of included patients was (31.9 ± 2.5 weeks), mean birth weight was (1840 ± 583 g) and 43 (66.2%) were males. The mortality rate in those infants was 12.3 %. Gestational age, birth weight, and Apgar score were significantly lower among mortality cases compared to surviving cases (P < 0.05). Conclusion: Prolonged PPROM before the 34th gestational week is associated with high rate of morbidity and mortality, for which early identification of risk factors for developing PPROM can help in reducing the risk for preterm labors and subsequent burden on healthcare system.

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Effect of Maternal Race on Outcome of Preterm Infants in the Military

PEDIATRICS ◽

10.1542/peds.91.3.572 ◽

1993 ◽

Vol 91 (3) ◽

pp. 572-577

Author(s):

David N. Greenberg ◽

Bradley A. Yoder ◽

Reese H. Clark ◽

Clifford A. Butzin ◽

Donald M. Null

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Military Hospital ◽

Free Access ◽

Multiple Gestation ◽

Entire Study ◽

The Mean ◽

Maternal Race

Previous studies suggest that low birth weight black infants have less morbidity and birth-weight-specific mortality during the perinatal period than low birth weight white infants. We studied the effect of maternal race on outcome in preterm infants born at a military hospital that offers free access to obstetric and neonatal care. Between January 1, 1986, and December 31, 1991, data were prospectively collected on all 667 infants delivered at Wilford Hall USAF Medical Center with an estimated gestational age of less than 35 weeks. Three hundred ninety-two white infants and 165 black infants were included in the data analysis. The mean (±SD) birth weight was 1701 ± 65 g for white infants and 1462 ± 66 g for black infants. The mean estimated gestational age was 31.0 ± 3.2 weeks for white infants and 29.9 ± 3.8 weeks for black infants. Preeclampsia was more frequent in black mothers than in white mothers for the entire study population (21% vs 14%), but the birth weight differential between races remained after correction for preeclampsia. There were no significant differences between races in stillbirths, gender, maternal age, maternal transfer status, number of prenatal visits, or percentages of mothers with small-for-gestational-age infants, multiple-gestation infants, prolonged rupture of membranes, or initial prenatal visit during the first trimester. Intraventricular hemorrhage was more frequent in white infants at 27 through 29 weeks estimated gestational age (50% vs 13%). There were no significant differences between the two groups in survival or in the occurrence of severe infraventricular hemorrhage or bronchopulmonary dysplasia. It is concluded that preterm black infants are smaller than preterm white infants when matched for gestational age despite essentially equal utilization of prenatal care. However, maternal race has little direct effect on the survival of liveborn preterm infants in this population.

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Auditory pathway maturational study in small for gestational age preterm infants

CoDAS ◽

10.1590/2317-1782/201420130078 ◽

2014 ◽

Vol 26 (4) ◽

pp. 286-293 ◽

Cited By ~ 6

Author(s):

Rosanna Giaffredo Angrisani ◽

Edna Maria Albuquerque Diniz ◽

Ruth Guinsburg ◽

Alexandre Archanjo Ferraro ◽

Marisa Frasson de Azevedo ◽

...

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Small For Gestational Age ◽

Otoacoustic Emissions ◽

Newborn Infants ◽

Tone Burst ◽

Auditory Pathway ◽

Auditory Brainstem ◽

Cross Sectional ◽

Brainstem Response

PURPOSE: To follow up the maturation of the auditory pathway in preterm infants small for gestational age (SGA), through the study of absolute and interpeak latencies of auditory brainstem response (ABR) in the first six months of age.METHODS: This multicentric prospective cross-sectional and longitudinal study assessed 76 newborn infants, 35 SGA and 41 appropriate for gestational age (AGA), born between 33 and 36 weeks in the first evaluation. The ABR was carried out in three moments (neonatal period, three months and six months). Twenty-nine SGA and 33 AGA (62 infants), between 51 and 54 weeks (corrected age), returned for the second evaluation. In the third evaluation, 49 infants (23 SGA and 26 AGA), with age range from 63 to 65 weeks (corrected age), were assessed. The bilateral presence of Transient Evoked Otoacoustic Emissions and normal tympanogram were inclusion criteria.RESULTS: It was found interaural symmetry in both groups. The comparison between the two groups throughout the three periods studied showed no significant differences in the ABR parameters, except for the latencies of wave III in the period between three and six months. As for the maturation with tone burst 0.5 and 1 kHz, it was found that the groups did not differ.CONCLUSION: The findings suggest that, in the premature infants, the maturational process of the auditory pathway occurs in a similar rate for SGA and AGA. These results also suggest that prematurity is a more relevant factor for the maturation of the auditory pathway than birth weight.

