scholarly journals Role of traditional medicines in the management of cancer

2014 ◽  
Vol 2 (4) ◽  
pp. 215-224
Author(s):  
Mohammed Husain G ◽  
Abdul Waheed M
Keyword(s):  
Side Effects ◽  
Therapeutic Potential ◽  
Scientific Data ◽  
Driving Factors ◽  
Biologically Active ◽  
Traditional Medicines ◽  
Cancer Management ◽  
Tumour Remission

Context: Increasing numbers of cancer patients are looking towards traditional medicines (TM) in an effort to sustain tumour remission or halt the metastasis. TM such as Chinese Traditional Medicines, Ayurveda and Unani Medicines are being used in many parts of world from centuries. However, scientific data is lacking for the clinical use of majority of these medicines in cancer management and systematic clinical evaluation is mandatory before recommending long term use. Objective: The role of traditional medicine for prevention and management of cancer are reviewed in this paper which will help to take a step further to bring these TM into mainstream therapy. Methods: Traditional knowledge about the claims of therapeutic potential is collected. Emphasis was given to the use of plant derived products. Further efforts were made to identify the driving factors for use of such TM for the cure of cancer. Results: There are several driving factors which attract patients towards TM out of which minimum side effects of TM remains on the priority. Apart from being used as standalone therapy, TM is progressively becoming more popular as adjuvant therapy to improve effectiveness of conventional treatment and to reduce the side effects of chemotherapy or radiation therapy. Conclusion: Patients are inclining towards TM due to diverse reasons. The search for anticancer drugs from herbs has been very productive and advances in pharmacological techniques have exerted enormous drive on the research and development of new biologically active compounds of plant origin, which may act alone or in synergistic manner.

Placental Therapy as Panacea: An Insight to Its Therapeutic Potential

2020 ◽  
Vol 06 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Madhu Gupta ◽  
Ramesh K. Goyal
Keyword(s):  
Tissue Regeneration ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Bioactive Components ◽  
Biochemical Mechanisms ◽  
Clinically Significant ◽  
Available Information ◽  
Clinical Potential ◽  
Placental Extract

Abstract:: The placenta that maintains and regulates the growth of fetus, consists of various biological treasures nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Their therapeutic usefulness can well define in the terms of biochemical mechanisms of various components present in it. Biomedical waste derived extract is also a panacea for treatment of various diseases. Placental therapy has been reported specifically to have potent action on recovery of diseases and tissue regeneration. Placental bioactive components and their multi targeting identity prompted us to compile the précised information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with clinically significant statistical conclusions. In the light of available information and the usefulness of the placental extract, it is necessary for the development of various formulations for various unmet meet for the treatment as well as access their adverse effects as well as contradictions and precisely evaluated in the short and in the long-term periods.

scholarly journals Natural Antioxidants in Anemia Treatment

2021 ◽  
Vol 22 (4) ◽  
pp. 1883
Author(s):  
Coralia Cotoraci ◽  
Alina Ciceu ◽  
Alciona Sasu ◽  
Anca Hermenean
Keyword(s):  
Plant Extracts ◽  
Iron Homeostasis ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
Natural Antioxidants ◽  
Peptide Hormone ◽  
Biologically Active ◽  
Major Public Health Problem ◽  
Stomach Pain

Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

scholarly journals Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Binaya Wasti ◽  
Zhifeng Chen ◽  
Yi Ke ◽  
Wen Tao Duan ◽  
Shao-Kun Liu ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Sex Hormones ◽  
Human Body ◽  
Therapeutic Potential ◽  
Corticosteroid Treatment ◽  
Sex Hormone ◽  
Asthma Prevalence ◽  
Term Survival

Sex hormone has become a “hot topic” to evaluate the hormonal therapeutic potential in severe asthma. Th17 cell is one of the main influencing factors involved in the pathogenesis of severe asthma, hence also called as kernel of severe asthma, and Th17 subtype of non-T2 asthma is less responsive (resistance) to inhaled corticosteroid (ICS), so severe in nature. Methyl-CpG binding domain protein 2 (MBD2) is overexpressed and regulates the Th17 differentiation, showing the possibility of therapeutic target in treating Th17 mediated severe asthma. Sex hormone fluctuates at the different physiobiological conditions of the human body and affects the asthma pathobiology showing its role in asthma prevalence, severity, remission, and therapy. This review briefly overviews the sex hormones, their influence in asthma at the different physiobiological conditions of human body, and MBD2 severe asthma connection with the possible therapeutic potential of sex steroids in MBD2 mediated Th17 predominant severe asthma. Male sex hormone tends to show a beneficial effect and possibly downregulates the expression of Th17 cells via regulating MBD2 through a mechanism distinct from corticosteroid treatment and guides us towards discovery of new therapeutic agent, reduces the asthma-related complications, and promotes long-term survival by lowering the risk of therapy-resistant issues of old age severe asthma.

