scholarly journals Renal Metastases from ACC of the Nasal Cavity

2021 ◽  
Vol 8 (3) ◽  
pp. 19-21
Author(s):  
Jihene Feki ◽  
Maissa Lajnef ◽  
Manel Mellouli ◽  
Kheireddine Ben mahfoudh ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Systemic Chemotherapy ◽  
Perineural Invasion ◽  
Slow Growth ◽  
Lung Metastases ◽  
Radiological Evaluation ◽  
Adenoid Cystic ◽  
Secretory Glands ◽  
Renal Metastases ◽  
Line Chemotherapy

Adenoid cystic carcinoma (ACC) is a rare malignant cancer that arises from secretory glands. Slow growth, perineural invasion, and late recur-rences are the main characteristics of ACC. Only few cases of kidney metastases from ACC have been reported in the literature. We report here the case of a 66-year-old female patient who presented with bilateral renal metastases from ACC of the nasal cavity, detected 14 years after treatment of primary tumor and 6 years after metastasectomy of lung metastases. Histological examination confirmed diagnosis and the patient was treated with systemic chemotherapy. Radiological evaluation showed stability of the disease. However, a progression with occurrence of metastases in other sites (lung and bones) has been observed after 7 months. She is still receiving second-line chemotherapy. To the best of our knowledge, this is the second case of kidney metastases from ACC of the nasal cavity.

scholarly journals Primary Adenoid Cystic Carcinoma of the Frontal Sinus: Case Description of a Previously Unreported Entity and Literature Review

2019 ◽  
Vol 98 (4) ◽  
pp. E8-E12 ◽  
Author(s):  
Giancarlo Tirelli ◽  
Vincenzo Capriotti ◽  
Giovanni Sartori ◽  
Margherita Tofanelli ◽  
Alberto Vito Marcuzzo
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Frontal Sinus ◽  
Perineural Invasion ◽  
Slow Growth ◽  
State Of The Art ◽  
Subcutaneous Tissue ◽  
Free Flap Reconstruction ◽  
Epithelial Tumor ◽  
Adenoid Cystic ◽  
Malignant Epithelial Tumor

Sinonasal adenoid cystic carcinoma is a rare malignant epithelial tumor characterized by slow growth, multiple local recurrences, and perineural invasion; surgery followed by radiotherapy provides the best overall survival by means of an endoscopic, craniofacial, or combined approach. We present a previously undescribed case of frontal sinus adenoid cystic carcinoma involving the subcutaneous tissue and the dura mater treated with an open technique, free flap reconstruction, and hadron therapy together with a summary of the state of the art.

scholarly journals Renal Metastases from a Nasal Cavity Mixed Squamous Cell and Adenoid Cystic Carcinoma: A Case Report

2020 ◽  
Vol 21 ◽  
Author(s):  
Raffaele Longo ◽  
Camille Jaud ◽  
William Gehin ◽  
Laurent Hennequin ◽  
Claire Bastien ◽  
...  
Keyword(s):  
Case Report ◽  
Nasal Cavity ◽  
Adenoid Cystic Carcinoma ◽  
Squamous Cell ◽  
Adenoid Cystic ◽  
Renal Metastases

scholarly journals An Unusual Presentation of Adenoid Cystic Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Kurren S. Gill ◽  
Mark A. Frattali
Keyword(s):  
Early Diagnosis ◽  
Nasal Cavity ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Perineural Invasion ◽  
Case Reports ◽  
Diagnosis And Treatment ◽  
Biological Behavior ◽  
High Tendency ◽  
Adenoid Cystic

Adenoid cystic carcinoma (ACC) is a relatively rare tumor of epithelial cell origin, most commonly arising from major salivary glands. It is uncommonly found outside the major or minor salivary glands and is especially rare when located in the nasal cavity. Diagnosis and treatment of ACC pose numerous challenges, partly due to its biological behavior of slow growth, high tendency of local recurrence, and perineural invasion. We present the case of a 67-year-old male with complaints of facial pain and swelling, with a CT scan showing a soft tissue mass extending from the right nasal cavity with osseous destruction. Biopsy revealed ACC with perineural invasion. ACC of the nasal cavity continues to pose diagnostic and therapeutic challenges to physicians. Because this rare pathology presents in a vague manner, early diagnosis requires a high index of suspicion for this disease and close follow-up care. Since ACC of the nasal cavity is seldom reported in the literature, it is our hope that reporting these rare instances as case reports will heighten physician awareness of this rare disease, allowing for early diagnosis and treatment.

