EFFECTS OF THE THYROID STATE, SEASON AND CASTRATION ON THE ADRENAL GLANDS IN MALE RABBITS

1954 ◽  
Vol 11 (2) ◽  
pp. 103-109 ◽  
Author(s):  
M. MAQSOOD

SUMMARY The influence of the thyroid state, season and castration on the weight of the adrenals of the young male rabbit at different ages has been studied. Administration of thyroxine in doses about 30–50% above the estimated rate of secretion of thyroxine for a period of 4 weeks resulted in a significant increase in the weight of the adrenals, while treatment with thiouracil caused a significant decrease in adrenal weight. Thyroxine, when injected in doses below or about equal to the estimated rate of thyroxine secretion, did not affect the weight of the adrenals. On the other hand, prolonged mild hyperthyroidism resulted in an insignificant decrease in the weight of the adrenals. The weights of the adrenals in experimental and control animals during the summer months were significantly lower than those obtained in the winter. This was probably due to a decrease in the rate of secretion of thyroxine which occurred presumably as a result of high environmental temperature during the summer. Castration did not affect the weight of the adrenals of 8-week-old male rabbits after a period of 4 weeks, but resulted in a significant increase in the weight of the adrenals after a period of 24 weeks. The possible existence of an interrelationship between the thyroid, adrenals and gonads is discussed.

1959 ◽  
Vol 37 (5) ◽  
pp. 661-670 ◽  
Author(s):  
Rosemary Molloy ◽  
Doris Nicholls ◽  
William Farrington ◽  
R. J. Rossiter

Further observations are described on the measurement of the incorporation of inorganic phosphate labelled with P32 into the inorganic phosphate of the adrenal gland to assess the immediate pituitary–adrenal response when cold acclimatized and non-acclimatized rats are exposed to more severe cold (2 hours at −5 °C). In rats acclimatized to cold by conditioning to 3 °C for 4 weeks, this immediate pituitary–adrenal response was considerably less than that in non-acclimatized rats maintained at room temperature (22 °C). The reduction in the immediate pituitary–adrenal response took 3 to 4 weeks to develop and persisted for 12 hours, but not for 4 days. Rats that were conditioned to −5 °C by exposures for 2 or 6 hours daily for 4 weeks showed no reduction in the immediate pituitary–adrenal response to more severe cold, but there was a significant decrease in this response in rats conditioned for 6 hours daily for 8 weeks.Rats acclimatized to cold by conditioning to 3 °C for 4 weeks showed greater survival when exposed to an environmental temperature of −15 °C than rats conditioned to 22 °C. Rats that were conditioned to −5 °C for brief daily periods (2 hours or 6 hours) for 4 weeks or 8 weeks also survived exposure to severe cold (−22 °C) better than rats maintained at room temperature.In general, significant increases in adrenal weight were found in those cold-conditioned rats that showed a reduced pituitary–adrenal response. However, it is concluded that the development of increased survival on exposure to severe cold, by a process of conditioning to less severe cold, is not necessarily accompanied by a reduction in the immediate pituitary–adrenal response to severe cold, or by an increase in weight of the adrenal glands.


1985 ◽  
Vol 58 (5) ◽  
pp. 1511-1516 ◽  
Author(s):  
S. L. Pardue ◽  
J. P. Thaxton ◽  
J. Brake

This study was conducted to determine if ascorbic acid (AA) 1) increases resistance to high environmental temperature in young chickens and 2) alters heat-induced changes in several physiological responses. Groups of male chicks received either a standard ration containing 1,000 mg/kg (ppm) of AA or the ration without AA. Chicks were brooded for 3 wk and then maintained at 22 +/- 0.8 degrees C. At 4 wk of age, both AA-supplemented and control chicks were exposed to 30 min of heating (43 +/- 0.1 degrees C and 40 +/- 2% rh) on each of 3 consecutive h in an environmentally controlled chamber. Chicks were challenged with sheep erythrocytes (1 ml, 10(5) cells, iv) 12 h postheating. Heating reduced plasma potassium, body weight gain, relative bursa and spleen weights, and anti-sheep erythrocyte levels. Heating increased cloacal temperature, plasma protein, corticosteroid levels, and mortality. AA ameliorated many of these stress-related responses.


1950 ◽  
Vol 7 (1) ◽  
pp. 82-85 ◽  
Author(s):  
M. MAQSOOD

The effect of thyroidal stimulation on the weight of adrenals of the growing male mouse, kept at environmental temperatures of 24 and 30° C. for 3–4 weeks, has been studied. The administration of thyroxine (as iodinated protein) in sufficient dosages caused a significant increase in the weight of the adrenals of male mice kept at 24° C. whereas thiouracil caused a significant decrease. High environmental temperature alone caused a significant decrease in the weight of the adrenals, probably due to a decrease in the thyroid secretion rate which occurred at that temperature. The decrease in the weight of the adrenals was checked to some extent by the administration of very small doses of thyroxine; however, larger doses caused a decrease in the adrenal weight of the thyroprotein-treated mice. Hypothyroidism produced at 30° C. also resulted in a significant decrease in the weight of the adrenals.


