THE RESEARCHER'S CHILD

PEDIATRICS ◽  
1986 ◽  
Vol 77 (3) ◽  
pp. 381-381
Author(s):  
Paulette Mehta
Keyword(s):  
Research Work ◽  
Complete Information ◽  
Research Data ◽  
First Year ◽  
Telephone Number ◽  
Number Of Children ◽  
Birthday Party ◽  
First Year Of Life ◽  
The Impact ◽  
Spread Sheet

Our daughter Asha grew up among endless conversations of our research work. Her first year of life unfolded between the pages of the book we edited on Platelets, Prostaglandins and Cardiovascular Disease. Subsequently, as she grew, nighttime discussions were on platelets and prostaglandins, dinner conversations on meetings and abstracts, bedtime stories were our manuscripts, and family albums were stacked with slides relating to our research data. Vacations were squeezed in between Mommy's and Daddy's presentations at various meetings. Nevertheless, Jay and I never noticed that Asha was different from any of her school friends. Recently, however, in preparation for her seventh birthday party, I told my daughter to bring me telephone numbers of her school friends so I could call their mothers to invite them. To my surprise, Asha returned home the next day with a 12-column spread sheet. The spread sheet was neatly labeled: Invitation List for Asha Mehta's Seventh Birthday Party. Each column was neatly sublabeled: Guest Number, Name, Date of Birth, Address, Nationality, Mother's Name, Father's Name, Number of Children in Family, Telephone Number, Response of Parents, and Remarks. Each row contained complete information on each potential guest. Finally, each column was boxed off, as though ready for statistical analysis. We finally realized the impact that our lives had had on our little child.

scholarly journals The impact of the number of children in the family on the breastfeeding duration and vaccination coverage

2020 ◽  
Vol 101 (4) ◽  
pp. 538-543
Author(s):  
A V Alekseeva ◽  
E N Berezkina ◽  
K E Moiseeva ◽  
Sh D Kharbediya
Keyword(s):  
Vaccination Coverage ◽  
Negative Relationship ◽  
Vaccination Schedule ◽  
Breastfeeding Duration ◽  
First Year ◽  
Number Of Children ◽  
The Family ◽  
Preventive Vaccination ◽  
First Year Of Life ◽  
The Impact

Aim. To assess the impact of the number of children in the family on breastfeeding duration and vaccination coverage. Methods. 1724 mothers of 1-year old children were randomly chosen from seven children's polyclinics in St. Petersburg for an anonymous survey that was conducted by a specially designed form Questionnaire of a mother of 1-year old children. The questionnaire comprised of 20 open-ended and closed-ended questions, and included questions about: (1) timing of the attachment to the breast in obstetric hospitals; (2) causes and timing of breastfeeding abandonment; (3) presence or absence of vaccinations in the first year of life according to the National preventive vaccination schedule; (4) and reasons for mothers refusing to vaccinate their children. Results. The proportion of mothers who started artificial feeding in maternity wards immediately after the birth of the baby was the smallest among women for whom this baby was the first-born (3.4%), and the largest among families with many children (11.3%). On average, mothers with one child are breastfed until 7.360.11 months, with two children until 8.290.11 months, with three or more children until 8.780.10 months. By using one-way analysis of variance (ANOVA), it was shown the effect of the number of children in the family on the duration of breastfeeding (F=3.3). Correlation analysis revealed the negative relationship of the number of children in the family with the proportion of women who continued breastfeeding until 3 and 6 months (rxy=0.82 and rxy=0.88, respectively), and positive relationship with the proportion of mothers who continued to breastfeeding the baby after reaching a year (rxy=0.89). 12.3% of children of one-child families were not vaccinated according to the National preventive vaccination schedule, 17.7% with two-child families, 28.1% in families with three or more children. It was revealed the significant cross-group effect of the number of children in the family to vaccination coverage (F=48.7). With an increase in the number of children in the family, vaccination coverage decreases, both in general (rxy=0.88) and against individual infections, including hepatitis B, diphtheria, whooping cough, tetanus, polio, measles and rubella (rxy from 0.80 to 0.90). Conclusion. The number of children in a family impacts mothers' refusals of breastfeeding and vaccination; the more children in a family, the more prolonged breastfeeding, but less vaccination coverage due to the health status of children in the first year of life.

