Perinatal Manifestations of Maternal Yellow Nail Syndrome

A term female firstborn infant had unexplained nonimmune fetal hydrops and recurrent left chylothorax at 4 weeks of age. A few months before conception, her mother had had acute dystrophic nail changes and is being treated for recurrent sinusitis, bronchiectasis, and a deficiency of serum IgG2. We suggest that they both suffer from a dominantly inherited congenital lymphedema syndrome known as `yellow nail dystrophy.' Prenatal manifestation of this disorder has not been reported previously. The child's anthropometric and neurological development was normal at 1 year of age, whereas mild ankle edema and marbling of the skin of the limbs were salient clinical findings. Inherited lymphedema leading to nonimmune fetal hydrops also has been recognized in chromosomal disorders, Noonan's syndrome, multiple pterygium syndrome, pulmonary lymphangiectasis, and mixed-vessel lymphatic dysfunction. Indicators of parental lymphedema are not on record in those instances.

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NAIL DYSTROPHY IN PSORIATIC ARTHRITIS PRESENTING AS NAIL ONYCHOMYCOSIS: A CASE REPORT

Hand Surgery ◽

10.1142/s0218810412720161 ◽

2012 ◽

Vol 17 (01) ◽

pp. 139-142 ◽

Cited By ~ 1

Author(s):

Joon Yub Kim ◽

Goo Hyun Baek ◽

Hyun Sik Gong

Keyword(s):

Case Report ◽

Psoriatic Arthritis ◽

Skin Lesion ◽

Joint Infection ◽

Interphalangeal Joint ◽

Nail Dystrophy ◽

Rare Form ◽

Nail Changes ◽

Methotrexate Treatment ◽

Dystrophic Nail

Dystrophic nail changes without a skin lesion is a rare form of psoriasis. We describe a patient that presented with a chronic nail onychomycosis and a destructive thumb interphalangeal joint which was initially considered as onychomycotic joint infection, and was later diagnosed as having dystrophic nail changes in psoriatic arthritis and coexistent onychomycosis. The nail changes were completely normalized after methotrexate treatment.

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Nail changes in lichen planus may resemble those of yellow nail syndrome

British Journal of Dermatology ◽

10.1046/j.1365-2133.2000.03460.x ◽

2000 ◽

Vol 142 (4) ◽

pp. 848-849 ◽

Cited By ~ 20

Author(s):

A. Tosti ◽

B.M. Piraccini ◽

N. Cameli

Keyword(s):

Lichen Planus ◽

Yellow Nail Syndrome ◽

Nail Changes

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Psoriatic Nails: A Prospective Clinical Study

Journal of Cutaneous Medicine and Surgery ◽

10.1007/s10227-002-0143-0 ◽

2003 ◽

Vol 7 (4) ◽

pp. 317-321 ◽

Cited By ~ 77

Author(s):

Joanna Salomon ◽

Jacek C. Szepietowski ◽

Alina Proniewicz

Keyword(s):

Clinical Study ◽

Skin Disorder ◽

Fungal Infections ◽

Prospective Clinical Study ◽

Common Symptom ◽

Clinical Parameters ◽

Nail Dystrophy ◽

Predisposing Factor ◽

Nail Changes ◽

Nail Involvement

Background: Psoriasis is a widespread skin disorder in which nail involvement is a common symptom. Many psoriatic patients have nail changes morphologically resembling onychomycosis. Objective: The present study was undertaken (1) to evaluate the frequency of nail involvement in psoriatic patients, (2) to assess the types of nail changes in psoriasis, (3) to find eventual relationships between nail involvement and some clinical parameters, and finally (4) to determine the prevalence of fungal nail infections in psoriatic individuals. Material and Methods: One hundred six patients hospitalized in our department due to exacerbation of psoriasis participated in the study. Each patient underwent dermatologic examination with special attention paid to the nail changes. In any case of abnormalities clinically suspected of fungal infection, further mycological investigations were performed. Results: Nail changes were present in 83 patients (78.3%) with psoriasis. The most common nail abnormality observed on both fingernails and toenails was subungual hyperkeratosis. Hyperkeratosis, onychorrexis, and discoloration of nail plates were observed significantly more often on toenails. Pitting and longitudinal ridges were significantly more frequent on fingernails. Patients with psoriatic nail dystrophy were significantly older than psoriatic patients without nail abnormalities. Nails were involved statistically more often in patients with arthropathic psoriasis. Positive mycological cultures were obtained from 18% of patients with nail changes. The most commonly isolated fungi were molds. Conclusions: Dystrophic nails are frequently found in psoriatic individuals, especially those suffering from arthropathic psoriasis. Subungual hyperkeratosis and pitting are the most typical lesions. It is difficult to assess definitively whether psoriasis is a predisposing factor to the development of fungal infections of the nails.

