scholarly journals Lab-on-a-chip rendszerek a betegágy melletti diagnosztikában

2015 ◽  
Vol 156 (52) ◽  
pp. 2096-2102 ◽  
Author(s):  
Barnabás Szabó ◽  
András Borbíró ◽  
Péter Fürjes
Keyword(s):  
High Selectivity ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Modern Medicine ◽  
Laboratory Diagnostics ◽  
Biomolecular Recognition ◽  
Measurement Systems ◽  
Therapeutic Decisions ◽  
Immediate Analysis ◽  
New Situation

The need in modern medicine for near-patient diagnostics being able to accelerate therapeutic decisions and possibly replacing laboratory measurements is significantly growing. Reliable and cost-effective bioanalytical measurement systems are required which – acting as a micro-laboratory – contain integrated biomolecular recognition, sensing, signal processing and complex microfluidic sample preparation modules. These micro- and nanofabricated Lab-on-a-chip systems open new perspectives in the diagnostic supply chain, since they are able even for quantitative, high-precision and immediate analysis of special disease specific molecular markers or their combinations from a single drop of sample. Accordingly, crucial requirements regarding the instruments and the analytical methods are the high selectivity, extremely low detection limit, short response time and integrability into the healthcare information networks. All these features can make the hierarchical examination chain shorten, and revolutionize laboratory diagnostics, evolving a brand new situation in therapeutic intervention. Orv. Hetil., 2015, 156(52), 2096–2102.

scholarly journals Simple and Cost-Effective Electrochemical Method for Norepinephrine Determination Based on Carbon Dots and Tyrosinase

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4567 ◽  
Author(s):  
Sylwia Baluta ◽  
Anna Lesiak ◽  
Joanna Cabaj
Keyword(s):  
Electrochemical Method ◽  
Gold Electrode ◽  
High Selectivity ◽  
Limit Of Detection ◽  
Cost Effective ◽  
Differential Pulse ◽  
Modern Medicine ◽  
Limit Of Quantification ◽  
Voltammetric Techniques ◽  
Pulse Voltammetry

Although neurotransmitters are present in human serum at the nM level, any dysfunction of the catecholamines concentration may lead to numerous serious health problems. Due to this fact, rapid and sensitive catecholamines detection is extremely important in modern medicine. However, there is no device that would measure the concentration of these compounds in body fluids. The main goal of the present study is to design a simple as possible, cost-effective new biosensor-based system for the detection of neurotransmitters, using nontoxic reagents. The miniature Au-E biosensor was designed and constructed through the immobilization of tyrosinase on an electroactive layer of cysteamine and carbon nanoparticles covering the gold electrode. This sensing arrangement utilized the catalytic oxidation of norepinephrine (NE) to NE quinone, measured with voltammetric techniques: cyclic voltammetry and differential pulse voltammetry. The prepared bio-system exhibited good parameters: a broad linear range (1–200 μM), limit of detection equal to 196 nM, limit of quantification equal to 312 nM, and high selectivity and sensitivity. It is noteworthy that described method was successfully applied for NE determination in real samples.

scholarly journals 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
John-Alexander Preuss ◽  
Janina Bahnemann ◽  
Alexander Heisterkamp ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Cells ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Manipulation ◽  
Hydrodynamic Focusing ◽  
Trapping Region ◽  
Dual Beam ◽  
3D Printed ◽  
On Chip

Abstract3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

scholarly journals Remote Reflectivity Sensor for Industrial Applications

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1301
Author(s):  
Federico Cavedo ◽  
Parisa Esmaili ◽  
Michele Norgia
Keyword(s):  
Low Cost ◽  
Cost Effective ◽  
Industrial Applications ◽  
Interference Immunity ◽  
Surface Reflection ◽  
Measurement Systems ◽  
Digital Detector ◽  
Reflected Light ◽  
Surface Optical ◽  
Diffused Light

A low-cost optical reflectivity sensor is proposed in this paper, able to detect the presence of objects or surface optical properties variations, at a distance of up to 20 m. A collimated laser beam is pulsed at 10 kHz, and a synchronous digital detector coherently measures the back-diffused light collected through a 1-inch biconvex lens. The sensor is a cost-effective solution for punctual measurement of the surface reflection at different distances. To enhance the interference immunity, an algorithm based on a double-side digital baseline restorer is proposed and implemented to accurately detect the amplitude of the reflected light. As results show, the sensor is robust against ambient light and shows a strong sensitivity on a wide reflection range. The capability of the proposed sensor was evaluated experimentally for object detection and recognition, in addition to dedicated measurement systems, like remote encoders or keyphasors, realized far from the object to be measured.

scholarly journals Potential of Therapeutic Bacteriophages in Nosocomial Infection Management

2021 ◽  
Vol 12 ◽  
Author(s):  
Nannan Wu ◽  
Tongyu Zhu
Keyword(s):  
Nosocomial Infection ◽  
Nosocomial Infections ◽  
Pathogenic Bacteria ◽  
Cost Effective ◽  
Good Manufacturing Practice ◽  
Modern Medicine ◽  
Patient Treatment ◽  
Phage Library ◽  
Infection Management ◽  
The Impact

