scholarly journals Treatment of febrile seizures with intermittent clobazam

1997 ◽  
Vol 55 (4) ◽  
pp. 757-761 ◽  
Author(s):  
Maria Luiza G. Manreza ◽  
José Luiz D. Gherpelli ◽  
Lúcia R. Machado-Haertel ◽  
Cristiane C. Costas Pedreira ◽  
Carlos O. Heise ◽  
...  
Keyword(s):  
Central Nervous System Infection ◽  
Drug Efficacy ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Intermittent Therapy ◽  
Simple Type ◽  
Recurrent Vomiting ◽  
Symptomatic Seizures ◽  
Febrile Episodes ◽  
A Prospective Study

Fifty children, 24 female and 26 male, with ages varying from 6 to 72 months (mean=23.7 m.) that experienced at least one febrile seizure (FS) entered a prospective study of intermittent therapy with clobazam. Cases with severe neurological abnormalities, progressive neurological disease, afebrile seizures, symptomatic seizures of other nature, or seizures during a central nervous system infection were excluded. Seizures were of the simple type in 25 patients, complex in 20 and unclassified in 5. The mean follow-up period was 7.9 months (range=l to 23 m.), and the age at the first seizure varied from 5 to 42 months (mean=16.8 m.). Clobazam was administered orally during the febrile episode according to the child's weight: up to 5 kg, 5 mg/day; from 5 to 10 kg, 10 mg/day; from 11 to 15 kg, 15 mg/day, and over 15 kg, 20 mg/day. There were 219 febrile episodes, with temperature above 37.8 °C, in 40 children during the study period. Twelve children never received clobazam and 28 received the drug at least once. Drug efficacy was measured by comparing FS recurrence in the febrile episodes that were treated with clobazam with those in which only antipyretic measures were taken. Ten children (20%) experienced a FS during the study period. Of the 171 febrile episodes treated with clobazam there were only 3 recurrences (1.7%), while of the 48 episodes treated only with antipyretic measures there were 11 recurrences (22.9%), a difference highly significant (p<0.0001). Adverse effects occurred in 10/28 patients (35.7%), consisting mainly in vomiting, somnolence and hyperactivity. Only one patient had recurrent vomiting which lead to drug interruption. These effects did not necessarily occurred in every instance the drug was administered, being present in one febrile episode and not in the others. We conclude that clonazepam is safe and efficacious in preventing FS recurrence. It may be an alternative to diazepam in the intermittent treatment of FS recurrence.

scholarly journals Serum Sodium Level on the Recurrence of Febrile Seizure within the Same Febrile Illness-Experience in a District Level Hospital

2019 ◽  
Vol 32 (1) ◽  
pp. 39-45
Author(s):  
M Luthfor Rahman ◽  
Belal Hossain ◽  
Belal Uddin ◽  
Sanaul Haq Mia
Keyword(s):  
Serum Sodium ◽  
Febrile Seizure ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Central Nervous System Infection ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Cross Sectional ◽  
Recurrent Seizure

Introduction: Febrile convulsion is the most common seizure disorder in the pediatric age group. It occurs in 2-5% of children. A febrile seizure is a seizure accompanied by fever (temperature 100.4°F or 38°C by any method), without central nervous system infection, that occurs in infants and children 6 through 60 months of age. Aim: The study was conducted to see the effect of serum sodium level on the recurrence of febrile seizure during the same febrile illness. Materials and Method: A cross-sectional descriptive study which enrolled 65 children admitted with febrile seizures at 100 bed district hospital, Naogaon. They were divided in to two groups, those with a single seizure and the rest were children with more than one seizures. Serum sodium levels were estimated after stabilization of patients. The probability of recurrent febrile seizures and serum sodium level was analyzed. Results: Hyponatremia (serum sodium <135 mmol/l) was seen in 12(18.5%) of 65 children and the remaining 81.5% children had normal serum sodium level (serum sodium 135-145 mmol/l). Among the hyponatremia group all children developed more than one seizure during the same febrile episode. The mean serum sodium level in patients with single and recurrent seizure was 138.48±2.17mmol/l and 135.27±3.11mmol/(P<0.001). The relationship between the probability of a recurrent seizure and serum sodium level is statistically highly significant. Conclusion: Estimation of the seum sodium in children with febrile seizures help in deciding for admission in hospital as well as to predict seizure recurrence within the same febrile episode. TAJ 2019; 32(1): 39-45

scholarly journals A study of etiology and characteristics of febrile convulsions and epilepsy among children

