scholarly journals Imported Canine leishmaniasis in Romania: a Case Report

2018 ◽  
Vol 75 (1) ◽  
pp. 125
Author(s):  
Gina Corina TOMA ◽  
Marian TAULESCU ◽  
Viorica MIRCEAN ◽  
Angela Monica IONICĂ ◽  
Roxana CORA ◽  
...  
Keyword(s):  
Clinical Examination ◽  
Case Reports ◽  
Rapid Test ◽  
Serum Biochemistry ◽  
Skin Lesions ◽  
Needle Aspiration ◽  
Canine Leishmaniasis ◽  
Public Health Perspective ◽  
History Of ◽  
Progressive Weight Loss

Canine leishmaniasis (CanL) is a zoonotic disease considered endemic in the Mediterranean region. Romania is traditionally regarded as a non-endemic country.Considering the zoonotic character of the disease, this study aims to increase the knowledge on diagnostic aspects of CanL.A 2-year-old, mix breed male dog, recently returned from Italy had a history of progressive weight loss and skin lesions. The clinical examination was followed by hematology and serum biochemistry, fine-needle aspiration of lymph nodes, impression smears, VetExpert® rapid test Leishmania Ab, and PCR. The clinical examination revealed muscle atrophy, non-pruritic crusting dermatitis, ulcers, and lymphadenopathy. Hematology showed severe anemia. The serum biochemistry revealed hyperproteinaemia, hypoalbuminemia, hyperglobulinemia. Cytological exams evidenced the intracellular amastigotes in macrophages, confirmed by rapid test and PCR.In Romania, under the light of the new case reports, leishmaniasis should be reconsidered from both veterinary and public health perspective.

scholarly journals Identification of Mycobacterium genavense natural infection in a domestic ferret

2018 ◽  
Vol 31 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Bérengère Dequéant ◽  
Quentin Pascal ◽  
Héloïse Bilbault ◽  
Elie Dagher ◽  
Maria-Laura Boschiroli ◽  
...  
Keyword(s):  
Natural Infection ◽  
Abdominal Ultrasound ◽  
Needle Aspiration ◽  
Mesenteric Lymph Nodes ◽  
Mustela Putorius ◽  
Tissue Samples ◽  
Acid Fast Bacilli ◽  
Mycobacterium Genavense ◽  
History Of ◽  
Progressive Weight Loss

A 6-y-old neutered male ferret ( Mustela putorius furo) was presented because of a 1-mo history of progressive weight loss, chronic cough, and hair loss. On clinical examination, the animal was coughing, slightly depressed, moderately hypothermic, and had bilateral epiphora. Thoracic radiography was suggestive of severe multinodular interstitial pneumonia. Abdominal ultrasound examination revealed hepatosplenomegaly and mesenteric and pancreaticoduodenal lymphadenopathy. Fine-needle aspiration of the pancreaticoduodenal lymph node, followed by routine Romanowsky and Ziehl–Neelsen stains, revealed numerous macrophages containing myriad acid-fast bacilli, leading to identification of mycobacteriosis. Autopsy and histologic examination confirmed the presence of disseminated, poorly defined, acid-fast, bacilli-rich granulomas in the pancreaticoduodenal and mesenteric lymph nodes, intestines, and lungs. Destaining of May-Grünwald/Giemsa–stained slides with alcohol, and then restaining with Ziehl–Neelsen, revealed acid-fast rods and avoided repeat tissue sampling without affecting the Ziehl–Neelsen stain quality and cytologic features. Tissue samples were submitted for a PCR assay targeting the heat shock protein gene ( hsp65) and revealed 100% homology with Mycobacterium genavense. We emphasize the use of special stains and PCR for identification of this potential zoonotic agent.

Interesting case of dual pathology: Crohn’s disease and Peutz-Jeghers syndrome

2020 ◽  
Vol 13 (10) ◽  
pp. e234513
Author(s):  
Mantej Sehmbhi ◽  
Penelope Sellers ◽  
Jonathan Segal ◽  
Susan Clark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Interesting Case ◽  
Night Sweats ◽  
History Of ◽  
Progressive Weight Loss ◽  
Inflammatory Bowel ◽  
Peutz Jeghers Syndrome ◽  
The Uk

An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn’s disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.

