scholarly journals Antioxidative system capacity after a 10-day-long intensive training course and one-month-long recovery in military cadets

2021 ◽  
Vol 9 (1) ◽  
pp. 62-69
Author(s):  
Liana Plavina ◽  
Oksana Kolesova ◽  
Jelena Eglite ◽  
Andris Cakstins ◽  
Silva Cakstina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Military Personnel ◽  
Initial Level ◽  
Military Training ◽  
System Capacity ◽  
Antioxidative System ◽  
Intensive Training ◽  
Training Course ◽  
Before And After ◽  
The One

Optimization of training and minimization of injuries are topical for the physical performance of military personnel. Physical and psycho-emotional load, fatigue, sleep deprivation, and dietary limits can lead to the development of oxidative stress (OS) and injuries in specific military training. This study investigated markers of OS and muscle damage in military cadets after a 10-day-long intensive training course and a one-month-long recovery. The sample included 42 cadets (2 females and 40 males) aged from 22 till 34. Myoglobin, catalase activity (CAT), superoxide dismutase activity (SOD), and total antioxidants capacity (TAC) in plasma were measured. OS was assessed by the glutathione index. The results revealed an increasing level of myoglobin, increasing glutathione index, and no changes in CAT, SOD, and TAC during the intensive training course. After the one-month-long recovery, myoglobin was back to normal, the activity of CAT and TAC was higher than before and after the training course, while SOD did not change after the recovery. The glutathione index decreased after the one-month-long recovery, but it was not reached the initial level before the intensive training. In sum, the observed grade of OS positively affected the capacity of the antioxidative system with some sign of a need for a longer rest.

Survival Training Effects on Oxidative Stress and Muscle Damage Biomarkers of Naval Cadets

2020 ◽  
Vol 91 (9) ◽  
pp. 720-724
Author(s):  
Andrzej Tomczak ◽  
Ewa Jówko ◽  
Paweł Różański
Keyword(s):  
Oxidative Stress ◽  
Muscle Damage ◽  
Biochemical Parameters ◽  
Initial Level ◽  
Military Training ◽  
Venous Blood ◽  
Lipid Hydroperoxides ◽  
Naval Academy ◽  
Training Effects ◽  
Damage Indicators

INTRODUCTION: It is important for military commanders to know the extent of fatigue experienced by soldiers undergoing a long-term military training. This knowledge can enable them to determine the level of physical capabilities of soldiers. The present study aimed to evaluate changes in the level of chosen biochemical parameters in blood during the survival training of Polish Naval Academy cadets. METHODS: Participating voluntarily in the research study were 14 cadets. All subjects were men, ages 23.1 2.0 yr. During the 36-h survival training, the subjects were deprived of sleep. The following biochemical parameters were assessed in venous blood collected from the cadets: creatine kinase (CK) activity, concentration of lipid hydroperoxides (LOOHs), superoxide dismutase activity (SOD), and glutathione peroxidase activity (GPx). RESULTS: After 36 h of training a significant increase was observed in CK (from 183.1 up to 530.2 U L1), LOOHs (from 1.72 up to 3.74 mol L1), and GPx (from 27.4 up to 36.4 U gHb1). After 12 h of rest, the level of LOOHs returned to the initial level, GPx activity did not change significantly, and CK activity was significantly higher than those at baseline (422.3 U L1). DISCUSSION: The 36-h survival training increased oxidative stress, which contributed to the damage to muscle cells in the group of cadets of the Polish Naval Academy. The intensity of postexercise changes in the level of oxidative damage indicators is dependent on the initial level of enzymatic antioxidant defense. The 12-h recovery proved to be too short to regenerate the damaged muscle tissue. Tomczak A, Jówko E, Różański P. Survival training effects on oxidative stress and muscle damage biomarkers of naval cadets. Aerosp Med Hum Perform. 2020; 91(9):720724.

scholarly journals Readiness of military personnel for high intensity combat training course

2019 ◽  
Vol 68 ◽  
pp. 02012
Author(s):  
Liana Plavina ◽  
Silva Smagare ◽  
Andris Cakstins ◽  
Silvija Umbrasko
Keyword(s):  
Military Personnel ◽  
Muscle Tone ◽  
Military Training ◽  
Frontal Plane ◽  
Physical Load ◽  
Musculoskeletal Symptoms ◽  
Training Course ◽  
Combat Training ◽  
Anthropometric Characteristics ◽  
Health Disorders

