scholarly journals Enrofloxacin and Ciprofloxacin Residues in Table Eggs: Distribution and Heat Treatment Effect

Author(s):  
Akram ALABOUDI ◽  
Dhary Alewy ALMASHHADANY ◽  
Ehab ABU-BASHA ◽  
Immadidden MUSALLAM

A 500 composite egg samples (2500 eggs-each sample represented by 5 eggs) collected from layer farms and local markets from all over Jordan were studied for presence of antimicrobials using Premi®Test screening test. Positive samples indicated by inhibition of microbial growth represented 12.8% out of total screened egg samples. Positive samples were examined quantitatively using HPLC technique to detect the presence of enrofloxacin and ciprofloxacin. Ciprofloxacin and enrofloxacin residues were detected in 1% and 0.8% of the total samples, respectively, where both drugs were recovered from white but not yolk. The effect of boiling on either drugs concentration in fortified white or yolk was demonstrated by gradual increases in the mean reduction percentages within treatment time with an average of 87% reduction after 15 minutes of boiling for both drugs and egg compartments and 5 minutes of frying at 160°C. The average concentration reduction percentages by the end of four weeks of refrigeration of fortified yolk and white were around 45 and 50% for enrofloxacin and ciprofloxacin respectively. The significance and mechanism of drug deposition and reduction during processing is being highlighted.

1995 ◽  
Vol 10 (2) ◽  
pp. 362-365 ◽  
Author(s):  
I. Tanahashi ◽  
M. Yoshida ◽  
Y. Manabe ◽  
T. Tohda

Small Ag particles were embedded in SiO2 glass thin films by a multi-target sputtering method. The mean diameter of Ag particles in the as-deposited film with 28.0 at. % of Ag was estimated to be 4.4 nm and it was increased to 24.0 nm when the film was heat-treated at 700 °C for 3 h. The diameter was proportional to the cube root of the heat-treatment time, suggesting that the Ag particles grew in the supersaturated solid solution. In the optical absorption spectra of the heat-treated films, the absorption peak due to the surface plasmon resonance of Ag particles was observed about 410 nm. The peak intensity became large and the full width at half maximum of the absorption band was decreased with increasing the diameter of Ag particles.


2020 ◽  
Vol 132 (5) ◽  
pp. 1473-1479 ◽  
Author(s):  
Eun Young Han ◽  
He Wang ◽  
Dershan Luo ◽  
Jing Li ◽  
Xin Wang

OBJECTIVEFor patients with multiple large brain metastases with at least 1 target volume larger than 10 cm3, multifractionated stereotactic radiosurgery (MF-SRS) has commonly been delivered with a linear accelerator (LINAC). Recent advances of Gamma Knife (GK) units with kilovolt cone-beam CT and CyberKnife (CK) units with multileaf collimators also make them attractive choices. The purpose of this study was to compare the dosimetry of MF-SRS plans deliverable on GK, CK, and LINAC and to discuss related clinical issues.METHODSTen patients with 2 or more large brain metastases who had been treated with MF-SRS on LINAC were identified. The median planning target volume was 18.31 cm3 (mean 21.31 cm3, range 3.42–49.97 cm3), and the median prescribed dose was 27.0 Gy (mean 26.7 Gy, range 21–30 Gy), administered in 3 to 5 fractions. Clinical LINAC treatment plans were generated using inverse planning with intensity modulation on a Pinnacle treatment planning system (version 9.10) for the Varian TrueBeam STx system. GK and CK planning were retrospectively performed using Leksell GammaPlan version 10.1 and Accuray Precision version 1.1.0.0 for the CK M6 system. Tumor coverage, Paddick conformity index (CI), gradient index (GI), and normal brain tissue receiving 4, 12, and 20 Gy were used to compare plan quality. Net beam-on time and approximate planning time were also collected for all cases.RESULTSPlans from all 3 modalities satisfied clinical requirements in target coverage and normal tissue sparing. The mean CI was comparable (0.79, 0.78, and 0.76) for the GK, CK, and LINAC plans. The mean GI was 3.1 for both the GK and the CK plans, whereas the mean GI of the LINAC plans was 4.1. The lower GI of the GK and CK plans would have resulted in significantly lower normal brain volumes receiving a medium or high dose. On average, GK and CK plans spared the normal brain volume receiving at least 12 Gy and 20 Gy by approximately 20% in comparison with the LINAC plans. However, the mean beam-on time of GK (∼ 64 minutes assuming a dose rate of 2.5 Gy/minute) plans was significantly longer than that of CK (∼ 31 minutes) or LINAC (∼ 4 minutes) plans.CONCLUSIONSAll 3 modalities are capable of treating multiple large brain lesions with MF-SRS. GK has the most flexible workflow and excellent dosimetry, but could be limited by the treatment time. CK has dosimetry comparable to that of GK with a consistent treatment time of approximately 30 minutes. LINAC has a much shorter treatment time, but residual rotational error could be a concern.


