scholarly journals COVID-19: Threat or Opportunity?

2020 ◽  
Vol 38 (3) ◽  
Author(s):  
Mozhgan Rivaz ◽  
Seyed Mojtaba Kazemi ◽  
Mina Mosallanezhad
Keyword(s):  
Herd Immunity ◽  
Healthcare Providers ◽  
The Novel ◽  
Social Psychological ◽  
Mortality And Morbidity ◽  
Cultural Aspects ◽  
The World ◽  
Distribution Of Resources ◽  
The Face ◽  
Novel Coronavirus

The COVID-19 pandemic is spreading quickly. Despite scientists’ best efforts all over the world, there is not a vaccine or definite treatment for it and the novel coronavirus remains a threat to humanity with far-reaching, and in many cases, irredeemable consequences for the economic, political, social-psychological , and cultural aspects of humans’ lives.(1)The quick transmission and fatality of the disease, absence of herd immunity, lack of or inequitable distribution of resources, e.g. Personal Protective Equipment ( PPE), and the existing challenges in the implementation of social distancing result in a daily increase in the number of victims and, consequently, an ever-expanding workload in healthcare systems worldwide. Moreover, the increasing mortality and morbidity of COVID-19 and lack of hospital beds and ventilators have led to healthcare provider’s exhaustion and burnout.(1,2) Healthcare providers, especially nurses are the most vulnerable group in the face of the current disaster. Unfortunately, In the world, many front-line experts have lost their lives.(3)

NEW INSPIRATION FROM CHINA'S PHILOSOPHY OF "UNITY OF MAN AND HEAVEN": CONTEMPORARY INTERNATIONAL RELATIONS UNDER THE COVID-19 PANDEMIC

2021 ◽  
pp. 21-34
Author(s):  
PU JINGXIN
Keyword(s):  
International Relations ◽  
Human Society ◽  
The Novel ◽  
The World ◽  
The Face ◽  
New Type ◽  
Novel Coronavirus ◽  
The Ancient Chinese ◽  
Self Protection ◽  
Harmonious Community

Abstract: The danger of the novel coronavirus has not yet come to an end, and new variants have begun to attack the world. What philosophy should humankind’s strategy be based on when human society as a group is fighting against Covid-19, as the pandemic ravages the world? Unfortunately, political leaders of various countries have failed to achieve the overall awareness of attacking the pandemic for a shared future for mankind so far. In the face of the pandemic, mankind as a whole urgently needs to break through the narrow nation-oriented ideology of seeking only self-protection. The International Community should establish a new type of international cooperation featuring the concept of harmony of "all things under heaven as a unity". The international relations system dominated by the power ofwestern discourse is now in a bottleneck. The main aim of this article is to study the ancient Chinese wisdom of "the Unity of Man and Heaven" philosophy and build a global harmonious community. The author argues that the “export” of the aforementioned wisdom must be a priority for Chinese scholars. Keywords: Tao; Unity of Man and Heaven; Novel Coronavirus; Anthropocentrism; Harmony.

scholarly journals Modeling the incidence and death rates of COVID-19 pandemic in different regions of the world

2020 ◽  
Vol 9 (s1) ◽  
Author(s):  
Ricardo Puziol de Oliveira ◽  
Jorge Alberto Achcar ◽  
Altacílio Aparecido Nunes
Keyword(s):  
The Novel ◽  
Factors Affecting ◽  
Health Authorities ◽  
Global Pandemic ◽  
Counting Data ◽  
Proposed Model ◽  
The World ◽  
Hard Times ◽  
The Face ◽  
Novel Coronavirus

AbstractThis paper reports a broad study using epidemic-related counting data of COVID-19 disease caused by the novel coronavirus (SARS-CoV-2). The considered dataset refers to 119 countries’ daily counts of reported cases and deaths in a fixed period. For the data analysis, it has been adopted a beta regression model assuming different regions of the world where it was possible to discover important economic, health and social factors affecting the behavior of the pandemic in different countries. The Bayesian method was applied to fit the proposed model. Some interesting conclusions were obtained in this study, which could be of great interest to epidemiologists, health authorities, and the general public in the face of the forthcoming hard times of the global pandemic.

