Influence of Bisphosphonates on Alveolar Bone Loss Around Osseointegrated Implants

2011 ◽  
Vol 37 (3) ◽  
pp. 335-346 ◽  
Author(s):  
Talal M Zahid ◽  
Bing-Yan Wang ◽  
Robert E Cohen
Keyword(s):  
Dental Implants ◽  
Alveolar Bone ◽  
Smoking Status ◽  
Estimating Equation ◽  
Implant Failure ◽  
Success Rates ◽  
Osseointegrated Implants ◽  
The University ◽  
The Relationship

Abstract The relationship between bisphosphonates (BP) and dental implant failure has not been fully elucidated. The purpose of this retrospective radiographic study was to examine whether patients who take BP are at greater risk of implant failure than patients not using those agents. Treatment records of 362 consecutively treated patients receiving endosseous dental implants were reviewed. The patient population consisted of 227 women and 135 men with a mean age of 56 years (range: 17–87 years), treated in the University at Buffalo Postgraduate Clinic from 1997–2008. Demographic information collected included age, gender, smoking status, as well as systemic conditions and medication use. Implant characteristics reviewed included system, date of placement, date of follow-up radiographs, surgical complications, number of exposed threads, and implant failure. The relationship between BP and implant failure was analyzed using generalized estimating equation (GEE) analysis. Twenty-six patients using BP received a total of 51 dental implants. Three implants failed, yielding success rates of 94.11% and 88.46% for the implant-based and subject-based analyses, respectively. Using the GEE statistical method we found a statistically significant (P  =  .001; OR  =  3.25) association between the use of BP and implant thread exposure. None of the other variables studied were statistically associated with implant failure or thread exposure. In conclusion, patients taking BP may be at higher risk for implant thread exposure.

Evaluation of 3- to 8-Year Treatment Outcomes and Success Rates With 6 Implant Brands in Partially Edentulous Patients

2012 ◽  
Vol 38 (S1) ◽  
pp. 441-448 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Mehrdad Radvar ◽  
Hamid Reza Arab ◽  
Hamid Reza Boostani ◽  
Elham Ghiami
Keyword(s):  
Bone Loss ◽  
Statistical Significance ◽  
Implant Failure ◽  
Success Rates ◽  
Missing Teeth ◽  
Bleeding On Probing ◽  
Osseointegrated Implants ◽  
Probing Depth ◽  
Edentulous Patients ◽  
The Relationship

The use of osseointegrated implants as a foundation for the prosthetic replacement of missing teeth has become widespread, with new dental implant systems being introduced every year. There is growing interest in identifying the factors associated with implant failure, such as implant type. This study was designed to establish the relationship between implant type and success. Eighty-eight patients (mean age, 52 years) with 268 implants (110 BioHorizons, 60 ITI, 60 Paragon, 18 Xive, six 3i, and 19 Allfit) participated in this 5-year retrospective study. Statistical significance was defined for P < .05. Peri-implant probing depth was associated with bone loss and bleeding on probing. Implant failure was not associated with implant brand. Maximal (or minimal) peri-implant probing depth and bone loss values were seen at anterior regions (or premolars). Maximal (or minimal) bleeding on probing was seen at the posterior (or anterior) region. No significant differences were observed between the different systems in terms of implant failure.

scholarly journals Factors Affecting Implant Failure and Marginal Bone Loss of Implants Placed by Post-Graduate Students: A 1-Year Prospective Cohort Study

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4511
Author(s):  
Gian Maria Ragucci ◽  
Maria Giralt-Hernando ◽  
Irene Méndez-Manjón ◽  
Oriol Cantó-Navés ◽  
Federico Hernández-Alfaro
Keyword(s):  
Graduate Students ◽  
Dental Implants ◽  
Implant Failure ◽  
Success Rates ◽  
Contributing Factors ◽  
Marginal Bone Loss ◽  
Post Graduate ◽  
One Year ◽  
The One

