scholarly journals Association between Apoϵ4 allele and cardiometabolic and social risk factors with cognitive impairment in elderly population from Bogota

2021 ◽  
Vol 15 (4) ◽  
pp. 497-509
Author(s):  
Olga Lucia Pedraza ◽  
Isis Camacho ◽  
Fabio Alexander Sierra ◽  
Rubio-Gómez Cladelis ◽  
Ana Maria Salazar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Elderly Population ◽  
Cross Sectional Study ◽  
Interquartile Range ◽  
Social Risk ◽  
Allele Carrier ◽  
Social Risk Factors ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT Being an ϵ4 carrier in the Apoϵ gene has been suggested as a modifying factor for the interaction between cardio-metabolic, social risk factors, and the development of cognitive impairment. Objective: The main objective of this study was to assess the existence of such interaction in a sample of Bogota’s elderly population. Methods: A cross-sectional study was conducted with 1,263 subjects older than 50 years. Each participant was diagnosed by consensus, after neuropsychological and neuropsychiatric evaluations, under a diagnosis of normal cognition, mild cognitive impairment (MCI) according to Petersen’s criteria, or dementia according to DSM-IV criteria. Apoϵ was typified and an analysis of MoCA test was performed in each group carrying or not ϵ4 allele. Results: Our study showed that 75% were women with a median age of 68 years (interquartile range 62–74 years) and a median schooling for 6 years (interquartile range 4–12 years). Dementia was related to low education level of ≤5 years OR=11.20 (95%CI 4.99–25.12), high blood pressure (HBP) OR=1.45 (95%CI 1.03–2.05), and age over 70 years OR=7.68 (95%CI 3.49–16.90), independently of being or not an ϵ4 allele carrier. Diabetic subjects with dementia carrying ϵ4 allele showed a tendency to exhibit lower scores on the MoCA test, when compared with noncarriers’ diabetic subjects with dementia. Conclusions: The presence of ϵ4 allele does not modify the relationship between cognitive impairment and the different cardio-metabolic and social risk factors, except in diabetic subjects ϵ4 carriers with dementia who showed a tendency to exhibit lower scores of the MoCA test, when compared with noncarriers’ diabetic subjects with dementia.

scholarly journals Sickness Presence among Health Care Professionals: A Cross Sectional Study of Health Care Professionals in Slovenia

2020 ◽  
Vol 17 (1) ◽  
pp. 367 ◽  
Author(s):  
Alenka Skerjanc ◽  
Metoda Dodic Fikfak
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Sick Leave ◽  
Health Care Professionals ◽  
Cross Sectional Study ◽  
Social Risk ◽  
Sectional Study ◽  
Social Risk Factors ◽  
Cross Sectional ◽  
Sickness Presence

Background and objectives: Presenteeism is a relatively new phenomenon that people, despite complaints and ill health that should prompt them to rest and take sick leave, go to work in any case. The highest sickness presence is largely to be found in the care and welfare and educational sectors. The aim of the study is to investigate the relations between different factors and sickness presence among health care professionals. Materials and Methods: A cross-sectional study was conducted at the largest hospital in Slovenia involving 5865 health care professionals employed at the University Medical Centre Ljubljana in the period between 1 January 2010 and 31 December 2010. Logistic regression methods were used to assess the associations between risk factors and their interactions and sickness presence. Results: Besides high odds for sickness presence in multivariate modelling for acute (OR = 359.7; 95%CI = 89.1–1452.8) and chronic disease (OR = 722.5; 95%CI = 178.5–2924.5) the highest odds were calculated for poor self-related health (OR = 3.0; 95%CI = 1.9–4.8), no possibility of replacement (OR = 1.9; 95%CI = 1.5–2.3), sickness absence > two times a year (OR = 1.6; 95%CI = 1.2–2.1), disabled workers (OR = 1.6; 95%CI = 1.0–2.5), and lower salary when on sick leave (OR = 1.5; 95%CI = 120–1.9). Risk factors interactions were not found to be associated with sickness presence among health care workers. Conclusions: The pre-requisite for higher sickness presence is workers’ bad health. The results indicate that sickness presence was associated with psycho social risk factors at work and their economic consequences. Continued sickness presence might have negative rather than positive consequences on work and health care professionals’ health in the future. Sickness presence needs to be taken into account for health care organizers.

