Special Susceptibility of Children to Radiation Effects

PEDIATRICS ◽  
1983 ◽  
Vol 72 (6) ◽  
pp. 890-890
Author(s):  
Keyword(s):  
Breast Cancer ◽  
Radiation Effects ◽  
Age Groups ◽  
Peak Frequency ◽  
Marshall Islands ◽  
Nuclear War ◽  
Delayed Effects ◽  
Effects Of Radiation ◽  
Age Range ◽  
Intense Heat

In a nuclear war, children who survive the acute effects of radiation—the blast and intense heat—may also have to survive the loss or disability of parents who provide food, shelter, and love, so necessary for physical and emotional development. The likelihood of provision of even limited medical services following a nuclear blast is virtually nil. Finally, persons exposed to radiation as children have a substantially greater susceptibility to delayed effects than do those persons exposed as adults. 1. The peak frequency for leukemia is higher and occurs earlier among those less than 15 years of age exposed to radiation than among those who are older. 2. Breast cancer occurs excessively when females who were exposed to radiation during childhood reach the usual age for developing this malignancy. The rates for breast cancer for those who were 10 to 19 years of age at the time of the bomb are greater than those for females who were older at that time. Unexpectedly, an excessive occurrence of breast cancer has been observed among females who were 9 years old or younger at the time of the bomb, an age range when they would have had very little breast tissue. If cases continue to occur at the same rate as these women grow older, the excessive occurrence of breast cancer will be greater than among all other age groups. 3. Persons less than 30 years old at the time of the bomb are apparently more susceptible than older persons to radiogenic thyroid cancer. Benign thyroid tumors have occurred among nearly all children exposed to radioiodine-containing fallout from a nuclear weapons test on the Marshall Islands in 1954.

Heterozygous Tsc2 (Tsc2+/–) mouse model to study induced renal cancer in response to ionizing radiation at low doses

2018 ◽  
Vol 40 (6) ◽  
pp. 782-790 ◽  
Author(s):  
Sureshkumar M A ◽  
Caroline R Delma ◽  
Krishnan Manickam ◽  
Sumathy Mohan ◽  
Samy L Habib ◽  
...  
Keyword(s):  
Mouse Model ◽  
Hematological Parameters ◽  
Age Groups ◽  
High Dose Rate ◽  
Tumor Formation ◽  
High Dose ◽  
Mice Model ◽  
Delayed Effects ◽  
Radiosensitive Organs ◽  
Effects Of Radiation

Abstract Kidneys are one of the main dose-limiting organs in radiotherapeutic procedures of lower abdomen. Likewise, the threat of exposure of radiosensitive organs such as kidneys in warfare or radiation accidents among military personal or due to terrorist activities in general public is of increasing concern. These events warrant the need for appropriate animal models to study the acute and chronic effects of low- and high-dose rate radiation exposures. In this study, for the first time, we validated Tsc2+/– mouse model to study whether radiation accelerates carcinogenesis in kidneys. Tsc2+/– mice at increasing age groups at 8 and 10 months were exposed to repeated doses of gamma radiation (0.4 Gy × 5) and assessed for aggravated kidney tumor formation at 2 months post-irradiation. Animals from irradiated group showed a significant increase in numbers of bilateral, multifocal tumors compared with mock-irradiated animals. Intra-glomerular reactive oxygen species (ROS) levels measured by dihydroethidium florescence showed significant increases in ROS production in irradiated Tsc2+/– mice compared with non-irradiated animals. Similarly, selective hematological parameters and glomerular filtration rate were further reduced significantly in irradiated Tsc2+/– mice. Tsc2 protein, tuberin in irradiated mice, however, remains at the same reduced levels as that of the mock-irradiated heterozygous Tsc2 mice. The results indicate that radiation alters kidney homeostatic function and influences high spontaneous incidence of renal cell carcinoma in this rodent model. Repurposing of Tsc2+/– mice model will, therefore, provide a unique opportunity to study acute and delayed effects of radiation in the development of kidney cancers.

