scholarly journals GENETIC CHARACTERISTICS OF THE POPULATION LIVING IN THE TERRITORY OF THE REPUBLIC OF BASHKORTOSTAN

2016 ◽  
Vol 18 (1) ◽  
pp. 58-66 ◽  
Author(s):  
M. A. Loginova ◽  
I. V. Paramonov ◽  
V. N. Pavlov ◽  
G. Sh. Safuanova
Keyword(s):  
Haplotype Analysis ◽  
Human Leukocyte ◽  
The Other ◽  
Hematopoietic Stem ◽  
Genetic Characteristics ◽  
Leukocyte Antigen ◽  
Republic Of Bashkortostan ◽  
The Russian Federation ◽  
The Republic ◽  
New Alleles

Sequence based typing was used to identify human leukocyte antigen (HLA)-A, -B, -C, -DRB1 alleles in 1,064 recruited volunteers in the Republic of Bashkortostan of the Russian Federation for unrelated hematopoietic stem cell registry. During the carried out research two new alleles were identified in the studied population; one was registered in the WHO Nomenclature Committee for Factors of the HLA System, the other one was submitted for registration. In this population 17 HLA-A, 29 – HLA-B, 13 – HLA-C, 13 – HLA-DRB1 groups of alleles were selected. Allele frequencies of more than 10% included HLA-A*02 (29.37%), 24 (12.92%), 01 (11.84%), 03 (11.61%), HLA-B*35 (11.51%), 07 (10.76%), HLA-C*07 (22.56%), 06 (15.51%), 04 (13.06%), 03 (10.43%), 12 (10.24%), HLA-DRB1*07 (17.25%), 15 (12.73%), 13 (11.98%), 01 (11.84%), 04 (11.61%). 711 HLA-A-B-C-DRB1 four-locus haplotypes were determined using the software Arlequin v.3.1. The most frequently observed four-locus haplotypes were A*02-B*13-C*06-DRB1*07, A*03-B*35-C*07-DRB1*15, A*02- B*07-C*07-DRB1*15 with frequencies of 2.89%, 2.18% and 1.93%, respectively. The distribution of alleles and haplotype analysis allowed comparing the populations of the Republic of Bashkortostan with the other Russian populations.

scholarly journals Transplantation for bone marrow failure: current issues

Hematology ◽  
2016 ◽  
Vol 2016 (1) ◽  
pp. 90-98 ◽  
Author(s):  
Régis Peffault de Latour
Keyword(s):  
Bone Marrow Failure ◽  
Clonal Evolution ◽  
Human Leukocyte ◽  
Unrelated Donor ◽  
Hematopoietic Stem ◽  
Leukocyte Antigen ◽  
Sibling Donor ◽  
Alternative Donor

Abstract The preferred treatment of idiopathic aplastic anemia (AA) is allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)–identical sibling donor. Transplantation from a well-matched unrelated donor (MUD) may be considered for patients without a sibling donor after failure of immunosuppressive therapy, as may alternative transplantation (mismatched, cord blood or haplo-identical HSCT) for patients without a MUD. HSCT may also be contemplated for congenital disorders in cases of pancytopenia or severe isolated cytopenia. Currently, HSCT aims are not only to cure patients but also to avoid long-term complications, notably chronic graft-versus-host disease (GVHD), essential for a good quality of life long term. This paper summarizes recent advances in HSCT for idiopathic and inherited AA disorders. The effect of age on current transplantation outcomes, the role of transplantation in paroxysmal nocturnal hemoglobinuria, and the prevention of GVHD are also discussed. Emerging strategies regarding the role of up-front unrelated donor and alternative donor HSCT in idiopathic AA, along with advances in the treatment of clonal evolution in Fanconi anemia, are also examined.

SPECIALIZATION OF GRAIN PRODUCTION BY ZONE IN THE REPUBLIC OF BASHKORTOSTAN

2021 ◽  
Vol 0 (3) ◽  
pp. 45-49
Author(s):  
S.SH. ASLAEVA ◽  
◽  
R.F. GATAULLIN ◽  
Keyword(s):  
High Volume ◽  
Forest Steppe ◽  
Grain Production ◽  
Natural Conditions ◽  
Main Condition ◽  
Republic Of Bashkortostan ◽  
General Scientific ◽  
The Subject ◽  
The Russian Federation ◽  
The Republic

