scholarly journals Phytochemistry and pharmacological activities of Saponaria officinalis L.: A review

2021 ◽  
Vol 13 (1) ◽  
pp. 10809
Author(s):  
Satish CHANDRA ◽  
Dharmendra S. RAWAT ◽  
Arun BHATT
Keyword(s):  
Skin Diseases ◽  
Antioxidant Properties ◽  
Future Research ◽  
Northern Asia ◽  
Medicinal Uses ◽  
Anticancer Properties ◽  
Native Place ◽  
Important Medicinal Plant ◽  
Different Parts ◽  
Saponaria Officinalis

Saponaria officinalis is an important medicinal plant cultivated in different parts of the globe for its beautiful flowers. Species is commonly known as soapwort. Central Europe is considered as native place for the species and has been introduced in Northern Asia, West Asia, Northern Europe and America. Plant of the species are perennial, stem erect, branched, leaves ovate or ovate-lanceolate, inflorescence dense cymes, calyx green or reddish, often cleft, petals pink to white, fruit capsules, seeds tuberculate-reniform and numerous per fruit. Indigenous people of different parts of the world use this species to cure various ailments. Traditionally roots of the species have been used as urine remover. It is also used for cough, bronchitis, stomach disorders, bone deformations, rheumatism, pimples, skin diseases, bile disorders, liver problems and respiratory system diseases. The leaves were rubbed on the skin as a repellent and also used as sanitizer, diuretic and in liver diseases. Saporins are ribosome inhibitory proteins and play important role for anticancer properties. Different types of saponins are synthesized by the species exhibit anticancer, antimicrobial, insecticidal and antioxidant properties. The present review is focused on the traditional medicinal uses of species along with phytochemical and pharmacological studies. This review will provide a ground for future research of the species.

scholarly journals In vitro antimicrobial, anti-oxidant properties and GC-MS analysis of the crude methanolic extract and fractions of Solanum dasyphyllum Schumach and Thonn. leaves

2020 ◽  
Author(s):  
Oladapo Elijah Oyinloye ◽  
Olumuyiwa. S. Alabi ◽  
Olusegun. G. Ademowo
Keyword(s):  
Crude Extract ◽  
Skin Diseases ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Kinetics Study ◽  
Medicinal Uses ◽  
Ms Analysis ◽  
Soxhlet Apparatus ◽  
Anti Oxidant ◽  
Time Kill

Abstract Background: Solanum dasyphyllum is a plant with several ethno-medicinal uses as food and medicine in treatment of fever, skin diseases, inflammation, stomach ache and some systemic infections. To date there is little scientific validation of the folkloric claims of S. dasyphyllum compared to other species of the Solanaceae family. This study determined the antimicrobial and antioxidant potential of methanol extract and fractions of the leaves of S. dasyphyllum and analysed the phyto-constituents using GC-MS technique.Methods: The dried leaves of S. dasyphyllum were extracted by Soxhlet apparatus with 80% methanol and the crude extract subjected to Phytochemical screening and liquid-liquid fractionation. Crude extract and fractions were subjected to antimicrobial screening, minimum inhibitory concentrations (MICs) and minimum bactericidal/fungicidal concentrations (MBC/MFC) determination and time-kill kinetics study. Crude extract was assayed for antioxidant activity and analysed by GC-MS.Results: Percentage yield of S. dasyphyllum was 12.5% and tested positive for flavonoids, alkaloids, saponins, cyanogenic glycosides, tannins and reducing sugars. The crude extract and fractions were active on all the isolates at concentrations >0.5 mg/mL. MICs of the crude extract and fractions ranged between 0.25 and >4 mg/mL, MBC ranged between 1 and >4 mg/mL and MFC ranged between 0.5 and >4 mg/mL. The MBC/MIC ratio was >4 for dichloromethane fractions against S. aureus (ratio 8) and MFC/MIC ratio ethylacetate fraction against the fungi isolates (ratio 8). The time-kill kinetics study showed dichloromethane and ethylacetate fractions to be bactericidal with zero viable count at 4 - 6hours against the isolates. The crude extract displayed moderate antioxidant with weak DPPH radical scavenging activity. The GC-MS analysis showed 29 metabolites including the phenols and polyphenols derivatives, eucalyptol, levomenthol, benzofuranone derivative, diethyl phthalate, neophytadiene, 1-Docosene, 17-Pentatriacontene, Phytol, Thunbergol and esters of decanoic acid derivatives all of which are known to have anti-infective and anti-oxidant properties.Conclusion: This study therefore confirmed the ethno-medicinal claim of S. dasyphyllum and thus elucidates the potentials of the plant as a good source of bioactive compounds including those with strong anti-infective and antioxidant properties.