Statement of the problem: Most of the clinical documentation of implant success and survival published in the literature have been issued by either experienced teams from university settings involving strict patient selection criteria or from seasoned private practitioners. By contrast, studies focusing on implants placed and rehabilitated by inexperienced post-graduate students are scarce. Purpose: To record failure rates and identify the contributing factors to implant failure and marginal bone loss (MBL) of implants placed and rehabilitated by inexperienced post-graduate students at the one-year follow-up. Material and Methods: A prospective cohort study was conducted on study participants scheduled for implant therapy at the International University of Catalonia. An experienced mentor determined the treatment plan in accordance with the need of each participant who signed an informed consent. All surgeries and prosthetic rehabilitation were performed by the post-graduate students. Implant failure rate, contributors to implant failure, and MBL were investigated among 24 variables related to patient health, local site, and implant and prosthetic characteristics. The risk of implant failure was analyzed with a simple binary logistic regression model with generalized equation equations (GEE) models, obtaining unadjusted odds ratios (OR). The relationship between MBL and the other independent variables was studied by simple linear regression estimated with GEE models and the Wald chi2 test. Results: One hundred and thirty dental implants have been placed and rehabilitated by post-graduate students. Five implants failed before loading and none after restoration delivery; survival and success rates were 96.15% and 94.62%, respectively. None of the investigated variables significantly affected the implant survival rate. At the one-year follow-up, the mean (SD) MBL was 0.53 (0.39) mm. The following independent variables significantly affected the MBL: Diabetes, implant depth placement. The width of keratinized tissue (KT) and probing depth (PD) above 3 mm were found to be good indicators of MBL, with each additional mm of probing depth resulting in 0.11 mm more MBL. Conclusion: The survival and success rates of dental implants placed and rehabilitated by inexperienced post-graduate students at the one-year follow-up were high. No contributing factor was identified regarding implant failure. However, several factors significantly affected MBL: Diabetes, implant depth placement, PD, and width of KT. Clinical Implications: Survival and success rates of dental implants placed and rehabilitated by inexperienced post-graduate students were high at the one-year follow-up, similar to experienced practitioners. No contributing factors were identified regarding implant failure; however, several factors significantly affected MBL: Diabetes, implant depth placement, PD, and KM.

scholarly journals Selective Serotonin Reuptake Inhibitors and the Risk of Osseointegrated Implant Failure

2014 ◽  
Vol 93 (11) ◽  
pp. 1054-1061 ◽  
Author(s):  
X. Wu ◽  
K. Al-Abedalla ◽  
E. Rastikerdar ◽  
S. Abi Nader ◽  
N.G. Daniel ◽  
...  
Keyword(s):  
Dental Implants ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Serotonin Reuptake Inhibitors ◽  
Implant Failure ◽  
Selective Serotonin ◽  
Osseointegrated Implants ◽  
Increased Risk

Selective serotonin reuptake inhibitors (SSRIs), the most widely used drugs for the treatment of depression, have been reported to reduce bone formation and increase the risk of bone fracture. Since osseointegration is influenced by bone metabolism, this study aimed to investigate the association between SSRIs and the risk of failures in osseointegrated implants. This retrospective cohort study was conducted on patients treated with dental implants from January 2007 to January 2013. A total of 916 dental implants in 490 patients (94 implants on 51 patients using SSRIs) were used to estimate the risk of failure associated with the use of SSRIs. Data analysis involved Cox proportional hazards, generalized estimating equation models, multilevel mixed effects parametric survival analysis, and Kaplan-Meier analysis. After 3 to 67 mo of follow-up, 38 dental implants failed and 784 succeeded in the nonusers group, while 10 failed and 84 succeeded in the SSRI-users group. The main limitation of this retrospective study was that drug compliance dose and treatment period could not be acquired from the files of the patients. The primary outcome was that compared with nonusers of SSRIs, SSRI usage was associated with an increased risk of dental implants failure (hazard ratio, 6.28; 95% confidence interval, 1.25-31.61; p = .03). The failure rates were 4.6% for SSRI nonusers and 10.6% for SSRI users. The secondary outcomes were that small implant diameters (≤4 mm; p = .02) and smoking habits ( p = .01) also seemed to be associated with higher risk of implant failure. Our findings indicate that treatment with SSRIs is associated with an increased failure risk of osseointegrated implants, which might suggest a careful surgical treatment planning for SSRI users.

