scholarly journals Eating Fast and Until Full Is Associated with Elevated Alanine Aminotransferase Activity in Japanese Schoolchildren: A Cross-Sectional Study

2021 ◽  
Vol 253 (1) ◽  
pp. 11-18
Author(s):  
Akira Minoura ◽  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Rimei Nishimura ◽  
Reika Yoshida ◽  
...  
Keyword(s):  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Aminotransferase Activity ◽  
Cross Sectional ◽  
Eating Fast ◽  
Alanine Aminotransferase Activity

scholarly journals Alanine Aminotransferase Activity in Hypothyroid Patients: A Cross Sectional Study

2013 ◽  
Vol 12 (3) ◽  
pp. 49-51
Author(s):  
Md Aminul Haque Khan ◽  
Md Rezwanur Rahman ◽  
Rawnak Jahan
Keyword(s):  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Aminotransferase Activity ◽  
Cross Sectional ◽  
Serum Alanine Aminotransferase ◽  
Significant Difference ◽  
Relationship Of ◽  
Hypothyroid Patients ◽  
Alanine Aminotransferase Activity

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum alanine aminotransferase activity. Very few studies have been done regarding serum alanine aminotransferase activity in hypothyroid patients and, as far we know, no such study has been done in our populations. So, we designed this study in our population for evaluation of serum alanine aminotransferase activity in hypothyroid patients. The objective of this study was to assess serum alanine aminotransferase activity in hypothyroid patients and to find out relationship of alanine aminotransferase activity with severity of hypothyroidism. Methods: It was a retrospective cross sectional study to evaluate the serum alanine aminotransferase activity of hypothyroid patients and to find out relationship of alanine aminotransferase activity with severity of hypothyroidism and the values were compared with that of age and sex matched healthy euthyroid controls. Statistical analyses were performed by using SPSS for Windows version 12.0. Unpaired ‘t’ test was done to find out any significant difference between the cases and controls with respect to age and serum alanine aminotransferase activity. Chisquare test was done to find out any significant difference between the cases and controls with respect to sex. Pearson correlation coefficient test was done to see the correlation of alanine aminotransferase activity with the severity of hypothyroidism. Results: Mean serum alanine aminotransferase activity was found significantly higher in hypothyroid patients compared to that of controls. Conclusion: Results of our study suggest that increased serum alanine aminotransferase activity is associated with hypothyroidism. Therefore, patients presenting with increased ALT activity with normal liver function tests are recommended to be investigated to explore hypothyroidism. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 49-51

scholarly journals Prevalence of Elevated Alanine Aminotransferase by Diagnostic Criterion, Age, and Gender among Adolescents

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jing Zhang ◽  
Zheng-Ying Wang ◽  
Jing-Ping Zhang ◽  
Hua Zhou ◽  
Zan Ding
Keyword(s):  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adolescent Population ◽  
School Based ◽  
And Gender ◽  
Diagnostic Criterion ◽  
Preventive Role ◽  
Alt Activity

Background. Serum alanine aminotransferase (ALT) activity was measured not only to detect liver disease, but also to monitor overall health. The purpose of this study was to obtain the prevalence of elevated ALT levels among adolescents. Methods. In a school-based cross-sectional study, a representative sample was analyzed from 9 middle and high schools in Shenzhen, China, during 2017 to 2018. Elevated ALT was defined as diagnostic criterion I (>30 U/L for boys and >19 U/L for girls) and diagnostic criterion II (>40 U/L). Results. From the adolescent population, a total of 7281 students (boys, 4014, and girls, 3267) aged from 10 to 17 years were collected. The prevalence of elevated ALT was 7.11% (6.88% for boys and 7.41% for girls) by criterion I and 2.72% (3.96% for boys and 1.19% for girls) by criterion II. Based on the Shenzhen census and Chinese national census population, the adjusted prevalence of elevated ALT was 7.65% (boys 7.19% and girls 8.21%) and 6.79% (boys 6.07% and girls 7.56%) by criterion I and 2.85% (boys 4.20% and girls 1.16%) and 2.43% (boys 3.49% and girls 1.29%) by criterion II. For age, the overall trends were increasing progressively, regardless of the use of diagnostic criteria for an elevated ALT activity. Conclusions. This study supplements the gap that the prevalence of elevated ALT levels differed in gender, age, and criteria among adolescents of Shenzhen. We should take the prevalence as a predictor and continue to play a warning and preventive role in preparation for further intervention.

scholarly journals Homocysteine and cobalamin status in German vegans

2004 ◽  
Vol 7 (3) ◽  
pp. 467-472 ◽  
Author(s):  
Annika Waldmann ◽  
Jochen W Koschizke ◽  
Claus Leitzmann ◽  
Andreas Hahn
Keyword(s):  
Aspartic Acid ◽  
Cross Sectional Study ◽  
Plasma Homocysteine ◽  
Animal Origin ◽  
Sectional Study ◽  
Aminotransferase Activity ◽  
Cross Sectional ◽  
Food Frequency ◽  
Folate Concentration ◽  
Homocysteine Concentration

