scholarly journals The Importance of Correlation of T-helper and T-supressor Limfocitary Subpopulations – Indicators of Animals Immune Status

2018 ◽  
Vol 75 (2) ◽  
pp. 195
Author(s):  
Rita GOLBAN
Keyword(s):  
Immune System ◽  
Immune Status ◽  
Age Groups ◽  
T Helper ◽  
Newborn Animal ◽  
Animal Organism ◽  
T Helper Lymphocytes ◽  
Scientific Investigations ◽  
Newborn Calves

The scientific investigations reflected in this study present the research in dynamics of the activity of correlating T-helper and T-suppressor immunocompetent cells at the newborn calves in different age periods. In the scientific research is presented the main effector role of these indicators, regarding the importance of the immune system through the ability to synthesize lymphokines, etc. The researches reveal T-helper and T-suppressor level of lymphocytes at all research ages. Thus at 10 days the concentration of T-helper lymphocytes was 7.85±0.001 and 8.30±0.08; 7.57 ± 0.008 at the age of 20 and 30 days, compared to T-suppressor lymphocytes, which in these age groups was equal to 6.0 ± 0.08; 6.33 ± 0.08 and 6.0±0.08. The results of the investigations offer the possibility to understand that the correlation of some lymphocytary subpopulations of the newborn animal organism provides the possibility of installing a strong immunity and ensures the maintenance of the biochemical homeostasis of the organism.

Immunological aspects of urethral stenosis. Involvement of the S100 protein-positive dendritic cells

1995 ◽  
Vol 62 (1_suppl) ◽  
pp. 53-58
Author(s):  
C. Cracco ◽  
S. Biasiol ◽  
G. Filogamo ◽  
S. Rocca Rossetti
Keyword(s):  
Dendritic Cells ◽  
Immune System ◽  
Morphological Changes ◽  
S100 Protein ◽  
Healthy Skin ◽  
T Helper ◽  
Urethral Stenosis ◽  
T Helper Lymphocytes ◽  
Accessory Cells ◽  
Dermatological Disorders

— Within the superficial layers of healthy skin and of some mucosae there is a Population of accessory cells of the immune system, able to interact with T helper lymphocytes. Such cells, called tissular dendritic cells (DCs), increase their density and display different morphological features in a variety of immunologically-mediated dermatological disorders. In the present work we investigated DCs within the various urethral segments, both in normal conditions and in urethral stenosis. The specimens, obtained from urethrectomies and urethroplasties with end-to-end anastomosis, were stained with anti-S100 protein antibody and immunofluorescence techniques. We demonstrated an increasing density of S100 protein-positive epithelial DCs from the Prostatic urethra to the glandular one, where DCs were also larger and richer in dendritic Processes. In urethral stenosis the intraepithelial infiltrate of ramified DCs was much denser than any other control. We therefore hypothesize a role for the immune system in the development and maintenance of urethral stenoses, where, as already demonstrated for other types of pathological scarring, morphological changes of DCs serve as clues to their functional activation.

The Role of T-helper Lymphocytes in Priming for Experimental Autoimmune Glomerulonephritis in the BN Rat

1993 ◽  
Vol 6 (5) ◽  
pp. 571-585 ◽  
Author(s):  
John Reynolds ◽  
Beverley A. Sallie ◽  
Christos Syrganis ◽  
Charles D. Pusey
Keyword(s):  
T Helper ◽  
T Helper Lymphocytes ◽  
Experimental Autoimmune

scholarly journals Immunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments

2015 ◽  
Vol 7 (2) ◽  
pp. 62-67
Author(s):  
ASM Giasuddin ◽  
KA Jhuma ◽  
AMM Haq ◽  
MM Haque
Keyword(s):  
Rheumatoid Arthritis ◽  
Adult Population ◽  
Chronic Inflammatory Disease ◽  
Age Group ◽  
T Helper ◽  
T Helper Lymphocytes ◽  
Th17 Lymphocytes ◽  
Recent Developments ◽  
Cytokine Cascade