AGE FEATURES OF MOLECULAR-BIOLOGICAL SUBTYPES OF BREAST CANCER

2020 ◽  
Vol 17 (2) ◽  
pp. 187-192
Author(s):  
E.A. Novikova ◽  
◽  
O.V. Kostromina ◽  
D.V. Mikhailov ◽  
S.L. Leontiev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptors ◽  
Age Groups ◽  
Luminal A ◽  
Ki 67 ◽  
Luminal B ◽  
Age Related ◽  
Age Features ◽  
Immunohistochemical Studies ◽  
Triple Negative Subtype

Aim. The aim of the study was to determine the presence of peculiarities of the age structure in patients with various surrogate molecular biological subtypes of breast cancer. Materials and research methods. This work analyzes the age-related characteristics of the occurrence of molecular biological subtypes in 499 patients with invasive breast cancer. All cases were divided into 5 molecular biological subtypes based on immunohistochemical studies of hormone receptors, Her2, Ki-67. The average age of the patients was 53.4±0.39 years, the predominant group was patients from 50 to 60 years (37.2% of the total). Research results. In patients under 40 years old, the triple negative subtype prevailed (44.8%). Luminal A subtype prevailed in the groups 51-60 years old (more than 41.4%) and over 60 years old (39.7%). Luminal B (Her2-) subtype was equally found in all age groups.

scholarly journals Exploring Why Adult Mexican Males Do Not Get Vaccinated: Implications for COVID-19 Preventive Actions

2020 ◽  
Vol 42 (4) ◽  
pp. 515-527
Author(s):  
V. Nelly Salgado de Snyder ◽  
Deliana Garcia ◽  
Roxana Pineda ◽  
Jessica Calderon ◽  
Dania Diaz ◽  
...  
Keyword(s):  
Preventive Medicine ◽  
Age Groups ◽  
Adult Males ◽  
Cross Sectional ◽  
Administrative Services ◽  
Minority Males ◽  
Socially Disadvantaged ◽  
Preventive Actions ◽  
Socially Excluded ◽  
Age Range

Vaccination is the single most important preventive medicine action worldwide. However, there are inequalities in the procurement of vaccines particularly among US ethnic and racial minority males when compared to the rest of the US population. This study explored the reasons given by adult Mexican-origin males residing in Texas, for obtaining or not, immunizations. This was a cross-sectional, exploratory study with a sample of convenience of 401 adult males (age range 18–79) who were invited to participate in the study while waiting their turn to receive administrative services at the Mexican Consulate in Austin Texas. Data was collected in Spanish with a seven-item multiple choice questionnaire, using electronic tablets. The majority of respondents received their last vaccination longer than 5 years earlier. A higher percentage of individuals in the older age groups received a vaccine in the last year, as opposed to their younger counterparts who obtained their last immunization 3 to 5 years earlier. Among the reasons given for not getting vaccinated were lack of time or money, feared injections and side effects, insufficient information, interest or motivation. Others did not get vaccines because they perceived themselves to be healthy and did not feel sick. Findings from this study have important implications for future preventive medicine and vaccination practices that reach socially excluded groups in times of COVID-19. Recommendations are made to facilitate access to vaccines to the target group of this study and other socially disadvantaged populations in the global health context.

scholarly journals Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 324
Author(s):  
Ho-Seok Oh ◽  
Sung-Kyu Kim ◽  
Hyoung-Yeon Seo
Keyword(s):  
Health Insurance ◽  
Age Groups ◽  
Osteoporotic Fractures ◽  
Prescription Data ◽  
Diagnostic Codes ◽  
Number Of Patients ◽  
Upper And Lower Extremities ◽  
Fractures Of The Spine ◽  
And Gender ◽  
Age Range

