scholarly journals Cytotoxicity and wound healing potential of jasmine essential oil

2021 ◽  
Vol 16 (1) ◽  
pp. 77-82
Author(s):  
Shakila Sadasivam ◽  
M. Jawaharlal ◽  
Haripriya Shanmugam
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Antimicrobial Activities ◽  
Cytotoxicity Activity ◽  
Skin Cell ◽  
Cosmetic Industry ◽  
Healing Property ◽  
Jasminum Sambac ◽  
Wound Healing Property

Jasminum sambac is an important fragrant and commercial flower crop of South India. Jasmine essential oil (JEO) is valued for its fragrance which is used mainly in the perfumery and cosmetic industry. JEO exhibits anti-inflammatory, antimicrobial activities and are used in the treatment of skin disorders. This present study was taken with the objective of understanding the cytotoxic and wound healing activity of JEO. JEO at different concentrations for cytotoxicity activity (0.5, 0.75, 1.0, 1.25 and 1.5 μg) and wound healing property (1.0, 1.25, 1.75 and 2.0 μg) were analyzed in-vitro for L929 skin cell lines. The results indicate that, JEO have moderate cytotoxic activity and lower wound healing property.

Wound healing property of isolated compounds from Boesenbergia kingii rhizomes

2016 ◽  
Vol 184 ◽  
pp. 42-48 ◽  
Author(s):  
Teeratad Sudsai ◽  
Chatchai Wattanapiromsakul ◽  
Supinya Tewtrakul
Keyword(s):  
Wound Healing ◽  
Healing Property ◽  
Wound Healing Property

scholarly journals EXTRACTION, ISOLATION, AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS AND ESSENTIAL OIL FROM SYZYGIUM JAMBOS

2017 ◽  
Vol 10 (8) ◽  
pp. 194
Author(s):  
Mosad Ahmed Ghareeb ◽  
Manal Mortady Hamed ◽  
Abdel-aleem Hassan Abdel-aleem ◽  
Amal Mohamed Saad ◽  
Mohamed Sayed Abdel-aziz ◽  
...  
Keyword(s):  
Essential Oil ◽  
Radical Scavenging ◽  
Agar Plate ◽  
Antimicrobial Activities ◽  
Butanol Extract ◽  
Syzygium Jambos ◽  
Isolation And Characterization ◽  
Total Antioxidant ◽  
Total Oil

Objectives: Over the past few decades, phenolic compounds become important due to it has been associated with protection against different diseasesand sensory point of vision. Hence, at the present study, there has been a growing interest to carry out structural elucidation and characterization ofthe pure isolates from Syzygium jambos.Methods: S. jambos dried powder leaves were extracted by soaking in 85% methanol solvent at room temperature 25±2°C. The antioxidative activityof the isolates was assessed according to 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and phosphomolybdenum assays.Results: A total of 8 compounds were isolated from the n-butanol extract of S. jambos (Family Myrtaceae) plant, they were identified as quercetin-3-O-rutinoside (1), prenylbenzoic acid 4-β-D-glucoside (2), morolic acid 3-O-caffeate (3), 5,4’-dihydroxy, 7-methoxy, 6-methyl-flavone (4),3,4,5-trihydroxybenzoic acid (5), quercetin (6), isoetin-7-O-β-D-glucopyranoside (7), and (4’-hydroxy-3’-methoxyphenol-β-D-[6-O-(4”-hydroxy-3”,5”-dimethoxylbenzoate)] glucopyranoside) (8). Compounds 5 and 6 showed the most radical scavengers among the tested compounds with SC50 values of5.50 and 4.30 μg/ml, respectively, compared to ascorbic acid as standard and the total antioxidant capacity (TAC) values of 605.0 and 680.59 mg ascorbicacid equivalent/g compound, respectively. In vitro antimicrobial activities of the isolated compounds were tested using disc agar plate method againstfour pathogenic microbial strains including Gram-positive, Gram-negative bacteria and yeast with inhibition zones from 9 to 19 mm. Gas chromatographymassspectrometry analysis for the essential oil provides twenty four identified components representing 92% of its total oil composition.Conclusion: The results supported that S. jambos could be attributed to sources of natural antioxidant and antimicrobial applications.

scholarly journals Determination of Chemical Composition, In Vitro and In Silico Evaluation of Essential Oil from Leaves of Apium graveolens Grown in Saudi Arabia

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7372
Author(s):  
Ahmed I. Foudah ◽  
Mohammed H. Alqarni ◽  
Aftab Alam ◽  
Mohammad Ayman Salkini ◽  
Pravej Alam ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Essential Oil ◽  
In Silico ◽  
Docking Simulation ◽  
Antimicrobial Activities ◽  
Apium Graveolens ◽  
Gas Chromatography Mass Spectrometry ◽  
Major Constituent ◽  
Anti Inflammatory

The aim of this study was to explore the composition and evaluate the in silico and in vitro antioxidants and antimicrobial and anti-inflammatory effects of Apium graveolens var. dulce leaves essential oil (AGO) collected from Al-Kharj (Saudi Arabia). AGO was isolated using the hydro-distillation method, and its composition was studied using gas-chromatography-mass Spectrometry (GC–MS), antimicrobial activities using well diffusion assay, and antioxidant and anti-inflammatory activities using spectrophotometric methods. The pharmacological activities of their major compounds were predicted using PASS (prediction of activity spectra for substances) and drug-likening properties by ADME (absorption, distribution, metabolism, and excretion) through web-based online tools. Isocnidilide (40.1%) was identified as the major constituent of AGO along with β-Selinene, Senkyunolide A, Phytyl acetate, and 3-Butylphthalide. AGO exhibited a superior antibacterial activity, and the strongest activity was detected against Gram-positive bacteria and Candida albicans. Additionally, it exhibited a weaker antioxidant potential and stronger anti-inflammatory effects. PASS prediction supported the pharmacological finding, whereas ADMET revealed the safety of AGO. The molecular docking of isocnidilide was carried out for antibacterial (DNA gyrase), antioxidant (tyrosinase), and anti-inflammatory (cyclooxygenase-2) activities. The docking simulation results were involved hydrophilic interactions and demonstrated high binding affinity of isocnidilide for anti-inflammatory protein (cycloxygenase-2). The presence of isocnidilide makes AGO a potential anti-inflammatory and antimicrobial agent. AGO, and its major metabolite isocnidilide, may be a suitable candidate for the future drug development.

scholarly journals Characterization and Applications of Leaf Extracts of Hemigraphis Alternate

2019 ◽  
Vol 9 (1S6) ◽  
pp. 108-114
Keyword(s):  
Wound Healing ◽  
Crude Extract ◽  
Leaf Extract ◽  
Cellular Migration ◽  
Leaf Extracts ◽  
Ic50 Value ◽  
The Gift ◽  
Healing Property ◽  
Low Cytotoxicity ◽  
Wound Healing Property

Natural products carry out various capabilities and a lot of them have thrilling and useful organic activities. The gift take a look at turned into undertaken to analyze the bioactive compounds and the pharmacological capacity of leaf extract of Hemigraphis alternata. The presence of numerous compounds become characterized by way of FTIR and GCMS. ROS effect and wound recuperation assets have been analyzed and it discovered that crude extract is greater powerful inhibiting ROS manufacturing and it has high wound healing property with properly cellular migration in dose based way. The cytotoxic nature of leaf extract also analyzed with the aid of MTT assay and it suggests low IC50 value of 329.95 µG/ml. The result discovered that the crude extract of H.Alternata leaf is a great wound healer with low cytotoxicity.

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