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Influence of Maternal Preeclampsia on Neurodevelopmental Outcomes of Preterm Infants

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2018.737 ◽

2018 ◽

Vol 24 (2) ◽

pp. 99

Author(s):

Halil Degirmencioglu ◽

Birgul Say ◽

Zeynep Ustunyurt ◽

Serife Suna Oguz

Keyword(s):

Cerebral Palsy ◽

Preterm Infants ◽

Gestational Age ◽

Infant Development ◽

Neurodevelopmental Outcome ◽

Control Group ◽

Neurodevelopmental Outcomes ◽

Term Outcome ◽

Long Term Outcome ◽

The Mean

Objective: The aim of this study was to determine the neurodevelopmental outcome of preterm infants born to mothers with preeclampsia and to compare them with preterm controls.Study design: This was a retrospective, observational study in a large, tertiary, neonatal intensive care unit. Neurodevelopmental evaluations using Bayley Scales of Infant Development II were performed in 226 two-year-old infants with birth weight ≤1500 g and gestational age ≤32 weeks who were born to mothers with preeclampsia and in 493 infants who were born after normotensive pregnancies, matched for gestational age and gender.Results: The mean gestational ages of the infants in the preeclampsia and control groups were 29.9±2.3 weeks and 28.7±4.1 weeks, respectively (p<0.001). A total of 372 infants with a mean age of 19.2±3.2 months were assessed for long-term outcome. The mean mental developmental index score was significantly higher, and the percentage of infants with cerebral palsy was significantly lower, in the preeclampsia group compared with the control group (p=0.03 and p=0.02, respectively). However, no overall significant differences in neurodevelopmental impairment rates were found between the two groups (p=0.08).Conclusion: Maternal preeclampsia seems to be a protector factor for the development of cerebral palsy in preterm infants.

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Relationship between plasma creatinine concentration and glomerular filtration in preterm newborn infants

Revista do Hospital das Clínicas ◽

10.1590/s0041-87811999000400004 ◽

1999 ◽

Vol 54 (4) ◽

pp. 121-126 ◽

Cited By ~ 6

Author(s):

Mário Cícero Falcão ◽

Yassuhiko Okay ◽

José Lauro Araújo Ramos

Keyword(s):

Glomerular Filtration Rate ◽

Creatinine Clearance ◽

Glomerular Filtration ◽

Preterm Infants ◽

Gestational Age ◽

Filtration Rate ◽

Newborn Infants ◽

Plasma Creatinine ◽

Preterm Newborn ◽

The Third

Fluid management and dosage regimens of drugs in preterm infants should be based on the glomerular filtration rate. The current methods to determine glomerular flitration rate are invasive, time-consuming, and expensive. In contrast, creatinine clearance can be easy obtained and quickly determined. The purpose of this study was to compare plasma creatinine on the third and seventh day of life in preterm newborn infants, to evaluate the influence of maternal creatinine, and to demonstrate creatinine clearance can be used as a reliable indicator of glomerular filtration rate. We developed a prospective study (1994) including 40 preterm newborns (gestational age < 37 weeks), average = 34 weeks; birth weight (average) = 1840 g, in the first week of life. Inclusion criteria consisted of: absence of renal and urinary tract anomalies; O2 saturation 3 92%; adequate urine output (>1ml/kg/hr); normal blood pressure; absence of infections and no sympathomimetic amines in use. A blood sample was collected to determine plasma creatinine (enzymatic method) on the third and seventh day of life and creatinine clearance (CrCl) was obtained using the following equation: <IMG SRC="http:/img/fbpe/rhc/v54n4/1065e1.gif" WIDTH=287 HEIGHT=96>, k = 0.33 in preterm infant All plasma creatinine determinations showed normal values [third day: 0.78 mg/dl ± 0.24 (mean ± SD)and seventh day: 0.67 mg/dl ± 0.31 - (p>0.05)]. Also all creatinine clearance at third and seventh day of life were normal [third day: 19.5 ml/min ± 5.2 (mean ± SD) and seventh day: 23.8 ml/min ± 7.3 - (p>0,05)]. All preterm infants developed adequate renal function for their respective gestational age. In summary, our results indicate that, for clinical practice, the creatinine clearance, using newborn length, can be used to estimate glomerular filtration rate in preterm newborn infants.