scholarly journals The relationship between social risk factors and latent tuberculosis infection among individuals residing in England: a cross-sectional study

2020 ◽  
Vol 5 (12) ◽  
pp. e003550
Author(s):  
Swaib A Lule ◽  
Rishi K Gupta ◽  
Maria Krutikov ◽  
Charlotte Jackson ◽  
Jo Southern ◽  
...  
Keyword(s):  
Substance Misuse ◽  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
Social Risk ◽  
Social Risk Factors ◽  
Cross Sectional ◽  
History Of ◽  
The Uk ◽  
The Relationship ◽  
Deprived Areas

ObjectiveTo investigate the relationship between social risk factors and latent tuberculosis infection (LTBI) among individuals who are eligible for LTBI screening in the United Kingdom (UK).MethodsThis cross-sectional study used data collected in the UK Prognostic Evaluation of Diagnostic Interferon-Gamma Release Assays (IGRAs) Consortium Study which enrolled 9176 recent tuberculosis (TB) contacts and migrants at National Health Service (NHS) facilities and community settings in the UK. The study outcome was LTBI (positive IGRA test (QuantiFERON-TB Gold In-Tube or T-SPOT.TB)). The main exposures were history of smoking, history of substance misuse, homelessness, prison stay and socioeconomic deprivation.Results4914 (56.2%) individuals resided in the most deprived areas and 2536 (27.6%) had LTBI. In the multivariable analysis (adjusting for age, gender, place of birth, ethnicity, HIV status, BCG vaccination and recent TB contact) living in the least deprived areas compared with living in the most deprived areas was associated with reduced odds of LTBI (odds ratio (OR)=0.68, 95% CI: 0.51 to 0.90) while ever been homeless (OR=1.50, 95% CI: 1.02 to 2.21) was associated with increased odds of LTBI. Smoking, homelessness and substance misuse were not associated with LTBI.ConclusionSocial deprivation could be an important risk factor for LTBI, highlighting the social inequality in the burden of TB infection in the UK. Migrants and TB contacts who were socially deprived or homeless were at a significantly higher risk for LTBI, thus tailored intense public health interventions to these groups may help to reduce the risk of future TB disease.Trial registration numberClinicalTrials.gov Registry (NCT01162265).

scholarly journals Sex Differences in the Association Between Obesity and Cognitive Impairment in a Low-Income Elderly Population in Rural China: A Population-Based Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Dandan Guo ◽  
Xin Zhang ◽  
Changqing Zhan ◽  
Qiuxing Lin ◽  
Jie Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Low Income ◽  
Elderly Population ◽  
Elderly Women ◽  
Rural China ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Elderly Men ◽  
Cross Sectional

Background: Obesity is a potentially modifiable risk factor for cognitive impairment. However, sex-specific relationships between obesity and cognitive impairment in late life remain unclear.Objective: We aimed to assess sex differences in the association between various obesity parameters and cognitive impairment in a low-income elderly population in rural China.Methods: A population-based cross-sectional study was conducted to collect basic information from elderly residents aged 60 years and older from April 2014 to August 2014 in rural areas of Tianjin, China. Obesity parameters, including body mass index (BMI) and waist circumference (WC), and Mini Mental State Examination scores were measured, and the relationships between these variables were assessed.Results: A total of 1,081 residents with a mean age of 67.70 years were enrolled in this study. After adjusting for age, educational attainment, smoking status, drinking status, physical exercise participation, and the presence of diabetes and hyperlipidemia, blood pressure group; a high BMI was found to be associated with an increased prevalence of cognitive impairment in elderly women. Each 1-unit increase in BMI was associated with a 5.9% increase in the prevalence of cognitive impairment. WC was related to the prevalence of cognitive impairment in elderly men, and each 1-cm increase in WC was associated with a 4.0% decrease in the prevalence of cognitive impairment. However, there were no significant associations between WC and cognitive function in women or between BMI and cognitive impairment in men.Conclusion: A greater WC was positively associated with better cognitive function in low-income elderly men in rural China, whereas a higher BMI was associated with an increased risk of cognitive impairment in elderly women, independent of sociodemographic, lifestyle, and health-related comorbid factors. Our results suggest weight management of elderly women in rural China may have cognitive benefits. However, randomized controlled trials would be needed to confirm causality.

