EFFECTS OF VASOPRESSIN ON TOAD BLADDER MEMBRANE PROTEINS: RELATIONSHIP TO TRANSPORT OF SODIUM AND WATER
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SUMMARY The results support previous findings that vasopressin produces dephosphorylation of a toad bladder membrane protein of 50000 mol. wt. At vasopressin concentrations of 50 mu./ml phosphorylation of this protein was 60 ± 7% of the control level, and maximal natriferic and hydro-osmotic responses were observed in intact bladders. However, at concentrations of vasopressin of 10 mu./ml when a maximal natriferic response but no significant hydro-osmotic response were observed, there was no significant difference in phosphorylation of the proteins from control or vasopressin-treated bladders. We conclude that the 50000 mol. wt membrane protein is likely to be associated with the hydro-osmotic response of the toad bladder to vasopressin.
1991 ◽
Vol 261
(1)
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pp. C143-C153
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2005 ◽
Vol 33
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pp. 910-912
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1988 ◽
Vol 21
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pp. 429-477
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1996 ◽
Vol 109
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pp. 1215-1227
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