A study of the association of serum uric acid levels with alanine aminotransferase and gamma-glutamyl transferase levels in non-alcoholic fatty liver disease patients diagnosed by imaging studies

Background: Non-alcoholic fatty liver disease (NAFLD) is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver. In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported. The aim of the study was to perform cross-sectional study to determine the association between serum uric acid levels and the levels of serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), in NAFLD patients.Methods: In this hospital-based cross-sectional study, 300 patients with diagnosed NAFLD were included during the one-year period from July 2015 to June 2016.Results: Elevation of alanine aminotransferase levels was seen in a total of 93 cases (31%) and elevation of GGT levels in NAFLD patients was seen in 112 patients out of a total of 300 (37.33%). Hyperuricemia was observed in 99 cases out of a total of 300 cases of NAFLD (33%). A significant association was observed between the two parameters.Conclusions: The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83 %) (p<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (p<0.001). The relationship between rising uric acid levels with rising ALT and GGT levels in these patients was also found to be statistically significant.

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Relationship Between Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease in the Non-Obese Chinese Population: A Secondary Analysis Based on A Cross-Sectional Study

10.21203/rs.3.rs-193365/v1 ◽

2021 ◽

Author(s):

Shengqiang Gao ◽

Kuvaneshan Ramen ◽

Shian Yu ◽

Jiansheng Luo

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Chinese Population ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Relationship Of ◽

The Relationship ◽

Alcoholic Fatty Liver Disease

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is linked to some metabolic disorders. Herein, we explored the relationship of levels of serum uric acid （SUA）with NAFLD in a population of non-obese Chinese. Methods: This was a cross-sectional study that involved 183,903 Chinese men and women with an average age of 40.98 years who underwent physical examinations at a health screening center at Wenzhou People’s Hospital. We defined NAFLD by ultrasound detection of steatosis. We employed univariate analysis along with multivariate Cox proportional hazards analyses to investigate the relationship of SUA level with NAFLD. Moreover, we employed the receiver operating characteristic curve to establish the SUA cutoffs of estimating NAFLD. Results: Overall, 25,501 participants (13.9%) had NAFLD. The NAFLD ORs were 1.47 (95% CI 1.35 to 1.59), 2.01 (95% CI 1.85 to 2.18) and 2.77 (95% CI 2.55 to 3.02) compared with Q1.AUC values for SUA ratios was 0.728. The optimal SUA level cut-off value for identification of NAFLD was 287.5, with a specificity and a sensitivity of 60.7% and 73.9%, respectively.Conclusion: High Serum uric acid levels shows positive correlation with NAFLD. SUA constitutes a cheap, simple, non-invasive, as well as a beneficial biomarker that could be utilized to forecast NAFLD in the non-obese Chinese population.

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Association between serum gamma-glutamyl transferase and serum uric acid levels in Chinese females: A cross-sectional study

Endocrine Research ◽

10.1080/07435800.2017.1300809 ◽

2017 ◽

Vol 42 (4) ◽

pp. 296-301 ◽

Cited By ~ 1

Author(s):

Zhao Ya ◽

Liu Fei ◽

Zeng Yue ◽

Liu Dan ◽

Lin Neng-bo ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Cross Sectional Study ◽

Gamma Glutamyl Transferase ◽

Sectional Study ◽

Cross Sectional ◽

Gamma Glutamyl ◽

Glutamyl Transferase

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Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study

Journal of Hepatology ◽

10.1016/j.jhep.2008.11.021 ◽

2009 ◽

Vol 50 (5) ◽

pp. 1029-1034 ◽

Cited By ~ 149

Author(s):

Youming Li ◽

Chengfu Xu ◽

Chaohui Yu ◽

Lei Xu ◽

Min Miao

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver Disease ◽

Acid Level ◽

Serum Uric Acid Level ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Correlation Between Anthropometric Measurements and Non-alcoholic Fatty Liver Disease in Individuals With Obesity Undergoing Bariatric Surgery: Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-021-05470-2 ◽

2021 ◽

Author(s):

Silênio Souza Reis ◽

Guilherme Hoverter Callejas ◽

Rodolfo Araújo Marques ◽

Martinho A. Gestic ◽

Murillo P. Utrini ◽

...

Keyword(s):

Bariatric Surgery ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Anthropometric Measurements ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Higher Healthy Lifestyle Score is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and older Chinese adults: a community-based cross-sectional study

Public Health Nutrition ◽

10.1017/s1368980021000902 ◽

2021 ◽

pp. 1-9

Author(s):

Yun-yang Deng ◽

Qing-wei Zhong ◽

Hai-li Zhong ◽

Feng Xiong ◽

Yue-bin Ke ◽

...

Keyword(s):

Physical Activity ◽

Liver Disease ◽

Fatty Liver Disease ◽

Healthy Lifestyle ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Abstract Objective: Previous studies have reported inverse associations between certain healthy lifestyle factors and non-alcoholic fatty liver disease (NAFLD), but limited evidence showed the synergistic effect of those lifestyles. This study examined the relationship of a combination of lifestyles, expressed as Healthy Lifestyle Score (HLS), with NAFLD. Design: A community-based cross-sectional study. Questionnaires and body assessments were used to collect data on the six-item HLS (ranging from 0 to 6, where higher scores indicate better health). The HLS consists of non-smoking (no active or passive smoking), normal BMI (18·5–23·9 kg/m2), physical activity (moderate or vigorous physical activity ≥ 150 min/week), healthy diet pattern, good sleep (no insomnia or <6 months) and no anxiety (Self-rating Anxiety Scale < 50), one point each. NAFLD was diagnosed by ultrasonography. Setting: Guangzhou, China. Participants: Two thousand nine hundred and eighty-one participants aged 40–75 years. Results: The overall prevalence of NAFLD was 50·8 %. After adjusting for potential covariates, HLS was associated with lower presence of NAFLD. The OR of NAFLD for subjects with higher HLS (3, 4, 5–6 v. 0–1 points) were 0·68 (95 % CI 0·51, 0·91), 0·58 (95 % CI 0·43, 0·78) and 0·35 (95 % CI 0·25, 0·51), respectively (P-values < 0·05). Among the six items, BMI and physical activity were the strongest contributors. Sensitivity analyses showed that the association was more significant after weighting the HLS. The beneficial association remained after excluding any one of the six components or replacing BMI with waist circumference. Conclusions: Higher HLS was associated with lower presence of NAFLD, suggesting that a healthy lifestyle pattern might be beneficial to liver health.

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Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children

Journal of Clinical Medicine ◽

10.3390/jcm10132812 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2812

Author(s):

Cristina Bellarosa ◽

Giorgio Bedogni ◽

Annalisa Bianco ◽

Sabrina Cicolini ◽

Diana Caroli ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Serum Bilirubin ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

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