scholarly journals PENGARUH PENYAKIT KRONIS DAN GAYA HIDUP TERHADAP KINERJA VERBAL FLUENCY KATEGORIK PADA LANSIA

2019 ◽  
Vol 37 (1) ◽  
Author(s):  
Jessica Alysia ◽  
Yvonne Suzy Handajani ◽  
Nelly Tina Widjaja ◽  
Yuda Turana
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cognitive Impairment ◽  
Chronic Illness ◽  
Chronic Diseases ◽  
Verbal Fluency ◽  
Cross Sectional Study ◽  
Education Level ◽  
Cross Sectional ◽  
History Of

CHRONIC DISEASES AND LIFESTYLE IMPACT TO CATEGORY VERBAL FLUENCY PERFORMANCE IN ELDERLYABSTRACTIntroduction: In recent studies, chronic illness and sedentary lifestyle were found to bea risk factors for cognitive impairment. Verbal fluency (VF) is one of the most used instruments.Aim: To determine cognitive impairment using VF and its correlation with risk factors (chronic illness and lifestyle) in elderly.Method: This cross-sectional study was conducted toward 121 elderly respondents in August–September 2017 at Pusaka, West Jakarta. Cognitive impariment was assessesed using VF. VF otherwise disturbed if the value <16.03. Heart disease and stroke were determined by anamnesis. Blood pressure was determined using Riester tensimeter. that has been calibrated. Cholesterol and blood sugar were determined using laboratory result by CHOD-PAP method. Smoking was determined by asking the history of smoking. Physical activity was determined by 24-hour activity recall. Nutrition Intake was determined by food record.Results: There were 63.6% subjects wno had VF impairment. Most respondent were over 65 years old (71.9%), female (66.1%) and education level more than 6 years (72.7%). VF had a significant assosiation with education level (p=0.020; OR=3.792), and without cardiovascular disease (p=0.023; OR=0.111).Discussion: The mayority of respondents had VF impairment, lower education was consistenly as a risk factors while no history of cardiovascular disease as a protective factors of language impairment.Keywords: Chronic diseases, cognitive impairment, lifestyle, verbal fluencyABSTRAKPendahuluan: Pada beberapa penelitian terbaru ditemukan bahwa faktor risiko seperti penyakit kronis dan gaya hidup buruk meningkatkan risiko terkena gangguan fungsi kognitif. Salah satu instrumen yang sering digunakan adalah verbal fluency (VF).Tujuan: Mengetahui gambaran fungsi kognitif dengan instrumen VF dan hubungannya dengan faktor risiko (penyakit kronis dan gaya hidup) pada lansia.Metode: Penelitian potong lintang ini dilaksanakan pada 121 responden lansia pada bulan Agustus-September 2017 di Pusaka Jakarta Barat. Gangguan fungsi kognitif dinilai menggunakan instrumen VF. Verbal fluency dikatakan terganggu dengan nilai <16,03. Penyakit jantung dan stroke didapatkan dari anamnesis. Tekanan darah dari hasil pengukuran menggunakan tensimeter yang telah dikalibrasi sebelumnya. Pengukuran kolesterol dan gula darah didapatkan dari hasil laboratorium dengan metode CHOD-PAP. Merokok didapat dari anamnesis. Aktivitas fisik dinilai dari 24-hour activity recall. Asupan nutrisi dinilai dari kuisioner food record.Hasil: Hasil penelitian ini menunjukkan subjek dengan gangguan VF sebanyak 63,6%. Mayoritas responden berusia diatas 65 tahun (71,9%), dengan jenis kelamin wanita (66,1%) dan tingkat pendidikan diatas 6 tahun (72,7%). Hasil analisis menunjukan bahwa instrumen VF memiliki hubungan bermakna dengan tingkat pendidikan rendah (p=0,020; RO=3,792), dan tidak berpenyakit jantung (p=0,023; RO=0,111).Diskusi: Mayoritas responden memiliki gangguan bahasa, pendidikan rendah diketahui secara konsisten sebagai faktor risiko sementara tidak ada riwayat penyakit jantung sebagai faktor protektif untuk gangguan fungsi bahasa.Kata kunci: Gangguan fungsi kognitif, gaya hidup, penyakit kronis, verbal fluency

