Features of pain syndrome in women with different forms of endometriosis

2018 ◽  
pp. 87-89
Author(s):  
V.D. Vorobii ◽  
Keyword(s):  
Menstrual Cycle ◽  
Severe Pain ◽  
Analogue Scale ◽  
Chronic Pelvic Pain ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Control Group ◽  
Moderate Pain ◽  
Group Control ◽  
Group Control Group

The objective: to assess the type and intensity of pain in women with different endometriosis forms. Materials and methods. The research included 65 women with diagnosis of external genital endometriosis who formed I group. 38 patients with internal genital endometriosis consisted II group. Control group involved 30 persons of reproductive age without diagnosis of genital endometriosis. Visual Analogue Scale (VAS) was used to determine intensity of pain. Results. Chronic pelvic pain was more typical for patients in II group than in I (χ2=12.11; p<0.001). Also 69.23% women in I group and 86.84% in II suffered from dysmenorrhea, 43.08% and 42.11% respectively – from dyspaurenia, 10.77% and 15.79% – from dyschezia. 57.89% women in II group complained of pain which was not connected with menstrual cycle that was more often, than in I group (χ2=4.73; p=0.03). 10.77% patients with external genital endometriosis had no complaints against none women with internal endometriosis. According to VAS results mild (43.08%) and moderate (46.15%) pain was more often by external endometriosis. Only 10.77% of persons in I group indicated on severe pain. While, by internal endometriosis quantity of women with mild and moderate pain was less than by external one (28.95% and 36.84% respectively) and one third of individuals in this groups suffered from severe pain (34.21%; χ2=6.98; p=0.008). Conclusion. Pain syndrome is the typical clinical manifestation in women with endometriosis. Type of pain, its intensity is more severe by internal genital endometriosis than by external one. Key words: endometrios, pain, assessment.

Clinical and sonological features in endometriomas in women of reproductive age

2016 ◽  
pp. 85-89
Author(s):  
О. Shapoval ◽  
Keyword(s):  
Endometrial Hyperplasia ◽  
Benign Tumor ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Ovarian Endometriosis ◽  
Gynecological Examination ◽  
Different Characteristics ◽  
Ovarian Endometriomas

The objective: to study the prevalence of ovarian endometriosis in women of reproductive age, the features of clinical and ultrasound picture of endometriosis. Patients and methods. The study involved 22 patients with endometriomas, the control group – 50 women gynecological and somatically healthy. Results. The incidence of ovarian endometriomas in the structure of benign tumor-like formations of ovaries is 0.62%. In 72.73% of ovarian endometriomas occur on a background of concomitant gynecological pathology. Clinically, in 77.27% of cases there is a pain syndrome, in 59.09% – algomenorrhea, in 13.64% – infertility; 18.18% of cases endometriomas remain «dumb» and proceed with the erased clinical picture. Sonologically in patients with endometriomas adenomyosis, endometrial hyperplasia, changes in the contralateral ovary are determined. Conclusion. Without additional methods of diagnostic gynecological examination may identify the 3 cm tumor-like formation of the ovary with different characteristics, which does not allow to differentiate endometrioma from inflammation, functional and ovarian tumors. Ultrasound can diagnose pathological ovarian formation of 1 cm, detailing the nature of the cyst. Key words: endometriosis, reproductive age, retrospective analysis, ultrasound.

scholarly journals Efficacy of ketamine for postoperative pain following robotic thyroidectomy: A prospective randomised study

2017 ◽  
Vol 46 (3) ◽  
pp. 1109-1120 ◽  
Author(s):  
Jiwon Lee ◽  
Hee-Pyoung Park ◽  
Mu-Hui Jeong ◽  
Je-Do Son ◽  
Hyun-Chang Kim
Keyword(s):  
Postoperative Pain ◽  
Severe Pain ◽  
Analogue Scale ◽  
Postoperative Pain Management ◽  
Robotic Thyroidectomy ◽  
Control Group ◽  
Randomised Study ◽  
Pain Scores ◽  
Vas Scores ◽  
Induction Of Anaesthesia

