Assessing cardiovascular risk in ATM heterozygotes

Summary Objective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 ± 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]; p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations.

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POS1281 HOW DOES OBESITY INFLUENCE THE FEATURES OF KNEE OSTEOARTHRITIS?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3602 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 923.4-924

Author(s):

H. Hachfi ◽

D. Khalifa ◽

M. Brahem ◽

N. Ben Chekaya ◽

M. Younes

Keyword(s):

Knee Osteoarthritis ◽

Functional Impairment ◽

Statistical Significance ◽

Obese Group ◽

University Hospital ◽

Obese Patients ◽

Cross Sectional ◽

Duration Of Symptoms ◽

Lequesne Index ◽

The Mean

Background:Knee osteoarthritis and obesity are both major health problems. It is now admitted that the prevalence of knee osteoarthritis gets higher with obesity and that weight loss helps knee function and allows patients to avoid surgery.Objectives:The aim of this study was to study the influence of obesity on knee osteoarthritis features.Methods:A cross-sectional study was conducted in the university hospital Taher Sfar of Tunisia over a period of 6 months. Patients who had knee osteoarthritis confirmed by radiographs were included. Sociodemographic, clinical, radiological and therapeutic data were collected from medical records and visits. Obesity was defined by a body mass index (BMI) ≥30. Functional impairment was assessed by the Womac index and Lequesne index.Results:The study included 186 patients. There were 31 males and 155 femmes. The mean age was 60±10 years. The percentage of obese patients was 53,8%. The mean age was similar in both groups obese and non obese. There were more women in the obese group compared to the non obese group (p=0.0001), more patients who had diabetes mellitus and dyslipidemia (p=0.002). Non-obese patients had a shorter duration of symptoms with no statistical significance (p=0.151). Obese patients had more involvement of both knees (p<0.0001). Obesity did not have an impact on pain severity. Severity of radiological images (p=0,0001) were more frequent in obese patients. Functional impairment was similar in both groups. However, the percentage of patients having a very important functional impairment with Lequesne index was higher in obese patients (p<0.029). Obese patients also needed more physical therapy sessions (p=0.035).Conclusion:Knee osteoarthritis in obese patients is characterized with the femlae gender predominance, bilateral knee involvement, and a more severe images on radiographs. Thus the need for better control of weight and the importance of physical activity.References:[1]Coggon D, Reading I, Croft P, et al. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord J Int Assoc Study Obes 2001; 25: 622–627.Disclosure of Interests:None declared

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Analysis of Surgical Recurrence after Larynx Microsurgery for Benign Lesions

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1718529 ◽

2020 ◽

Author(s):

Maria Theresa Costa Ramos de Oliveira Patrial ◽

Rogério Hamerschmidt ◽

Jorge Eduardo Fouto Matias ◽

Evaldo Dacheux de Macedo Filho ◽

Bettina Carvalho

Keyword(s):

Statistical Significance ◽

Cross Sectional Study ◽

Cross Sectional ◽

Associated Lesions ◽

Surgical Recurrence ◽

Retrospective Data Collection ◽

The Mean ◽

And Gender ◽

Benign Laryngeal Lesions ◽

Reinke Edema

Abstract Introduction The study of larynx lesions is of great importance. More than 50% of people with vocal complaints have benign vocal fold alterations and some require surgery. Objective To determine which factors are related to surgical recurrence of benign laryngeal lesions and to determine which videolaryngoscopic diagnoses are related to the risk or protection of surgical relapses over time. Methods Observational, analytical, cross-sectional study with retrospective data collection of 1,383 surgeries in 1,301 patients. Results The mean age at the first surgery was 39.2 years old. The predominant gender was female (65.6%).There were 396 cases of polyps (25.34%), 349 cases of cysts (22.33%), 261 cases of Reinke edema (16.7%), 175 cases of nodules (11.2%), 153 cases of minor structural alterations (MSAs) (9.79%), 94 cases of leukoplakia (6.01%), 77 cases of granulomas (4.93%) and 58 cases of pseudocysts (3.71%). The age presented statistical significance with the risk of surgical relapses (p = 0.016). Male gender was associated with the greatest chance of relapse.Diagnosis of granuloma (p < 0.001) and of leukoplakia (p < 0.001) were associated with a higher risk of surgical recurrence. Cyst diagnosis was associated with protection (p = 0.015) in relation to the chance of further surgeries. Patients with associated lesions, bilaterals or voice professionals did not present a statistically significant association with surgical recurrence. Conclusion Age and gender are statistically related to the increase of surgical relapses. Leukoplakia and granuloma are associated with increased surgical relapses. Patients submitted to cyst microsurgery appear to be protected against surgical recurrence.