scholarly journals A study on predictors of low birth weight

2021 ◽  
Vol 8 (4) ◽  
pp. 689
Author(s):  
Jillela Mahesh Reddy ◽  
Sasi Priya Aravalli
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Signs And Symptoms ◽  
Educational Status ◽  
Premature Delivery ◽  
Social Risk ◽  
Social Risk Factors ◽  
Maternal Weight ◽  
Cross Sectional

Background: purpose of this study was to determine prevalence of maternal and social risk factors of low birth weight. The purpose of this study is to prevalence of maternal and social risk factors of low birth weight.Methods: The cross-sectional and comparative study was carried out by reviewing medical records of newborn delivered for one year in 250 newborn. Birth weight was categorized into two as low birth weight (birth weight <2500 grams), considered as cases, and normal birth weight (birth weight ≥2500 grams), considered as controls or the reference birth weight.Results: In our study mother’s age, socioeconomic, educational status, occupation as significant variables to be associated with low birth weight. caesarean section increased significantly with decrease in gestational age and maternal weight, history of abortion, iron supplementation Hypertension, anemia, and DM are Predictors of maternal and obstetric with low birth weight.Conclusions: Prompt identification of causes and prevention of premature delivery, proper knowledge of signs and symptoms of pregnancy complications, and preventing any physical trauma or its potential causes are recommended during pregnancy to prevent low birth weight. 

scholarly journals A biopsychosocial model of violence when sleepwalking: Review and reconceptualisation

BJPsych Open ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 96-101 ◽  
Author(s):  
Helen M. Stallman ◽  
Andrea Bari
Keyword(s):  
Risk Factors ◽  
Biopsychosocial Model ◽  
Empirical Literature ◽  
Social Risk ◽  
Social Risk Factors ◽  
Violent Behaviour ◽  
Prevention And Treatment ◽  
Serious Injury ◽  
The Relationship ◽  
Consequences Of Violence

SummaryViolence towards others during sleepwalking is relatively uncommon, but can result in serious injury or even death. Much of the research in this field has focused on the forensic consequences of violence during sleepwalking without sufficient attention to an understanding of the risk factors for violence during sleepwalking and the development of prevention and interventions based on these risk factors. This paper reviews the characteristics of impulsive violence in general and reconceptualises violence during sleepwalking as an extension of this prior vulnerability. We propose a biopsychosocial model of the risk for violence during sleepwalking that is supported through a review of empirical literature both within sleepwalking and violent behaviour more generally. Biological, psychological and social risk factors are hypothesised to mediate the relationship between sleepwalking and violence. Implications for prevention and treatment of this potentially fatal problem are discussed.

