scholarly journals COMPARATIVE ANALYSIS OF CYTOKINE PRODUCTION BY BLOOD IMMUNOCOMPETENT CELLS AND TUMOR IN DIFFERENT AGE GROUPS OF PATIENTS WITH INVASIVE DUCTAL CARCINOMA

2017 ◽  
Vol 19 (5) ◽  
pp. 567-576 ◽  
Author(s):  
T. A. Kunts ◽  
E. S. Mikhaylova ◽  
I. O. Marinkin ◽  
N. A. Varaksin ◽  
A. I. Autenshlyus
Keyword(s):  
Comparative Analysis ◽  
Invasive Ductal Carcinoma ◽  
Cytokine Production ◽  
Ductal Carcinoma ◽  
Age Groups ◽  
Immunocompetent Cells

scholarly journals The effect of canceroembryonic antigen on cytokine production by immunocompetent blood cells in patients with breast cancer

2018 ◽  
Vol 17 (3) ◽  
pp. 5-12 ◽  
Author(s):  
A. I. Autenshlus ◽  
T. A. Kunts ◽  
K. V. Karpukhina ◽  
E. S. Mikhailova ◽  
N. A. Varaksin ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Immune Cells ◽  
Blood Cells ◽  
Cytokine Production ◽  
Ductal Carcinoma ◽  
Precancerous Lesions ◽  
Breast Tumors ◽  
Precancerous Conditions ◽  
Immunocompetent Cells ◽  
Gm Csf

Aim. Investigation of the influence of canceroembryonic antigen (CEA) on the immune cells in patients with breast tumors.Materials and methods. Peripheral blood of 67 patients with invasive ductal carcinoma (n = 44), fibroadenoma (n = 12) and breast pre-cancer (n = 11). In the supernatants of the blood cells cytokine production induced by CEA was determined by ELISA.Results.It was found that CEA stimulated production of IL-6, IL-8, IL-10, IL-1β, IL-1Ra, TNFα, G-CSF, GM-CSF and the protein MCP-1 by blood immune cells in patients with fibroadenoma compared with groups of patients with invasive ductal carcinoma and precancerous lesions. Stimulation index of CEA on cytokine production by immunocompetent cells in patients in these groups was lower than in groups of patients with fibroadenoma due to initially high levels of spontaneous cytokine production.Results.  In  patients  with  fibroadenoma  CEA  was  found  to  stimulate  the  production  of  IL-6,  IL-8,  IL-10,  IL-1β,  IL-1Ra,  TNFa,  G-CSF,  GM-CSF  and  MCP-1  compared  with  groups  of  patients  with  invasive ductal carcinoma and precancerous conditions. Indexes of the influence of CEA on cytokine production by immunocompetent cells in these groups was lower than in the fibroadenoma due to initially high spontaneous production of cytokines.Conclusion.  Evident  spontaneous  cytokine-producing  function  of  immunocompetent  blood  cells  was revealed in patients with invasive ductal carcinoma and precancerous conditions compared to patients with fibroadenoma.  The  differences  between  the  indices  of  CEA  influence  on  cytokine  production  in  patients with malignant, benign and precancerous conditions can serve as a basis for the development of methods of differential diagnosis of breast tumors.

Mammographic features of invasive lobular and invasive ductal carcinoma of the breast: a comparative analysis

1995 ◽  
Vol 68 (809) ◽  
pp. 450-453 ◽  
Author(s):  
E J Cornford ◽  
A R M Wilson ◽  
E Athanassiou ◽  
M Galea ◽  
I O Ellis ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Clinicopathological Variants of Breast Cancer in a Tertiary Care Hospital in Pakistan

2021 ◽  
Vol 15 (1) ◽  
pp. 28-31
Author(s):  
Raja Najam ul Haq ◽  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Tertiary Care ◽  
Age Groups ◽  
Subsequent Treatment ◽  
Cancer Type ◽  
Care Hospital ◽  
Elderly Age