2010 ◽  
Vol 39 (11) ◽  
pp. 1678-1683 ◽  
Author(s):  
Ji-Sun Kim ◽  
Yu-Jin Kim ◽  
Jung-Mi Park ◽  
Tae-Jip Kim ◽  
Beom-Soo Kim ◽  
...  

Author(s):  
Ewa A. Burian ◽  
Lubna Sabah ◽  
Klaus Kirketerp-Møller ◽  
Elin Ibstedt ◽  
Magnus M. Fazli ◽  
...  

Acute wounds may require cleansing to reduce the risk of infection. Stabilized hypochlorous acid in acetic buffer (HOCl + buffer) is a novel wound irrigation solution with antimicrobial properties. We performed a first-in-man, prospective, open-label pilot study to document preliminary safety and performance in the treatment of acute wounds. The study enrolled 12 subjects scheduled for a split-skin graft transplantation, where the donor site was used as a model of an acute wound. The treatment time was 75 s, given on 6 occasions. A total of 7 adverse events were regarded as related to the treatment; all registered as pain during the procedure for 2 subjects. One subject had a wound infection at the donor site. The mean colony-forming unit (CFU) decreased by 41% after the treatment, and the mean epithelialization was 96% on both days 14 (standard deviation [SD] 8%) and 21 (SD 10%). The study provides preliminary support for the safety, well-tolerance, and efficacy of HOCl + buffer for acute wounds. The pain was frequent although resolved quickly. Excellent wound healing and satisfying antimicrobial properties were observed. A subsequent in vitro biofilm study also indicated good antimicrobial activity against Pseudomonas aeruginosa with a 96% mean reduction of CFU, when used for a treatment duration of 15 min ( P < .0001), and a 50% decrease for Staphylococcus aureus ( P = .1010). Future larger studies are needed to evaluate the safety and performance of HOCl + buffer in acute wounds, including the promising antimicrobial effect by prolonged treatment on bacterial biofilms.


Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4102
Author(s):  
Jan Stindt ◽  
Patrick Forman ◽  
Peter Mark

Resource-efficient precast concrete elements can be produced using high-performance concrete (HPC). A heat treatment accelerates hardening and thus enables early stripping. To minimise damages to the concrete structure, treatment time and temperature are regulated. This leads to temperature treatment times of more than 24 h, what seems too long for quick serial production (flow production) of HPC. To overcome this shortcoming and to accelerate production speed, the heat treatment is started here immediately after concreting. This in turn influences the shrinkage behaviour and the concrete strength. Therefore, shrinkage is investigated on prisms made from HPC with and without steel fibres, as well as on short beams with reinforcement ratios of 1.8% and 3.1%. Furthermore, the flexural and compressive strengths of the prisms are measured directly after heating and later on after 28 d. The specimens are heat-treated between 1 and 24 h at 80 °C and a relative humidity of 60%. Specimens without heating serve for reference. The results show that the shrinkage strain is pronouncedly reduced with increasing temperature duration and rebar ratio. Moreover, the compressive and flexural strength decrease with decreasing temperature duration, whereby the loss of strength can be compensated by adding steel fibres.


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