scholarly journals An examination of factors related to plagiarism and a five-year follow-up of plagiarism at an Australian university

2011 ◽  
Vol 7 (1) ◽  
Author(s):  
Guy J Curtis ◽  
Razma Popal
Keyword(s):  
Academic Integrity ◽  
Educational Programs ◽  
Present Survey ◽  
Student Plagiarism ◽  
Perceived Seriousness ◽  
The University ◽  
The Relationship ◽  
Integrity Issue

In this paper we report the results of a survey of student plagiarism carried out at the University of Western Sydney (UWS). This survey examined rates of plagiarism,understanding of plagiarism, perceived seriousness of plagiarism, and factors thought to be related to plagiarism such as the pressure students place on themselves to achieve high grades. Students who achieved higher grades plagiarised less than students who had lower grades. Perceived seriousness of plagiarism, students' competitiveness, and students' self-imposed pressure to achieve high grades were correlated negatively with incidence of plagiarism. Perceived seriousness of plagiarism mediated the relationship between self-imposed pressure to achieve good grades and rates of plagiarism. The data from the present survey (conducted in 2009) were compared with data from comparable students who completed the same survey at UWS five years earlier (2004). The comparison between the 2009 and 2004 data suggested a reduction in prevalence of plagiarism and an increase in both understanding and perceived seriousness of plagiarism between 2004 and 2009. We suggest that plagiarism may be reduced by means of educational programs that promote the perception of plagiarism as a serious academic integrity issue.

scholarly journals Relationship between episodes of unsustained VTs detected early after an ICD implant and subsequent monomorphic VTs causing appropriate therapy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J Jimenez-Candil ◽  
J Perez ◽  
M Sanchez ◽  
J Hernandez ◽  
J.L Morinigo ◽  
...  
Keyword(s):  
Estimating Equation ◽  
Left Ventricular ◽  
Adjusted Risk ◽  
Bland Altman Method ◽  
Appropriate Therapy ◽  
The Difference ◽  
Mean Cycle ◽  
Ventricular Tachycardias ◽  
The Relationship

Abstract Introduction Non-sustained ventricular tachycardias (NSVT) are observed frequently among ICD patients with left ventricular dysfunction (LVD). Purpose To analyze the relationship between episodes of NSVTs and monomorphic VTs (MVTs) that subsequently cause appropriate therapies. Methods 416 ICD patients with LVD (LVEF <45%) followed for 41±27 months. ICD programming (detection and therapies) was standardized. NSVT was defined as any VT of ≥5 beats which did not met the detection criteria occurring within the first 6 months after ICD implant. We analyzed 2201 NSVTs (10+7 beats), which occurred in 250 of the 416 patients (Median=2; IQR=0–7). The mean cycle length (CL) of NSVT was 323±32 ms (adjusted per multiple episodes/patient, generalized estimating equation method (GEEM)). Results During the follow-up, 1441 MVT occurred in 183 patients. After showing a significant correlation between burden of NSVT and the occurrence of appropriate therapies due to MVT (C coefficient=0.68; p<0.001), we observed that subjects with >5 NSVT presented an excess of adjusted risk: HR=1.97 (95% CI=1.45–2.72); p<0.001. However, the adjusted mean CL of NSVTs was similar in patients with (322±34) vs. without MVT (324±26 ms); p=0.3. Among patients who presented NSVTs and MVTs (n=145 subjects), we analyzed the relationship between the adjusted mean CL of the NSVTs (n=1288 episodes) and the CL of the first appropriate therapy due to MVT occurring subsequently. We found a significant and positive correlation between the two (r=0.88; p<0.001); the strongest correlation was observed in subjects with >5 NSVTs (r=0.97, n=52)). The robustness of such correlation was similar in individuals with ischemic (r=0.86; n=91) versus non-ischemic cardiomyopathy (r=0.90; n=54), and in primary (r=0.86; n=75) versus secondary prevention (r=0.90; n=70). The agreement between the CL of first MVT and the adjusted mean CL of NSVT episodes (GEEM) was determined according to the Bland-Altman Method. The difference between the two values was 2±8.3 ms, with only 7.6% (11/145) of patients in whom the difference between the two CL was outside the concordance limits. The agreement was greater, again, in individuals with >5 NSVTs. As shown in the Figure, in more than 95% of patients both values were within the interval of agreement (0.32±4 ms). Conclusions 1-The burden of NSVTs occurring early after an ICD implant, but not their CL, is associated with a higher incidence of appropriate therapies due to MVT at follow-up. 2-The CL of the NSVTs and that of the first and subsequent MVTs is virtually the same in patients with higher NSVT burden. Therefore, it could be the same tachycardia, but with different duration. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Adolescent wine consumption is inversely associated with long-term weight gain: results from follow-up of 20 or 22 years

