Plasma patterns of LH, FSH and prolactin in rats with a polycystic ovarian condition induced by oestradiol valerate

1987 ◽  
Vol 114 (1) ◽  
pp. 33-39 ◽  
Author(s):  
P. M. Grosser ◽  
G. F. McCarthy ◽  
B. Robaire ◽  
R. Farookhi ◽  
J. R. Brawer
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Pulse Amplitude ◽  
Blood Sampling ◽  
Pulse Period ◽  
Ovary Syndrome ◽  
Blood Concentrations ◽  
Blood Samples ◽  
Mean Frequency ◽  
The Mean

ABSTRACT The patterns of plasma LH, FSH and prolactin concentrations were investigated in rats with a polycystic ovary condition (PCO). The condition was induced by treatment with oestradiol valerate 9 weeks before blood sampling. Serial blood samples were taken at 10-min intervals for 4 h from ten rats with PCO. All samples were assayed for LH, those from five animals for FSH and those from the remaining five animals for prolactin. In addition, five control animals with normal oestrous cycles were sampled during oestrus and the samples assayed for LH. Mean concentrations of LH, FSH and prolactin in rats with PCO were 140 ng/l, 76 μg/l and 7·6 μg/l respectively. All three hormones exhibited an episodic pattern. The mean peak amplitudes of LH, FSH and prolactin were 120 ng/l, 25 μg/l and 3·5 μg/l respectively. All three hormones exhibited a similar mean frequency of four or five episodes per 4 h. The LH and FSH patterns were closely synchronized; nearly all FSH peaks coincided with LH peaks. The prolactin pattern did not, however, correlate with that of the gonadotrophins. Despite the persistent oestrous condition of the animals with PCO, it was clear that their pattern of LH did not resemble that of cyclic animals in normal oestrus; in the normally cyclic animals in oestrus the pulse period was nearly twice as long and the pulse amplitude was more than sixfold greater than those in animals with PCO. We conclude that the unique episodic patterns of gonadotrophins are more important than mean blood concentrations of these hormones in establishing and maintaining the polycystic ovary syndrome. J. Endocr. (1987) 114, 33–39

scholarly journals Comparing the Effect of Metformin and Acarbose Accompanying Clomiphene on the Successful Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome

2016 ◽  
Vol 8 (9) ◽  
pp. 281
Author(s):  
Masomeh Rezai ◽  
Mohmmad Jamshidi ◽  
Robabeh Mohammadbeigi ◽  
Fariba Seyedoshohadaei ◽  
Somaye Mohammadipour ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Treatment Period ◽  
Ovulation Induction ◽  
Glucose Tolerance Test ◽  
Polycystic Ovary ◽  
Tolerance Test ◽  
Ovary Syndrome ◽  
Infertile Women ◽  
The Mean

The aim of this study was to compare the effects of Metformin and Acarbose accompanying Clomiphene on the successful ovulation induction in infertile women with polycystic ovary syndrome.This randomized double blind clinical trial study was performed on 60 women with polycystic ovary syndrome. Women were selected and randomly divided in two control and intervention groups. Intervention group received Acarbose 100 mg/day for 3 months. In the first, second, and third weeks, they received 1 tablet, 2 tablets, and 3 tablets per day respectively. In addition, they received 100 mg Clomiphene from third to seventh day of menstruation, during the 3 month treatment period. The control group received Metformin 500 mg/day for 3 months. In the first, second, and third weeks, they received 1 tablet, 2 tablets, and 3 tablets per day respectively. In addition, they received 100 mg Clomiphene from third to seventh day of menstruation, during the 3 month treatment period. All the subjects in both groups before and after the treatment were examined for hirsutism, acne, oral glucose tolerance test, serum triglycerides, cholesterol, LDL, HDL. Also, induction of ovulation was assessed by vaginal ultrasound. The Mean of BMI and fasting glucose tolerance test in Acarbose group was less than Metformin group (P = 0.05). The mean of triglycerides, LDL and HDL levels did not differ between the two groups after the intervention (P > 0.05). The mean of cholesterol levels were different in the two groups after the intervention (P = 0.04). Frequency of ovulation induction in those who received Acarbose (78.5%) was more than those who received Metformin (46.6) (P = 0.012). Comparing with Metformin, Acarbose accompanying Clomiphene was more effective in ovulation induction and decreasing body mass index in infertile women with polycystic ovary syndrome.

scholarly journals CLINICAL, BIOCHEMICALAND HORMONE PROFILE IN HIRSUTE VS NONHIRSUTE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