A case of palmar hypopigmentation induced by capecitabine in a gastrointestinal cancer patient

2021 ◽  
pp. 107815522110279
Author(s):  
Julian Gratiaux ◽  
Chloé Gossery ◽  
Chirine Rezzag-Mahcene ◽  
Damien Botsen ◽  
Laetitia Visseaux ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Adverse Drug Reaction ◽  
Case Reports ◽  
Antineoplastic Agent ◽  
Skin Lesions ◽  
Severe Adverse Effect ◽  
Gastrointestinal Cancers ◽  
History Of ◽  
The Common ◽  
Cutaneous Adverse Drug Reaction

Introduction Capecitabine is an antimetabolite antineoplastic agent widely used in the treatment gastrointestinal cancers. The common frequently reported cutaneous adverse drug reaction associated with capecitabin are a palmar-plantar erythrodysesthesia syndrome, rash and hyperpigmentation. This case reports a capecitabine-induced palmar hypopigmentation. Case report We report the case of a 74-years old patient with jejunum adenocarcinoma treated by capecitabine. The patient developed a pseudo-vitiligo after 2 cycles capecitabine and without history of cutaneous disorders. The skin lesions were characterized with skin hypopigmentation on both hands. Management and outcome: The hypopigmentation slowly recovered after capecitabine discontinuation. Conclusion This is the first described case of pseudo-vitiligo induced by capecitabine. This impressive but non-severe adverse effect should be known by oncologists and oncology pharmacists to reassure the patients in particular about the possible recovery after discontinuation of capecitabine.

scholarly journals The Hematological and Biochemical Manifestations of Cutane-ous Leishmaniasis in a Shih Tzu-Terrier Dog with Severe Infection: A Case Report

2020 ◽  
Author(s):  
Mahmooud AHMADI-HAMEDANI ◽  
Hediyeh HOSSEINPOUR ◽  
Hesamodin ESKAFIAN ◽  
Shayan DAVARPANAH
Keyword(s):  
Severe Infection ◽  
Skin Lesions ◽  
Needle Aspiration ◽  
Canine Leishmaniasis ◽  
Significant Weight Loss ◽  
Fine Needle ◽  
Left Shift ◽  
Clinicopathological Findings ◽  
Leishmania Amastigotes ◽  
Veterinary Hospital

Cutaneous involvement in canine leishmaniasis, caused by Leishmania infantum, is the most frequent clinical manifestation of the zoonotic infectious disease. A 4-month-old female Shih Tzu-terrier dog with significant weight loss and depression and chronic erosive skin lesions around eyes and the area above the nose was presented to the Semnan University Veterinary Hospital teaching, Semnan, Iran. The main clinicopathological findings included marked leukocytosis, neutrophilia, left shift, monocytosis, mild hypoproteinemia, and hypoalbuminemia. The diagnosis of leishmaniasis was performed based on the presence of a large number of Leishmania amastigotes in skin Fine Needle Aspiration (FNA). The dog was euthanized and sent to the autopsy department for further investigation.

First Autochthonous Case of Emerged Zoonotic Cutaneous Leishmaniasis in Mazandaran Province, Northern Iran: kDNA-PCR Evidence Base

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatemeh Niksolat ◽  
Rabeeh Tabaripour ◽  
Lotfollah Davoodi ◽  
Mahdi Fakhar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Skin Lesions ◽  
Needle Aspiration ◽  
Evidence Base ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Zoonotic Cutaneous Leishmaniasis ◽  
Smear Preparation ◽  
History Of

: In the last decade, several cases of cutaneous leishmaniasis (CL) have been recorded by the provincial health center of Mazandaran Province, northern Iran. However, there is no documented report of autochthonous CL in the province yet. The patient, a 59-year-old female, known case of diabetes mellitus, lived in rural area of Kiasar district (in eastern part of the Mazandaran) with 5 skin lesions suspected of having vasculitis, without history of traveling to the endemic areas of CL, was admitted to Imam Khomeini teaching hospital, Sari. To rule out CL, fine needle aspiration (FNA) procedure was used aseptically for the patient. Laboratory investigations showed Leishman bodies (amastigotes) by direct smear preparation and species identification confirmed Leishmania major (L. major) by polymerase chain reaction (PCR) molecular method. Accordingly, this is the first documented report of autochthonous CL in Mazandaran Province. Overall, due to the abundance of probable rodent reservoir hosts and confirmation of infection of sandflies (Phlebotomus papatasi) with L. major in the Kiasar district, where our patient was living there, it seems that CL emerged in the eastern part of the province. Therefore, further studies on rodents and sandflies fauna in terms of emerging leishmanial infection in the area is recommended.