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Pratiksha Poudel ◽  
Kamila Ismailova ◽  
Lars Bo Andersen ◽  
Sofus C. Larsen ◽  
Berit L. Heitmann
Keyword(s):  
Weight Gain ◽  
Alcohol Consumption ◽  
Smoking Status ◽  
Alcoholic Beverage ◽  
Activity Levels ◽  
Inverse Association ◽  
Wine Consumption ◽  
The Relationship

Abstract Background Several studies have suggested a link between the type of alcoholic beverage consumption and body weight. However, results from longitudinal studies have been inconsistent, and the association between adolescent alcohol consumption long-term weight gain has generally not been examined. Methods The study was based on data from 720 Danish adolescents aged between 15 to 19 years at baseline from the Danish Youth and Sports Study (YSS). Self-reported alcohol use, height, weight, smoking, social economic status (SES) and physical activity levels were assessed in baseline surveys conducted in 1983 and 1985, and in the follow up survey which was conducted in 2005. Multiple linear regression analyses were used to examine the association between alcohol consumption in adolescence and subsequent weight gain later in midlife. Results There was no significant association between total alcohol consumption during adolescence and change in BMI into midlife (P = 0.079) (β − 0.14; 95% CI -0.28, 0.005). Wine consumption was found to be inversely associated to subsequent BMI gain (P = 0.001) (β − 0.46; 95% CI -0.82, − 0.09) while the results were not significant for beer and spirit. The relationship did not differ by gender, but smoking status was found to modify the relationship, and the inverse association between alcohol and BMI gain was seen only among non-smokers (P = 0.01) (β − 0.24; 95% CI -0.41, − 0.06) while no association was found among smokers. Neither adolescent nor attained socioeconomic status in adulthood modified the relationship between alcohol intake and subsequent BMI gain. Conclusion Among non-smoking adolescents, consumption of alcohol, and in particular wine, seems to be associated with less weight gain until midlife. Trial registration The YSS cohort was retrospectively registered on August 2017. (Study ID number: NCT03244150).

scholarly journals Assessment of Dental Implants with Modified Calcium-Phosphate Surface in a Multicenter, Prospective, Non-Interventional Study: Results up to 50 Months of Follow-Up

2019 ◽  
Vol 10 (1) ◽  
pp. 5
Author(s):  
Carles Subirà-Pifarré ◽  
Cristina Masuet-Aumatell ◽  
Carlos Rodado Alonso ◽  
Ricardo Medina Madrid ◽  
Cosimo Galletti
Keyword(s):  
Clinical Practice ◽  
Survival Rate ◽  
Calcium Phosphate ◽  
Observational Study ◽  
Dental Implants ◽  
Daily Practice ◽  
High Rate ◽  
Osseointegrated Implants ◽  
Study Results

Prescription of implant treatments is very widespread at present, mainly due to the low rate of annual loss and, to date, few studies have assessed their survival in the routine clinical practice of dentistry. The purpose of this observational study was to evaluate the effectiveness of dental implants with a calcium-phosphate surface in the daily practice of dental clinics. A multicenter, prospective, non-interventional, observational study was performed, in which three experienced practitioners (one maxillofacial and two oral surgeons) inserted implants using standard external and internal hexagon connections in adult patients requiring ≥1 osseointegrated implants to replace missing teeth. Follow-up was performed for 24 months after implant loading. Two hundred and twelve subjects were included (51.5% men), with a mean age of 51.2 ± 11.90 years, in whom 544 implants were inserted. 87.2% of the patients received 1–4 implants. The preferred connection system was internal hexagon (73.5%). There were nine failures, with an interval survival rate (ISR) at 24 months of 100% and a cumulative survival rate (CSR) of 98.3%. In conclusion, implants with a modified calcium-phosphate surface are associated with a high rate of survival and may be considered a method of choice in clinical practice.