Objective Although robotic thyroidectomy (RoT) is a minimally invasive surgery, percutaneous tunneling causes moderate to severe pain immediately postoperatively. We evaluated the efficacy of ketamine for postoperative pain management in patients following RoT. Methods Sixty-four patients scheduled for RoT were randomly divided into two groups. In the ketamine group (n = 32), ketamine was infused from induction of anaesthesia until the end of the procedure (0.15-mg/kg bolus with continuous infusion at 2 µg/kg/min). In the control group (n = 32), the same volume of saline was infused. Visual analogue scale (VAS) scores for acute and chronic pain, the incidence of hypoesthesia, postoperative analgesic requirements, and complications related to opioids or ketamine were compared between the two groups. Results The VAS pain scores were significantly lower in the ketamine group up to 24 h postoperatively. The VAS pain score when coughing was significantly higher in the control group than in the ketamine group at 24 h postoperatively. A significantly greater proportion of patients in the control group required rescue analgesics. Complications were comparable in both groups. Conclusions Ketamine infusion decreased pain scores for 24 h postoperatively and reduced analgesic requirements without serious complications in patients following RoT. Trial Registration: Clinicaltrials.gov Identifier: NCT01997801

scholarly journals Medical and social aspects in women of reproductive age with chronic pelvic pain

2021 ◽  
Vol 6 ◽  
pp. 71-76
Author(s):  
S.О. Shurpyak ◽  
O.B. Solomko
Keyword(s):  
Vitamin D ◽  
Pelvic Pain ◽  
Severe Pain ◽  
Chronic Pelvic Pain ◽  
Previous Treatment ◽  
Reproductive Age ◽  
Medical Documentation ◽  
Social Characteristics ◽  
Irritable Bowel ◽  
First Time

The objective: a study of the medical and social characteristics of women in reproductive age with chronic pelvic pain on the basis of retrospective analysis.Materials and methods. The analysis of medical documentation of 314 patients in reproductive age with a verified diagnosis of chronic pelvic pain (CPP) was performed on the basis of studying of case histories and outpatient cards. Data were analyzed: anthropometric data, age, body mass index, place of residence, gynecological pathology, duration and nature of the menstrual cycle, comorbidities, previous treatment, disease duration, pain intensity, bad habits, number of pregnancies and births, reproductive plans and other methods examination.Results. It was found that more than a third of women, who were treated for pathologies that cause CPP, need medical help again. 58 % of patients sought help for CPP for the first time, 42 % had already received treatment for CPP. Concomitant non-gynecological pathology is more often observed in such patients (48.7 %).The most commonly diagnosed were interstitial cystitis (42 %) and irritable bowel syndrome (34 %). The combination of gynecological, urological and surgical pathology was found in 22 % of patients. Patients with CPP had deficiency in vitamin D (68 % of the 162 patients tested for vitamin D) and had subjectively more severe pain. At the same time, the lack of routine examination of thyroid function and vitamin D status attracted attention. Simultaneously, women with CPP are much more likely than the general population to have infertility (56.4 %), and the incidence of miscarriage is twice as high as the population, with a tendency to recurrent pregnancy loss.Conclusions. Concomitant non-gynecological pathology, infertility, miscarriage, vitamin D deficiency and subjectively more severe pain are more common in women with chronic pelvic pain. However, the level of diagnosing thyroid pathology and determining the concentration of vitamin D in such patients is insufficient.

scholarly journals Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease

2019 ◽  
Vol 68 (3) ◽  
pp. 51-60 ◽  
Author(s):  
Maria I. Yarmolinskaya ◽  
Saimat Sh. Tkhazaplizheva ◽  
Arseniy S. Molotkov ◽  
Natalia N. Tkachenko ◽  
Valentina L. Borodina ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Melatonin Receptors ◽  
Reproductive Age ◽  
Control Group ◽  
Eutopic Endometrium ◽  
Relative Expression ◽  
Treatment Regimens ◽  
Daily Urine ◽  
New Treatment

Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor pathways. Melatonin may act through both membrane and nuclear receptors. In the present work, the expression of MTR1 and MTR2 melatonin receptors was studied in the eutopic endometrium and endometrioid heterotopies, and the level of melatonin metabolite, 6-sulfatoxymelatonin, in daily urine in patients with genital endometriosis (GE) was analyzed. Study design, materials and methods. The experimental group included 67 patients of reproductive age with a verified diagnosis of GE, and the control group consisted of 18 individuals with an ovulatory menstrual cycle without gynecological pathology. The 6-sulfatoxymelatonin level in daily urine was determined by enzyme immunoassay. The study of MTR1 and MTR2 melatonin receptor expression in the endometrium and endometrioid heterotopies was performed in 24 patients with GE and in 10 women of reproductive age who were examined for infertility who did not have gynecological pathology based on diagnostic laparoscopy. To study the expression of melatonin receptors, the endometrium and endometrial heterotopy sampling was carried out from day 18 to day 22 of the menstrual cycle. Morphological assessment included histological and immunofluorescence studies using confocal laser scanning microscopy. Results. In patients with GE, there was found a tendency to a decrease in 6-sulfatoxymelatonin excretion in daily urine compared to the control group. It was also found that the total relative expression area of melatonin receptors in the endometrium of women with GE was significantly lower compared to the endometrium of patients from the control group. Significant differences between the average brightness and optical density were not found. In addition, it was revealed that the relative expression areas of MTR1 and MTR2 melatonin receptors in the eutopic endometrium and in endometrioid heterotopies did not differ significantly. A negative correlation was stated between the relative expression area of melatonin receptors and GE prevalence. Particular attention is paid to the role of melatonin in the development of GE and to the possibilities of working out new treatment regimens with its use. Conclusion. The data obtained confirm the undoubted role of melatonin in the pathogenesis of GE, however, the development of new treatment regimens with its use requires further study.

scholarly journals A study on the use of henna plant (Lawsonia inermis Linn) for the treatment of fungal disease (Trichophypton verrucosum) in calves

2021 ◽  
Vol 71 (4) ◽  
pp. 2483
Author(s):  
H. HIZLI
Keyword(s):  
Clinical Examination ◽  
Treatment Process ◽  
Fungal Disease ◽  
Repeated Measurement ◽  
Control Group ◽  
Lawsonia Inermis ◽  
Group Control ◽  
Animal Material ◽  
Holstein Calves ◽  
Group Control Group

The aim of this study was to investigate the usability of henna plant (Lawsonia inermis Linn) in the treatment of dermatophytosis lesions (Trichophypton verrucosum) in cattle. The animal material of the trial consisted of 50 holstein calves between the ages of 4 and 6 months, who were found to have a dermatophytosis lesion on their face and neck in their clinical examination. The experiment was organized on a three-group repeated measurement trial plan. I. Group: Trichlorfon (Neguvon 75%, Bayer) ointment, II. Group: Henna applied, and III. Group: Control Group, no treatment, and 20 (10 females, 10 males), 20 (10 females, 10 males), and 10 (5 females, 5 males) totally 50 calves used, respectively. The research was continued for 14 days until the lesions were completely healed. I. and II. Groups were observed the best healing in the calves, respectively. In the III. Group without any treatment, there was no improvement and the lesions were enlarged. In addition, the effect of gender in the treatment process of dermatophytosis lesions was insignificant. As a result of this study, it is thought that henna plant can be used in the treatment of dermatophytosis.

scholarly journals The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats

2019 ◽  
Vol 9 (1) ◽  
pp. 79-83
Author(s):  
Ayman S. Mohamed ◽  
Eman Y. Salah EL Din ◽  
Neveen A. Farag ◽  
Abdel Rahman A. Tawfik
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Body Weight Gain ◽  
Control Group ◽  
High Dose ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Hypoglycemic Agent ◽  
Group Control ◽  
Group Control Group

Background: Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity. Objective: The present work aimed to characterize the malformations induced by moderate and high dose of Ech during pregnancy. Methods: In this study, eighteen (18) female pregnant rats were assigned into 3 groups (6 rats/ group); control group, low dose Ech (0.1 mg/kg) and high dose Ech (1 mg/kg). Results: The high dose of Ech caused a significant decrease in the number of embryos, uteri weight, body weight gain, placenta weight, and embryo weight and length. Also, the high dose led to a significant increase in serum AST, ALT, ALP, urea and uric acid of mothers. Conclusion: Our findings revealed the first teratogenic effects of high dose Ech. The teratogenic mechanism of Ech works through induction of the hypoglycemic condition in pregnant rats.