scholarly journals A REVIEW OF BOTANY, THERAPEUTIC VALUE, PHYTOCHEMISTRY, AND PHARMACOLOGY OF CUSSONIA PANICULATA

2019 ◽  
pp. 1-6
Author(s):  
ALFRED MAROYI
Keyword(s):  
Herbal Medicine ◽  
Skin Diseases ◽  
Intestinal Parasites ◽  
Biological Activities ◽  
Triterpene Glycosides ◽  
Future Research ◽  
Steroidal Saponin ◽  
Scientific Publications ◽  
Triterpenoid Saponins ◽  
Medicinal Uses

Cussonia paniculata is a small tree widely used as herbal medicine throughout its distributional range in southern Africa. This study is aimed at providing a critical review of the botany, biological activities, phytochemistry, and medicinal uses of C. paniculata. Documented information on the botany, biological activities, medicinal uses, and phytochemistry of C. paniculata was collected from several online sources which included BMC, Scopus, SciFinder, Google Scholar, Science Direct, Elsevier, PubMed, and Web of Science. Additional information on the botany, biological activities, phytochemistry, and medicinal uses of C. paniculata was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the University library. This study showed that the bark, fruits, leaves, roots, and stems of C. paniculata are used as emetic, immune booster, and herbal medicine for dysmenorrhea, intestinal parasites and worms, mental problems, boils, shingles and skin diseases, indigestion and stomach complaints, sores, and wounds. Phytochemical compounds identified from the leaves of C. paniculata include acetylated triterpene glycosides, unacetylated triterpene glycosides, flavonoid, steroidal saponin, and triterpenoid saponins. Pharmacological research revealed that C. paniculata extracts have analgesic, antibacterial, anticancer, anti-inflammatory, antiplasmodial, antiprotozoan, Aβ42 protein reduction, and cytotoxicity activities. Future research should focus on evaluating the phytochemical, pharmacological, and toxicological properties of C. paniculata crude extracts as well as compounds isolated from the species.

scholarly journals Phytochemical profiling and antioxidant activities of different parts of Artocarpus heterophyllus Lam. (Moraceae): A review on current status of knowledge

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
P. S. Sreeja Devi ◽  
Neethu S. Kumar ◽  
K. K. Sabu
Keyword(s):  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Current Status ◽  
Main Body ◽  
Huge Amount ◽  
Good Source ◽  
Medicinal Uses ◽  
Artocarpus Heterophyllus ◽  
Western Ghats Of India ◽  
Different Parts

Abstract Background Artocarpus heterophyllus Lam. (Jackfruit tree) is one of the most ancient fruits indigenous to Western Ghats of India. They are large edible summer fruits and are good source of nutritional and antioxidant components which hold their potential for nutraceutical development. Main body The present review attempts to document reports on the chemical and pharmacological investigations carried out with jackfruit. Research shows that the fruit contains a huge amount of phytochemicals such as phenolics, flavonoids, terpenoids, steroids, glycosides, saponins, alkaloids, and tannins which exhibit antioxidant properties. Conclusions Diversity of secondary metabolites present in the jackfruit shows that it is a functionally, nutritionally, and medicinally important fruit. Detailed studies are essential for awareness among people for the proper use of jackfruit as a functional food and utilize the medicinal uses of jackfruit.

scholarly journals Phytochemistry and medicinal values of Mahonia bealei: A review