scholarly journals Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Supriya D. Mahajan ◽  
Gregory G. Homish ◽  
Amanda Quisenberry
Keyword(s):  
Smoking Cessation ◽  
Microglial Activation ◽  
Therapeutic Potential ◽  
Nicotine Addiction ◽  
Neural Adaptations ◽  
Nicotine Abuse ◽  
Neuro Inflammation ◽  
Withdrawal Effects

Nicotine is the primary pharmacologic component of tobacco, and its highly addictive nature is responsible for its widespread use and significant withdrawal effects that result in challenges to smoking cessation therapeutics. Nicotine addiction often begins in adolescence and this is at least partially attributed to the fact that adolescent brain is most susceptible to the neuro-inflammatory effects of nicotine. There is increasing evidence for the involvement of microglial cells, which are the brain's primary homeostatic sensor, in drug dependence and its associated behavioral manifestations particularly in the adolescent brain. A hallmark of neuro-inflammation is microglial activation and activation of microglia by nicotine during adolescent development, which may result in long-term addiction to nicotine. This non-systematic review examines multifactorial etiology of adolescent nicotine addiction, neurobiology of nicotine addiction and the potential mechanisms that underlie the effects of nicotine on inflammatory signaling in the microglia, understanding how nicotine affects the adolescent brain. We speculate, that modulating homeostatic balance in microglia, could have promising therapeutic potential in withdrawal, tolerance, and abstinence-related neural adaptations in nicotine addiction, in the adolescent brain. Further, we discuss nicotine addiction in the context of the sensitization-homeostasis model which provides a theoretical framework for addressing the potential role of microglial homeostasis in neural adaptations underlying nicotine abuse.

The role of medication

2017 ◽  
Author(s):  
Tom Burns ◽  
Mike Firn
Keyword(s):  
Side Effects ◽  
Antipsychotic Medication ◽  
Mood Stabilizers ◽  
Clozapine Therapy

This chapter focuses mainly on the importance of maintenance antipsychotic medication and mood stabilizers. It examines procedures to support persistence with these drugs and maintain engagement. The techniques for initiating and monitoring clozapine therapy in the community for patients with resistant schizophrenia are outlined. The practical processes for ensuring and conducting regular structured reviews of long-term medication, both to assess progress and to identify side effects, are described in detail. In addition, the judicious use of antidepressants and benzodiazepines is outlined.

Therapeutic Advances in Myeloproliferative Neoplasms: The Role of New-Small Molecule Inhibitors

2012 ◽  
pp. 406-410 ◽  
Author(s):  
Srdan Verstovsek
Keyword(s):  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Myeloproliferative Neoplasms ◽  
Janus Kinase ◽  
Treatment Focus ◽  
Rational Combination ◽  
Short And Long Term ◽  
Jak2 Inhibitors

Overview: The discovery that a somatic point mutation (JAK2V617F) in the Janus kinase 2 ( JAK2) is highly prevalent in patients with myeloproliferative neoplasms (MPNs) has been a crucial breakthrough in our understanding of the underlying molecular mechanisms of these diseases. Therefore, preclinical and clinical research in recent years has focused intensely on the development of new therapies targeted to JAK2. These efforts culminated in recent approval of ruxolitinib as the first official therapy for patients with intermediate- or high-risk myelofibrosis (MF). Therapy with JAK2 inhibitors substantially improves quality of life and reduces organomegaly in MF with or without JAKV617F mutation. Recent results suggest that patients with advanced MF may live longer when receiving therapy with ruxolitinib. However, JAK2 inhibitors do not eliminate the disease and new medications are needed to expand on the benefits seen with JAK2 inhibitors. Although many agents are still in the early stages of development, the wealth of publications and presentations has continued to support our growing understanding of the pathophysiology of MF as well as the potential short- and long-term outcomes of these new and diverse approaches to treatment. Focus of ongoing efforts is particularly on the improvements in anemia and fibrosis, as well as on rational combination trials of JAK2 inhibitors and other potentially active agents. Therapeutic potential and limitations of JAK2 inhibitors and other novel medications in clinical studies are reviewed.

scholarly journals A ROLE OF JALUAKAAVCHARANAAND NIMBA HARIDRACHOORNA LEPA IN TREATMENT OF INDRALUPTA - A CASE STUDY

2021 ◽  
Vol 9 (6) ◽  
pp. 1299-1302
Author(s):  
Sejalgamit Sejalgamit
Keyword(s):  
Side Effects ◽  
Female Patient ◽  
Hair Loss ◽  
Medical Science ◽  
Modern Science ◽  
Human Being ◽  
Contemporary Science

Hair is crowning glory and mark of identity of human being. Indralupata in modern science correlate with alopecia aereata. It is characterized by localised areas of non-scarring hair loss which can be co-related with indralupta. Due to side effects and limitation of contemporary science, some harmless and effective medicines are expected from alternative medical science. indralupta disease is described under heading of kshudraroga by sushruta, vagbhata etc.in modern science its main treatment is corticosteroids which is having harmful side effects and not advisable for long term use.so it is necessary to find better remedies .it can be easily fulfilled by Ayurveda. Here, a case of female patient suffering from indralupta was successfully treated with jaluaka and haridra and nimbalepa. Keywords: kshudraroga, indralupta, jaluaka, haridra and nimbalepa

scholarly journals Role of centchroman versus danazol in treatment of benign breast disorders