scholarly journals Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study

2017 ◽  
Vol 49 (5) ◽  
pp. 1602019 ◽  
Author(s):  
Meghan B. Azad ◽  
Lorena Vehling ◽  
Zihang Lu ◽  
David Dai ◽  
Padmaja Subbarao ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Respiratory Health ◽  
Birth Cohort Study ◽  
P Value ◽  
First Year ◽  
Dependent Manner ◽  
Complementary Foods ◽  
Adjusted Rate ◽  
First Year Of Life ◽  
The Impact

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35–0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20–0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43–0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61–1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

scholarly journals The development of the cortisol response to dyadic stressors in Black and White infants

2018 ◽  
Vol 30 (5) ◽  
pp. 1995-2008 ◽  
Author(s):  
Andrew Dismukes ◽  
Elizabeth Shirtcliff ◽  
Christopher W. Jones ◽  
Charles Zeanah ◽  
Katherine Theall ◽  
...  
Keyword(s):  
Urban Life ◽  
First Year ◽  
Strange Situation ◽  
Cortisol Reactivity ◽  
Hypothalamic Pituitary Adrenal ◽  
Black And White ◽  
First Year Of Life ◽  
The Impact ◽  
Still Face Paradigm ◽  
Strange Situation Procedure

AbstractAcute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course.

Impact of intrapartum antibiotics on the infant gastrointestinal microbiome: a narrative review

2021 ◽  
pp. archdischild-2021-322590
Author(s):  
Laura Diamond ◽  
Rachel Wine ◽  
Shaun K Morris
Keyword(s):  
Gestational Age ◽  
Beta Diversity ◽  
Mode Of Delivery ◽  
Alpha Diversity ◽  
First Year ◽  
Feeding Method ◽  
Alpha And Beta Diversity ◽  
Ovid Medline ◽  
First Year Of Life ◽  
The Impact

BackgroundThe composition of the infant gastrointestinal (GI) microbiome has been linked to adverse long-term health outcomes and neonatal sepsis. Several factors are known to impact the composition of the microbiome, including mode of delivery, gestational age, feeding method and exposure to antibiotics. The impact of intrapartum antibiotics (IPAs) on the infant microbiome requires further research.ObjectiveWe aimed to evaluate the impact of IPAs on the infant GI microbiome.MethodsWe searched Ovid MEDLINE and Embase Classic+Embase for articles in English reporting on the microbiome of infants exposed to IPAs from the date of inception to 3 January 2021. Primary outcomes included abundance and colonisation of Bifidobacterium and Lactobacillus, as well as alpha and beta diversity.Results30 papers were included in this review. In the first year of life, following exposure to IPAs, 30% (6/20) of infant cohorts displayed significantly reduced Bifidobacterium, 89% (17/19) did not display any significant differences in Lactobacillus colonisation, 21% (7/34) displayed significantly reduced alpha diversity and 35% (12/34) displayed alterations in beta diversity. Results were further stratified by delivery, gestational age (preterm or full term) and feeding method.ConclusionsIPAs impact the composition of the infant GI microbiome, resulting in possible reductions Bifidobacterium and alpha diversity, and possible alterations in beta diversity. Our findings may have implications for maternal and neonatal health, including interventions to prevent reductions in health-promoting bacteria (eg, probiotics) and IPA class selection.

scholarly journals Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother–child cohort studies

2013 ◽  
Vol 110 (11) ◽  
pp. 2058-2068 ◽  
Author(s):  
Leda Chatzi ◽  
Raquel Garcia ◽  
Theano Roumeliotaki ◽  
Mikel Basterrechea ◽  
Haizea Begiristain ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Dairy Products ◽  
Meta Analysis ◽  
Maternal Diet ◽  
First Year ◽  
Processed Meat ◽  
High Intake ◽  
Meat Intake ◽  
First Year Of Life ◽  
The Impact