AbstractObjective:The study aimed to evaluate the homocysteine and cobalamin status of German vegans and determine whether the intake of very small amounts of foods of animal origin can improve this status.Design and setting:Cross-sectional study, Germany.Subjects:The dietary and nutritional intakes of 131 vegans (73 women, 58 men; a range: 20.2–82.1 years) were evaluated using a general questionnaire and two food–frequency questionnaires.Results:The prevalence of inadequate cobalamin status in volunteers of the German Vegan Study was 28.2%, and that of hyperhomocysteinaemia, 38.1%. Moderate vegans were affected to a lesser extent than were strict vegans. Duration of veganism and cobalamin concentration were inversely correlated (Spearman'sr= -0.175,P= 0.047). Folate concentration and erythrocyte aspartic acid aminotransferase activity were not correlated with plasma homocysteine concentration, but duration of veganism correlated positively with homocysteine concentration (Spearman'sr= 0.319,P< 0.001). Cobalamin and homocysteine concentrations were inversely correlated (when controlling for duration of veganism;r= -0.602,P< 0.001).Conclusion:Cobalamin status needs to be improved in order to minimise the risk of hyperhomocysteinaemia.

scholarly journals Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Matthias Claus ◽  
Christoph Antoni ◽  
Bernd Hofmann
Keyword(s):  
Logistic Regression ◽  
Quantile Regression ◽  
Alanine Aminotransferase ◽  
Geometric Mean ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Multivariable Logistic Regression Model ◽  
Related Factors ◽  
Cross Sectional ◽  
Chemical Company

Abstract Background We aimed to determine the prevalence of elevated alanine aminotransferase (eALT) in employees of a German chemical company, and analyze its association with sociodemographic, work- and lifestyle-related factors. Methods The cross-sectional study is based on data surveyed from occupational health check-ups between 2013 and 2018 at the site clinic of a chemical company based in Ludwigshafen, Germany. We used logistic regression analyses to assess the association between sociodemographic, work- and lifestyle-related characteristics and eALT. Quantile regression technique was applied to investigate if associations vary across different quantiles of the ALT distribution. Results Participants (n = 15,348) were predominantly male (78.3%) with a mean age of 42.2 years (SD 10.7). The prevalence of eALT was 18.5% (21.6% in men/7.2% in women) with a geometric mean of 28.9 U/L (32.8 U/L in men/18.5 U/L in women). In the multivariable logistic regression model, odds of eALT were significantly higher for males (OR 2.61; 95%-CI 2.24–3.05), manual workers (OR 1.23; 95%-CI 1.06–1.43), overweight (OR 2.66; 95%-CI 2.36–3.00) or obese respondents (e.g. OR 7.88; 95%-CI 5.75–10.80 for obesity class III), employees who consume any number of alcoholic drinks/week (e.g. OR 1.32; 95%-CI 1.16–1.49 for ≥ 3 drinks per week) and diabetics (OR 1.47; 95%-CI 1.22–1.78). Additionally, season of participation was significantly associated with eALT, with odds being higher for participation in spring, fall or winter, as compared to summer. A significant interaction between age and gender (pInteraction < 0.001) was found, showing approximately a u-shaped age/ALT relationship in women and an inversely u-shaped relationship in men. Quantile regression showed an increasing positive effect of male gender, overweight/obesity, and for diabetics on ALT level when moving from the lowest (q0.1) to the highest (q0.9) considered quantile. Additionally, from the lowest to the highest quantile an increasing negative effect on ALT for older age was observed. Conclusions Prevalence of eALT in our sample of employees can be considered as high, with almost one in five participants affected. Identification of risk groups allows the implementation of targeted preventive measures in order to avoid transition to severe morbidity.

scholarly journals A study of the association of serum uric acid levels with alanine aminotransferase and gamma-glutamyl transferase levels in non-alcoholic fatty liver disease patients diagnosed by imaging studies

2021 ◽  
Vol 8 (7) ◽  
pp. 934
Author(s):  
Anant Parasher ◽  
Kunal Ranjan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Glutamyl Transferase ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver. In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported. The aim of the study was to perform cross-sectional study to determine the association between serum uric acid levels and the levels of serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), in NAFLD patients.Methods: In this hospital-based cross-sectional study, 300 patients with diagnosed NAFLD were included during the one-year period from July 2015 to June 2016.Results: Elevation of alanine aminotransferase levels was seen in a total of 93 cases (31%) and elevation of GGT levels in NAFLD patients was seen in 112 patients out of a total of 300 (37.33%). Hyperuricemia was observed in 99 cases out of a total of 300 cases of NAFLD (33%). A significant association was observed between the two parameters.Conclusions: The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83 %) (p<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (p<0.001). The relationship between rising uric acid levels with rising ALT and GGT levels in these patients was also found to be statistically significant.

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