Background: Breast cancer is a growing phenomenon among females which has ever-lasting ramifications on the patient as well as the family. The only way of subjugating breast cancer is through an efficient and effective screening and subsequent treatment process. Objective: This study aimed at identifying the different clinicopathological patterns of breast cancer and the age group most frequently targeted by CA breast. Study Design: A prospective study. Settings: Fauji Foundation Hospital (FFH), Rawalpindi and Foundation University Medical College (FUMC) Pakistan. Duration: Six months from January 2018 to June 2018. Methodology: This study included 224 female patients, irrespective of their nationality by convenience sampling, who underwent any kind of breast surgery. The patients were evaluated according to their age, side of breast involved, site of lump in the breast, histopathology report and type of lesion (inflammatory, benign or malignant). The data was entered and analyzed using IBM SPSS version 25. Results: Our study sample of 224 individuals was found to have about 23 different histopathological variants of breast cancer. Invasive ductal carcinoma was found in almost all age groups and it was also the most common variant (80.8%), followed by invasive lobular carcinoma (4%). Majority of the cases were recorded in the elderly age bracket from 55 to 65 years. Right breast was found to be involved in 53.6% of the cases whereas left breast involvement was at 44.2%. 5 patients had lesions in both of their breasts. Upper outer quadrant was affected in 88% females followed by upper inner quadrant (6.7%). All four quadrants were involved in only 3 patients. Conclusion: This study concluded that invasive ductal carcinoma is the commonest clinical as well as pathological type of CA breast. 181 females out of a total of 224 had invasive ductal carcinoma. Therefore, this particular breast cancer type merits our special attention. Our study further concluded that most of the breast pathologies were found in elderly females aged between 55 and 65 years.

Cytokine production by blood immune cells, tumor and its microenvironment, characteristic of extracellular matrix in patients with invasive ductal carcinoma of no special type

2019 ◽  
Vol 65 (5) ◽  
pp. 424-431
Author(s):  
A.I. Autenshlyus ◽  
K.I. Davletova ◽  
A.A. Studenikina ◽  
E.S. Mikhaylova ◽  
N.A. Varaksin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Invasive Ductal Carcinoma ◽  
Immune Cells ◽  
Cytokine Production ◽  
Ductal Carcinoma ◽  
Solid Phase ◽  
Enzyme Linked Immunosorbent Assay ◽  
Gm Csf ◽  
Lymphatic Metastases ◽  
The Moment

The aim of this research was to study cytokine production by blood immune cells, tumor, and its microenvironment, and characterize extracellular matrix of patients with invasive ductal carcinoma of no special type and lymphatic metastases. Spontaneous and polyclonal activators stimulated production of cytokines by blood immune cells, tumor and its microenvironment were studied in 95 patients with invasive ductal carcinoma of no special type. The concentration of IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF and MCP-1 was determined by the solid-phase enzyme-linked immunosorbent assay. The condition of fibrous component and presence of neutral glycoproteins and sulfated glycosaminoglycans were evaluated during the research of extracellular matrix. Regional lymphatic metastases were detected in 35 of 95 patients. It was shown that in the presence or absence of lymphatic metastases index of polyclonal activators influence on the production of cytokines by blood immune cells was different for IL-6, IL-8, and IL-1β; while in the case of cytokine production by tumor and its microenvironment the index of influence was different for IL-2 and IL-17. The presence of lymphatic metastases corresponded with the rise of cytokines spontaneous production, while the absence of lymphatic metastases corresponded with the rise of cytokines production stimulated by polyclonal activators. The value of indices of polyclonal activators influence on the production of cytokines by blood immune cells pointed to the highly stimulating effect of polyclonal activators while the value of indices of polyclonal activators influence on cytokines production by tumor and its microenvironments pointed to the low and sometimes even absent effect of polyclonal activators. Basing on these data we propose a ratio of indices of polyclonal activators influence for the better evaluation of the probability of lymphatic metastases during preoperative period. After characterizing extracellular matrix we found out a point threshold, which, in 100% of cases, predicted the presence of lymphatic metastases basing on the condition of extracellular matrix. Using the data acquired, we are proposing a risk group for metastasis among women with no lymphatic metastases in the moment of check-up.