Maternal diet during pregnancy might influence the development of childhood allergic disorders. The aim of the present study was to evaluate the impact of Mediterranean diet (MD) adherence during pregnancy on wheeze and eczema in the first year of life in two population-based mother–child cohorts in Spain and Greece. We studied 1771 mother–newborn pairs from the Spanish multi-centre ‘INMA’ (INfancia y Medio Ambiente) study (Gipuzkoa, Sabadell and Valencia) and 745 pairs from the ‘RHEA’ study in Crete, Greece. The symptoms of wheeze and eczema were based on the criteria of the International Study of Asthma and Allergies in Childhood. Maternal diet during pregnancy was assessed by FFQ and MD adherence was evaluated through an a priori score. Multivariate log-binomial regression models were used to adjust for several confounders in each cohort and summary estimates were obtained by a meta-analysis. MD adherence was not associated with the risk of wheeze and eczema in any cohort, and similar results were identified in the meta-analysis approach. High meat intake (relative risk (RR) 1·22, 95 % CI 1·00, 1·49) and ‘processed’ meat intake (RR 1·18, 95 % CI 1·02, 1·37) during pregnancy were associated with an increased risk of wheeze in the first year of life, while a high intake of dairy products was significantly associated with a decreased risk of infantile wheeze (RR 0·83, 95 % CI 0·72, 0·96). The results of the present study show that high meat intake during pregnancy may increase the risk of wheeze in the first year of life, while a high intake of dairy products may decrease it.

scholarly journals Determinants of Infant Susceptibility to Malaria During the First Year of Life in South Western Cameroon

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Tobias O. Apinjoh ◽  
Judith K. Anchang-Kimbi ◽  
Regina N. Mugri ◽  
Clarisse Njua-Yafi ◽  
Rolland B. Tata ◽  
...  
Keyword(s):  
Rainy Season ◽  
Intermittent Preventive Treatment ◽  
Preventive Treatment ◽  
Malaria Prevalence ◽  
Immunoglobulin M ◽  
Malaria Episode ◽  
Enzyme Linked Immunosorbent Assay ◽  
First Year ◽  
First Year Of Life ◽  
The Impact

Abstract Background.  Falciparum malaria is an important pediatric infectious disease that frequently affects pregnant women and alters infant morbidity. However, the impact of some prenatal and perinatal risk factors such as season and intermittent preventive treatment during pregnancy (IPTp) on neonatal susceptibility has not been fully elucidated. Methods.  A cohort of 415 infants born to women who were positive and negative for malaria was monitored in a longitudinal study in Southwestern Cameroon. The clinical and malaria statuses were assessed throughout, whereas paired maternal-cord and 1-year-old antimalarial antibodies were assayed by enzyme-linked immunosorbent assay. Infant susceptibility to malaria was ascertained after accounting for IPTp and season in the statistical analysis. Results.  Malaria prevalence was higher in women (P = .039) who delivered during the rainy season and their infants (P = .030) compared with their dry season counterparts. Infants born to women who were positive for malaria (6.40 ± 2.83 months) were older (P = .028) than their counterparts who were negative for malaria (5.52 ± 2.85 months) when they experienced their first malaria episode. Infants born in September–November (adjusted odds ratio [OR] = 0.31, 95% confidence interval [CI] = 0.13–0.72) and to mothers on 1 or no IPTp-sulfadoxine/pyrimethamine (SP) dose (adjusted OR = 0.51, 95% CI = 0.28–0.91) were protected, whereas those born in the rainy season (adjusted OR = 2.82, 95% CI = 1.21–6.55) were susceptible to malaria. Conclusions.  Intermittent preventive treatment during pregnancy and month of birth have important implications for infant susceptibility to malaria, with 2 or more IPTp-SP dosage possibly reducing immunoglobulin M production.

scholarly journals Reduced Efficacy of Intermittent Preventive Treatment of Malaria in Malnourished Children