Nosocomial infections (NIs) are hospital-acquired infections which pose a high healthcare burden worldwide. The impact of NIs is further aggravated by the global spread of antimicrobial resistance (AMR). Conventional treatment and disinfection agents are often insufficient to catch up with the increasing AMR and tolerance of the pathogenic bacteria. This has resulted in a need for alternative approaches and raised new interest in therapeutic bacteriophages (phages). In contrast to the limited clinical options available against AMR bacteria, the extreme abundance and biodiversity of phages in nature provides an opportunity to establish an ever-expanding phage library that collectively provides sustained broad-spectrum and poly microbial coverage. Given the specificity of phage-host interactions, phage susceptibility testing can serve as a rapid and cost-effective method for bacterial subtyping. The library can also provide a database for routine monitoring of nosocomial infections as a prelude to preparing ready-to-use phages for patient treatment and environmental sterilization. Despite the remaining obstacles for clinical application of phages, the establishment of phage libraries, pre-stocked phage vials prepared to good manufacturing practice (GMP) standards, and pre-optimized phage screening technology will facilitate efforts to make phages available as modern medicine. This may provide the breakthrough needed to demonstrate the great potential in nosocomial infection management.

scholarly journals One-Stage Bilateral Total Hip Arthroplasty. Modern Representations and Our Experience

2020 ◽  
Vol 106 (3) ◽  
pp. 52-62
Author(s):  
O.M. Kosiakov ◽  
P.V. Bulych ◽  
K.O. Hrebennikov ◽  
A.V. Myloserdov ◽  
Ye. V. Tuz ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Surgical Intervention ◽  
Joint Damage ◽  
Cost Effective ◽  
Modern Medicine ◽  
Postoperative Rehabilitation ◽  
Surgical Interventions ◽  
Total Hip ◽  
One Stage

Summary. Relevance. Total hip arthroplasty remains one of the most successful and cost-effective surgical interventions in modern medicine. This is proven by the ever-growing number of total arthroplasties worldwide, which reached 650,000 implantations in Europe only in 2018. In 2024, this number is expected to be 730,000 [1]. According to experts, from 15 to 25 percent of patients need a bilateral procedure [2, 8]. The experience of our Center allows us to recommend a successful one-stage replacement of both hip joints for patients with a number of medical and social comorbidities. Objective. The study is set out to highlight the possibilities of performing simultaneous bilateral arthroplasty of the hip joint in a group of patients with bilateral joint damage, as well as to substantiate the economic, medical and social benefits of this surgical intervention. Materials and Methods. We have analyzed the data from publications of our foreign colleagues. We also present our own observations – more than 100 cases over the past 11 years (2008-2019). Results. Based on data from foreign publications and our own observations, the undoubted advantages, features and limitations of this type of surgical intervention are shown. Complex cases of bilateral joint damage and the results of one-stage surgical treatment have been demonstrated. Conclusions. One-stage bilateral hip arthroplasty is the method of choice for symmetric lesions and should take its rightful place in the arsenal of modern orthopedics clinics. We continue to advocate simultaneous bilateral hip replacement for a selected group of healthy patients ≤65 years old. Thoughtful preoperative planning, surgical intervention lasting up to 90 minutes on each joint, careful postoperative monitoring, strictly controlled prevention of thromboembolic complications and active postoperative rehabilitation provide our patients with quick and safe functional recovery.

scholarly journals Cost Effective Wide Area Measurement Systems for Smart Power Network

2018 ◽  
Vol 5 (3) ◽  
pp. 85-93 ◽  
Author(s):  
Rahul Dubey ◽  
Marjan Popov ◽  
Jose de Jesus Chavez Muro
Keyword(s):  
Cost Effective ◽  
Area Measurement ◽  
Wide Area ◽  
Power Network ◽  
Smart Power ◽  
Measurement Systems

Biological and medicinal application of Cucumis sativus Linn. – review of current status with future possibilities

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anayatullah Khan ◽  
Anuradha Mishra ◽  
Syed Misbahul Hasan ◽  
Afreen Usmani ◽  
Mohd Ubaid ◽  
...  
Keyword(s):  
Cucumis Sativus ◽  
Cost Effective ◽  
Pharmacological Action ◽  
Modern Medicine ◽  
Current Status ◽  
Synthetic Drugs ◽  
Wide Range ◽  
Increasing Demand ◽  
Calcium Iron ◽  
Whole Plants