2021 ◽  
Vol 18 (10) ◽  
pp. 2219-2227
Author(s):  
Mohib Ullah Kakar ◽  
Muhammad Saeed ◽  
Ke Luo ◽  
Imran Suheryani ◽  
Wu Shuang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Synergistic Effects ◽  
Scientific Evidence ◽  
Therapeutic Agents ◽  
Future Research ◽  
Medicinal Uses ◽  
Mahonia Bealei ◽  
Different Parts

Purpose: To review the medicinal uses of Mahonia bealei, an important member of the genus Mahonia, with a focus on its various applications in Traditional Chinese Medicine, as well as published scientific evidence on its effectiveness. Methods: Information in all available literature was retrieved using different search engines including NCBI, ISI Web of Knowledge and Google. Results: Several compounds have been extracted from M. bealei. These include alkaloids, triterpenes, flavonoids, phytosterols and lignans. Traditionally, the plant is used to treat dysentery, diarrhea and inflammation. Globally, scientists have used in vitro and in vivo techniques to evaluate the usefulness of compounds extracted from M. bealei with respect to their antibacterial, anti-inflammatory, antitumor, antioxidant as well as anti-gastrin properties. Conclusion: Different parts of this plant still remain underexplored. Moreover, comparison of the properties of the isolated compounds has not been carried out, nor are there reports on the synergistic effects of extracts of the plant. Therefore, future research to address these areas may be useful in the discovery of new therapeutic agents.

scholarly journals The Medicinal Uses of Tinospora Cordifolia (Gurjo)

2019 ◽  
pp. 52-56
Author(s):  
Suraj Raj Adhikari ◽  
Kusum Pokhrel
Keyword(s):  
Respiratory Tract Infections ◽  
Tinospora Cordifolia ◽  
Medicinal Uses ◽  
The Family ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Tract Infections ◽  
Deciduous Shrub ◽  
Important Medicinal Plant ◽  
Different Parts

Tinospora cordifolia is a perennial, climbing deciduous shrub. This plant belongs to the family Menispermaceae. A variety of phytochemical constituents have been isolated from different parts of T. cordifolia. These compounds belong to different groups such as alkaloids, steroids, diterpenoid lactones, aliphatic compounds, glycosides and polysaccharides. It is a widely used plant in Ayurvedic systems of medicine. Stem, roots and leaves are the most important parts of the plant, which are used in traditional systems of medicines. It possesses anti-neoplastic, antioxidant, anti-hyperglycemic and hepatoprotective properties. It is the important medicinal plant used in traditional Ayurvedic medicine for the treatment of fever, cold, diabetes, respiratory tract infections etc. This paper presents an appraisal of medicinal properties and pharmaceutical importance of Tinospora cordifolia.

scholarly journals Cissampelos capensis L.f. (Menispermaceae): Review of its medicinal uses, phytochemical and pharmacological properties

2020 ◽  
Vol 11 (4) ◽  
pp. 5948-5955
Author(s):  
Alfred Maroyi
Keyword(s):  
Skin Diseases ◽  
Pharmaceutical Products ◽  
Future Research ◽  
Pharmacological Properties ◽  
Scientific Publications ◽  
Medicinal Uses ◽  
Sexually Transmitted ◽  
Traditional Medicines ◽  
Gastrointestinal Problems ◽  
Cytotoxicity Activities

Cissampelos capensis L.f. is a perennial climber widely used as a traditional medicine in South Africa. This study was aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of C. capensis. Documented information on the pharmacological properties, phytochemistry and medicinal uses of C. capensis was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study revealed that leaf, rhizome and root infusions and decoctions of C. capensis are mainly used as a blood purifier, and traditional medicines for respiratory problems, ulcers, sores and wounds, skin and stomach cancers, snakebite, sexually transmitted infections, skin diseases, diabetes and gastrointestinal problems. Phytochemical compounds identified from the species include alkaloids, essential oils, flavonoids, phenolics, saponins and tannins. Pharmacological research revealed that C. capensis extracts and compounds isolated from the species have anthelmintic, antibacterial, antifungal, antidiabetic, antimalarial, hepatotoxicity, spermatozoa and cytotoxicity activities. Documentation of the medicinal uses, phytochemistry and pharmacological properties of C. capensis is vital as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. There is a need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since C. capensis contains potentially toxic compounds.