scholarly journals Àgbájọ Ọwọ́ : An African Moral Theory of Survival in the Age of Covid-19

2021 ◽  
Vol 4 (2) ◽  
pp. 12-21
Author(s):  
Abosede Priscilla Ipadeola
Keyword(s):  
Infectious Diseases ◽  
Moral Theory ◽  
Ethical Theory ◽  
The Novel ◽  
Human Beings ◽  
The World ◽  
Impending Death ◽  
The Face ◽  
Capitalist World ◽  
Novel Coronavirus

This paper examines some of the moral questions surrounding the novel coronavirus, the cause of a new pandemic that just hit the world between late 2019 and early 2020. Coronaviruses are highly contagious and deadly infectious diseases, and victims are urged to do all within their power to ensure that the infection is not spread to healthy people. The central questions involved include the following: why should a person suffer and possibly die alone due to an infection that they must have contracted from someone else? Why should they choose to act ethically in the face of impending death? Why should people who have contracted the disease through no known fault of their own choice to protect others from contracting it? In summary, why should a person who has contracted coronavirus act selflessly? When the cure is eventually discovered, why should knowledge of it be democratized in a capitalist world? These are some of the questions that this paper addresses by juxtaposing Hobbes’ argument that human beings are fundamentally selfish with the African ethical theory of Àgbájọ ọwọ́. The paper argues that the moral theory, which enhances survival is best in the age of the COVID-19 pandemic.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

Mansfield Park

2008 ◽  
Author(s):  
Jane Austen ◽  
Jane Stabler
Keyword(s):  
The Novel ◽  
Mansfield Park ◽  
Sexual Jealousy ◽  
The Family ◽  
The World ◽  
The Face

‘Me!’ cried Fanny … ‘Indeed you must excuse me. I could not act any thing if you were to give me the world. No, indeed, I cannot act.’ At the age of ten, Fanny Price leaves the poverty of her Portsmouth home to be brought up among the family of her wealthy uncle, Sir Thomas Bertram, in the chilly grandeur of Mansfield Park. There she accepts her lowly status, and gradually falls in love with her cousin Edmund. When the dazzling and sophisticated Henry and Mary Crawford arrive, Fanny watches as her cousins become embroiled in rivalry and sexual jealousy. As the company starts to rehearse a play by way of entertainment, Fanny struggles to retain her independence in the face of the Crawfords’ dangerous attractions; and when Henry turns his attentions to her, the drama really begins… This new edition does full justice to Austen’s complex and subtle story, placing it in its Regency context and elucidating the theatrical background that pervades the novel.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

scholarly journals Management challenges in patients with comorbid COVID-19 associated delirium and serious mental illness – A case series

2021 ◽  
pp. 009121742098597
Author(s):  
Saba Syed ◽  
Michael Couse ◽  
Rashi Ojha
Keyword(s):  
Mental Illness ◽  
Serious Mental Illness ◽  
Healthcare Providers ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Active Management ◽  
The Novel ◽  
Psychiatric Facility ◽  
Medical Teams ◽  
Novel Coronavirus

Background There is still a lot unknown about the novel Coronavirus Disease 19 (COVID-19) and its effects in humans. This pandemic has posed several challenging clinical situations to healthcare providers. Objective We hope to highlight the distinctive challenges that COVID-19 presents in patients with serious mental illness and what steps primary medical teams can take to co-manage these patients with the psychiatry consultants. Methods We present a retrospective chart review of four patients who were on psychotropic polypharmacy and admitted to our hospital from the same long-term psychiatric facility with COVID-19 delirium and other associated medical complications. Results We illustrate how the primary medical teams and psychiatrists collaborated in clinical diagnosis, treatment, and management. Conclusions Patients with serious mental illness and COVID-19 infection require active collaboration between primary medical teams and psychiatrists for diagnostic clarification, reduction of psychotropic polypharmacy to avoid adverse effects and drug-drug interactions, prevention of psychiatric decompensation, and active management of agitation while balancing staff and patient safety concerns.

Sign in / Sign up

Export Citation Format

Share Document