2020 ◽  
pp. 28-30
Author(s):  
Amaladasu Prasanthi
Keyword(s):  
Blood Glucose ◽  
Polycystic Ovary Syndrome ◽  
Clinical Symptoms ◽  
Polycystic Ovary ◽  
Fasting Blood Glucose ◽  
Clinical History ◽  
Positive Trend ◽  
Ovary Syndrome ◽  
Hormone Profile ◽  
The Mean

Background: Polycystic ovary syndrome (PCOS), a common endocrinopathy present with variety of phenotypes with broad spectrum of clinical symptoms. Hyperandrogenism characterized with the presence of hirsutism remains an important feature of PCOS. Aim: The present study was conducted to assess difference in the clinical, biochemical and hormone profile in hirsute and non-hirsute females with PCOS. Methods: Detailed physical and clinical history was taken in all subjects. Hormonal and biochemical assays were performed by ECLIA. Results: 105 normoglycemic cases were enrolled for this study. The mean age of patients was 22.19 ±4.4 years and the mean age of menarche was 13.3±1.4 years. Acne was present in more than 50% of our cases. 81% cases were hirsute and only 19% were non- hirsute. Mean fasting blood glucose and triglycerides were found to be statistically significant between the two groups. A positive trend of hirsutism was found to be associated with irregular cycles and family history of type-2 diabetes mellitus (T2DM). Conclusion: The mean blood glucose and triglycerides was elevated in hirsute PCOS, while as BMI, weight and waist circumference was slightly elevated in non-hirsute PCOS females.

scholarly journals Evaluation the levels of some hormones in women with polycystic ovary syndrome

2019 ◽  
Vol 24 (5) ◽  
pp. 25
Author(s):  
Namareq Ata allah Mohemeed1 ◽  
Firas Shawki Abdul-razzak2
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Control Group ◽  
Age Group ◽  
Ovary Syndrome ◽  
Blood Samples ◽  
Healthy Women ◽  
Stimulating Hormone

This study was conducted on 40 Samples of Patients with polycystic ovary syndrome (PCOS) after their diagnosis, The study aimed to identify the most important  hormonal disorders associated  with  this syndrome . The study begins from Octobar 2017 to March 2018 , the age from(19-45) years .Blood samples were taken during the (2-4( days of menstrual cycle and the selected samples were compared with 20 healthy women as control group ,and the following hormones were evaluated Luteninzing hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin (PRL),Testosterone (Testo) and Oxytocin (OX) ,the study showed a high significant in the concentrations of OX ,Testo and LH (P≤0.01) , a high significant in the PRL concentration (P≤0.05) and a high significant in the FSH concentration (P≤0.05(,the results were distributed to three groups according to BMI ,age and treatment, in term BMI it was divided into three groups, BMI(18.5-24.9)(25.0-29.9) (≥30)kg/m2 the results showed a high significant (P≤0.05)  in the LH and OX concentration in  group BMI (18.5-24.9)kg/m2 and in both PRL and Testo in group BMI(≥30)kg/m2. in term age, it was divided into three groups (19-26) (27-35) (36-45)years, the results showed a high significant (P≤0.05) in LH  and Testo concentration at age group (36-45)years ,compared to other groups, and a high significant (P≤0.05) in both PRL and OX, between three group of age , treatment it was divided  into three groups of metformin, progesterone contraceptive used and non-used of the treatment .the results showed a high significant (P≤0.05) in LH, PRL, OX and Testo concentrations, and a high significant (P≤0.05) of FSH in women treated compared with non-used  .   http://dx.doi.org/10.25130/tjps.24.2019.085

scholarly journals Analyzing the biochemical, clinical, and hormonal characteristics of patients with polycystic ovary syndrome

2021 ◽  
Vol 38 (4) ◽  
pp. 478-484
Author(s):  
Tuğba GÜRBÜZ ◽  
Şebnem ALANYA TOSUN
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Blood Sugar ◽  
Polycystic Ovary ◽  
Fasting Blood Sugar ◽  
P Value ◽  
Type I ◽  
Ovary Syndrome ◽  
Gynecology And Obstetrics ◽  
Significant Difference ◽  
The Mean

