scholarly journals Association between Serum Alanine Transaminase and Cardiometabolic Risk in Overweight and Obese Children

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Haq T ◽  
Hannan MA ◽  
Hasanat MA ◽  
Fariduddin M
Keyword(s):  
Cardiometabolic Risk ◽  
Alanine Transaminase ◽  
Obese Children

Effectiveness of a Multidisciplinary Lifestyle Intervention to Reduce Obesity among Children and Adolescents

2020 ◽  
Vol 35 (2) ◽  
pp. 111-118
Author(s):  
Md Rizwanul Ahsan ◽  
Sabrina Makbul ◽  
Probir Kumar Sarkar
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Children And Adolescents ◽  
Physical Performance ◽  
Cardiometabolic Risk ◽  
Dietary Habits ◽  
Obese Children ◽  
Height Ratio ◽  
Waist To Height Ratio ◽  
Family Based

Background: Now a days unhealthy lifestyle primarily responsible for the dramatic increase obesity among children and adolescents. Objective: The purpose of the study is to see the effects of a multidisciplinary lifestyle intervention to reduce obese children and adolescents. The main outcome was cardiometabolic risk based on the waist-to-height ratio (WHTR) measurement. Secondary outcomes were (1) changes in body composition; (2) adherence to a Mediterranean diet; and (3) physical performance. Methods: The study involved 64 overweight/obese children or adolescents conducted at Dhaka Shishu Hospital from October 2017 to September 2018. The intervention was multidisciplinary including nutrition, exercise, and psychological aspects based on a family-based approach; it was delivered for six months for children and three months for adolescents. Before and after the intervention, several anthropometric measures height, body weight, body mass index (BMI), waist circumference, and body composition, cardiometabolic risk index waist-to-height ratio (WHTR), and dietary habits of the participants and their families were evaluated. In addition, a set of functional motor fitness tests was performed to evaluate physical performance measures. Results: After the intervention both children and adolescents showed a significant reduction in body weight, BMI, waist circumference, fat mass, and WHTR index and an improvement of fat-free mass, adherence to the Mediterranean diet, and physical fitness performance. Conclusion: A short term family-based multidisciplinary approach is effective in ameliorating the health status, dietary habits, and physical performance in children and adolescents. DS (Child) H J 2019; 35(2) : 111-118

Bisphenol A and cardiometabolic risk factors in obese children

2014 ◽  
Vol 470-471 ◽  
pp. 726-732 ◽  
Author(s):  
Naila Khalil ◽  
James R. Ebert ◽  
Lei Wang ◽  
Scott Belcher ◽  
Miryoung Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bisphenol A ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

scholarly journals High normal post-load plasma glucose, cardiometabolic risk factors and signs of organ damage in obese children

Obesity ◽  
2014 ◽  
Vol 22 (8) ◽  
pp. 1860-1864 ◽  
Author(s):  
Procolo Di Bonito ◽  
Maria Rosaria Licenziati ◽  
Marco Giorgio Baroni ◽  
Tiziana Congiu ◽  
Michela Incani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasma Glucose ◽  
Cardiometabolic Risk ◽  
Organ Damage ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

scholarly journals Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function

2016 ◽  
Vol 116 (5) ◽  
pp. 805-815 ◽  
Author(s):  
Liane Correia-Costa ◽  
Teresa Sousa ◽  
Manuela Morato ◽  
Dina Cosme ◽  
Joana Afonso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Renal Function ◽  
Cardiometabolic Risk ◽  
Linear Trend ◽  
Normal Weight ◽  
No Production ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional

AbstractOxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8–9 years. Anthropometrics, 24-h ambulatory blood pressure, pulse wave velocity (PWV), insulin resistance (homoeostasis model assessment index (HOMA-IR)), inflammatory/metabolic biomarkers, estimated glomerular filtration rate (eGFR), plasma total antioxidant status (TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were compared among normal weight, overweight and obese groups, according to WHO BMI z-score reference. U-Isop were increased in the obese group, whereas U-NOx were increased in both overweight and obese children. U-Isop were positively correlated with U-H2O2, myeloperoxidase (MPO), high-sensitivity C-reactive protein, HOMA-IR and TAG. TAS correlated negatively with U-Isop and MPO and positively with PWV. HOMA-IR and U-H2O2 were associated with higher U-Isop, independently of BMI and eGFR, and total cholesterol and U-H2O2 were associated with U-NOx, independently of BMI, eGFR values and P-NOx concentration. In overweight and obese children, eGFR decreased across P-NOx tertiles (median: 139·3 (25th, 75th percentile 128·0, 146·5), 128·0 (25th, 75th percentile 121·5, 140·4), 129·5 (25th, 75th percentile 119·4, 138·3), Pfor linear trend=0·003). We conclude that oxidant status and NO are increased in relation to fat accumulation and, even in young children, they translate into higher values of cardiometabolic risk markers and affect renal function.

scholarly journals Differences in Cardiometabolic Risk between Insulin-Sensitive and Insulin-Resistant Overweight and Obese Children

2015 ◽  
Vol 11 (3) ◽  
pp. 289-296 ◽  
Author(s):  
Unab I. Khan ◽  
Aileen P. McGinn ◽  
Carmen R. Isasi ◽  
Adriana Groisman-Perelstein ◽  
Pamela M. Diamantis ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Obese Children ◽  
Insulin Resistant

scholarly journals Screening for Non-Alcoholic Fatty Liver Disease (NAFLD) among Obese and Overweight Children: Prevalence and predictors