2017 ◽  
Vol 4 (6) ◽  
pp. 2093
Author(s):  
Habib G. Pathan ◽  
Abdul Naseer Abdul Bari ◽  
Prashant R. Kokiwar
Keyword(s):  
Tertiary Care ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
Simple Type ◽  
Upper Respiratory Tract ◽  
Tertiary Care Centre ◽  
Febrile Convulsions ◽  
Male Preponderance ◽  
Symptomatic Seizures ◽  
Acute Symptomatic Seizures

Background: Globally in all parts of the world, epilepsy is the most common neurological disorder of chronic nature. Seizures among children are common and challenging for the pediatrician. The objective of this study was to study etiology and characteristics of febrile convulsions and epilepsy among childrenMethods: The present study was a prospective observational study conducted in a tertiary care centre among subjects who had seizures. Subjects were recruited from pediatric ward, consecutively hospitalization of pediatric patients, and of either sex who presented with history of seizures. The data included demographic details and history.Results: Total febrile seizures were 25.46% and overall incidence was around 2.57%. Preponderance of male constituting 62.65% over female 37.35% was observed. Most of the febrile seizures were simple type. Fever due to upper respiratory tract infection was commonest cause. It was not associated with any complications. Epileptic cases were 38.65% of total cases and overall incidence was 3.9%. In this group also, there was male preponderance. It increased with age. Commonest presentations of epileptic seizures were generalized in 67.46%. Most common cause of acute symptomatic seizures was viral encephalitis (28.34%). Numbers of deaths were more in acute symptomatic. Conclusions: As there were no morbidity and mortality with febrile seizures so it is possible to explain the benign nature of febrile seizures to their parents. Acute symptomatic seizures are to be identified and treated immediately.

scholarly journals SCN1A Variants in vaccine‐related febrile seizures: A prospective study

2019 ◽  
Vol 87 (2) ◽  
pp. 281-288 ◽  
Author(s):  
John A. Damiano ◽  
Lucy Deng ◽  
Wenhui Li ◽  
Rosemary Burgess ◽  
Amy L. Schneider ◽  
...  
Keyword(s):  
Prospective Study ◽  
Febrile Seizures ◽  
A Prospective Study

Pediatric Seizures and Status Epilepticus

2020 ◽  
Author(s):  
Lindsey Retterath ◽  
Dale Woolridge
Keyword(s):  
Status Epilepticus ◽  
Pediatric Patients ◽  
Febrile Seizures ◽  
Pediatric Emergency ◽  
Initial Management ◽  
Symptomatic Seizures ◽  
Algorithmic Approaches ◽  
Work Up ◽  
Acute Symptomatic Seizures ◽  
Management Work

Seizures represent a common neurologic complaint among pediatric patients in the emergency department (ED). They can be classified as generalized or focal. In terms of etiology, seizures are most basically broken down into “acute symptomatic” seizures, which are due to another primary medical cause, and unprovoked seizures which occur as a primary pathology. Febrile seizures are the most common types of seizures in children, which themselves can be simple or complex. The most concerning seizures are those which associate with meningismus, encephalitis, metabolic derangements, intracranial mass, and, of course those which progress to status epilepticus. Significantly, it is appropriate and even critical to assume status epilepticus and intervene accordingly whenever a child arrives to the ED seizing for an unspecified period of time. This review covers the initial evaluation, resuscitation, management, work-up, and disposition of pediatric patients who present to the emergency room with seizures. Figures in this chapter illustrate stepwise and algorithmic approaches to initial management, expanded differential, systematic diagnostic approach, and disposition for pediatric patients presenting with seizures and status epilepticus. Tables list important physical exam components for evaluating children with seizures, classifications of seizures, common seizure look-alikes in children, features of febrile seizures, etiologies of pediatric seizures. This review contains 5 figures, 11 tables, and 22 references. Key Words: pediatric seizures, febrile seizures, pediatric neurologic emergencies, pediatric emergency medicine, status epilepticus 