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Clinical Estimation of Liver Size in Newborn Infants

PEDIATRICS ◽

10.1542/peds.75.1.128 ◽

1985 ◽

Vol 75 (1) ◽

pp. 128-128

Author(s):

SHAI ASHKENAZI ◽

FRANCIS MIMOUNI ◽

PAUL MERLOB ◽

SALOMON H. REISNER

Keyword(s):

Newborn Infant ◽

Gestational Age ◽

Small For Gestational Age ◽

Newborn Infants ◽

Practical Approach ◽

Costal Margin ◽

Liver Size ◽

Routine Measurement ◽

The Right ◽

Liver Edge

In Reply.— Brion and Avni have compared the clinical estimation of liver size by the liver span and the size of its edge below the right costal margin. Some of their results are in accordance with ours, such as the lack of differences between the measurements immediately after birth and a few days later, and the reduced size of liver edge found in our preliminary measurements in infants who were small for gestational age (Table). It seems to us that the practical approach to the clinical estimation of liver size in the newborn should include routine measurement of liver edge in every healthy newborn infant.

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INVESTIGATING THE PHOTOTHERAPY THRESHOLDS IN PRETERM INFANTS

Paediatrics & Child Health ◽

10.1093/pch/pxy054.073 ◽

2018 ◽

Vol 23 (suppl_1) ◽

pp. e28-e28 ◽

Cited By ~ 1

Author(s):

Thivia Jegathesan ◽

Michael Sgro ◽

Vibhuti Shah ◽

Aidan Campbell ◽

Douglas Campbell

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Chart Review ◽

Age Groups ◽

Retrospective Chart Review ◽

Term Infants ◽

Treatment Thresholds ◽

Weight Outcomes ◽

The Mean ◽

Current Guidelines

Abstract BACKGROUND Currently there are limited guidelines for the management of hyperbilirubinemia in preterm infants. Current guidelines are limited to individual sites and are consensus-based opinions. The current decrease in chronic bilirubin encephalopathy in preterm infants is a result of liberal use of phototherapy that are not based on evidence from a large dataset of preterm infants. The pattern of bilirubin levels in preterm is unclear and currently based on clinical judgement. Nomograms in term infants has been proven to be beneficial and effective in reducing unnecessary treatment of hyperbilirubinemia. A nomogram designed for preterm infants would allow health professionals to quantify risk based on evidence based methods and reduce the number of test done on preterm infants. OBJECTIVES The objectives of this study are 1) To determine photherapy thresholds in preterm infants and 2) To determine the normative pattern of bilirubin values in preterm infants. DESIGN/METHODS A multi-site retrospective chart review of preterm infants ≤ 35 weeks gestation born between January 2012- November 2017 was conducted. The following data was collected; all TSB, postnatal hours of age, duration of phototherapy, infant characteristics (gestational age, birth weight, outcomes) and maternal history (inter and anter partum medication). TSB samples prior to the initiation of phototherapy were analyzed per hour and stratified by gestational age groups. RESULTS A total of 330 preterm infants were included in the retrospective review (50 24-28 weeks gestation, 100 29-32 weeks gestation, and 180 33–35 weeks gestation). The mean peak bilirubin in infants 33-35 week gestation was 198 umol/L at 4 days. These infants were started on phototherapy at a mean age of 89 hours. At 24 hours of age these infants’ bilirubin was 104 umol/L (72-189umol/L). The mean peak bilirubin in infants 29–32 weeks gestation was 181umol/L at 5 days. At 24 hours of age the mean bilirubin was 109 umol/L. Finally in infants 24–28 weeks gestation the mean peak bilirubin was 127 umol/L at 4 days. These infants were started on phototherapy at 44 hours of age. CONCLUSION Bilirubin values in preterm infants is hetergenous across gestional ages. Phototherapy treatment thresholds are lower in preterm infants between 24–28 weeks gestation. A nomogram for preterm infants maybe possible in infants between 29–35 weeks. Further research is required to determine hour specific bilirubin levels in preterm infants.

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