scholarly journals Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

2013 ◽  
Vol 74 (03) ◽  
pp. 118-125 ◽  
Author(s):  
Moran Amit ◽  
Yoav Binenbaum ◽  
Kanika Sharma ◽  
Ramer Naomi ◽  
Ramer Ilana ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Adenoid Cystic Carcinoma ◽  
Paranasal Sinuses ◽  
Meta Analysis ◽  
Adenoid Cystic

scholarly journals N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Candace A. Frerich ◽  
Hailey N. Sedam ◽  
Huining Kang ◽  
Yoshitsugu Mitani ◽  
Adel K. El-Naggar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Transcriptional Activity ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Rna Seq ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Myb Proteins ◽  
Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

scholarly journals Clinicopathological Features of Adenoid Cystic Carcinoma: An Institutional Perspective

2020 ◽  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Perineural Invasion ◽  
Neck Region ◽  
The Body ◽  
Clinicopathologic Features ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Significant Difference ◽  
Histologic Pattern

Introduction: Adenoid cystic carcinoma is a rare salivary gland malignancy that can occur in any part of the body, its clinicopathologic features are scarcely reported in locoregional literature. Therefore, in this study we aimed to evaluate the clinicopathologic features of adenoid cystic carcinoma in our population and to determine the association of age and site of its occurrence with histologic pattern and perineural invasion. Methods: We retrospectively analyzed 30 cases of adenoid cystic carcinoma that underwent surgical resections or biopsies from March 2009 to February 2020 at Liaquat National Hospital and Medical College, Karachi. Clinical and histopathological parameters including age, site, histological pattern and perineural invasion were determined and association between different parameters was analyzed. Results: Mean age of the patients was 30 + 16.1 years. Cribriform pattern was most common histologic pattern (63.3%) while head and neck region was the most common site of occurrence (83.3%). Perineural invasion which is one of the most important prognostic factors in adenoid cystic carcinoma was present in approximately half of the patients (46.7%). No significant association of age and site was found with histologic pattern and perineural invasion. Conclusion: Adenoid cystic carcinoma is a rare malignancy most commonly occurring in head and neck region with a high frequency of perineural invasion. No significant difference of histologic pattern and histologic prognostic parameter like perineural invasion was noted at different ages and different sites in our study.

Slug silencing inhibited perineural invasion through regulation of EMMPRIN expression in human salivary adenoid cystic carcinoma

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 2161-2169 ◽  
Author(s):  
Baolei Wu ◽  
Jianhua Wei ◽  
Zhiqiang Hu ◽  
Chun Shan ◽  
Lei Wang ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Perineural Invasion ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

scholarly journals Adenoid Cystic Carcinoma of the Lacrimal Gland in a 45 Years Old Male: Case Report and Review of Literature

2019 ◽  
Vol 9 (1) ◽  
pp. 49-53
Author(s):  
Akhlaque Hossain Khan ◽  
Nazmin Ahmed ◽  
Narendra Shalike ◽  
Abul Bashar Md Abdul Matin ◽  
Firoj Ahmed Al Amin ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Lacrimal Gland ◽  
Perineural Invasion ◽  
Adult Population ◽  
Treatment Options ◽  
Current Treatment ◽  
Adenoid Cystic ◽  
History Of ◽  
Lacrimal Fossa ◽  
Pathologic Analysis

Adenoid cystic carcinoma (ACC) is a rare malignant tumor that can manifests as proptosis in adult population. They account for 1.6% of all orbital tumors. Despite their rarity, they are the second most frequent epithelial neoplasms occurring in the lacrimal gland after pleomorphic adenomas. This kind of tumors are commonly occur in the salivary glands but can metastasize to lung, breast ,brain and sinuses in hematogenous route.We describe a patient who presented with protrusion of right eyeball, developing over 8 years with history of intermittent watery discharge for 4 years. His magnetic resonance imaging showed a retrobulbarextraconal soft tissue lesion around the lacrimal fossa with invasion and erosion of the adjacent bone. The patient underwent right sided orbito-pterional craniotomy and gross total removal of tumor. Pathologic analysis showed neoplastic cells in a predominantly cribriform pattern with features of perineural invasion and diagnosed as a case adenoid cystic carcinoma of the lacrimal gland. We review the incidence, clinical features, radiographic and histopathologic features of these rare, aggressive malignancies along with current treatment options with reference to the relevant literatures. Bang. J Neurosurgery 2019; 9(1): 49-53

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