The Effects of Clomipramine Hydrochloride in Cats With Psychogenic Alopecia: A Prospective Study

2006 ◽  
Vol 42 (5) ◽  
pp. 336-343 ◽  
Author(s):  
Petra A. Mertens ◽  
Sheila Torres ◽  
Carl Jessen
Keyword(s):  
Clinical Trial ◽  
Prospective Study ◽  
Treatment Duration ◽  
Drug Efficacy ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
A Prospective Study ◽  
To Receive ◽  
Insufficient Number

A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.

scholarly journals Iron Deficiency Association as A Possible Cause of First Febrile Seizure

2021 ◽  
Vol 15 (5) ◽  
pp. 1728-1730
Author(s):  
Zarmast Khan ◽  
Zabit Khan Naibzai ◽  
M. Adnan Ahmed Sethi ◽  
Shahid Ghaffar ◽  
Sumera Makhdoom ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Deficiency Anemia ◽  
First Episode ◽  
Medicine Department ◽  
The Relationship ◽  
Controlled Clinical Study ◽  
Possible Cause

Aim: A controlled clinical study was conducted to investigate the relationship between iron deficiency and first episode of febrile seizure in children 6-60 months of age. Place and Duration:In the Pediatric Medicine department of ShifaInternationalHospital Islamabadforsix months duration from 15thMay 2020 to 30thNovember 2020. Methods:Hematological parameters for iron levels, including HB, MCV, MCHC and plasma ferritin, were determined in 75 patients who experienced a first febrile episode. 75 children without febrile seizures were taken as controls and the same markers were compared in both groups. Results: The most important factors influencing the first attack of febrile seizure were HB, MCV, and serum ferritin levels. Conclusion: Iron deficiency is significantly associated with the occurrence of the first febrile episode in children. Key words:Iron deficiency anemia, Iron deficiency, Febrile convulsions, Febrile attacks.

scholarly journals PROFILE OF HISTORY OF FEBRILE SEIZURE IN PATIENTS WITH EPILEPSY

2022 ◽  
Vol 8 (1) ◽  
pp. 21-24
Author(s):  
Rayhan Muhammad Basyarahil ◽  
Wardah Rahmatul Islamiyah ◽  
Prastiya Indra Gunawan
Keyword(s):  
Febrile Seizure ◽  
Age Of Onset ◽  
Central Nervous System Infection ◽  
Sampling Technique ◽  
Febrile Seizures ◽  
The Body ◽  
Population Sampling ◽  
History Of ◽  
History Of Epilepsy ◽  
Patients With Epilepsy

Background: Febrile seizure is convulsions with fever (temperature ³38°C) with no central nervous system infection that commonly found in children (6-60 months). Febrile seizures do not always mean the child has epilepsy. However, febrile seizures can be a possible long-term risk factor for epilepsy. Objective: The objective of this study is to know the profile of febrile seizure in patients with epilepsy. Methods: A retrospective descriptive study on 23 patients with epilepsy in the EEG Department of Neurology, Dr. Soetomo General Hospital, Surabaya, Indonesia in the period 2018-2019 based on inclusion and exclusion criteria. The total number of epilepsy patients is 849 patients, 216 of whom had a history of febrile seizure. Among 216 epilepsy patients who had a history of febrile seizures, 23 of them were qualified as the sample. The sampling technique used was total population sampling. The instrument of this research is the patients’ medical record. Data analysis is carried out descriptively. Results: The characteristics of the history of febrile seizures that found in patients with epilepsy are more patients are male, have the age of onset on less than 2 years old, have the body temperature more than 38.3°C, have the seizure duration less than 15 minutes, have focal seizures, have recurrent seizures in 24 hours, have a history of more than one febrile seizure, have accompanying neurological disorders, and have no family history of epilepsy. Conclusion: Febrile seizure is still becoming a concern because there is a possibility that it may develop into epilepsy. Even though, not all children who experience febrile seizure will generate epilepsy.

scholarly journals Utility of serial procalcitonin measurement in management of febrile neutropenia in a resource constrained setting.