High standards of physical ability and health are essential for Military personnel and its career. Training of military personnel in field conditions is an essential process. The aim of the study was to evaluate readiness of cadets to high physical load during the combat training course (CTC). We carried out the following: evaluated posture status, analysed anthropometric characteristics, controlled parameters of musculoskeletal system such as muscle tone, muscle strength characteristics, and provided Nordic Questionnaire list containing a figure of Human Body, where a respondent marked the regions of musculoskeletal disorder (pain). All subjects gave their informed consent to the protocol approved by the local Medical Ethics Committee of Rıga Stradiņš University for biomedical research. Combat training course has duration of ten days and includes various physical, tactical, and psychological activities in military conditions that are a compulsory part of study process in National Defence Academy of Latvia. Cadets are facing complex challenges in tactical situations where they can approve their physical abilities, endurance and psychological persistence. They have dietary and sleeping deprivation during the course. We provided standardized Nordic Questionnaire for analysis and evaluation of musculoskeletal disorders in the study group and indicated main problematic regions with musculoskeletal symptoms. The general health status of participants was checked by medical specialists in military Medical Centre and advanced examination was done by Sports medicine doctor. The aim of the study is to analyse the posture status, foot status, to make muscle functional tests that allow managing pre-courses training program for CTC participants and optimizing adaptation of participants of the course to field condition of military training. Evaluating musculoskeletal symptoms cadets indicated that main problematical regions were lower back and knee. In 77% (42/54) of cases cadets with lower limb hyper-tonus had asymmetric posture in frontal plane. Analysis of anthropometric characteristics showed that body mass index changes were in the interval from 21.34 to 33.24. BMI value for 32.2% of participants corresponded to the standards of WHO recommendations. Analysis of posture and foot status was important for provision of preventive measures and reduction of the risk of health disorders related to high physical load in military environment. Persons with expressed asymmetry of posture and foot during dynamic load and static load can have overstress with high risk of health disorders, musculoskeletal pathology and psychological overload.

scholarly journals Training Preceptors of Obstetrics-Gynecology Residents through the One-minute Preceptor Model

2021 ◽  
Vol 43 (08) ◽  
pp. 622-626
Author(s):  
Michelle Araújo Machado ◽  
Elaine Lira Medeiros
Keyword(s):  
Emergency Department ◽  
Teaching Hospital ◽  
Northeastern Brazil ◽  
Traditional Teaching ◽  
Training Course ◽  
Pedagogical Training ◽  
Before And After ◽  
Three Stages ◽  
The One

Abstract Objective To analyze the effect of the One-minute Preceptor model for preceptors who work at the emergency department of a maternity teaching hospital. Methods  A quantitative intervention study conducted with Obstetrics and Gynecology residency preceptors at a maternity teaching hospital in northeastern Brazil. Three stages were performed: 1) a preintervention survey with the residents; 2) planning and execution of a pedagogical training course for the preceptors, which involved a lecture and a dramatization about the One-Minute Preceptor model; and 3) thirty days after the intervention, the residents answered another survey about the model and its repercussions and advantages. Results The preintervention assessment with the residents showed that 91.7% agreed that there were discrepancies regarding the teaching model among the preceptors. After the training, all preceptors agreed that the model engages the student in the decision-making process, and that they would apply it to their routine. The postintervention results showed that 95.8% agreed that the model is more inviting than traditional teaching approaches. There was a perception of improvement in learning among 70.9% of the residents. In addition, the present study found a significant change in feedback before and after implementing the model, from 20.8% to 66.7%. Conclusion The training course of preceptors in the One-Minute Preceptor model proved to be efficient in providing formative feedback to residents in the emergency department of a maternity school. Further studies are needed to assess the consolidation of the methodology in the long term.

EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING

2020 ◽  
pp. 14-18
Author(s):  
A. M. Fomin
Keyword(s):  
Clinical Effect ◽  
High Efficiency ◽  
Initial Level ◽  
Synthetic Polymer ◽  
Complex Treatment ◽  
Direct Hemoperfusion ◽  
Selective Sorption ◽  
Positive Clinical Effect ◽  
Before And After

A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.

Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance

2018 ◽  
Vol 69 (8) ◽  
pp. 2172-2176
Author(s):  
Catalin Victor Sfarti ◽  
Alin Ciobica ◽  
Carol Stanciu ◽  
Gheorghe G. Balan ◽  
Irina Garleanu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoscopic Sphincterotomy ◽  
Specific Activity ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Oxidative Stress Parameter ◽  
Extrahepatic Cholestasis ◽  
Biliary Clearance ◽  
Oxidative Stress Status ◽  
Before And After

Choledocholithiasis may cause biliary obstruction which leads to hepatocellular injury. Oxidative stress has been proposed as a possible mechanism involved in this disorder. This study evaluates the oxidative stress burden in patients with choledocholithiasis and secondary cholestasis, before and after endoscopic sphincterotomy. Experimental part: Patients diagnosed with choledocholithiasis and secondary extrahepatic cholestasis were included in the study between January 1st 2016 and October 31st 2016. In all patients oxidative stress markers were collected within 2 hours before and 48 hours after therapeutic ERCP. Selected markers were superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA). The results were compared to those from a group of 40 healthy subjects. Significantly lower concentrations of SOD (p = 0.03) and GPX (p [ 0.0001) activities, associated with an increased level of MDA level (p [ 0.0001) were shown in patients before biliary clearance compared with the healthy control group. After ERCP the only oxidative stress parameter which showed improvement was the SOD specific activity (p = 0.037). This study shows that extrahepatic cholestasis secondary to choledocholithiasis is associated with increased oxidative stress status. After biliary clearance one oxidative stress marker was significantly improved (SOD), suggesting a possible antioxidant effect of such procedure.

Evidences of Brain Plasticity and Motor Control Modulation after Hemodialysis Session by Helixone Membrane: BOLD-fMRI Study

2020 ◽  
Vol 19 (6) ◽  
pp. 466-477
Author(s):  
Saïd Boujraf ◽  
Rachida Belaïch ◽  
Abdelkhalek Housni ◽  
Badreeddine Alami ◽  
Tariq Skalli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Functional Activity ◽  
Brain Plasticity ◽  
Biological Assessment ◽  
Bold Fmri ◽  
Before And After ◽  
Total Antioxidant ◽  
Inflammatory State ◽  
Functional Control ◽  
The Impact

Objective: The aim of this paper is to demonstrate the impact of hemodialysis (HD) using synthetic Helixone membrane on brain functional control reorganization and plasticity in the cortical area generated while Oxidative Stress (OS) would be the main impacting agent. Methods: Indeed, 9 chronic HD patients underwent identical brain BOLD-fMRI assessment using the motor paradigm immediately before and after the same HD sessions. To assess the oxidative stress, the same patients underwent biological-assessment, including Malondialdehyde (MDA) and Total- Antioxidant-Activity (TAOA) reported in earlier papers. Results: BOLD-fMRI maps of motor areas obtained from HD-patients before and after HD sessions revealed a significant enhancement of activation volume of the studied motor cortex after HD reflecting brain plasticity. Results were correlated with OS assessed by the measurement of MDA and TAOA; this correlation was close to 1. Conclusion: Indeed, HD enhances the inflammatory state of brain tissues reflected by the increased OS. The functional brain reaction demonstrated a functional activity reorganization to overcome the inflammatory state and OS enhanced by HD process. This functional activity reorganization reveals brain plasticity induced by OS originated by HD.

Situationism and War Crimes

2018 ◽  
Author(s):  
Matthew Talbert ◽  
Jessica Wolfendale
Keyword(s):  
Military Personnel ◽  
Military Training ◽  
War Crimes ◽  
Situational Pressures

Chapter 2 applies the situationist view to war crimes. A number of the experiments discussed in Chapter 1 focus on situations that seem directly relevant to the circumstances in which war crimes occur. For this reason, several social psychologists and philosophers argue that situationism offers the most plausible explanation of how and why war crimes occur. According to the situationist view, war crimes can occur as a result of both immediate battlefield conditions, and the ongoing situational pressures of military training and culture. Advocates of this view argue that this combination of situational forces undermines the ability of military personnel to recognize and act on relevant moral considerations, leading them to believe that certain acts, such as torture, are permissible. Thus military personnel may be unable to recognize illegal and immoral orders, even in situations arising far from the heat of battle.

