Relation of corona-specific health literacy to use of and trust in information sources during the COVID-19 pandemic

Background COVID-19 has developed into a worldwide pandemic which was accompanied by an «infodemic» consisting of much false and misleading information. To cope with these new challenges, health literacy plays an essential role. The aim of this paper is to present the findings of a trend study in Switzerland on corona-specific health literacy, the use of and trust in information sources during the COVID-19 pandemic, and their relationships. Methods Three online surveys each with approximately 1′020 individuals living in the German-speaking part of Switzerland (age ≥ 18 years) were conducted at different timepoints during the COVID-19 pandemic, namely spring, fall and winter 2020. For the assessment of corona-specific health literacy, a specifically developed instrument (HLS-COVID-Q22) was used. Descriptive, bivariate, and multivariate data analyses have been conducted. Results In general, a majority of the Swiss-German population reported sufficient corona-specific health literacy levels which increased during the pandemic: 54.6% participants in spring, 62.4% in fall and 63.3% in winter 2020 had sufficient corona-specific health literacy. Greatest difficulties concerned the appraisal of health information on the coronavirus. The most used information sources were television (used by 73.3% in spring, 70% in fall and 72.3% in winter) and the internet (used by 64.1, 64.8 and 66.5%). Although health professionals, health authorities and the info-hotline were rarely mentioned as sources for information on the coronavirus, respondents had greatest trust in them. On the other hand, social media were considered as the least trustworthy information sources. Respondents generally reporting more trust in the various information sources, tended to have higher corona-specific health literacy levels. Conclusions Sufficient health literacy is an essential prerequisite for finding, understanding, appraising, and applying health recommendations, particularly in a situation where there is a rapid spread of a huge amount of information. The population should be supported in their capability in appraising the received information and in assessing the trustworthiness of different information sources.

Coating Liposomes with Ring-like PEG: Synthesis and Stealth Effect of Cholesterol-PEG-Cholesterol

Escaping from the immune system to achieve long circulating time is an essential prerequisite for targeting liposomes. Monomethoxy-poly (ethylene glycol)-distearoylphosphatidylethanolamine (mPEG-DSPE) is the most commonly used stealth polymer for long...

Parameter Reliability and Understanding Enzyme Function

Knowledge of the Michaelis–Menten parameters and their meaning in different circumstances is an essential prerequisite to understanding enzyme function and behaviour. The published literature contains an abundance of values reported for many enzymes. The problem concerns assessing the appropriateness and validity of such material for the purpose to which it is to be applied. This review considers the evaluation of such data with particular emphasis on the assessment of its fitness for purpose.

Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator

Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry. An essential prerequisite for successful DEM modelling of a twin-screw granulator is making the simulations tractable, i.e., reducing the significant computational cost while retaining the key physics. Four methods are evaluated in this paper to achieve this goal: (i) develop reduced-scale periodic simulations to reduce the number of particles; (ii) further reduce this number by scaling particle sizes appropriately; (iii) adopt an adhesive, elasto-plastic contact model to capture the effect of the liquid binder rather than fluid coupling; (iv) identify the subset of model parameters that are influential for calibration. All DEM simulations considered a GEA ConsiGma™ 1 twin-screw granulator with a 60° rearward configuration for kneading elements. Periodic simulations yielded similar results to a full-scale simulation at significantly reduced computational cost. If the level of cohesion in the contact model is calibrated using laboratory testing, valid results can be obtained without fluid coupling. Friction between granules and the internal surfaces of the granulator is a very influential parameter because the response of this system is dominated by interactions with the geometry.

Bioaugmentation of Corn Stalks Saccharification with Aspergillus Fumigatus Under Low/High Solid Loading Culture

Decomposed the dense structure of lignocellulosic feedstocks and hydrolysis lignocellulose into monosaccharide were essential prerequisite for bio-energy production at this level. In this study, a cellulosic fungi Aspergillus fumigatus CLL was conducted to pretreated the corn stalks under high/low solid loading culture to enhanced the cellulase saccharification performance. The results indicated that A. fumigatus CLL decomposed the corn stalks effectively under high/low solid loading culture, what’s more, A. fumigatus CLL completed the T. reesei cellulase system and promoted the corn stalks saccharification performance. 25.2% lignin was degraded after A. fumigatus CLL treated just for two day under low solid loading culture with holocellulose loss less than 10%. Meanwhile, the β-glucosidase of A. fumigatus CLL complemented the incomplete cellulase system of T. reesei, the maximum saccharification ratio of sample saccharified by T. reesei cellulase combined A. fumigatus CLL was comparable with the sample saccharified by commercial cellulase. Compared with raw corn stalks, the saccharification ratio of pretreated sample increased 3.1-3.4 fold. These results demonstrated that A. fumigatus CLL can be used for pretreatment of lignocellulosic materials to enhanced the saccharification performance.