2020 ◽  
Author(s):  
Rohan Halder ◽  
Tulika Seth ◽  
Pradeep Chaturvedi ◽  
Manoranjan Mahapatra ◽  
Hara Prasad Pati ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Fungal Infection ◽  
Sensitivity And Specificity ◽  
Febrile Episode ◽  
Common Cause ◽  
Fever Onset ◽  
Diagnostic Work ◽  
Febrile Episodes ◽  
Work Up ◽  
Diagnostic Work Up

Abstract Background: Febrile neutropenia is a common cause in morbidity and mortality during treatment of hematological neoplasms.Methods: Subjects included all cases admitted under hematology department with febrile neutropenia from February to June 2018. Diagnostic work up for each febrile episode was done including Procalcitonin (PCT) was sent at fever onset 0,24,48hour, day 7 and day 14.Results: Data was analyzed for 52 febrile episodes in 50 patients.PCT cut off value at 24 hours of ≤1.2ng/ml had a sensitivity and specificity of 62.5% and 87.5% for discriminating IFI and MDI (p=0.033). PCT had a negative predictive value of 70% for the diagnosis of IFI as compared to MDI. PCT cut-off of 0.4ng/ml on day 7 had a sensitivity and specificity of 60.98% and 100% respectively for discriminating IFI and PUO (p= 0.0001). There was a significant fall in the level of PCT by day 14(median fall in PCT of 10.8) in the group of patients who had both IFI+ MDI when compared to other groups (p=0.047). PCT level at 24 and 48hours can be a predictor of severity of infection.Conclusion: Procalcitonin at 24 hours could discriminate between bacterial and fungal infection and between fever due to fungal infection and disease fever.

Epidemiology of Epilepsy

2017 ◽  
Author(s):  
Dale C Hesdorffer
Keyword(s):  
Risk Factors ◽  
Low Socioeconomic Status ◽  
Febrile Seizures ◽  
Childhood Onset ◽  
Low Socioeconomic ◽  
Different Types ◽  
Symptomatic Seizures ◽  
Active Epilepsy ◽  
Acute Symptomatic Seizures ◽  
Health Planner

Epilepsy affects 1 out of every 26 people during their lifetime. Worldwide, the incidence of epilepsy ranges from 28.0/100,000 to 235.5/100,000, with the large variation attributable to differences in methodology across studies. The prevalence of active epilepsy provides important information about the burden of epilepsy in the population and spurs public health planner to assess the needs of the epilepsy population. The active prevalence of epilepsy ranges from 2.4/1,000 to 22.8/1,000 worldwide and more than 65 million people have active epilepsy. Risk factors for childhood-onset and adult-onset epilepsy are discussed, considering epilepsy etiologies (e.g., severe traumatic brain injury), newer risk factors without bidirectional relationships with epilepsy (e.g., low socioeconomic status), risk factors with bidirectional relationships (e.g., psychiatric disorders), and different types of acute symptomatic seizures (e.g., febrile seizures).

Treatment of type 2 and 4 olecranon fractures with locking compression plate osteosynthesis in horses: A prospective study (2002–2008)

2011 ◽  
Vol 24 (01) ◽  
pp. 57-61 ◽  
Author(s):  
M. Kummer ◽  
J. Auer ◽  
R. Hagen ◽  
A. Fuerst ◽  
M. Jackson
Keyword(s):  
Prospective Study ◽  
Plate Osteosynthesis ◽  
Severe Infection ◽  
Simple Type ◽  
Radial Fracture ◽  
Locking Compression Plates ◽  
A Prospective Study ◽  
University Of Zurich ◽  
Olecranon Fractures

SummaryThis prospective study describes a series of 18 olecranon fractures in 16 horses that were treated with locking compression plates (LCP). Twelve of the 18 fractures were simple (type 2), whereas six were comminuted (type 4). Six fractures were open and 12 were closed. Each horse underwent LCP osteosynthesis consisting of open reduction and application of one or two LCP. Complete fracture healing was achieved in 13 horses. Three horses had to be euthanatized: two because of severe infection and one because of a comminuted radial fracture 11 days after fixation of the olecranon fracture. Complications encountered after discharge of the horses from the Equine Hospital at the Vetsuisse Faculty (University of Zurich) included implant infection (n = 2) and lameness (n = 3), which were successfully treated with implant removal. Despite being easier to use, LCP osteosynthesis resulted in a clinical outcome similar to DCP osteosynthesis.

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