2009 ◽  
Vol 53 (5) ◽  
pp. 1753-1759 ◽  
Author(s):  
Ina Danquah ◽  
Ekkehart Dietz ◽  
Philipp Zanger ◽  
Klaus Reither ◽  
Peter Ziniel ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Intermittent Preventive Treatment ◽  
Preventive Treatment ◽  
Child Growth ◽  
Northern Ghana ◽  
First Year ◽  
Malnourished Children ◽  
Increased Risk ◽  
First Year Of Life ◽  
The Impact

ABSTRACT Intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) reduces malaria episodes by 20 to 59% across Africa. This protective efficacy, however, may be affected by the high frequency of malnutrition in African infants. We analyzed the impact of malnutrition as defined by anthropometry on the incidence of malaria and on the protective efficacy of IPTi in a cohort of 1,200 children in northern Ghana, where malaria is hyperendemic. These children received IPTi-SP or placebo at 3, 9, and 15 months of age and were monitored until 24 months of age. Malnutrition was present in 32, 40, and 50% of children at ages 3, 9, and 15 months, respectively. It was associated with increased risks of severe anemia and death but not an increased risk of malaria. Although malaria slightly contributed to chronic malnutrition, IPTi did not substantially improve child growth. Importantly, the protective efficacies of IPTi in malnourished children were roughly half or even less of those observed in nonmalnourished children. In the first year of life, IPTi reduced the incidence of malaria to a significantly lesser extent in infants who received both doses in a malnourished condition (25%; 95% confidence interval [CI], −7 to 48%) compared to that of nonmalnourished children (46%; 95% CI, 30 to 58%; P = 0.049). Moreover, in contrast to nutritionally advantaged children, the rate of severe malaria appeared to be increased in malnourished children who took IPTi. IPTi might exhibit reduced efficacy in regions of abundant malnutrition. Concomitant nutrition programs may be needed in these places to achieve the desired impact.

scholarly journals PECULIARITIES OF DIAGNOSTICS AND TREATMENT OF PARAPROCTITIS IN CHILDREN

2020 ◽  
Vol 24 (1) ◽  
pp. 29-34
Author(s):  
A. I. Kuzmin ◽  
A. G. Munin ◽  
M. A. Barskaya ◽  
M. I. Terekhina ◽  
Vladislav A. Zavyalkin ◽  
...  
Keyword(s):  
Ultrasound Examination ◽  
Fistula Formation ◽  
First Year ◽  
Perianal Area ◽  
Anal Glands ◽  
Surgical Infection ◽  
Intestinal Dysbiosis ◽  
One Step ◽  
First Year Of Life ◽  
The Impact

Relevance. Children with acute and chronic paraproctitis constitute 1-3% of hospitalized subjects with purulent surgical infection. Purpose. To study specific features of paraproctitis in children and to analyze outcomes of treatment. Material and methods. Case-histories of 218 children with acute and chronic paraproctitis were analyzed. Microbiological culture for pathogen identification was taken from paraproctitis focus, breast milk, from feces for conditionally pathogenic flora. The researchers also studied anamnesis, type of feeding, results of ultrasound examination of the perianal area and histological test of the material taken during surgery. Results. Patients with subcutaneous and subcutaneous-submucous paraproctitis constituted 95.5% [1]. The majority of patients with subcutaneous and subcutaneous-submucous paraproctitis - up to 62,5% - were children of the first 6 months of their life. The researchers defined age and etiopathogenic aspects of paraproctitis in children; the impact of provoking factors at acute paraproctitis as well as the specificity of chronic paraprocitis course and its treatment. 76 patients with acute paraproctitis had bottle and mixed feeding for the first 6 months of their life with further developed intestinal dysbiosis. In 112 children, conditionally pathogenic microorganisms were identified in 91 (81,2%) at the first year of their life. Ultrasound examination was sensitive for acute and chronic paraproctitis in about 90% [2, 3]. With the developed intestinal dysbiosis and immunological features of children at their first year of life , the process of acute paraproctitis was caused by the causal anal crypt and abnormal ducts of anal glands. It is considered to be the first step in fistula formation (fistulous abscess) [4-6]. The Gabriel surgery performed in acute paraproctitis was pathogenically verified because due to it one of the pathogenic steps was erradicated- pararectal fistula formation [7-11]. Disease relapse (pararectal fistula) was met in 7 patients. In average, hospitalization lasted for 7.1 days in acute paraproctitis and 8.4 in chronic paraproctitis. Conclusion. On analyzing etiopahogenic features of acute subcutaneous and subcutaneous-submucous paraproctitis, the authors recommend to perform a one-step surgical intervention.