1959 ◽  
Vol 37 (1) ◽  
pp. 661-670
Author(s):  
Rosemary Molloy ◽  
Doris Nicholls ◽  
William Farrington ◽  
R. J. Rossiter

Further observations are described on the measurement of the incorporation of inorganic phosphate labelled with P32 into the inorganic phosphate of the adrenal gland to assess the immediate pituitary–adrenal response when cold acclimatized and non-acclimatized rats are exposed to more severe cold (2 hours at −5 °C). In rats acclimatized to cold by conditioning to 3 °C for 4 weeks, this immediate pituitary–adrenal response was considerably less than that in non-acclimatized rats maintained at room temperature (22 °C). The reduction in the immediate pituitary–adrenal response took 3 to 4 weeks to develop and persisted for 12 hours, but not for 4 days. Rats that were conditioned to −5 °C by exposures for 2 or 6 hours daily for 4 weeks showed no reduction in the immediate pituitary–adrenal response to more severe cold, but there was a significant decrease in this response in rats conditioned for 6 hours daily for 8 weeks.Rats acclimatized to cold by conditioning to 3 °C for 4 weeks showed greater survival when exposed to an environmental temperature of −15 °C than rats conditioned to 22 °C. Rats that were conditioned to −5 °C for brief daily periods (2 hours or 6 hours) for 4 weeks or 8 weeks also survived exposure to severe cold (−22 °C) better than rats maintained at room temperature.In general, significant increases in adrenal weight were found in those cold-conditioned rats that showed a reduced pituitary–adrenal response. However, it is concluded that the development of increased survival on exposure to severe cold, by a process of conditioning to less severe cold, is not necessarily accompanied by a reduction in the immediate pituitary–adrenal response to severe cold, or by an increase in weight of the adrenal glands.


1966 ◽  
Vol 34 (1) ◽  
pp. 69-NP ◽  
Author(s):  
P. G. WALL

SUMMARY Localized X-irradiation of the adrenal glands of male rats aged 3–36 days inhibited subsequent gain in body weight and in the growth of the adrenal glands, the degree of retardation depending on the dose applied (400–1800 r.). The cortico-medullary ratio was essentially the same in irradiated and control animals. As judged by compensatory hypertrophy of one adrenal gland after the removal of the other, adrenal function was unaffected by X-irradiation within the range of doses and ages investigated.


1979 ◽  
Vol 42 (04) ◽  
pp. 1073-1114 ◽  

SummaryIn collaborative experiments in 199 laboratories, nine commercial thromboplastins, four thromboplastins held by the National Institute for Biological Standards and Control (NIBS & C), London and the British Comparative Thromboplastin were tested on fresh normal and coumarin plasmas, and on three series of freeze-dried plasmas. One of these was made from coumarin plasmas and the other two were prepared from normal plasmas; in each series, one plasma was normal and the other two represented different degrees of coumarin defect.Each thromboplastin was calibrated against NIBS&C rabbit brain 70/178, from the slope of the line joining the origin to the point of intersection of the mean ratios of coumarin/normal prothrombin times when the ratios obtained with the two thromboplastins on the same fresh plasmas were plotted against each other. From previous evidence, the slopes were calculated which would have been obtained against the NIBS&C “research standard” thromboplastin 67/40, and termed the “calibration constant” of each thromboplastin. Values obtained from the freeze-dried coumarin plasmas gave generally similar results to those from fresh plasmas for all thromboplastins, whereas values from the artificial plasmas agreed with those from fresh plasmas only when similar thromboplastins were being compared.Taking into account the slopes of the calibration lines and the variation between laboratories, precision in obtaining a patient’s prothrombin time was similar for all thromboplastins.


TAPPI Journal ◽  
2018 ◽  
Vol 17 (05) ◽  
pp. 295-305
Author(s):  
Wesley Gilbert ◽  
Ivan Trush ◽  
Bruce Allison ◽  
Randy Reimer ◽  
Howard Mason

Normal practice in continuous digester operation is to set the production rate through the chip meter speed. This speed is seldom, if ever, adjusted except to change production, and most of the other digester inputs are ratioed to it. The inherent assumption is that constant chip meter speed equates to constant dry mass flow of chips. This is seldom, if ever, true. As a result, the actual production rate, effective alkali (EA)-to-wood and liquor-to-wood ratios may vary substantially from assumed values. This increases process variability and decreases profits. In this report, a new continuous digester production rate control strategy is developed that addresses this shortcoming. A new noncontacting near infrared–based chip moisture sensor is combined with the existing weightometer signal to estimate the actual dry chip mass feedrate entering the digester. The estimated feedrate is then used to implement a novel feedback control strategy that adjusts the chip meter speed to maintain the dry chip feedrate at the target value. The report details the results of applying the new measurements and control strategy to a dual vessel continuous digester.


2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.


2010 ◽  
Vol 30 (6) ◽  
pp. 612-614
Author(s):  
Xiao FANG ◽  
Lin LUO ◽  
Lei ZHANG ◽  
Hai-xia QI ◽  
Xiao-dong LIU ◽  
...  

2013 ◽  
Vol 41 (2) ◽  
pp. 218-229
Author(s):  
Fakhry S Salem ◽  
Amany AM Abd Allah ◽  
Sahar S Abd El-Hamied ◽  
Doaa I A Mostafa

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