Abstract Objectives The increasing demand for herbal drugs for the human application is causing a growing demand for the cultivation of Medicinal Plants. This demand has developed because of cost-effective, plant-derived products rather than commercially available synthetic drugs. Cucumis sativus Linn. (Ver. Kheera) is a vegetable climber, species belongs to family Cucurbitaceae This species has a wide range of medicinal and biological applications thanks to its richness in carbohydrate, proteins, minerals (calcium, iron, magnesium, phosphorus, potassium, zinc) and secondary metabolites like alkaloids, tannins, flavonoids, saponins, and phenolic compounds These phytoconstituents may be responsible for allied therapeutic application. So, C. sativus possess wider applications for preventing certain ailments. Content The literature in various national and international journals and reports pertaining to the medicinal and nutritional uses were reviewed. The result revealed the current therapeutic applications of C. sativus whole plants other than the nutritional value. C. sativus pharmacological action includes antioxidant, anti-diabetic, UV protectant, hepatoprotective, gastroprotective, anti-helminthic, wound healing, antimicrobial, and anticancer. So, it could be useful for both preventive and additive therapy along with modern medicine for the better management of certain disorders. Summary and Outlook This review furnishes updated information about the phytoconstituents and their medicinal applications so that it can pose a path for the young researchers to do future findings.

Smart Water Level Monitoring System for Farmers

2019 ◽  
pp. 213-228
Author(s):  
Nalina Suresh ◽  
Valerianus Hashiyana ◽  
Victor Panduleni Kulula ◽  
Shreekanth Thotappa
Keyword(s):  
Water Level ◽  
Monitoring System ◽  
Cost Effective ◽  
Weather Conditions ◽  
Water Levels ◽  
Measurement Systems ◽  
Smart Water ◽  
Level Measurement ◽  
Level Monitoring ◽  
Water Level Monitoring

With advancement in technology and ever-changing weather conditions, accurate and affordable water level measurement systems has become necessary for farmers. This therefore brings about the need for a system incorporating the use of IoT technology that will monitor water levels at a cost-effective price with accurate and dependable results. The prototype will monitor water levels on a regular basis and the data captured will be stored in a database to help farmers improve the way they manage their water resource. Farmers will be able to monitor the water levels from any location at any given time. This chapter focuses on a Smart Water Level Monitoring System for Farmers and provides a smart way to manage water resources on farms in the most cost-effective and convenient manner for farmers.

scholarly journals 3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach

Micromachines ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 825
Author(s):  
Panagiotis Karayannis ◽  
Fotini Petrakli ◽  
Anastasia Gkika ◽  
Elias P. Koumoulos
Keyword(s):  
Effective Means ◽  
Ultrafine Particle ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Diagnostic Systems ◽  
Fused Filament Fabrication ◽  
Device Development ◽  
Volatile Organic ◽  
3D Printed ◽  
Safe By Design

The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Furthermore, the most crucial health risks involved in FFF processes are examined, placing the focus on the examination of ultrafine particle (UFP) and Volatile Organic Compound (VOC) emission hazards. Thus, a SbD scheme for lab-on-a-chip manufacturing is provided, while also taking into account process optimization for obtaining satisfactory printed LOC quality. This work can serve as a guideline for the effective application of FFF technology for lab-on-a-chip manufacturing through the safest applicable way, towards a continuous effort to support sustainable development of lab-on-a-chip devices through cost-effective means.

scholarly journals Accurate vision-based displacement and vibration analysis of bridge structures by means of an image-assisted total station

2018 ◽  
Vol 10 (6) ◽  
pp. 168781401878005 ◽  
Author(s):  
Mohammad Omidalizarandi ◽  
Boris Kargoll ◽  
Jens-André Paffenholz ◽  
Ingo Neumann
Keyword(s):  
Vibration Analysis ◽  
Expectation Maximization Algorithm ◽  
Cost Effective ◽  
Element Model ◽  
Distance Measurements ◽  
Target Pattern ◽  
Total Station ◽  
Measurement Systems ◽  
Bridge Structures ◽  
Short And Long Term

Today, short- and long-term structural health monitoring of bridge infrastructures and their safe, reliable and cost-effective maintenance have received considerable attention. For this purpose, image-assisted total station (here, Leica Nova MS50 MultiStation) as a modern geodetic measurement system can be utilized for accurate displacement and vibration analysis. The Leica MS50 measurements comprise horizontal angles, vertical angles and distance measurements in addition to the captured images or video streams with practical sampling frequency of 10 Hz using an embedded on-axis telescope camera. Experiments were performed for two case studies under (1) a controlled laboratory environment and (2) a real-world situation observing a footbridge structure using a telescope camera of the Leica MS50. Furthermore, two highly accurate reference measurement systems, namely, a laser tracker Leica AT960-LR and a portable shaker vibration calibrator 9210D in addition to the known natural frequencies of the footbridge structure calculated from the finite element model analysis are used for validation. The feasibility of an optimal passive target pattern and its accurate as well as reliable detection at different epochs of time were investigated as a preliminary step. Subsequently, the vertical angular conversion factor of the telescope camera of the Leica MS50 was calibrated, which allows for an accurate conversion of the derived displacements from the pixel unit to the metric unit. A linear regression model in terms of a sum of sinusoids and an autoregressive model of the coloured measurement noise were employed and solved by means of a generalized expectation maximization algorithm to estimate amplitudes and frequencies with high accuracy. The results show the feasibility of the Leica MS50 for the accurate displacement and vibration analysis of the bridge structure for frequencies less than 5 Hz.

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