scholarly journals Lost in Migration – Mirandese at a Crossroads

2019 ◽  
Vol 5 (1) ◽  
pp. 488-495
Author(s):  
Cláudia Martins ◽  
Sérgio Ferreira
Keyword(s):  
Minority Language ◽  
Three Dimensions ◽  
Highly Qualified ◽  
Linguistic Rights ◽  
The Bible ◽  
Literary Forms ◽  
Before And After ◽  
The 1960S ◽  
The One ◽  
The 19Th Century

AbstractThe linguistic rights of Mirandese were enshrined in Portugal in 1999, though its “discovery” dates back to the very end of the 19th century at the hands of Leite de Vasconcellos. For centuries, it was the first or only language spoken by people living in the northeast of Portugal, particularly the district of Miranda do Douro. As a minority language, it has always moved among three dimensions. On the one hand, the need to assert and defend this language and have it acknowledged by the country, which proudly believe(d) in their monolingual history. Unavoidably, this has ensued the action of translation, especially active from the mid of the 20th century onwards, with an emphasis on the translation of the Bible and Portuguese canonical literature, as well as other renowned literary forms (e.g. The Adventures of Asterix). Finally, the third axis lies in migration, either within Portugal or abroad. Between the 1950s and the 1960s, Mirandese people were forced to leave Miranda do Douro and villages in the outskirts in the thousands. They fled not only due to the deeply entrenched poverty, but also the almost complete absence of future prospects, enhanced by the fact that they were regarded as not speaking “good” Portuguese, but rather a “charra” language, and as ignorant backward people. This period coincided with the building of dams on the river Douro and the cultural and linguistic shock that stemmed from this forceful contact, which exacerbated their sense of not belonging and of social shame. Bearing all this in mind, we seek to approach the role that migration played not only in the assertion of Mirandese as a language in its own right, but also in the empowerment of new generations of Mirandese people, highly qualified and politically engaged in the defence of this minority language, some of whom were former migrants. Thus, we aim to depict Mirandese’s political situation before and after the endorsement of the Portuguese Law no. 7/99.

scholarly journals Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 478
Author(s):  
Ching Chang ◽  
Chien-Hao Huang ◽  
Hsiao-Jung Tseng ◽  
Fang-Chen Yang ◽  
Rong-Nan Chien
Keyword(s):  
Hepatic Encephalopathy ◽  
Real World ◽  
Ammonia Level ◽  
Decompensated Cirrhosis ◽  
Control Group ◽  
Multivariable Logistic Regression Model ◽  
Before And After ◽  
One Year ◽  
The One ◽  
Serum Ammonia

Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose for 3 to 6 months is recommended for the prevention of recurrent episodes of HE after the second episode. However, whether the combination for more than 6 months is superior to lactulose alone in the maintenance of HE remission is less evident. Therefore, the aim of this study is to evaluate the one-year efficacy of rifaximin add-on to lactulose for the maintenance of HE remission in Taiwan. Methods: We conducted a real-world single-center retrospective cohort study to compare the long-term efficacy of rifaximin add-on to lactulose (group R + L) versus lactulose alone (group L, control group). Furthermore, the treatment efficacy before and after rifaximin add-on to lactulose was also analyzed. The primary endpoint of our study was time to first HE recurrence (Conn score ≥ 2). All patients were followed up every three months until death, and censored at one year if still alive. Results and Conclusions: 12 patients were enrolled in group R + L. Another 31 patients were stratified into group L. Sex, comorbidity, ammonia level, and ascites grade were matched while age, HE grade, and model for end-stage liver disease (MELD) score were adjusted in the multivariable logistic regression model. Compared with group L, significant improvement in the maintenance of HE remission and decreased episodes and days of HE-related hospitalizations were demonstrated in group R + L. The serum ammonia levels were significantly lower at the 3rd and 6th month in group 1. Concerning changes before and after rifaximin add-on in group R + L, mini-mental status examination (MMSE), episodes of hospitalization, and variceal bleeding also improved at 6 and 12 months. Days of hospitalization, serum ammonia levels also improved at 6th month. Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.

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