To analyze the biochemical, clinical, and hormonal characteristics of patients with four phenotypes of Polycystic ovary syndrome (PCOS). A total of 225 patients admitted to Medistate Kavacık Hospital Gynecology and Obstetrics outpatient clinic and Giresun University Faculty of Medicine Gynecology and Obstetrics clinic between January 2019 and January 2020 diagnosed as PCOS and healthy controls were included in the study. The revised Rotterdam criteria were applied to diagnose PCOS. The patients with PCOS were divided into Type I classic, Type II classic, Ovulatory and Normoandrogenic PCOS. Biochemical, clinical, and hormonal values were compared. The mean age of the participants is 28 (±5.7) and the mean body mass index (BMI) is 26.15 (±5.36). The mean Ferriman Gallwey Score (FGS) is 7.4(±5.4), which is normal. There is a statistically significant difference between the four PCOS groups and control group in terms of age (p-value=0.000), BMI (p- value=0.000), Luteinizing hormone / Follicle stimulating hormone (LH/FSH) (p-value=0.000), and fasting blood sugar (p-value=0.01). There is a statistically significant difference among the four phenotypes in terms of BMI (p-value =0.002), LH/FSH (p-value =0.000), LH (p-value =0.000), free T4 (p-value =0.01), fasting insulin (p-value =0.001), total testosterone (p-value =0.000), FGS (p-value =0.000), etc. Age, BMI, LH/FSH, FSH, LH, fasting blood sugar, and hirsutism are good predictors of PCOS.

scholarly journals Serum Leptin Levels in Women with Polycystic Ovary Syndrome: The Role of Insulin Resistance/ Hyperinsulinemia1

1997 ◽  
Vol 82 (6) ◽  
pp. 1692-1696
Author(s):  
G. A. Laughlin ◽  
A. J. Morales ◽  
S. S. C. Yen
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Body Fat ◽  
Polycystic Ovary ◽  
Pulse Amplitude ◽  
Percent Body Fat ◽  
Ovary Syndrome ◽  
Serum Leptin ◽  
Insulin Levels

Abstract Polycystic ovary syndrome (PCOS) is associated with chronic anovulation, hyperandrogenemia, insulin resistance (IR)/hyperinsulinemia, and a high incidence of obesity. Thus, PCOS serves as a useful model to assess the role of IR and chronic endogenous insulin excess on leptin levels. Thirty-three PCOS and 32 normally cycling (NC) women of similar body mass index (BMI) were studied. Insulin sensitivity (SI) was assessed by rapid ivGTT in a subset of 28 PCOS and 29 NC subjects; percent body fat was determined by dual-energy x-ray absorptiometry (DEXA) in 14 PCOS and 17 NC. Fasting (0800 h) and 24-h mean hourly insulin levels were 2-fold higher (P < 0.0001), and SI was 50% lower (P = 0.005) in PCOS than in NC, while serum androstenedione (A), testosterone (T), 17-α hydroxyprogesterone (17OHP), and estrone (E1) levels were elevated (P < 0.0001), and sex hormone-binding globulin (SHBG) levels were decreased (P < 0.01). Twenty-four hour LH pulse frequency, mean pulse amplitude, and mean LH levels were elevated in PCOS (P < 0.001) as compared with NC. Serum leptin levels for PCOS (24.1 ± 2.6 ng/mL) did not differ from NC (21.5 ± 3.5 ng/mL) and were positively correlated with BMI (r = 0.81) and percent body fat (r = 0.91) for the two groups (both P < 0.0001). Leptin levels for PCOS and NC correlated positively with fasting and 24-h mean insulin levels (r = 0.81, P < 0.0001 for both PCOS and NC) and negatively with SI and SHBG levels. Leptin concentrations for PCOS, but not NC, correlated positively with 24-h mean glucose levels and inversely with 24-h mean LH levels and 24-h mean LH pulse amplitude. Leptin levels were not correlated with estrogen or androgen levels for either PCOS or NC, although leptin levels were positively related to the ratios of E1/SHBG and E2/SHBG for both PCOS and NC and to the ratio of T/SHBG for PCOS only. In stepwise multivariate regression with forward selection, only 24-h mean insulin levels contributed significantly (P < 0.01) to leptin levels independent of BMI and percent body fat for both PCOS and NC. Given this relationship and the presence of 2-fold higher 24-h mean insulin levels in PCOS, the expected elevation of leptin levels in PCOS was not found. This paradox may be explained by the presence of adipocyte IR specific to PCOS, which may negate the stimulatory impact of hyperinsulinemia on leptin secretion, a proposition requiring further study.