The main condition for specialization in agriculture is the production of those products for which there is the most favorable natural environment. The purpose of our study is to determine the nature of territorial specialization in grain production based on the level and its dynamics. The object of the research is the agriculture of the Republic of Bashkortostan, which is one of the leading in the Russian Federation. The subject of the research is the factors of formation of territorial specialization of grain production. The work was carried out on the basis of the application of general scientific research methods within the framework of comparative, logical, statistical analysis and graphic interpretation of the results. The territory of the Republic of Bashkortostan is divided according to the complex of natural conditions, respectively, and according to the peculiarities of agriculture, into six zones. We have grouped municipal districts according to the volume of grain production in statics and in dynamics. A map of the municipal districts of the Republic of Bashkortostan for the production of grain by agricultural zones has been built. It was revealed that the dynamics of grain production in the republic has a multidirectional character. In terms of grain production, many regions of the region are promising territories, which, despite the low volume of production, are characterized by positive dynamics, as well as stagnant territories, which are characterized, despite the high volume of production, by negative dynamics. Areas in which grain production is higher than the average for the region are located in agricultural zones belonging to the Southern forest-steppe, the Ural steppe, and the Trans-Ural steppe. But at the same time, in many areas of the Cis-Ural and Trans-Ural steppe, grain production is also increasing, many of them have grain-growing specialization. In the regions located in the southern forest-steppe, grain production is below the average level in the republic, sunflower is most of all cultivated. Agriculture in the republic must be developed in the direction of creating specialized zones, which will allow lower costs to ensure the growth of production. At the same time, the organizational and economic mechanism must change in such a way as to stimulate the specialization and concentration of production.

scholarly journals Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Paola Cruz-Tapias ◽  
Oscar M. Pérez-Fernández ◽  
Adriana Rojas-Villarraga ◽  
Alberto Rodríguez-Rodríguez ◽  
María-Teresa Arango ◽  
...  
Keyword(s):  
Risk Factor ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Genetic Characteristics ◽  
Latin Americans ◽  
Leukocyte Antigen

The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1∗03:01 (OR: 4.04; 95%CI: 1.41–11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1∗04:05 (OR: 4.64; 95%CI: 2.14–10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1∗04:01 (OR: 3.86; 95%CI: 2.32–6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1∗06:02 and DRB1∗15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1∗06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.

scholarly journals Focus on the spondyloarthritides. Can earlier diagnosis change the course of the disease?

2013 ◽  
pp. 277-283
Author(s):  
Domenico Galasso ◽  
Giovanni Forte ◽  
Norma Marigliano
Keyword(s):  
Strong Association ◽  
Human Leukocyte ◽  
Unknown Origin ◽  
Lower Limbs ◽  
Inflammatory Rheumatic Diseases ◽  
Genetic Characteristics ◽  
Leukocyte Antigen ◽  
Musculoskeletal Manifestations ◽  
Chronic Inflammatory Rheumatic Diseases ◽  
Juvenile Spondyloarthritis

The spondyloarthritides (or spondyloarthropathies) (SPAs) are chronic, inflammatory, rheumatic diseases of unknown origin, which share certain clinical, epidemiological, and genetic characteristics. They include ankylosing spondylitis, reactive arthritis (also known as the Reiter Syndrome), psoriatic arthritis, enteropathic spondyloarthropathy (ulcerative colitis, Crohn’s disease), undifferentiated spondyloarthritis, juvenile spondyloarthritis, and formes frustes such as acute anterior uveitis, spondyloarthritic carditis, and balanitis circinata. In the past, the SPAs were considered variants of rheumatoid arthritis, but it is now clear that they differ from the latter disease in terms of the pattern of articular and extra-articular involvement, their lack of association with seropositivity for rheumatoid factor, and their strong association with sacro-iliac joint bacino= pelvis sacro-iliac joint sacro-iliac joint sacro-iliac joint sacro-iliac joint sacro-iliac joint the class I human leukocyte antigen B27. sacro-iliac joint bacino= pelvis sacro-iliac joint sacro-iliac joint sacro-iliac joint sacro-iliac joint sacro-iliac joint Their general characteristics are axial involvement; enthesitis; peripheral arthritis involving the lower limbs, which is usually asymmetric; dactylitis; extra-articular manifestations involving the skin, eyes, bowel, and genitals. The musculoskeletal manifestations of the SPAs are due to inflammation at the level of the entheses. It is important to distinguish between the numerous clinical SPA variants based on analysis of symptoms, laboratory tests, and instrumental studies. Thanks to a greater understanding of the pathogenesis of the SPAs and the widespread availability of highly sensitive imaging modalities for their diagnosis, it is now possible to identify these diseases early and modify their course with effective therapy. This approach offers benefits to patients in terms of reduced morbidity and mortality and improved quality of life.

scholarly journals Study of actual nutrition in modern student youth

2020 ◽  
Vol 99 (3) ◽  
pp. 291-297
Author(s):  
Елена Юрьевна Горбаткова
Keyword(s):  
Russian Federation ◽  
State Policy ◽  
Nutritional Composition ◽  
The State ◽  
Fields Of Study ◽  
Healthy Nutrition ◽  
Republic Of Bashkortostan ◽  
The Russian Federation ◽  
The Republic