scholarly journals Pretibial myxedema in a euthyroid patient: a case report

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Rediet Ambachew ◽  
Tizita Yosef ◽  
Aklilu M. Gebremariam ◽  
Lishan Demere ◽  
Theodros Aberra ◽  
...  
Keyword(s):  
Case Reports ◽  
Skin Lesions ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Rare Presentation ◽  
Case Presentation ◽  
Normal Thyroid Function ◽  
History Of ◽  
Euthyroid Patient ◽  
Pretibial Myxedema

Abstract Background Pretibial myxedema also known as localized myxedema, thyroid dermopathy, or infiltrative dermopathy and rarely as localized mucinosis is an infrequent manifestation of Graves’ disease. It can appear before, during, or after the thyrotoxic state. Euthyroid pretibial myxedema is a rare presentation with few case reports in the literature. This case highlights the importance of considering pretibial myxedema when characteristic skin lesions are observed in a euthyroid patient. Case presentation A 72-year old male Ethiopian patient with a very rare presentation of biopsy-proven pretibial myxedema in a euthyroid state without history of thyroid disease and absence of thyroid autoimmune markers. Resolution of skin lesion was achieved after topical corticosteroid application. Conclusion Absence of history of thyroid disorder and normal thyroid function tests should not exclude the diagnosis of pretibial myxedema.

scholarly journals Leishmaniasis canina: diagnóstico y manejo terapéutico

2019 ◽  
Vol 5 ◽  
Author(s):  
Mónica Gisela Iniesta-Romero ◽  
Luis Fernando De Juan Guzmán ◽  
Juan Miguel Pérez-Enriquez ◽  
José Javier Castañeda-Corral ◽  
Adriana Mendez-Bernal ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Clinical Importance ◽  
Serum Biochemistry ◽  
Needle Aspiration ◽  
Protein Electrophoresis ◽  
Canine Leishmaniasis ◽  
Nasal Discharge ◽  
Adequate Treatment ◽  
Fine Needle ◽  
General Physical Examination

Descripción del caso clínico: Paciente canino de 3.6 años de edad que acude a consulta con historia de secreción nasal, epistaxis y lesiones dermatológicas y diarrea con un mes de evolución.Hallazgos clínicos: En el examen físico general se observó secreción nasal serosa en ambas narinas, nódulo en región del maxilar del lado derecho y linfadenomegalia poplítea. En las pruebas de laboratorio se reportaron los siguientes resultados: en la bioquímica sérica: hiperglobulinemia de 104 g/L (23 – 39); en la electroforesis de proteínas: incremento de gamma globulinas asociado a una gammapatía y se realizó aspirado con aguja delgada (ACAD) de linfonodo poplíteo y en su análisis se encontraron estructuras parasitarias compatibles con amastigotes de Leishmania spp.Tratamiento y evolución: Se instauró tratamiento médico con alopurinol, pentoxifilina y antimoniato de meglumina, éste último, únicamente por cuatro semanas debido a la falta de su distribución en México; con lo que se logra mantener a la paciente sin signos clínicos. La anemia se asocia al proceso inflamación crónica, por lo que se administró vitamina B12.Pruebas complementarias de laboratorio: Bioquímica sérica en cada consulta para evaluar función renal, electroforesis de proteínas y aspirado con aguja delgada (ACAD) de linfonodo poplíteoRelevancia clínica: La leishmaniasis canina es una enfermedad poco diagnosticada en México, los signos clínicos que se presentan son inespecíficos, por lo que no se da el tratamiento adecuado oportunamente y puede existir alta mortalidad de los pacientes con esta enfermedad. Es de importancia clínica saber que existen regiones en México en donde habitan especies de vectores que pueden transmitir la enfermedad. Abstract Case report: A canine patient of 3.6 years of age attending consultation with a history of nasal discharge, epistaxis and dermatological lesions and diarrhea with a month of evolution.Clinical findings: In the general physical examination, serous nasal secretion was observed in both nostrils, nodule in the maxillary region of the right side and popliteal lymphadenomegaly. In laboratory tests the following results were reported: in serum biochemistry: 104 g/L hyperglobulinemia (23 - 39); in protein electrophoresis: increased gamma globulins associated with a gammapaty; the popliteal lymphonode was aspirated with fine needle and in its analysis were found parasitic structures compatible with amastigotes of Leishmania spp.Treatment and evolution: Medical treatment with allopurinol, pentoxifylline and meglumine antimoniate, the latter, was instituted for only four weeks due to the lack of its distribution in Mexico, thus maintaining the patient without clinical signs. Anemia is associated with the chronic inflammation process, so vitamin B12 was administered.Laboratory tests: serum biochemistry in each consultation to evaluate renal function, protein electrophoresis and fine needle aspiration of popliteal lymphonode.Clinical relevance: Canine leishmaniasis is a poorly diagnosed disease in Mexico, the clinical signs that appear are nonspecific, therefore the adequate treatment is not given and there may be high mortality of patients suffering from the disease. It is of clinical importance to know that there are regions in Mexico where species of vectors that can transmit the disease live.Keywords: Spanish Water Dog, nasal discharge, hypotrichosis, blepharitis, lymphadenomegaly, canine leishmaniasis