Baccharoides lasiopus: Review of its Medicinal uses, Phytochemistry and Pharmacological Properties -

2020 ◽  
Vol 10 (5) ◽  
pp. 205-212
Author(s):  
Alfred Maroyi
Keyword(s):  
Traditional Medicine ◽  
Skin Diseases ◽  
Respiratory Infections ◽  
Sesquiterpene Lactones ◽  
Future Research ◽  
Pharmacological Properties ◽  
Scientific Publications ◽  
Medicinal Uses ◽  
Phytochemical Compounds

Baccharoides lasiopus is a woody shrub widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the pharmacological properties, phytochemistry, and medicinal uses of B. lasiopus. Documented information on the pharmacological properties, phytochemistry, and medicinal uses of B. lasiopus was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. The articles published between 1971 and 2020 were used in this study. This study showed that the leaves, roots, stems, whole plant parts, root and stem bark of B. lasiopus are widely used as galactagogue, purgative and anthelmintic, and traditional medicine for headache, liver diseases, skin diseases, respiratory infections, malaria, augment labour, convulsions, epilepsy, fainting, female reproductive problems, and gastro-intestinal problems. Phytochemical compounds identified from the species include elemanolide type sesquiterpene lactones, alkaloids, anthraquinones, cardiac glycosides, coumarins, flavonoids, phenolics, reducing sugars, saponins, steroids, tannins, terpenoids, and xanthines. Pharmacological research revealed that B. lasiopus extracts and compounds isolated from the species have anthelmintic, antibacterial, antifungal, antiviral, antihyperglycemic, antiplasmodial, antimalarial, antiprotozoal, haematological, hepatoprotective, hepatotoxicity, larvicidal, and cytotoxicity activities. Future research on B. lasiopus should focus on the possible biochemical mechanisms of action of both the crude extracts and identified phytochemical compounds including toxicological, in vivo, and clinical studies to corroborate the traditional medical applications of the species.

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents

2019 ◽  
Vol 20 (5) ◽  
pp. 376-389 ◽  
Author(s):  
Sonali Mishra ◽  
Nupur Srivastava ◽  
Velusamy Sundaresan ◽  
Karuna Shanker
Keyword(s):  
Secondary Metabolite ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Critical Discussion ◽  
Future Research ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Therapeutic Uses ◽  
Decalepis Arayalpathra