scholarly journals Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Chi Wang ◽  
Xin Chen ◽  
Peng-Yan Xie
Keyword(s):  
The Other ◽  
Control Group ◽  
Group Model ◽  
Model Group ◽  
Gastric Distention ◽  
Group Control ◽  
Gastrointestinal Side Effects ◽  
Esophageal Sphincter ◽  
Group Control Group ◽  
Common Cavity

Aim.To investigate the mechanisms of gastrointestinal side effects of tacrine, and find treatment methods with electroacupuncture (EA).Methods. Twenty-five healthy cats were randomly divided into 5 groups: gastric-distention group (model group), tacrine group (cholinesterase inhibitor), tacrine + sham acupoint group (control group), tacrine + PC6 (neiguan) group, and tacrine + ST36 (zusanli) group, with 5 cats in each group. Saline 2 mL i.p. was given 30 min before gastric distention in model group. Tacrine 5.6 mg/kg i.p. was given 30 minutes before gastric distention in the other groups. Tacrine + sham acupoint group (control group), tacrine + PC6 group, and tacrine + ST36 group received EA at corresponding acupoints during gastric distention. The frequency of TLESRs and LESP were recorded by using a perfused sleeve assembly.Results. Compared with the model group, tacrine significantly increased the frequency of gastric distention-induced TLESR (P<0.05) but did not influence the rate of common cavity during TLESR. Tacrine significantly increased the LESP, which could not remain during gastric distention. EA at PC6 could decrease the frequency of TLESR and maintain the increase of LESP, but EA at ST36 did not have these effects.Conclusion. Tacrine can significantly increase the gastric distention-induced transient lower esophageal sphincter relaxations (TLESRs). Electroacupuncture (EA) at PC6 may reverse the above side effect.

Dendritic cell vaccine as an alternative to opioid analgesia in patients with advanced cervical cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18022-e18022
Author(s):  
Anna P. Menshenina ◽  
Oleg I. Kit ◽  
Elena M. Frantsiyants ◽  
Tatiana I. Moiseenko ◽  
Ekaterina V. Verenikina ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pain Relief ◽  
Severe Pain ◽  
Pain Syndrome ◽  
Opioid Analgesics ◽  
Dendritic Cell Vaccine ◽  
Cell Vaccine ◽  
Advanced Cervical Cancer ◽  
Moderate Pain ◽  
Intense Pain

e18022 Background: Locally advanced and progressive cervical cancer is always accompanied by the pain syndrome. The common analgesics include non-steroidal anti-inflammatory drugs and opioids. The purpose of the study was to assess allogeneic dendritic cell vaccine (DCV) as an alternative analgesic in patients with advanced cervical cancer. Methods: The pain syndrome dynamics was assessed in 20 patients with advanced T3-4N1M0-1 cervical cancer receiving subcutaneous paravertebral injections of allogeneic DCV in a total alternating dose of 5-10 million cells every 2 weeks. Patients received DCV for one year, with a total of 24 vaccine therapy sessions and a total dosage of 180 million dendritic cells. The pain intensity was assessed on a verbal rating scale: 0 – no pain; 1 – mild pain; 2 – moderate pain; 3 – severe pain; 4 – extremely intense pain. Results: Prior to the therapy, 15 patients (75%) had severe pain; 2 (10%) - moderate pain; 3 (15%) - extremely intense pain. After 4-6 DCV injections, the pain intensity decreased, patients refused opioid analgesics. After 10-12 DCV sessions, 19 (95%) (p < 0.05) women had no pain at all, patients denied additional pain relief with non-opioid analgesics. Unrelieved pain was registered only in one cervical cancer patient. Conclusions: DCV injections in patients with advanced cervical cancer provide pain relief thereby improving their quality of life.