One of the most important factors affecting the health of modern youth is nutrition. Taking into account the timeliness of this problem, a research aimed at improving the quality of nutrition for students of higher education institutions of various fields of study (Ufa, the Republic of Bashkortostan) was executed. A software directed at studying the nutritional composition of the diet of students was developed, registered and tested. The development and implementation of the program were carried out taking into account regional features of nutrition of the population of the Republic of Bashkortostan. The food ration of university students of various fields of study was also evaluated according to food groups. The insufficiency of the daily ration based on a number of indics was revealed (according to nutritional composition and food products. The nutritional status of students according to the level of insufficiency of daily intake of nutrients in order to identify the degree of risk of abnormalities in the state of health development was evaluated also. According to the document of the Government of the Russian Federation “Fundamentals of the state policy of the Russian Federation in the field of healthy nutrition of the population for the period until 2020”, implementation the development of a set of measures aimed at reducing the prevalence of diseases associated with nutrition is one of the main directions of the state policy in the field of healthy nutrition. In this regard, a conceptual medical-pedagogical model aimed at forming a system of values in relation to healthy lifestyle among students was developed. Currently, there was executed an evaluation of the effectiveness of this model in the educational process of the M. Akmulla Bashkir State Pedagogical University. There was also been studied content of macro- and microelements in the venous blood of the students based on the changes in the quality of nutrition. There was also conducted analysis of hygienic conditions of students’ educational environment of leading universities in Ufa (the Republic of Bashkortostan).

scholarly journals Database of anthropogenic vegetation of the Urals and adjacent territories

2021 ◽  
Vol 38 ◽  
pp. 00037
Author(s):  
Yaroslav Golovanov ◽  
Larisa Abramova
Keyword(s):  
Average Height ◽  
Solidago Canadensis ◽  
Global Index ◽  
The Urals ◽  
Republic Of Bashkortostan ◽  
Anthropogenic Vegetation ◽  
Hordeum Jubatum ◽  
The Russian Federation ◽  
The Republic ◽  
Echinocystis Lobata

The main data on the geobotanical database – Database of antropogenic vegetation of Urals and adjacent territories registered in the Global Index of Vegetation-Plot Databases and the European Vegetation Archive are presented. The database includes more than 4,000 complete geobotanical relevés made between 1984 and 2020. The database contains the territories of 3 subjects of the Russian Federation (the Republic of Bashkortostan, Orenburg, Chelyabinsk regions) and 1 - the Republic of Kazakhstan (Aktobe region). For each relevés, a complete list of species with indication of abundance in points on the Braun-Blanquet scale. The main indicators (total cover, average height of the grass, etc.). For most descriptions, GPS coordinates and location are given. The ecological conditions were assessed with use of average values of E. Landolt scale. In the J. Braun-Blanquet classification system, all communities included in the database belong to nine vegetation classes (7 anthropogenic and 2 semi-natural), 75 associations and various types of communities. Geobotanical relevés with the dominance of such aggressive invasive species (Acer negundo, Ambrosia psylostachya, Echinocystis lobata, Elodea canadensis, Solidago canadensis, Heracleum sosnowskyi, Hordeum jubatum, Xanthium albinum etc.) are also included in the database.

HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism

Blood ◽  
2009 ◽  
Vol 113 (12) ◽  
pp. 2851-2858 ◽  
Author(s):  
Takakazu Kawase ◽  
Keitaro Matsuo ◽  
Koichi Kashiwase ◽  
Hidetoshi Inoko ◽  
Hiroh Saji ◽  
...  
Keyword(s):  
Acute Gvhd ◽  
Hematologic Malignancy ◽  
Human Leukocyte ◽  
Hematologic Malignancies ◽  
Hematopoietic Stem ◽  
Clinical Issue ◽  
Leukocyte Antigen ◽  
Unrelated Donors ◽  
Risk Of Relapse ◽  
Made In

Abstract The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, improving HSCT outcomes by separating GVL from GVHD is a key clinical issue. This cohort study registered 4643 patients with hematologic malignancies who received transplants from unrelated donors. Six major human leukocyte antigen (HLA) loci were retrospectively genotyped. We identified 4 HLA-Cw and 6 HLA-DPB1 mismatch combinations responsible for a decreased risk of relapse; of these, 8 of 10 combinations were different from those responsible for severe acute GVHD, including all 6 of the HLA-DPB1 combinations. Pairs with these combinations of HLA-DPB1 were associated with a significantly better overall survival than were completely matched pairs. Moreover, several amino acid substitutions on specific positions responsible for a decreased risk of relapse were identified in HLA-Cw, but not in HLA-DPB1. These findings might be crucial to elucidating the mechanism of the decreased risk of relapse on the basis of HLA molecule. Donor selection made in consideration of these results might allow the separation of GVL from acute GVHD, especially in HLA-DPB1 mismatch combinations.

Current trends in the use and payment of labor

2020 ◽  
pp. 12-18
Author(s):  
N. T. Rafikova ◽  
T. S. Trofimchuk
Keyword(s):  
Statistical Analysis ◽  
Russian Federation ◽  
Current Trends ◽  
Republic Of Bashkortostan ◽  
The Russian Federation ◽  
The Republic

The authors present the results of statistical analysis of the use of labor in the Russian Federation and, in particular, in agriculture of the Republic of Bashkortostan.

Sign in / Sign up

Export Citation Format

Share Document