scholarly journals Afrouxamento e fratura de parafusos em prótese sobre implante: revisão de literatura

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Adriano Paiano Daguano ◽  
Rodrigo Lorenzi Poluha
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Clinical Report ◽  
Complication Rates ◽  
Success Rates ◽  
Oral Implants ◽  
Clinical Complications ◽  
Implant Complications ◽  
Osseointegrated Implants

Próteses sobre implante representam um grande avanço para a odontologia, porém, complicações mecânicas como afrouxamento ou fratura do parafuso protético, têm sido relatadas. O presente trabalho objetiva revisar a literatura a respeito dessas complicações. O afrouxamento de um parafuso implica em sobrecarga aos demais parafusos que poderão também afrouxar e pode favorecer a ocorrência de falhas, uma delas é a fratura de parafusos e componentes. Quando ocorre a fratura o profissional deverá ter muito cuidado durante a remoção para não danificar a superfície do implante e/ou componente. A prevenção dessas complicações começa com o planejamento do tratamento e um ajuste oclusal adequado. Outro ponto importante são as consultas protéticas de manutenção e avaliação dos parafusos, com possível substituição preventiva.Descritores: Prótese Dentária Fixada por Implante; Implantes Dentários; Revisão.ReferênciasMoraschini V, Poubel LA, Ferreira VF, Barboza Edos S. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377-88.Liaw K, Delfini RH, Abrahams JJ. Dental implant complications. Semin Ultrasound CT MR. 2015;36(5):427-33.Nergiz I, Schmage P, Shahin R. Removal of a fractured implant abutment screw: a clinical report. J Prosthet Dent. 2004;91(6):513-17.Vahidi F, Pinto-Sinai G. Complications associated with implant-retained removable prostheses. Dent Clin North Am. 2015;59(1):215-26.Goodacre CJ, Bernal G, Rungcharassaeng K, Kan JY. Clinical complications with implants and implant prostheses. J Prosthet Dent. 2003;90(2):121-32.Insua A, Monje A, Wang HL, Miron RJ. Basis of bone metabolism around dental implants during osseointegration and peri-implant bone loss. J Biomed Mater Res A. 2017;105(7):2075-89.Al Jabbari Y, Fournelle R, Ziebert G, Toth J, Iacopino A. Mechanical behavior and failure analysis of prosthetic retaining screws after long-term use in vivo. Part 2: Metallurgical and microhardness analysis. J Prosthodont. 2008;17(3):181-91.Freitas R, Doria MC, Oliveira-Neto LA, Lorenzoni FC. Falha do parafuso passante em minipilar cônico angulado cone morse: relato de caso. Innov Implant J Biomater Esthet. 2010;5(2):65-69.Jung RE, Pjetursson BE, Glauser R, Zembic A, Zwahlen M, Lang NP. A systematic review of the 5-year survival and complication rates of implant-supported single crowns. Clin Oral Implants Res. 2008;19(2):119-30.Pjetursson BE, Tan K, Brägger U, Egger M, Zwahlen M. A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years. I. Implant-supported FPDs. Clin Oral Implants Res. 2004;15(6):625-42.Luterbacher S, Fourmousis I, Lang N, Brägger U. Fractured prosthetic abutments in osseointegrated implants: a technical complication to cope with. Clin Oral implants Res. 2000;11(2):163-70.Francis L, Zeenath H, Lylajam S, Harshakumar K. Implant screw fracture. J Dent Implant. 2013;3:181-83.Spazzin AO, Farina AP, Luthi LF, Consani RLX, Mesquita MF. Torque de afrouxamento dos parafusos protéticos em próteses mandibulares implanto-retidas com diferentes níveis de desajustes. UNOPAR Cient Ciênc Biol Saúde. 2009;11(1):5-8.Magrin GL, Dalago HR, Schuldt Filho G, Rodrigues MAP, De Bortoli Jr. N, Benfatti CAM et al. Avaliação transversal retrospectiva do desempenho clínico dos parafusos protéticos do sistema Implacil De Bortoli com cinco ou mais anos em função. ImplantNews 2014;11(3):385-91.Williamson RT, Robinson FG. Retrieval technique for fractured implant screws. J Prosthet Dent. 2001;86(5):549-50.