Rheumatoid arthritis (RA) is a chronic inflammatory disease occurring three times more in females throughout the world affecting 1-2% of the adult population in all ethnic groups, usually in the age group of 25-60 years. Although the role of CD4 + T helper lymphocytes in the aetiopathogenesis has been studied for more than three decades, the focus on CD4 + T helper type 17 (Th17) lymphocytes and its associated cytokines is much more recent. The cytokines such as IL-17 and IFN-g induce secondary cytokines such as IL-1, TNF-a , etc which possibly cause inflammation in joints. This cytokine cascade, therefore, offers a number of points and opportunities for immunointervention in RA. The present review article highlights some of the major aspects of the immunopathogenesis that involve Th17 cells and their association relevant to recent developments in the treatment of RA. DOI: http://dx.doi.org/10.3329/bjmb.v7i2.22415 Bangladesh J Med Biochem 2014; 7(2): 62-67

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

Role of T Helper Lymphocytes in Autoimmune Diseases

1989 ◽  
pp. 117-131
Author(s):  
Gérald J. Prud’homme ◽  
Nollaig A. Parfrey
Keyword(s):  
Autoimmune Diseases ◽  
T Helper ◽  
T Helper Lymphocytes

scholarly journals Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non-alcoholic fatty liver disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Victoria Cairoli ◽  
Elena De Matteo ◽  
Daniela Rios ◽  
Carol Lezama ◽  
Marcela Galoppo ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Immune Cell ◽  
Age Groups ◽  
Similar Proportion ◽  
Alcoholic Fatty Liver ◽  
T Helper Lymphocytes ◽  
Regulatory T Lymphocytes ◽  
Alcoholic Fatty Liver Disease ◽  
Cd4 Lymphocytes

AbstractThe immune response is critical in NAFLD pathogenesis, but the liver infiltrate’s composition and the role of each T cell population is still up for debate. To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations [Cytotoxic T Lymphocytes (CD8+), T helper Lymphocytes (CD4+), Regulatory T lymphocytes (Foxp3+) and Th17 (IL-17A+)] were evaluated. In portal/periportal (P/P) tracts, both age groups displayed a similar proportion of CD8+ and CD4+ lymphocytes. However, comparable Foxp3+ and IL-17A+ cell frequencies were observed in pediatric cases, meanwhile, in adults Foxp3+ was higher than IL-17A+ cells. Interestingly, IL-17A+ lymphocytes seemed to be nearly exclusive of P/P area in both age groups. In intralobular areas, both pediatric and adult cases showed CD8+ lymphocytes predominance with lower frequencies of CD4+ lymphocytes followed by Foxp3+ . Severe inflammation was associated with higher intralobular Foxp3+ lymphocytes (p = 0.026) in children, and lower P/P Foxp3+ and higher IL-17A+ lymphocytes in adults. All cases with fibrosis ≥ 2 displayed P/P low Foxp3+ and high IL-17A+ lymphocyte counts. Pediatric cases with worse steatosis showed high P/P CD4+ (p = 0.023) and intralobular CD8+ (p = 0.027) and CD4+ cells (p = 0.012). In NAFLD cases, the lymphocyte liver infiltrate composition differs between histological areas. Treg and Th17 balance seems to condition damage progression, denoting their important role in pathogenesis.

scholarly journals PECULIARITIES OF POST-FIRM REHABILITATION PIGLES DEPENDING ON THE SEASON OF BIRTH

2021 ◽  
pp. 122-128
Author(s):  
N. V. Efanova ◽  
L. M. Osina ◽  
S. V. Batalova
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
B Lymphocytes ◽  
Immune Status ◽  
Season Of Birth ◽  
B Lymphopoiesis ◽  
T Helper ◽  
Low Level ◽  
Different Seasons ◽  
Activated T Lymphocytes