The mean and the biological variation of insulin resistance does not differ between polycystic ovary syndrome and type 2 diabetes

2009 ◽  
Vol 46 (3) ◽  
pp. 218-221 ◽  
Author(s):  
Li Wei Cho ◽  
V Jayagopal ◽  
E S Kilpatrick ◽  
S L Atkin
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Postmenopausal Women ◽  
Polycystic Ovary ◽  
Biological Variation ◽  
Biological Variability ◽  
Ovary Syndrome ◽  
The Mean

Background There is an assumption that the mean and biological variation of insulin resistance (IR) is less in polycystic ovary syndrome (PCOS), and intuitively higher in type 2 diabetes (T2DM). To test this hypothesis we compared the mean and biological variation in IR in PCOS to that of T2DM and to age- and weight-matched controls. Methods Twelve PCOS, 11 matched healthy women; 12 postmenopausal diet-controlled T2DM and 11 matched healthy postmenopausal women were recruited. Blood samples were collected at 4-d intervals on 10 consecutive occasions. The biological variability of IR was derived on duplicate samples. Results Mean and biological variability of HOMA-IR for PCOS did not differ from T2DM. Both measures were higher than the matched controls. There was no difference in insulin or IR measures between the body mass index matched pre- and postmenopausal women. Percentage β cell function were 208.8%, 62.3%, 106.5% and 111.9%, respectively, in PCOS, postmenopausal women with T2DM, healthy premenopausal and healthy postmenopausal women. Conclusions The progression from PCOS to the development of T2DM is unlikely to be due to a further increase in IR (or variability), but rather the progressive failure of pancreatic beta cells with a decrease in insulin production. The clinical trial registration number for this study is ISRCTN65353256.

scholarly journals Glutathione-dependent enzymes in the follicular fluid of the first-retrieved oocyte and their impact on oocyte and embryos in polycystic ovary syndrome: A cross-sectional study

2020 ◽  
Author(s):  
Fatemeh Zal ◽  
Pardis Ahmadi ◽  
Maryam Davari ◽  
Fatemeh Khademi ◽  
Mojgan Akbarzadeh Jahromi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Antioxidant System ◽  
Follicular Fluid ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
The Mean

Background: Oxidative stress and GSH-dependent antioxidant system plays a key role in the pathogenesis of polycystic ovary syndrome (PCOS). Objective: We compared glutathione peroxidase (GPx) and glutathione reductase activities and reduced glutathione (GSH) levels in serum and follicular fluid (FF) of the first-retrieved follicle and their impact on quality of oocyte and embryo in PCOS women undergoing IVF. Materials and Methods: This cross-sectional study was conducted on 80 pairs of blood samples and FF of the first-retrieved follicle from PCOS women, at the Infertility center of Ghadir Mother and Child Hospital. The mean activity of GPx and GR, also GSH levels in the serum and FF were compared to the quality of the first follicle and resultant embryo. Results: Retrieved oocytes included 53 (66.25%) MII, 17 (21.25%) MI, and 10 (12.5%) germinal vesicles; after IVF 42 (52.50%) embryos with grade I and 11 (13.75%) with grade II were produced. The mean values for all three antioxidants were higher in the FF compared to serum (p < 0.001). Also all of the mean measured levels were significantly higher in the FF of the MII oocytes compared to that of oocytes with lower grades (p = 0.012, 0.006 and 0.012, respectively). The mean GPX activity and GSH levels were significantly higher in the serum (p = 0.016 and 0.012, respectively) and FF (p = 0.001 for both) of the high-quality grade I embryos. Conclusion: GSH-dependent antioxidant system functions more efficiently in the FF of oocytes and embryos with higher quality. Key words: In vitro fertilization, Glutathione, Antioxidant, Oocyte, Embryo. 

scholarly journals Prevalence and characteristics of polycystic ovarian syndrome in women attending in outpatient department of obstetrics and gynecology of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

2021 ◽  
Vol 10 (3) ◽  
pp. 830
Author(s):  
Kaniz Fatema ◽  
Tripti Rani Das ◽  
Rezaul Karim Kazal ◽  
Sharmeen Mahamood ◽  
Hasna Hena Pervin ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Genetic Disorder ◽  
Uterine Cancer ◽  
Reproductive Age ◽  
Observation Study ◽  
Ovary Syndrome ◽  
Hormonal Profile ◽  
The Mean ◽  
Medical University