scholarly journals Idiopathic multicentric Castleman disease preceded by cutaneous plasmacytosis successfully treated by tocilizumab

2020 ◽  
Vol 13 (11) ◽  
pp. e236283
Author(s):  
Tetsuro Aita ◽  
Sugihiro Hamaguchi ◽  
Yoko Shimotani ◽  
Yohei Nakamoto
Keyword(s):  
Interleukin 6 ◽  
Case Reports ◽  
Human Herpesvirus ◽  
Skin Lesions ◽  
Castleman Disease ◽  
Follicular Hyperplasia ◽  
Multicentric Castleman Disease ◽  
Interleukin 6 Receptor ◽  
History Of ◽  
Asymptomatic Phase

A woman aged 45 years with a 1.5-year history of violaceous plaques on the forehead and chest presented with fever, weight loss and aggravation of the plaques. Inflammatory markers and interleukin-6 level were elevated, and superficial lymphadenopathies and splenomegaly were identified by CT scan. Immunohistochemical findings of the lymph node and the skin showed polyclonal plasmacytosis and follicular hyperplasia, leading to the diagnosis of idiopathic multicentric Castleman disease (iMCD) after human herpesvirus-8 infection was excluded. The patient was successfully treated with anti-interleukin-6 receptor antibody, tocilizumab, following relapse after prednisolone therapy.Our literature review found 11 case reports of pathologically confirmed iMCD preceded by cutaneous plasmacytosis. The median duration of asymptomatic phase with only skin lesions was 7.5 years, whereas the phase lasted only for 1.5 years in our case. iMCD can develop shortly after asymptomatic cutaneous plasmacytosis. Tocilizumab can be a treatment of choice for this type of iMCD.

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

A Rare Case of Spinal Leprosy Mimicking Spinal Tuberculosis

2019 ◽  
pp. 33
Author(s):  
K Thuraikumar ◽  
V Naveen ◽  
Mustaqim A ◽  
Arieff AA ◽  
K Shri ◽  
...  
Keyword(s):  
Back Pain ◽  
Soft Tissue ◽  
Histopathological Examination ◽  
Posterior Instrumentation ◽  
Spinal Tuberculosis ◽  
Previous History ◽  
Skin Lesions ◽  
Titanium Implants ◽  
Paravertebral Abscess ◽  
History Of

Introduction: Spinal tuberculosis is the most common manifestation of extrapulmonar y tuberculosis. A combination of leprosy and tuberculosis is a rare entity.Case report: A 44-year-old male patient working as a laborer presented to our hospital with complaints of severe back pain and swelling over the back, difficulty in walking, associated with constitutional symptoms. On admission, he was febrile and had leukocytosis. Initial spine X-ray showed end plate destruction and increase in soft tissue shadow at the level of T8-T9. CT spine revealed thoracic paravertebral collection extending from T7 to T9 levels, suggest ive of tuberculous spondylitis with cold abscess. Patient refused a transpedicular biopsy and was started on anti-tubercular therapy. Two weeks after commencement of treatment, he developed worsening back pain and weakness of the lower extremities. MRI spine showed a paravertebral abscess and posterior soft tissue edema involving level of T7 to T11. Patient underwent a posterior decompression, debridement and posterior instrumentation. He was discharged well, there was improvement of his lower limb power. Upon clinic review, he complained of multiple hyperpigmented, painless, nonpruritic skin lesions over the trunk and back. No previous history of eczema, psoriasis and Tinea corporis. Given the history of allergy, initial impression was hypersensitivity reaction towards the titanium implants, and he was started on anti-histamines. However, there was no improvements seen. Histopathological examination of skin lesions revealed presence of granuloma within the dermis layer, composed of epitheloid, histiocytes, lymphocytes and plasma cells. Wade-Fite stain for Mycobacterium leprae is positive. Slit skin smear shows multibacillary leprosy. Patient was started on multidrug therapy (rifampicin, clofazimine and dapsone) for 1 year. He has recovered well.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 33

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