Evaluation of treatment of chronic pelvic pain in women with pelvic varicose veins

2016 ◽  
pp. 90-92
Author(s):  
S.O. Ostafiychuk ◽  
◽  
N.I. Henyk ◽  
N.V. Drohomyretska ◽  
P.R. Volosovsky ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Varicose Veins ◽  
Peak Systolic Velocity ◽  
Reproductive Age ◽  
Daily Activities ◽  
Moderate Intensity ◽  
Control Group ◽  
Internal Diameter ◽  
Internal Iliac

The objective: of our study was to evaluate the effectiveness of therapy of chronic pelvic pain (CPP) in women with pelvic varicose veins (PVV). Patients and methods. The study involved 62 women of reproductive age with CPP and PVV. Patients have received Normoven («Kyiv Vitamin Factory») in a dose 500 mg 2 times a day per os courses of 14 days each month for six months. To prevent recurrence of pain 30 women were prescribed the same drug prophylactically during 3 months after the basic course with repetition after 3 months. 32 patients did not receive Normoven as an prevention. The control group consisted of 30 healthy women. All women conducted clinical and laboratory examination, ultrasound and Doppler to determine the internal diameter ovaric, uterine, arcuate and internal iliac veins (cm), and the definition of peak systolic velocity of blood flow in the uterine veins (cm/s). Pain was assessed by Pain Assessment Scales. The resulting digital material were treated statistically using the program Microsoft Excel 2000 and Statistica 5.11. Results. We found that most of women were limited their daily activities, half have had sleep disorders, almost half was depressed, emotional lability with frequent changes of mood was observed in 79.0%, and a third of women were in depression. Most women feel cramping, aching and tender of pain of moderate intensity (82.2%). After 6 months of treatment with Normoven we noticed complete reduction of pain in 67.7% of women, in most women improved sleep, mood and normalization of daily activities. One-third of patients remained periodic light intensity pain. There was a significant decrease in pain intensity (p<0.05), which accoding to VAS score was 1.50±1.3 points. Conclusions. Periodic preventive courses of Normoven allowed to prevent recurrence of congestive pelvic syndrome and pelvic pain in 90.0% of patients. Key words: chronic pelvic pain, varicose veins of the pelvis, Normoven.

scholarly journals Fat absorption after total gastrectomy in rats submitted to Roux-en-Y or Rosanov-like double-transit technique

2006 ◽  
Vol 21 (6) ◽  
pp. 380-384 ◽  
Author(s):  
Gustavo Sevá-Pereira ◽  
Luiz Roberto Lopes ◽  
Nelson Ary Brandalise ◽  
Nelson Adami Andreollo
Keyword(s):  
Total Gastrectomy ◽  
The Other ◽  
Control Group ◽  
Fat Absorption ◽  
Group Control ◽  
Fat Malabsorption ◽  
Group Control Group

PURPOSE: Steatorrhea is one of the most common complications in reconstruction after total gastrectomy. Many reconstruction techniques after total gastrectomy have been developed in order to avoid these undesirable effects, but each one of them has some inconvenience. In this experiment, a modified Rosanov technique that keeps duodenal transit, evaluation of fat absorption after gastrectomy was tested. METHODS: Three groups of rats with the same characteristics were used. Total gastrectomy was performed in two groups: one was operated on and transit was reestablished by the Roux-en-Y technique (group Y), while the other was submitted to the modified Rosanov technique (group R). Following surgery, a handmade hyper fatty diet (11% of fat) was offered. A third group (control - group C) was not operated but was submitted to the same conditions of the other groups, and used for reference steatocrit values. The animals underwent laparotomy 14 days after surgery and had their feces collected from cecum to determine their steatocrit by analysis of their values. RESULTS: Steatocrit values for groups R and C (mean 5.16% and 4.15% respectively) were similar (p > 0.1), while group Y had significantly higher values (mean = 28.18%, p = 0.0001 - p < 0,05). This was attributed to the fact that group R animals had their duodenal transit patent, decreasing the complications expected in the Roux-en-Y reconstruction. CONCLUSIONS: Steatorrhea in the modified Rosanov technique was similar to the control group, while Roux-en-Y reconstruction presented higher steatorrhea and fat malabsorption.

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