Background: Polycystic ovary syndrome (PCOS) is a heterogenous, multifactorial, complex genetic disorder. Most commonly, it affects the females of reproductive age. This is one of the most widespread diseases across the world and if left untreated, may result in infertility and even uterine cancer. Methods: A cross sectional observation study of 100 PCOS patients was carried out from August 2018 to July 2019 in gynecology out-patient department of Bangabandhu Sheikh Mujib medical university, Dhaka. In this study clinical, biochemical and hormonal profile of these patients were analyzed and correlation was done between clinical features and biochemical and hormonal profile. Results: The prevalence of PCOS was 6.11% in the gynecology out-patient visits and 35.39% among infertile women. The mean age group of the patients was 24.3±5.16 SD. The mean BMI was 24.66±5.34 SD. The mean duration of infertility was 5.17 years. The prevalence of metabolic syndrome in our study was 15.0%. In this study menstrual irregularity was the most common complaint. Spearman’s correlation between various clinical and laboratory parameters showed positive correlation exists between BMI and testosterone (r=0.4824; p<0.0001).Conclusions: The study showed that most of our polycystic ovary syndrome subjects were present with oligomenorrhea. Hirsutism and central obesity were also common presentation. Obese women with PCOS had more severe ovulatory dysfunction and need more attention for their appropriate management. 

Evaluation of serum lipid profile and sex hormones in women with polycystic ovary syndrome - A comparative study

2021 ◽  
Vol 16 (11) ◽  
pp. 13-18
Author(s):  
Pravesh Hegde ◽  
Lakshmi Manjeera ◽  
Prasanna Shetty Kumar ◽  
Shilpa S. Shetty ◽  
Suchetha N. Kumari
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Lipid Profile ◽  
Sex Hormones ◽  
Polycystic Ovary ◽  
Clinical Manifestations ◽  
Sex Hormone ◽  
Control Group ◽  
Ovary Syndrome ◽  
The Mean

Polycystic ovary syndrome (PCOS), an endocrinological disorder with lipid disturbances leads to a wide spectrum of clinical manifestations including menstrual irregularities, infertility, obesity and hyperandrogenism. This study aimed to determine the levels of lipid profile and sex hormones and its effect on PCOS from a State in southern India. This comparative hospital-based study was conducted in the State of Karnataka, India from June 2019 to January 2020. 57 age-matched PCOS and 67 healthy controls were enrolled for the study. Fasting glucose, insulin, lipid profile and sex hormone levels were analyzed after taking informed consent from all participants. The mean age of patients with PCOS was 25.05 ± 6.04 years and the mean age of subjects in the control group was 27.36 ± 7.08 years. Lipid profile showed statistically significant increased levels of triglyceride 147.3±86.6 (p<0.05) and decreased levels of HDL 52.2±8.7 (p<0.05) whereas hormones LH and testosterone were significantly higher in women with PCOS when compared to controls. The altered lipid profile, sex hormone and insulin levels exhibit a key role in the pathophysiology of PCOS that affects health. Insulin resistance is found to be linked with dyslipidemia in PCOS. Our findings suggest that the differences found may play a key role in the pathophysiology of PCOS which in turn affects the health and therefore it is advisable to emphasize the necessity for screening insulin resistance and perform early and periodic examination of lipid profile and sex hormones in women with PCOS to reduce complications.

scholarly journals Prevalence of depression and quality of life in polycystic ovary syndrome patients at a tertiary care hospital: a cross-sectional study

2019 ◽  
Vol 8 (6) ◽  
pp. 2251
Author(s):  
Radhika Gollapudi ◽  
Venu Madhavi Lanke ◽  
Manaswini Namilakoda
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Prevalence Of Depression ◽  
The Mean

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy among women of reproductive age. Physical symptoms in PCOS cause depression and decrease the Quality of Life (QoL). The objective was to study the prevalence of depression in women suffering from PCOS and to assess its correlation with QoL.Methods: This was a cross sectional study conducted among one hundred patients diagnosed with PCOS. Women 18-40 years of age diagnosed with PCOS were included in the study. Patients with known psychiatric illness were excluded. Depression severity was assessed with Hamilton depression (HAM-D) scale. The quality of life (QoL) was assessed with Polycystic ovary syndrome questionnaire (PCOSQ). The data was analyzed using SPSS 20.0 for Windows.Results: The mean age and BMI was 25.64±3.25 years and 26.78±2.72 kg/m2 respectively. The mean depression score was 12.46±6.18. QoL domains showed that the lowest score was in the menstrual problem with a mean of 12.48±4.44 and the highest was in the emotional domain with a mean of 28.07±11.17. The negative correlations were between age and Hamilton score (p < 0.05). The Hamilton score was negatively correlated with the emotional score (p <0.01) and weight score was positively correlated with infertility score (p <0.01).Conclusions: PCOS was clearly associated with depression and reduced QoL. This should warrant health professionals to consider routine screening for depression and assess the impact of symptoms on their QoL to improve patient outcomes.

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