Improved the Activity of Phosphite Dehydrogenase and its Application in Plant Biotechnology

Phosphorus (P) is a nonrenewable resource, which is one of the major challenges for sustainable agriculture. Although phosphite (Phi) can be absorbed by the plant cells through the Pi transporters, it cannot be metabolized by plant and unable to use as P fertilizers for crops. However, transgenic plants that overexpressed phosphite dehydrogenase (PtxD) from bacteria can utilize phosphite as the sole P source. In this study, we aimed to improve the catalytic efficiency of PtxD from Ralstonia sp.4506 (PtxDR4506), by directed evolution. Five mutations were generated by saturation mutagenesis at the 139th site of PtxD R4506 and showed higher catalytic efficiency than native PtxDR4506. The PtxDQ showed the highest catalytic efficiency (5.83-fold as compared to PtxDR4506) contributed by the 41.1% decrease in the Km and 2.5-fold increase in the kcat values. Overexpression of PtxDQ in Arabidopsis and rice showed increased efficiency of phosphite utilization and excellent development when phosphite was used as the primary source of P. High-efficiency PtxD transgenic plant is an essential prerequisite for future agricultural production using phosphite as P fertilizers.

Chromatography-Free Purification Strategies for Large Biological Macromolecular Complexes Involving Fractionated PEG Precipitation and Density Gradients

A complex interplay between several biological macromolecules maintains cellular homeostasis. Generally, the demanding chemical reactions which sustain life are not performed by individual macromolecules, but rather by several proteins that together form a macromolecular complex. Understanding the functional interactions amongst subunits of these macromolecular machines is fundamental to elucidate mechanisms by which they maintain homeostasis. As the faithful function of macromolecular complexes is essential for cell survival, their mis-function leads to the development of human diseases. Furthermore, detailed mechanistic interrogation of the function of macromolecular machines can be exploited to develop and optimize biotechnological processes. The purification of intact macromolecular complexes is an essential prerequisite for this; however, chromatographic purification schemes can induce the dissociation of subunits or the disintegration of the whole complex. Here, we discuss the development and application of chromatography-free purification strategies based on fractionated PEG precipitation and orthogonal density gradient centrifugation that overcomes existing limitations of established chromatographic purification protocols. The presented case studies illustrate the capabilities of these procedures for the purification of macromolecular complexes.

The role of empathy in ethics of radiological protection

Radiological protection is often considered a matter of scientific and technological facts only, not of value judgements. This perception is now gradually changing, especially with ICRP Publication 138, which addressed the ethical foundation of the system of radiological protection. It identified values which have guided the Commission’s recommendations over the decades, but have not always been made explicit. Four core values are discussed (beneficence/non-maleficence, prudence, justice, dignity) as well as three procedural values (accountability, transparency, inclusivity). The latter are considered critical to the practical implementation of the system of radiological protection. Here we are exploring empathy as a procedural values complementing the three identified in ICRP Publication 138. Empathy can be defined as the “capability (or disposition) to immerse oneself in and to reflect upon the experiences, perspectives and contexts of others”. It is often understood as a skill that one either has or has not, but research has shown it can be taught and therefore can be required as an attitude of those working in health care, education, design, and technology. We suggest it is an essential prerequisite to the assessment and management of any radiological situation and the health problems accruing from it. The concerns of people affected, their needs and wishes need to be taken seriously from the very beginning of any decision-making process. Even if they are considered unfounded and exaggerated, the insights they provide will be valuable for the understanding of the overall situation. Without empathy, our practice of beneficence and non-maleficence as well as solidarity would be oddly limited.

Statehood: the Essential Prerequisite for Law and Liberty

The attempt to subject Poland and Hungary to procedures under EU law for allegedly not respecting European values has its roots both in the supranational nature of the EU project and also in the differing concepts of the nation in the Eastern and Western halves of the continent. The hegemonic West is deeply post-modern while former Communist states have retained some faith in the nation. Globalisation generally, and the EU project in particular, are based on functionalist assumptions whose origins lie in the early 19th century, yet these fail to understand the eminently political nature of law: all jurisdictions are rooted in society and the state and it is the role of government to adjudicate between the competing claims of citizens. This makes it very difficult, impossible even, to formulate universal rights since their formulation and application depend on interpretation, i.e. on jurisdiction, and therefore on the sovereignty of the ultimate decision-maker.

F-ONTOCOM: A Fuzzified Cost Estimation Approach for Ontology Engineering

Estimating effort is an essential prerequisite for the wide-scale dispersal of ontologies. Not much attention has yet been paid to this essential aspect of ontology building. To date, ONTOCOM is the most prominent model for ontology cost estimation. Many factors influencing the building cost of an ontology are depicted by linguistic terms like Very High, High, . . . and so on; making them vague and indistinct. This fuzziness is quite uncertain and must be taken into consideration. The available effort estimation models do not consider the uncertainty of fuzziness. In this work, we propose an effort estimation methodology for ontology engineering using Fuzzy Logic i.e. F-ONTOCOM (Fuzzy-ONTOCOM) to overcome of uncertainty and imprecision. We have defined the corresponding Fuzzy sets for each effort multiplier and its associated linguistic value, and represented the same by triangular membership functions. F-ONTOCOM is applied to a dataset of 148 ontology projects and evaluated over various evaluation criteria. FONTOCOM outperforms the existing effort-estimation models; it has been concluded that F-ONTOCOM improves the cost estimation accuracy and estimated cost is very close to actual cost.