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Diagnostic accuracy of enthesis ultrasound in the diagnosis of early spondyloarthritis

Annals of the Rheumatic Diseases ◽

10.1136/ard.2010.134965 ◽

2010 ◽

Vol 70 (3) ◽

pp. 434-439 ◽

Cited By ~ 70

Author(s):

Eugenio de Miguel ◽

Santiago Muñoz-Fernández ◽

Concepción Castillo ◽

Tatiana Cobo-Ibáñez ◽

Emilio Martín-Mola

Keyword(s):

New York ◽

Diagnostic Accuracy ◽

Statistical Significance ◽

Area Under The Curve ◽

Roc Curves ◽

Controlled Study ◽

Diagnostic Classification ◽

Hla B27 ◽

Cross Sectional ◽

Ultrasound Score

ObjectiveTo determine the sensitivity and specificity of enthesis ultrasound for the diagnostic classification of early spondyloarthritis.MethodsA cross-sectional, blinded and controlled study. Standardised bilateral ultrasound of six entheses (Madrid sonography enthesitis index (MASEI)) was performed. Accepted diagnostic classification criteria were used as the gold standard. Validity was analysed by receiver operating characteristic (ROC) curves. Values of p<0.05 were considered significant.Results113 early spondyloarthritis patients were included (58 women/55 men), 57 non-inflammatory control individuals (29 women/28 men) and 24 inflammatory control individuals (11 women/13 men). The evolution time of spondyloarthritis was 10.9±7.1 months. At least some grade of sacroiliitis on x-ray was present in 59 patients, but only five fulfilled the radiographic sacroiliitis New York criteria. Human leucocyte antigen B27 (HLA-B27) was positive in 42% of patients. No statistical differences were found for the enthesis score among diagnostic spondyloarthritis subtypes form of presentation (axial, peripheral or mixed) or HLA-B27 positivity. The MASEI score achieved statistical significance for gender. The ultrasound score was 23.36±11.40 (mean±SD) in spondyloarthritis patients and 12.26±6.85 and 16.04±9.94 in the non-inflammatory and inflammatory control groups (p<0.001), respectively. The ROC area under the curve was 0.82, and a cut-off point of ≥20 points achieved a likelihood ratio of 5.30 and a specificity of 89.47%.ConclusionsEntheses are affected early in spondyloarthritis, and the incidence of involvement is higher in men and independent of the spondyloarthritis diagnostic subtype, HLA-B27 status or presentation pattern. The enthesis ultrasound score seems to have diagnostic accuracy and may be useful for improving the diagnostic accuracy of early spondyloarthritis.

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Association between Diabetic Retinopathy and Chronic Periodontitis—A Cross-Sectional Study

Medical Sciences ◽

10.3390/medsci6040104 ◽

2018 ◽

Vol 6 (4) ◽

pp. 104 ◽

Cited By ~ 1

Author(s):

Veena H. R. ◽

Sribhargava Natesh ◽

Sudhir Patil

Keyword(s):

Diabetic Retinopathy ◽

Serum Creatinine ◽

Glycated Haemoglobin ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Chronic Inflammatory Condition ◽

The Mean

Periodontal disease (PD), a chronic inflammatory condition characterized by destruction of the supporting tissues of the teeth, increases the risk of complications in diabetics. Diabetic retinopathy (DR) is a microvascular complication of prolonged hyperglycaemia. There appears to be a similarity in the pathogenesis of DR and PD. Hence, this study aimed to investigate the association, if any, between DR and PD, correlate the severity of DR with the severity of PD, and investigate the association between glycated haemoglobin (HbA1c), serum creatinine and periodontal variables. The periodontal status of 200 adult diabetic patients in the age group of 30–65 years with varying severity of DR was assessed. Evaluation of the severity of PD was assessed by recording clinical parameters. Haematological investigations including glycated haemoglobin (HbA1c) and serum creatinine were estimated before the initiation of treatment for DR. A statistically significant association between the mean duration of diabetes mellitus (DM) and the severity of DR and PD was found. The severity of PD was directly correlated with the severity of DR. There was a significant association between the levels of HbA1c and serum creatinine and severity of DR and PD. There could be a plausible relationship between DR and PD. Further prospective studies on a larger population with longer follow-ups are required to ascertain whether PD and its severity directly affect the progression and severity of DR.

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Dyslipidemia and its Relationship with Cardiovascular Risk Factors in a Selected Population of Siliguri City, West Bengal, India.