The Relationship Between Recommended and None Recommended Food Scores on Cardiovascular Risk Factors in Obese and Overweight Adult Women: A Cross Sectional Study

2020 ◽  
Author(s):  
Maryam Sabbari ◽  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Khadijeh Mirzaei
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Abdominal Obesity ◽  
Lower Risk ◽  
Cross Sectional Study ◽  
Composition Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Abstract Objective: No studies have examined the relationship between recommended food score (RFS), none recommended food score (NRFS) and cardiovascular risk factors. This study was conducted to evaluate the association of RFS and NRFS with cardiovascular risk factors in overweight and obese women.Methods: This cross-sectional study was performed on 379 overweight and obese (BMI ≥25 kg/m2) women aged 18-48 years. Anthropometric measurements and body composition analysis were assessed in all participants. Dietary intake was assessed by a valid and reliable food frequency questionnaire (FFQ) containing 147 items and RFS and NRFS calculated. Biochemical assessments including TC, HDL, LDL, TG, FBS, insulin, HOMA-IR and hs-CRP were quantified by ELISA.Results: The mean age and BMI of participants were 36.73±9.21 (y) and 31.17±4.22 (kg/m²) respectively. Binary logistic analysis showed that participants in the highest quartile of the RFS compared to the lowest quartile had 82% lower risk for Hypertriglyceridemia [OR=0.18, 95%CI=0.06-0.53, P=0.002] and 91% lower risk for abdominal obesity [OR=0.09, 95%CI=0.008-1.04, P=0.05]. in addition, Participants who were in the highest quartile of the RFS compared to the lowest quartile had lower HOMA-IR [OR=0.29, 95%CI=0.08-1.00, P=0.05]. subjects with high adherence to the NRFS had lower HDL [OR=2.11, 95%CI=1.08-4.12, P=0.02] and higher risk for Hypertriglyceridemia [OR=2.95, 95%CI=1.47-5.94, P=0.002] compared to low adherence. Conclusions: There was an inverse significant association between adherence to RFS and risk of Hypertriglyceridemia, insulin resistance, and abdominal obesity. There was a significant association between NRFS and Hypertriglyceridemia, and also we found an inverse relationship between NRFS and HDL.

scholarly journals Nutritional Status and Risk Factors for Frailty in Community-Dwelling Older People: A Cross-Sectional Study

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1041 ◽  
Author(s):  
Pilar Pérez-Ros ◽  
Rafael Vila-Candel ◽  
Lourdes López-Hernández ◽  
Francisco Miguel Martínez-Arnau
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Nutritional Status ◽  
Older People ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Community Dwelling Older People ◽  
The Relationship

Objective: This study aims to assess the relationship that frailty has with nutritional status and functional risk factors in community-dwelling older adults. Methods: Cross-sectional study in community-dwelling older people, independent for walking and without impaired cognition. Frailty was assessed by Fried criteria. Nutritional status was analyzed by the Mini Nutritional Assessment Short Form (MNA-SF), biochemical markers (albumin, total proteins, cholesterol, lymphocytes, and hemoglobin); and anthropometric parameters (body mass index [BMI], body fat percentage, handgrip, and perimeters). A comprehensive geriatric assessment analyzed other risk factors: functionality, cognition, falls, comorbidity, polypharmacy, physical activity, and quality of life (QoL). Results: We included 564 elderly people with a mean age of 76.05 (standard deviation 3.97) years; 63.1% (n = 356) were women, and 83.9% (n = 473) were prefrail, and frail. The sample presented high functionality and a nutritional status with a predominance of overweight and obesity. Factors associated with frailty (R2 = 0.43) were age over 75 years (odds ratio [OR] 3.31, 95% confidence interval [CI] 1.76, 6.21; p < 0.001), female gender (OR 2.37, 95% CI 1.24, 4.52; p = 0.009), anemia (OR 2.45, 95% CI 1.19, 5.02; p = 0.015), falls (OR 1.94, 95% CI 1.12, 3.25; p = 0.016) and the fear of falling (OR 4.01: 95% CI 1.76, 9.16; p = 0.001). Performing more than 3 weekly hours of physical activity was found to be a protective factor (OR 0.23, 95% CI 0.15, 0.35; p < 0.001). Conclusions: The relationship between frailty and malnutrition in functionally independent community-dwelling older people is unclear. More studies are needed to know what nutritional markers are related to frailty, cognition, and functionality in order to discriminate the risk factors for community-dwelling older people at risk of malnutrition and dependency.

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