Prognostic implication of GATA3 gene mutation on survival in invasive ductal carcinoma of the breast.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13114-e13114
Author(s):  
Karthik Kailasam ◽  
Mohammad Omaira ◽  
Hardik Satish Chhatrala ◽  
Marie Ravichandar
Keyword(s):  
Mammary Gland ◽  
Median Survival ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Age Groups ◽  
Gene Mutations ◽  
Cell Phenotype ◽  
Age Group ◽  
Carcinoma Of The Breast ◽  
Gata3 Mutation

e13114 Background: GATA3 encodes a transcription factor, which is involved in activation and suppression of genes involved in cell maturation. GATA3 is necessary in the adult mammary gland to maintain the integrity and function of the luminal epithelium. Methods: METABRIC project funded by cancer research UK, the British Columbia cancer foundation and the Canadian breast cancer foundation mapped 173 gene mutations and amplifications in 2,433 primary breast tumors. Retrospective analysis was done for patients with invasive ductal carcinoma of the breast in the age group 30-60; to study the effect of GATA3 mutation on survival. Median survival was obtained from Kaplan-Meier plot, and mortality between groups was compared by Odds ratio (OR). Results: A total of 1500 patients across all age groups had invasive ductal carcinoma. 650 were within the age group 30-60; of which 234 died due to the disease, 360 were alive and 55 died due to other causes. 398 patients (61.2%) tested positive for estrogen receptor (ER) and 521 patients (80.2%) were negative for HER2 (human epidermal growth factor receptor 2). TP53 (50%) and PIK3CA (36%) mutations were more prevalent. GATA3 mutation was found in 79 patients (12.34%); among which, all 79 patients tested positive for ER (100%) and 74 patients (94.9%) negative for HER2. 10 patients (12.7%) died due to the disease, 62 patients (78.5%) were alive and 7 patients (8.9%) died due to other causes. Hence, patients with GATA3 mutations were more likely to survive (OR 4.66; CI 2.33-9.29 p < 0.0001) than patients without the mutation. The median survival for patients with GATA3 mutation (300 months) was also greater than patients without the mutation (219 months). In addition, patients with GATA3 mutation were more likely to be ER positive and HER2 negative. Conclusions: In the mammary gland, GATA3 is required for luminal epithelial cell differentiation. Loss of GATA3 results in de-differentiation to stem cell phenotype. It is found that GATA3 mutation correlates with a better prognosis compared to more common TP53 and PIK3CA gene mutations.

Unemployment as an indicator of economic security in the employment sector: A regional dimension

2020 ◽  
Vol 16 (4) ◽  
pp. 715-729
Author(s):  
T.N. Savina
Keyword(s):  
Comparative Analysis ◽  
Age Groups ◽  
National Development ◽  
Federal District ◽  
Economic Security ◽  
Employment Policy ◽  
Multivariate Statistical ◽  
Band Theory ◽  
The Republic ◽  
The Impact

Subject. To achieve a high level of economic security is a key priority of national development. Employment reveals one of the most important aspects of social development of the individual that is associated with his or her needs satisfaction in the sphere of employment and is boon to economic security. Objectives. The purpose of the study is to show the impact of unemployment on economic security in employment. Methods. I apply such scientific methods as dialectical, historical and logical unity, structural and functional analysis, traditional techniques of economic analysis and synthesis. The methods of multivariate statistical and comparative analysis serve as a methodological basis of the study. To determine the indicator of unemployment, I use the band theory. Results. I underpin the growing role of employment in ensuring economic security. The paper presents a comprehensive assessment of the unemployment status and a comparative analysis of the indicator in the Republic of Mordovia, the Volga Federal District, and the Russian Federation as a whole. I identify trends in the average duration of unemployment, show the distribution of unemployed by level of education and age groups. Conclusions. The average annual unemployment rate in the Republic of Mordovia is lower than in Russia and the Volga Federal District. The findings may be useful for public authorities to substantiate their employment policy at both macro- and meso-levels, for designing programs and strategies for socio-economic development of regions and the social security doctrine, as well as in practical activities of employment services.

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