To investigate the incidence and characteristics of osteoporosis and osteoporotic fractures in Korea, we used the Health Insurance Review and Assessment Service (HIRA) database. Patients over 50 years old, who were diagnosed or treated for osteoporosis and osteoporotic fractures in all hospitals and clinics, were analyzed between 1 January 2009 and 31 December 2017 by using the HIRA database that contains prescription data and diagnostic codes. These data were retrospectively analyzed by decade and age-specific and gender-specific incidents in each year. We also evaluated other characteristics of patients including medication state of osteoporosis, primary used medical institution, regional-specific incidence of osteoporosis, and incidence of site-specific osteoporotic fractures. The number of osteoporosis patients over 50 years old, as diagnosed by a doctor, steadily increased from 2009 to 2017. The number of osteoporosis patients was notably greatest in the 60′s and 70′s age groups in every study period. Patients undergoing treatment for osteoporosis increased significantly (96%) from 2009 to 2017. Among the patients diagnosed with osteoporosis, the proportion who experienced osteoporotic fracture increased gradually (60%) from 2009 to 2017. The number of patients with osteoporotic fractures of the spine and hip was highest in the 70 to 90 age range, and the number of patients with osteoporotic fractures in the upper and lower extremities was highest in the 50 to 70 age range. Understanding the trends of osteoporosis in Korea will contribute to manage the increased number of patients with osteoporosis and osteoporotic fractures.

scholarly journals Older Adults and Technology Use: A Systematic Literature Review

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 823-823
Author(s):  
Hyung Wook Choi ◽  
Rose Ann DiMaria-Ghalili ◽  
Mat Kelly ◽  
Alexander Poole ◽  
Erjia Yan ◽  
...  
Keyword(s):  
Older Adults ◽  
Technology Use ◽  
Age Groups ◽  
Well Being ◽  
Sample Population ◽  
Age Cohorts ◽  
Fine Grained ◽  
Nuanced Understanding ◽  
Smart Technologies ◽  
Age Range

Abstract Researchers are increasingly interested in leveraging technology to support the physical and mental well-being of older adults. We systematically reviewed previous scholars’ criteria for sampling older adult populations, focusing on age cohorts (namely adults over 65) and their use of internet and smart technologies. We iteratively developed keyword combinations that represent older adults and technology from the retrieved literature. Between 2011 and 2020, 70 systematic reviews were identified, 26 of which met our inclusion criteria for full review. Most important, not one of the 26 papers used a sample population classification more fine-grained than “65 and older.” A knowledge gap thus exists; researchers lack a nuanced understanding of differences within this extraordinarily broad age-range. Demographics that we propose to analyze empirically include not only finer measures of age (e.g., 65-70 or 71-75, as opposed to “65 and older”), but also those age groups’ attitudes toward and capacity for technology use.

scholarly journals An evaluation of the factor structure of the Self-Assessed Wisdom Scale (SAWS) and the creation of the SAWS-15 as a short measure for personal wisdom

2021 ◽  
pp. 1-11
Author(s):  
Trilas M. Leeman ◽  
Bob G. Knight ◽  
Erich C. Fein ◽  
Sonya Winterbotham ◽  
Jeffrey Dean Webster
Keyword(s):  
Factor Analysis ◽  
Factor Structure ◽  
Latent Variables ◽  
Emotional Regulation ◽  
Short Form ◽  
Age Groups ◽  
Total Sample ◽  
Future Research ◽  
Personal Wisdom ◽  
Age Range

ABSTRACT Objectives: Although wisdom is a desirable life span developmental goal, researchers have often lacked brief and reliable construct measures. We examined whether an abbreviated set of items could be empirically derived from the popular 40-item five-factor Self-Assessed Wisdom Scale (SAWS). Design: Survey data from 709 respondents were randomly split into two and analyzed using confirmatory factor analysis (CFA). Setting: The survey was conducted online in Australia. Participants: The total sample consisted of 709 participants (M age = 35.67 years; age range = 15–92 years) of whom 22% were male, and 78% female. Measurement: The study analyzed the 40-item SAWS. Results: Sample 1 showed the traditional five-factor structure for the 40-item SAWS did not fit the data. Exploratory factor analysis (EFA) on Sample 2 offered an alternative model based on a 15-item, five-factor solution with the latent variables Reminiscence/Reflection, Humor, Emotional Regulation, Experience, and Openness. This model, which replicates the factor structure of the original 40-item SAWS with a short form of 15 items, was then confirmed on Sample 1 using a CFA that produced acceptable fit and measurement invariance across age groups. Conclusions: We suggest the abbreviated SAWS-15 can be useful as a measure of individual differences in wisdom, and we highlight areas for future research.

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