scholarly journals Implant Treatment in an Urban General Dentistry Residency Program: A 4-Year Retrospective Study

2004 ◽  
Vol 30 (6) ◽  
pp. 364-368 ◽  
Author(s):  
Mohamed A. Maksoud ◽  
Clifford B. Starr
Keyword(s):  
Dental Implants ◽  
Survival Rates ◽  
First Year ◽  
University Of Florida ◽  
Residency Programs ◽  
Implant Therapy ◽  
The University ◽  
Implant Treatment ◽  
Florida College

Abstract Little data have been published on the survival rates of implants placed in dental residency programs. This study reports on the outcome of dental implants placed by first-year general dentistry residents in the University of Florida College of Dentistry–Jacksonville Clinic. The patients for this study received both surgical and restorative implant therapy from 1998 to 2002. A total of 108 patients (62 women, 46 men) were treated with dental implants. On average, a patient was 52.9 years old and received 2.6 implants. A variety of simple and complex restorative procedures were performed. Advanced general dentistry residents in conjunction with supervisory faculty treated all cases. The cumulative implant survival was 98.2%. Follow-up varied from 6 months to 4 years after placement. Cases included implants not yet loaded as well as implants loaded for 3 years or more. The findings of this study compare favorably with published studies and were unexpected in light of the residents' limited clinical experience.

scholarly journals Vaginal microbiota diversity and paucity of Lactobacillus species are associated with persistent hrHPV infection in HIV negative but not in HIV positive women

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eileen O. Dareng ◽  
Bing Ma ◽  
Sally N. Adebamowo ◽  
Ayotunde Famooto ◽  
Jacques Ravel ◽  
...  
Keyword(s):  
Estimating Equation ◽  
Vaginal Microbiota ◽  
Lactobacillus Species ◽  
Hiv Positive ◽  
Linear Discriminant ◽  
Hiv Positive Women ◽  
The Relationship ◽  
High Diversity ◽  
Hiv Negative

Abstract The vaginal microbiota is thought to play a role in modulating risk of high-risk human papillomavirus (hrHPV) infection. We examined the relationship between the vaginal microbiota and persistent hrHPV infection in HIV-negative and HIV-positive women. We used 16S-rRNA sequencing to characterize the vaginal microbiota of two serial samples taken six months apart from 211 Nigerian women (67%, 142/211 HIV-positive and 33%, 69/211 HIV-negative) and evaluated the association between the vaginal microbiota and persistent hrHPV infection using generalized estimating equation logistic regression models and linear discriminant analysis effect size (LEfSe) algorithm to identify phylotypic biomarkers of persistent hrHPV infection. The high diversity microbiota, Community State Type IV-B, was the most prevalent in both HIV-negative (38% at baseline, 30% at the follow-up visit) and HIV-positive (27% at baseline, 35% at the follow-up visit) women. The relationship between the vaginal microbiota and persistent hrHPV was modified by HIV status. In HIV-negative women, women with Lactobacillus dominant microbiota had lower odds (OR: 0.35, 95% CI 0.14–0.89, p = 0.03) of persistent hrHPV compared to women with Lactobacillus deficient microbiota. While among HIV-positive women, the odds of being persistently infected with hrHPV was higher in women with Lactobacillus dominant microbiota (OR: 1.25, 95% CI 0.73–2.14 p = 0.41). This difference in effect estimates by HIV was statistically significant (p = 0.02). A high diversity vaginal microbial community with paucity of Lactobacillus species was associated with persistent hrHPV infection in HIV-negative women but not in HIV-positive women.

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