Background: Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter is used primarily for nutrition besides its therapeutic values. Traditional preparations/formulations from its tuber are used as a vitalizer and blood purifier drink. The folklore medicinal uses cover inflammation, cough, wound healing, antipyretic, and digestive system management. A comprehensive review of the current understanding of the plant is required due to emerging concerns over its safety and efficacy. Objective: The systematic collection of the authentic information from different sources with the critical discussion is summarised in order to address various issues related to botanical identity, therapeutic medicine, nutritional usage, phytochemical, and pharmacological potentials of the D. arayalpathra. Current use of traditional systems of medicine can be used to expand future research opportunities. Materials and Methods: Available scripted information was collected manually, from peered review research papers and international databases viz. Science Direct, Google Scholar, SciFinder, Scopus, etc. The unpublished resources which were not available in database were collected through the classical books of ‘Ayurveda’ and ‘Siddha’ published in regional languages. The information from books, Ph.D. and MSc dissertations, conference papers and government reports were also collected. We thoroughly screened the scripted information of classical books, titles, abstracts, reports, and full-texts of the journals to establish the reliability of the content. Results: Tuber bearing vanilla like signature flavor is due to the presence of 2-hydroxy-4-methoxybenzaldehyde (HMB). Among five other species, Decalepis arayalpathra (DA) has come under the ‘critically endangered’ category, due to over-exploitation for traditional, therapeutic and cool drink use. The experimental studies proved that it possesses gastro-protective, anti-tumor, and antiinflammatory activities. Some efforts were also made to develop better therapeutics by logical modifications in 2-Hydroxy-4-methoxy-benzaldehyde, which is a major secondary metabolite of D. arayalpathra. ‘Amruthapala’ offers the enormous opportunity to develop herbal drink with health benefits like gastro-protective, anti-oxidant and anti-inflammatory actions. Results: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e. 2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. Chemical Compounds: 2-hydroxy-4-methoxybenzaldehyde (Pubchem CID: 69600), α-amyrin acetate (Pubchem CID: 293754), Magnificol (Pubchem CID: 44575983), β-sitosterol (Pubchem CID: 222284), 3-hydroxy-p-anisaldehyde (Pubchem CID: 12127), Naringenin (Pubchem CID: 932), Kaempferol (Pubchem CID: 5280863), Aromadendrin (Pubchem CID: 122850), 3-methoxy-1,2-cyclopentanedione (Pubchem CID: 61209), p-anisaldehyde (Pubchem CID: 31244), Menthyl acetate (Pubchem CID: 27867), Benzaldehyde (Pubchem CID: 240), p-cymene (Pubchem CID: 7463), Salicylaldehyde (Pubchem CID: 6998), 10-epi-γ-eudesmol (Pubchem CID: 6430754), α -amyrin (Pubchem CID: 225688), 3-hydroxy-4-methoxy benzaldehyde (Pubchem CID: 12127).

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

scholarly journals Strobilanthes heyneanus root extract as a potential source for antioxidant and antimicrobial activity

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vijayakumar Sundaram ◽  
Selvaraju Sadhasivam ◽  
Sivaraj Chandrasekaran ◽  
Raaman Nanjian ◽  
Arjun Pandian
Keyword(s):  
Dermal Fibroblast ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Fibroblast Cell ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Scavenging Activity ◽  
Medicinal Uses

Abstract Background Strobilanthes heyneanus (Nilgirianthus heyneanus) belongs to the family Acanthaceae that contains many species with potential for diverse medicinal uses. It is also called ‘Karun kurinji’ and is commonly found in the South-West regions of India. The species are commonly used in rheumatic complaints, sprain of the ankle, and hernia. The objectives of the study were to evaluate the antioxidant activity, phytochemical analysis, and antibacterial activities of the root extract of S. heyneanus. Results The radical scavenging and reduction assays such as DPPH● radical and OH● radical scavenging assays, as well as phosphomolybdenum reduction and Fe3+ reducing power assays, were determined for the root extract. The highest DPPH● radical scavenging activity was 88.23 ± 1.32 at 120 μg/mL concentration, and the calculated IC50 was 38.52 μg/mL concentration. The highest OH● radical scavenging activity was 51.28 ± 1.06 at 120 μg/mL concentration, and the calculated IC50 was 51.28 μg/mL concentration. The highest ABTS●+ radical scavenging activity was 91.28 ± 1.12 at 30 μg/mL concentration, and the calculated IC50 was 33.92 μg/mL concentration. The highest phosphomolybdenum reduction was 87.43 ± 0.90 at 120 μg/mL concentration, and the calculated RC50 was 24.74 μg/mL concentration. The highest Fe3+ reduction was 89.38 ± 0.98 at 120 μg/mL concentration, and the calculated RC50 was 31.06 μg/mL concentration. The antibacterial activity of S. heyneanus showed the highest zone of inhibition of 24 mm for Salmonella typhi with 500 μg/mL concentration. The cytotoxicity limits of the root extracts were tested by MTT assay using human dermal fibroblast cell lines, reflecting > 90% cell viability at a concentration of 500 μg/mL. Conclusions The current study showed that the root extract of S. heyneanus has better antioxidant properties and potential anti-bacterial compounds. The phytochemical analysis of the root extract showed the presence of alkaloids, steroids, terpenoids, phenols, flavonoids, tannins, saponins, glycosides, and carbohydrates, which are responsible for the antibacterial root extract of S. heyneanus synergistically.

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