scholarly journals Prevalence of ABO, RhD and other clinically significant Blood Group Antigens among blood donors at tertiary care center, Gwalior

2020 ◽  
Vol 9 (2) ◽  
pp. 437
Author(s):  
Shelendra Sharma ◽  
Dharmesh Chandra Sharma ◽  
Sunita Rai ◽  
Anita Arya ◽  
Reena Jain ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Care Center ◽  
Tertiary Care ◽  
Blood Group Antigens ◽  
Tertiary Care Center ◽  
Clinically Significant

scholarly journals PREVALENCE OF BLOOD GROUP ANTIGENS OTHER THAN ABO-RhD IN HEALTHY BLOOD DONORS AT A TERTIARY CARE CENTER IN WESTERN RAJASTHAN, INDIA

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ravindra Kumar Yadav ◽  
Dev Raj Arya ◽  
N.L. Mahawar ◽  
Arun Bharti ◽  
Shailendra Vashistha ◽  
...  
Keyword(s):  
Blood Group ◽  
Analytical Study ◽  
Blood Donors ◽  
Care Center ◽  
Tertiary Care ◽  
Blood Group Antigens ◽  
Tertiary Care Center ◽  
Cross Sectional ◽  
Donor Population ◽  
Compatible Blood

Introduction: It is important to know the frequencies of the various antigens to predict the availability of blood units for alloimmunized patients. Because of the fact that there is always a chance of diversity in phenotype pattern of a donor population, we decided to conduct a study on antigen phenotyping of regular blood donors. Methodology: This blood bank based cross-sectional analytical study was carried out amongst 500 voluntary blood donors over a period of 8 months, i.e., from April, 2019 to November, 2019. Samples from all these donors were subjected to extended phenotyping (C, c, E, e, K, M, N, S, Jka, Jkb, Fya, Fyb, Lea and Leb). Results: In present study, we observed the percentage frequencies of C, c, E, e, K, M, N, S, P1, Lea, Leb, Jka, Jkb, Fya and Fyb antigens as 75.6%, 53.2%, 18.4%, 97.75%, 3.8%, 82.4%, 58.4%, 43.8%, 66.2%, 16.8%, 52.6%, 80.0%, 67.6%, 79.4% and 54.6% respectively. Conclusion: Outcomes of such studies can be used to formulate a rare blood group donor registry and compatible blood can be provided to the patients (especially those requiring multiple transfusions). Keywords: Antigens, Phenotyping, Blood donors.

scholarly journals Evaluation of the Quantiplex Human Immunodeficiency Virus Type 1 RNA 3.0 Assay in a Tertiary-Care Center

2000 ◽  
Vol 7 (1) ◽  
pp. 122-124 ◽  
Author(s):  
Howard Gale
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Immunodeficiency Virus ◽  
Clinically Significant

ABSTRACT The Quantiplex human immunodeficiency virus type 1 RNA 3.0 Assay (bDNA) (Bayer Diagnostics, Walpole, Mass.) produced linear and reproducible (intra-assay and interassay) results over its quantification range of 50 to 500,000 copies/ml of plasma with 96% specificity. A threefold or 0.5-log10 change or greater was clinically significant for serial patient samples.

The impact of clinically significant discrepancies from primary pathological review of transurethral bladder resection specimens upon repeat review at a tertiary care center.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 4552-4552
Author(s):  
Lamont J. Barlow ◽  
Edan Shapiro ◽  
Jennifer Ahn ◽  
Mitchell C. Benson ◽  
James M. McKiernan
Keyword(s):  
Clinical Care ◽  
Care Center ◽  
Tertiary Care ◽  
Tumor Stage ◽  
Tertiary Care Center ◽  
Urologic Oncology ◽  
Internal Review ◽  
Clinically Significant ◽  
Muscle Invasion ◽  
The Impact

4552 Background: Internal review of outside pathology slides is a common practice among urologic oncologists at tertiary care facilities, and discrepancies have a potential to directly affect the choice of treatment. While repeat prostate biopsy review has been extensively studied, there is little data available on the impact of repeat reviews of bladder biopsies. The purpose of the current study is to perform a standardized comparison of original and internal pathology reviews of identical bladder specimens to characterize the impact of repeat review on treatment decisions. Methods: Using the Columbia Urologic Oncology Database, a retrospective analysis of 91 consecutive patients who underwent bladder resections at outside institutions from 2008-2012 with secondary referral to a single urologist and internal review at our institution was conducted. Characteristics of both original pathology reports and internal reviews were collected and compared by blinded reviewers. A discrepancy in one of the following characteristics was considered treatment-altering: presence of muscularis in specimen or tumor involvement in muscularis. Additional clinically-significant discrepancies including presence of secondary histology, carcinoma in situ, lymphovascular invasion, micropapillary features, tumor stage, and overall accumulative discrepancy rate were also analyzed. Results: Median time from original procedure to internal review was 34 days (range: 9-368). 56/91 (62%) patients had at least one of the predefined clinically-significant discrepancies. 27/91 (30%) patients had at least one treatment-altering discrepancy, including 25 with discrepant muscle in specimen and 11 with discrepant muscle invasion. Regarding tumor stage, 8 patients were upstaged, 71 were unchanged, and 12 were downstaged on internal review. Conclusions: Repeat pathologic review of primary bladder specimens at a tertiary care center has the potential to alter clinical care for the majority of patients. Further studies are needed to determine if these discrepancies and the decisions they influence have a significant impact on patient outcomes.

scholarly journals Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Divjot Singh Lamba ◽  
Ravneet Kaur ◽  
Sabita Basu
Keyword(s):  
Racial Differences ◽  
Blood Group ◽  
Blood Donors ◽  
Blood Group Antigen ◽  
Blood Group System ◽  
Blood Group Antigens ◽  
Young Females ◽  
Group System ◽  
Clinically Significant ◽  
Antigen Frequency

Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine.Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied.Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency wasFya(87.3%) andFyb(58.3%).Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients.

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