Asian Journal of Medical Sciences ◽

10.3126/ajms.v5i1.8474 ◽

2013 ◽

Vol 5 (1) ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Ritam Banerjee ◽

Sharmistha Bhattacherjee ◽

Kuntala Ray ◽

Jayanta Kumar Roy ◽

Saikat Datta ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

West Bengal ◽

Medical Science ◽

Cross Sectional Study ◽

Dietary Fats ◽

Age Group ◽

Chi Square ◽

Cross Sectional

Background: Dyslipidemia, one of the classical Framingham risk factors of cardiovascular diseases, accounts significantly to the rise of non communicable diseases in India. Urbanization, along with greater consumption of dietary fats and decreased physical activity, has led to an increase in this problem manifold. Objectives: To determine the prevalence of dyslipidemia among urban adults of Siliguri city, West Bengal and to identify the cardio-vascular risk factors associated with it. Methods: This descriptive, cross-sectional study was carried out among the 226 adults aged ≥20yrs in an urban area of Siliguri city, West Bengal, India. Data was collected by detailed history and physical examination; biochemical measurements were done using standards procedures. Dyslipidemia was defined by the presence of one or more than one abnormal serum lipid concentration. Statistical analysis was done using chi-square test, t test and logistic regression analysis using SPSS 20 software (Chicago, IL, USA). Results: Dyslipidemia was prevalent among 78.4 % of the total study subjects. Dyslipidemia was more in males than in females & in both males and females it was more prevalent in the age group 40 -59 years than in any other age group. It was associated with higher odds of major cardiovascular risk factors like hypertension, hyperglycemias, and tobacco use. Conclusion: Dyslipidemia remains a significant and growing problem in this part of the country. The reduction in the disease burden will require changes in life style as well as in national policies. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8474 Asian Journal of Medical Science Vol.5(1) 2014 pp.1-8

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Prevalence and Associated Factors of Hypertension Among Adults living in the City of Bandundu, Republic Democratic Republic of the Congo. A Population-Based Cross-Sectional Study.

10.21203/rs.3.rs-144209/v1 ◽

2021 ◽

Author(s):

Ferdinand Mukoso ◽

Aliocha Nkodila ◽

François Lepira ◽

Pascal Bayauli ◽

Yves Lubenga ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Sleep Duration ◽

Subclinical Atherosclerosis ◽

Statistical Significance ◽

Epidemiological Data ◽

Cluster Sampling ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Factors Associated

Abstract Background and aim: In limited resource settings, reliable epidemiological data generated from hypertension high risk geographical areas or people is a prerequisite for the planning of proven and effective interventions. The aim of the present survey was to assess the prevalence, awareness, control and factors associated with hypertension in adults living in the port City of Bandundu, located in the southwestern part of DRC.Methods: a cross-sectional survey using a modified WHO STEPwise questionnaire for data collection during face-to face interviews was conducted from 1st May to 30th October 2018. A multistage cluster sampling method was used and inclusion criteria were age ≥18 years and informed consent. Information on demographic parameters, behavioral lifestyles, anthropometric and blood pressure (BP) measurements was obtained. Hypertension was defined as an average of two BP ≥ 140/90 mmHg or self-reported history of antihypertensive medication use. Independent factors associated with hypertension were identified using logistic regression analysis. P<0.05 defined the level of statistical significance. Results: The prevalence of hypertension was 34,5% (Women 36,6 %). Older age (p<0.001), subclinical atherosclerosis (p= 0.021), sleep duration <8 hours (p<0.002), diabetes mellitus (p<0.001), and obesity (p= 0.009) emerged as main cardiovascular risk factors associated with hypertension.Conclusion: Hypertension was characterized by a high prevalence, low rate of awareness and suboptimal BP control, high cardiovascular risk and associated sleep duration and obesity as modifiable risk factors.

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Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

Human & Experimental Toxicology ◽

10.1177/0960327109354311 ◽

2009 ◽

Vol 28 (12) ◽

pp. 739-745 ◽

Cited By ~ 20

Author(s):

Davood Attaran ◽

Shahrzad M Lari ◽

Mohammad Khajehdaluee ◽

Hossein Ayatollahi ◽

Mohammad Towhidi ◽

...

Keyword(s):

Lung Function ◽

Sulfur Mustard ◽

Chronic Obstructive ◽

Case Group ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Highly Sensitive ◽

The Mean ◽

Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

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Prevalence and Predictors of Stress among Bankers in Enugu State South-East Nigeria

Journal of Community Medicine and Primary Health Care ◽

10.4314/jcmphc.v32i2.6 ◽

2020 ◽

Vol 32 (2) ◽

pp. 68-79

Author(s):

T.J. Okwor ◽

A.C. Ndu ◽

S.U. Arinze-Onyia ◽

I.J. Ogugua ◽

I.M. Obionu ◽

...