The features of the rehabilitation of the immune system of piglets after weaning were studied in connection with different seasons of farrowing. To fulfill this goal, 4 groups were formed from the offspring of sows of the SM-1 breed of Novosibirsk selection. The 1st group included piglets from winter farrowings, and the 2nd, 3rd and 4th groups, respectively, young animals born in spring, summer and autumn. Each group consisted of 30 animals. Studies of indicators of the immune status were carried out before weaning and 30 days after weaning. Weaning of piglets from sows with their subsequent regrouping in the educational farm «Tulinskoye» is carried out at the age of 60 days. The research results have shown that the state of the immune status of 2- and 3-month-old pigs is seasonal. Piglets born in autumn show the best indicators of leukopoiesis, T-, B-lymphopoiesis, the formation of functionally mature T-lymphocytes, activated T-lymphocytes and antitelogenesis. The second position in terms of the intensity of leukopoiesis, antitelogenesis and B-lymphopoiesis is occupied by young animals born in summer. Piglets raised in winter differ from their peers in a low level of IgM synthesis, while piglets born in spring have the lowest total numbers of T-lymphocytes, T-helper inductors, T-killer suppressors, B-lymphocytes and IgG. A month after weaning, animals, regardless of the season of birth, showed a statistically significant decrease in T-lymphopoiesis. The activity of the T-link of the immune system decreased most significantly in young animals obtained in spring. However, in contrast to their peers, youngsters born in the spring showed a statistically significant increase in blood IgM and IgG concentrations. In piglets born in winter, summer and autumn, the activity of IgM synthesis, on the contrary, decreased, while the formation of IgG remained at the same level.

scholarly journals Follow-up evaluation of the immunological status of children admitted for acute cerebral nervous system infections: a retrospective study

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Giulia Spina ◽  
Bozzola Elena ◽  
Carsetti Rita ◽  
Piano Mortari Eva ◽  
Cristina Mascolo ◽  
...  
Keyword(s):  
Nervous System ◽  
Immune System ◽  
High Frequency ◽  
Immune Status ◽  
Follow Up Study ◽  
Laboratory Investigations ◽  
Pediatric Infections ◽  
Immunological Alterations

Abstract Background Acute Cerebral Nervous System Infections (ACNS) may cause death or severe complications even to promptly treated children. The role of the immune system in influencing the course and the outcome of meningitis has been studied but it is not yet completely understood. The aim of the research is to ascertain whether children who experienced ACNS infection had a normal immune system. Methods Patients under 18 years of age admitted at Bambino Gesù Children from January 2006 till June 2016 for meningitis were asked to participate to the follow-up study. The immune status was evaluated both clinically and by laboratory investigations. Results Most of the patients over 3 years at follow up had at least one immunological alteration at follow-up evaluation (74%). Considering ACNS infection etiology, certain pathogens were almost exclusive of patients affected by some immunological alteration, regardless of their age. Discussion Our preliminary results indicate that sub-clinical immunological defects may be associated to ACNS pediatric infections. Moreover, to the best of our knowledges, this is the first study correlating pathogens to immune evaluation in ACNS infections. It is, however, important to underline the high frequency of persistent immunological alterations in the analyzed patients. Further studies are needed to confirm our conclusions. Conclusions We recommend an immunological assessment at follow up evaluation in children who experienced an ACNS infection.

scholarly journals Immune system in development and progression of viral myocardial damage

2021 ◽  
Vol 66 (3) ◽  
pp. 27-33
Author(s):  
I. M. Khegai ◽  
I. I. Trunina ◽  
T. A. Chebotareva ◽  
G. K. Khodikyan ◽  
P. V. Shumilov
Keyword(s):  
Immune System ◽  
Myocardial Damage ◽  
T Helper ◽  
T Helper 17 ◽  
Cardiac Pathology ◽  
Inflammatory Heart Disease ◽  
Interleukin 17A ◽  
Treg Lymphocytes ◽  
Th17 Cytokine

This review demonstrates the role of the immune system in the development and progression of cardiac pathology caused by viral infection. The authors describe the role of lymphocytes (T- helper-17–Th17) in the viral persistence in myocardial tissue. They provide the information on increased level of interleukin-17A, the main Th17 cytokine in patients with dilated cardiomyopathy, which proves role of these cells in the progression of cardiac pathology. They discuss the role of T regulatory (Treg) lymphocytes in inflammatory heart disease.

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