2021 ◽  
Author(s):  
Srinivasan Thiagarajan ◽  
Sadhanandham Shrinuvasan ◽  
Thirunavukkarasu Arun Babu
Keyword(s):  
Liver Disease ◽  
Fatty Liver Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Alanine Transaminase ◽  
Overweight Children ◽  
Obese Children ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Non- alcoholic fatty liver disease (NAFLD) is increasingly recognised in obese and overweight children. NAFLD is the most common cause of chronic liver disease in these children. Objectives: To assess the prevalence of NAFLD and to identify the anthropometric, metabolic risk factors for NAFLD. Materials and methods: This cross sectional study was done with 154 overweight and obese children. The study population was divided into 2 groups based on the presence or absence of NAFLD by screening with ultrasonography and/or alanine transaminase levels. Anthropometric (Body mass index, waist circumference) and biochemical parameters (Total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein, Insulin, Homeostasis model assessment of insulin resistance (HOMA-IR), alanine transaminase, aspartate transaminase) were compared between these two groups. Results: NAFLD was diagnosed based on abnormal screening in 79 (51.3 %) overweight and obese children.. No age or gender difference was noted between 2 groups. NAFLD patients did not differ significantly from patients without NAFLD in age, Body mass index, systolic blood pressure, diastolic blood pressure and waist circumference. LDL Cholesterol levels were found significantly higher in the NAFLD group. There was no significant difference found in lipid profile apart from LDL cholesterol, aspartate transaminase and HOMA-IR between 2 groups. Conclusion: NAFLD is common in overweight and obese South Indian children. High LDL cholesterol level is a risk factor for NAFLD in these children. Screening of this high risk group for early diagnosis of NAFLD is essential to prevent and monitor further progression of the disease.

URIC ACID IS ASSOCIATED WITH CARDIOMETABOLIC RISK FACTORS IN OVERWEIGHT AND OBESE CHILDREN AND ADOLESCENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e18
Author(s):  
J. Alvarez ◽  
P. Redon ◽  
M. Torro ◽  
F. Aguilar ◽  
J. Redon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

Relationship between insulin resistance and puberty in children with increased cardiometabolic risk

2011 ◽  
Vol 152 (27) ◽  
pp. 1068-1074 ◽  
Author(s):  
Borbála Tobisch ◽  
László Blatniczky ◽  
László Barkai
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Cardiometabolic Risk ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Obese Children ◽  
T1 Stage

Epidemiologic data provide evidence that the frequency of obesity and cardiometabolic risk factors shows an increasing tendency in childhood. Insulin resistance plays a central role in the pathogenesis of cardiovascular and metabolic consequences of obesity. Transient decrease in the insulin sensitivity during puberty is a well-known physiological process; however, the feature of this phenomenon is not clear in obese children with increased cardiometabolic risk. Aim: The aim of the present study was to assess the effect of puberty on insulin resistance and metabolic parameters in obese children with and without increased cardiometabolic risk. Materials and methods: Anthropometric data, insulin levels during oral glucose tolerance test and lipid status were analyzed of 161 obese children aged 4-18 years. Σinsulin/Σglucose ratio was obtained during glucose load and HOMA index was used to assess insulin resistance. Children were sorted into prepubertal (T1), pubertal (T2-4) and postpubertal (T5) cohorts according to Tanner staging criteria and metabolic and insulin resistance parameters were evaluated. Increased cardiometabolic risk was defined as the presence of any two risk factors (elevated fasting plasma glucose, blood pressure, triglyceride or decreased HDL-cholesterol) in addition to obesity. Results: Out of 161 obese subjects, 43 (26.7%) had increased cardiometabolic risk. Decreased HDL-cholesterol and/or elevated triglyceride was observed in 101 (56.5%) cases. Impaired glucose tolerance and/or impaired fasting glucose was found in 23 (14.4%) cases. In subjects without increased cardiometabolic risk, the Σinsulin/Σglucose ratio in T1 stage was significantly lower than in T2-4 and T5 stages (p = 0.01). In children with increased cardiometabolic risk, the insulin/glucose ratio was similar in T1, T2-4 and T5 stages, however, it was significantly higher in T1 stage as compared to subjects without increased cardiometabolic risk (p = 0.04). In T2-4 and T5 stages, Σinsulin/Σglucose ratio did not differ between children with and without increased cardiometabolic risk. No difference was found in HOMA index between groups with and without increased cardiometabolic risk in T1 stage, however significantly higher levels were observed in subjects with increased cardiometabolic risk at T2-4 stages (p = 0.01), indicating the presence of fasting hyperinsulinemia in this cohort. Elevated HbA1c (≥6.0%) was found in 13 (16%) out of the 81 children investigated, of whom only two cases had abnormal oral glucose tolerance test. In cases having normal HbA1c, oral glucose tolerance test showed impaired glucose tolerance in 5 cases, impaired fasting glucose in 2 cases, both impaired glucose tolerance and impaired fasting glucose in 2 cases, and type 2 diabetes in 2 cases. Conclusion: Increased insulin resistance can be observed in obese children without increased cardiometabolic risk. In obese children with increased cardiometabolic risk, substantial insulin resistance occurs in prepuberty and it is present at similar level throughout puberty. Fasting insulin levels are elevated in obese subjects with increased cardiometabolic risk as compared to those without increased cardiometabolic risk. To reveal type 2 diabetes cases, HbA1c and oral glucose tolerance test results should be assessed parallel. Orv. Hetil., 2011, 152, 1068–1074.

Visfatin and its genetic variants are associated with obesity-related morbidities and cardiometabolic risk in severely obese children

2013 ◽  
Vol 9 (2) ◽  
pp. 81-91 ◽  
Author(s):  
S. Q. Ooi ◽  
R. M. E. Chan ◽  
L. K. S. Poh ◽  
K. Y. Loke ◽  
C. K. Heng ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Cardiometabolic Risk ◽  
Obese Children ◽  
Severely Obese
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