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Psoriatic onychodystrophy: clinical manifestations (part 1)

Vestnik dermatologii i venerologii ◽

10.25208/0042-4609-2018-94-6-7-14 ◽

2019 ◽

Vol 94 (6) ◽

pp. 7-14

Author(s):

A. V. Platonova ◽

A. S. Zhukov ◽

V. R. Khairutdinov ◽

A. V. Samtsov

Keyword(s):

Psoriatic Arthritis ◽

Prognostic Value ◽

Clinical Manifestations ◽

Pathological Changes ◽

Nail Bed ◽

Nail Changes ◽

Wide Range ◽

Mechanisms Of Formation ◽

The Relationship ◽

Dystrophic Nail

Psoriatic onychodystrophy is quite common in patients with psoriasis. Changes in psoriatic nails have a wide range of clinical manifestations, including symptoms of damage of the nail bed and/or nail matrix. The article presents information about clinical and pathological manifestations of psoriatic onychodystrophy, the mechanisms of formation of pathological changes. The existence of the relationship between the change of nail plates in patients with psoriasis and the development of psoriatic arthritis is explained, the prognostic value of individual symptoms is analyzed. The diagnostic criteria for the histological diagnosis of psoriatic onychodystrophy are described. The information about the occurrence of each symptom in patients with psoriasis with dystrophic nail changes is given.

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Nail Biopsy in the Diagnosis of Systemic Amyloidosis

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.2.4.9 ◽

2018 ◽

Vol 2 (4) ◽

pp. 252-255

Author(s):

Cristopher C Briscoe ◽

Zachary P Nahmias ◽

Ilana S Rosman ◽

Milan J Anadkat

Keyword(s):

Monoclonal Gammopathy ◽

Conventional Treatment ◽

Systemic Amyloidosis ◽

Al Amyloidosis ◽

Nail Dystrophy ◽

Hematopoietic Stem ◽

Nail Changes ◽

Unknown Significance ◽

History Of ◽

Low Threshold

A 60-year-old woman with a 13-year history of monoclonal gammopathy of unknown significance (MGUS) presented with worsening nail dystrophy. Prior workup for systemic amyloidosis had been unrevealing, and no other signs of cutaneous disease were present. Nail biopsy was consistent with amyloid deposition, and the patient subsequently underwent autologous hematopoietic stem cell transplantation for AL amyloidosis. In light of the growing literature regarding nail changes as a presenting sign of systemic amyloidosis and the promising utility of nail biopsy, we suggest a low threshold for biopsy in appropriate patients when nail changes characteristic of amyloidosis are refractory to conventional treatment.

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A Single Nail Dystrophy as a Unique Manifestation of Sarcoidosis: A Case Report

Skin Appendage Disorders ◽

10.1159/000518038 ◽

2021 ◽

pp. 1-4

Author(s):

Laura Mengeot ◽

Bernard Stallenberg ◽

Ivan Théate ◽

Oliver Vanhooteghem

Keyword(s):

Case Report ◽

Clinical Evaluation ◽

Systemic Disease ◽

Radiological Examination ◽

Bone Involvement ◽

Nail Dystrophy ◽

Nail Changes ◽

Osseous Involvement ◽

Nail Involvement

Sarcoidosis with nail involvement is rare and most commonly affecting plural digits. Nail changes are frequently an indication of systemic disease and underlying bone involvement, thus complete clinical evaluation with bone and thorax radiological examination is a necessity in suspected cases. We report a case of onychodystrophy with osseous involvement of only one finger as unique manifestation of sarcoidosis, which is very rare.

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Yellow Nail Syndrome – Diagnosis, Differential Diagnosis, Treatment Options

Internal Medicine Review ◽

10.18103/imr.v6i5.891 ◽

2020 ◽

Vol 6 (5) ◽

Author(s):

Eckart Haneke

Keyword(s):

Treatment Options ◽

Gastrointestinal Diseases ◽

Lower Limbs ◽

Yellow Nail Syndrome ◽

Nail Changes ◽

Syndrome Diagnosis ◽

Limb Edema ◽

Systemic Disorder ◽

Characteristic Features ◽

Slow Growing

Yellow nail syndrome (YNS) is a rare, but relatively well characterized triad of slow growing yellow nails, lymphedema of the distal portions of the upper and lower limbs as well as chronic infection of the respiratory tract and/or pleural effusion. The most characteristic features of this syndrome are the nail changes that allow the diagnosis to be made even if the triad is not complete. Yellow discoloration of the nails is nonspecific and often seen in onychomycosis, nail psoriasis, a variety of other conditions that are associated with onycholysis. Distal limb edema may not be very pronounced. In addition to the bronchopulmonary disorders, malignancies, chronic heart conditions and gastrointestinal diseases may occur. Treatment after exclusion of non-YNS conditions is aimed at finding the underlying systemic disorder, which usually requires a very long therapy and a lot of patience both from the patient as well as the treating physician.

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Yellow Nail Syndrome Presenting With a Pericardial Effusion: A Case Report and Review of the Literature

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475417738970 ◽

2017 ◽

Vol 22 (2) ◽

pp. 190-193 ◽

Cited By ~ 1

Author(s):

Laura C. Soong ◽

Richard M. Haber

Keyword(s):

Computed Tomography ◽

Case Report ◽

Pleural Effusion ◽

Pericardial Effusion ◽

Respiratory Tract ◽

Clinical Findings ◽

Review Of The Literature ◽

Pleural Effusions ◽

Yellow Nail Syndrome ◽

Tract Involvement

Yellow nail syndrome (YNS) is a constellation of clinical findings including at least 2 of the 3 features of thickened yellow nails, respiratory tract involvement, and lymphedema. We report the case of a middle-aged man presenting with dystrophic, thickened yellow nails; an idiopathic pericardial effusion in the absence of pleural effusion(s); and unilateral apical bronchiectasis found on computed tomography of the chest. This represents a unique presentation of YNS as the first report of a patient with YNS and a pericardial effusion in the absence of pleural effusions and lymphedema and is the 11th case report of YNS with pericardial effusion.

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