Keyword(s):

Sampling Method ◽

Statistical Significance ◽

Cross Sectional Study ◽

Cross Sectional ◽

Eastern State ◽

Management Standards ◽

The Mean ◽

Enugu State ◽

Multistage Sampling ◽

High Level

Background: The work environment is rapidly changing and in recent times, occupational stress poses a threat to the health, morale and productivity of workers and the organization. This study sought to determine the prevalence and predictors of stress among bankers in a south-eastern state of Nigeria. Methods: A descriptive cross-sectional study was carried out among 370 bankers in Enugu State, Nigeria using the Health, Safety, Executive (HSE) management standards indicator tool. Multistage sampling method was used to select participants. Statistical analysis was done using SPSS 22.0. Level of statistical significance was set at p< 0.05.Results: The mean age of the participants was 34.54±6.3 years while the mean years of work was 6.01±4.7years. One hundred and seventy-four (47%) reported high level of stress due to relationship at work while 318 (85.9%) reported low level of stress due to roles. Being 35 years or less was found to a predictor of high (AOR 0.55, CI 0.30-1.02) level of stress due to control.Work experience of 5 years or less was found to be a predictor of both high (AOR 0.74, CI 0.40--1.37) and low (AOR 0.99, CI 0.40-1.37) levels of stress due to control.Conclusion: This study has shown that the prevalence of stress was high among bankers in Enugu State, South-East Nigeria. There is, therefore, the need for routine stress assessment and interventions in the banking industry especially for those at high risk. Keywords: Bankers; HSE Stress Questionnaire; Stress; Workplace; Southeast Nigeria

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Associations between dietary insulin load with cardiovascular risk factors and inflammatory parameters in elderly men: a cross-sectional study

British Journal Of Nutrition ◽

10.1017/s0007114518003872 ◽

2019 ◽

Vol 121 (7) ◽

pp. 773-781 ◽

Cited By ~ 6

Author(s):

Hadis Mozaffari ◽

Nazli Namazi ◽

Bagher Larijani ◽

Pamela J. Surkan ◽

Leila Azadbakht

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Energy Content ◽

Cross Sectional Study ◽

Sectional Study ◽

Elderly Men ◽

Significant Positive Association ◽

Cross Sectional ◽

Hs Crp

AbstractGiven the limited research on dietary insulin load (DIL), we examined DIL in relation to cardiovascular risk factors and inflammatory biomarkers in elderly men. For the present cross-sectional study, we recruited 357 elderly men. Dietary intake was assessed using FFQ. DIL was estimated by multiplying the insulin index of each food by its energy content and frequency of consumption and then summing the final value of all food items. After adjustment for covariates, a significant positive association was observed between high DIL with fasting blood sugar (FBS) levels (OR: 7·52; 95 % CI 3·38, 16·75; P=0·0001) and high-sensitive C-reactive protein (hs-CRP) (OR: 3·03; 95 % CI 1·54, 5·94; P=0·001). However, there was no association between high DIL and BMI (OR: 1·43; 95 % CI 0·75, 2·75; P=0·27), serum TAG level (OR: 0·82; 95 % CI 0·26, 2·59; P=0·73), HDL-cholesterol (OR: 2·03; 95 % CI 0·79, 5·23; P=0·13) and fibrinogen (OR: 1·57; 95 % CI 0·80, 3·06; P=0·18). Overall, elderly men with high DIL had higher FBS and hs-CRP levels than those with low DIL. Future studies are needed to clarify the association between DIL and other cardiovascular risk factors in both men and women.

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Caring for the carer: quality of life and burden of female caregivers

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2018-0334 ◽

2019 ◽

Vol 72 (3) ◽

pp. 728-736

Author(s):

Michelly Guedes de Oliveira Araújo ◽

Michelinne Oliveira Machado Dutra ◽

Carla Carolina Silva Leite Freitas ◽

Tatiane Gomes Guedes ◽

Francisco Stélio de Souza ◽

...

Keyword(s):

Quality Of Life ◽

Standard Deviation ◽

Low Income ◽

Statistical Significance ◽

Cross Sectional ◽

Level Of Education ◽

Kolmogorov Smirnov ◽

Status Number ◽

The Mean

ABSTRACT Objective: To assess the quality of life and the burden of female caregivers. Method: Descriptive, cross-sectional, quantitative study carried out with 224 informal caregivers from March to July 2016. Three instruments were used: a characterization form for the caregiver, the WHOQOL-Bref questionnaire and the Zarit Burden Interview. The following tests were used: Cronbach’s Alpha, Kolmogorov-Smirnov, Kruskal-Wallis, Spearman and Mann-Whitney. Results: The mean age of caregivers was 51.8 years with a standard deviation of 13.7. They were predominantly married, had a low income and low level of education, were first-degree relatives, had been providing care for one to five years and presented some pathology. The associations of quality of life that presented statistical significance were: income, marital status, number of people living with the caregiver and time of care. Conclusion: The burden was negatively correlated with QOL, that is, the greater the burden, the more impaired will be the life of these caregivers.

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