scholarly journals Does the presence of non-refluxing hydroureter impact the management and outcome of high-grade hydronephrosis?

2019 ◽  
Vol 14 (3) ◽  
Author(s):  
Amr Hodhod ◽  
John-Paul Capolicchio ◽  
Roman Jednak ◽  
Sunny Wei ◽  
Mohamed Marzouk Abdallah ◽  
...  
Keyword(s):  
Conservative Management ◽  
Surgical Intervention ◽  
First Year ◽  
Voiding Cystourethrogram ◽  
High Grade ◽  
Fetal Ultrasound ◽  
Initial Management ◽  
Surgical Interventions ◽  
First Year Of Life ◽  
The Impact

Introduction: We aimed to evaluate the impact of non-refluxing hydroureter on the initial management of high-grade hydronephrosis (HGH) management. Moreover, we evaluated the occurrence of febrile urinary tract infection (FUTI) and surgical intervention for conservatively managed units. Methods: Patients’ charts with postnatal hydronephrosis from 2008‒2014 were retrospectively reviewed. We included patients who presented in the first year of life. All included patients had HGH (Society of Fetal Ultrasound [SFU] grades3 and 4) and all were non-refluxing using voiding cystourethrogram (VCUG). We categorized renal units into two groups: with hydroureteronephrosis (HUN) and without hydroureter (isolated hydronephrosis [IH]). We recorded the initial management. We evaluated the impact of non-refluxing hydroureter on hydronephrosis fate, FUTI, and change to surgery for those managed conservatively. Results: We included 169 patients (180 units). IH was diagnosed in 146 units (137patients), whereas 34 units (32 patients) had HUN. Median followup was 42.9 months. A total of 25.3% of IH units (37/146) had initial surgical management in comparison to 5.1% (2/34) of HUN units (p=0.01). During conservative management, nine HUN patients (30%) and 11 IH patients (10.7%) experienced FUTI (p=0.009). Surgical intervention after failed conservative management was indicated for 12 IH units (11%) and six HUN units (18.8%) (p=0.25). Anteroposterior diameter (APD) worsening was significantly associated with the change to surgery in IH group (p=0.003). More than half (52.3%) of IH units resolved during conservative management in comparison to 18.7% of HUN (p<0.001). HUN had longer time till resolution (log rank=0.004). Conclusions: IH units had more initial surgical interventions. The FUTI rate was much higher in association with dilated ureter even under antibiotic coverage. HUN was associated with less and slower resolution rate.

Breast-Feeding and Infectious Illness, Power and Confidence Intervals

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 1079-1080
Author(s):  
JUDY HOPKINSON
Keyword(s):  
Prospective Study ◽  
Confidence Intervals ◽  
Infant Feeding ◽  
Breast Feeding ◽  
First Year ◽  
Infectious Illness ◽  
A Prospective Study ◽  
First Year Of Life ◽  
The Impact ◽  
Breast Fed

The article "Relationship Between Infant Feeding and Infectious Illness: A Prospective Study of Infants During the First Year of Life" by Rubin et al in the April issue of Pediatrics was provocative. Like Mulford, I too am concerned about the definitions of breast-feeding used in the study. Breast-feeding and formula-feeding are defined in such a way that the study actually examines the impact of the degree of breast-feeding on health of breast-fed infants. This may be an important issue in Denmark where the incidence of breast-feeding at 1 month is more than 90%.

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