2021 ◽  
Vol 8 (2) ◽  
pp. 616
Author(s):  
Hanuman Ram Khoja ◽  
Bodu Ram Barala ◽  
Saurabh Sharma ◽  
Prabha Om ◽  
Devendra Saini
Keyword(s):  
Side Effects ◽  
Menstrual Cycle ◽  
Dynamic Structure ◽  
Physiological Changes ◽  
Lump Size ◽  
Medical College ◽  
Menstrual Irregularities ◽  
Lh Rh

Background: The breast is a dynamic structure that undergoes cyclical changes throughout the menstrual cycle. Any aberration from normal physiological changes in breast produces different problem in breast. Many drugs are used for treatment for these disorders like Danazol, Bromocriptine, Tamoxifen and LH-RH analogue but still no consensus for any drug is present.Methods: The aim of our study was to analyze the effectiveness of drug Centchroman and its comparison with Danazol in treatment of benign breast disorders in respect to symptoms relief, decrease in nodularity and lump size, recurrence, cost and side effects of drug. This prospective study was conducted on 250 patients of benign breast disorders attending surgical OPD between May 2018 to September 2019 in SMS medical college and Hospital, Jaipur.Results: Tolerance and improvements in symptoms in centchroman group was more than danazol (100% vs 92.8%) with less recurrence in former group. While side effects varied between the two groups with menstrual irregularities more common in centchroman group.Conclusions: The study shows that centchroman is safe, more effective and less expensive to Danazol for the treatment of benign breast disorders in long term.

scholarly journals Role of Mifepristone in treatment of uterine fibroid: an experience from tertiary care centre in South India

2019 ◽  
Vol 8 (3) ◽  
pp. 974
Author(s):  
S. V. Nachiketha ◽  
Veena Hadi
Keyword(s):  
Side Effects ◽  
Uterine Fibroid ◽  
Tertiary Care ◽  
Reproductive Age ◽  
Tertiary Care Centre ◽  
Common Benign Tumour ◽  
Fibroid Volume ◽  
Reproductive Age Group

Background: Uterine fibroid are the most common benign tumour of the uterus and is seen in 20% of women in their reproductive age group. The aim of the study was to evaluate effect of Mifepristone on uterine fibroid with reference to reduction in size of fibroid and change in symptomatic profile.Methods: It is a hospital based interventional study conducted at KIMS Hubli hospital. 98 patients with symptomatic fibroid uterus were given 50mg of Mifepristone on alternate day for 3 months.Results: Mifepristone treatment significantly reduced mean PBAC score from baseline score of 212.61 to 20.39 at the end of 3rd month of therapy. Mean fibroid volume also reduced significantly from baseline value of 237.95cm3 to 30.45cm3 after 3 months of treatment. At the end of therapy hemoglobin was raised from 9.57g/dl at baseline to 10.42g/dl after 3 months of treatment. No major side effects were observed, and 7% patients had hysterectomy.Conclusions: Mifepristone is very useful option in perimenopausal women with symptomatic fibroid. It reduces fibroid size and its symptoms without any major side effects. However, future long term RCTs are needed to assess the safety and efficacy of Mifepristone.

The Role of Bioactive Compounds and other Metabolites from Mushrooms against Skin Disorders- A Systematic Review Assessing their Cosmeceutical and Nutricosmetic Outcomes

2020 ◽  
Vol 27 (41) ◽  
pp. 6926-6965
Author(s):  
Oludemi Taofiq ◽  
Maria Filomena Barreiro ◽  
Isabel C.F.R. Ferreira
Keyword(s):  
Systematic Review ◽  
Bioactive Compounds ◽  
Skin Diseases ◽  
Scientific Data ◽  
Inflammatory Skin Diseases ◽  
Toxicological Studies ◽  
Pros And Cons ◽  
Long Term Studies

Bioactive compounds derived from mushrooms have been shown to present promising potential as cosmeceutical or nutricosmetic ingredients. Scientific data reviewed herein showed that extracts prepared from medicinal and edible mushrooms and their individual metabolites presented antiinflammatory, antioxidant, photoprotective, antimicrobial, anti-tyrosinase, anti-elastase, and anticollagenase activities. These metabolites can be utilised as ingredients to suppress the severity of Inflammatory Skin Diseases, offer photoprotection to the skin, and correct Hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps from the fruiting bodies to the final product: extraction optimization, estimation of the efficacy and safety claims, the use of micro and nanocarriers to allow for controlled release and the pros and cons associated with the use of extracts vs individual compounds. This systematic review highlights that mushrooms contain diverse biomolecules that can be sustainably used in the development of nutricosmetic and cosmeceutical formulations. Reports regarding stability, compatibility, and safety assessment, but also toxicological studies are still needed to be considered. Furthermore, some of the constraints and limitations hindering the development of this type of ingredients still require long-term studies to achieve major breakthroughs.

Sign in / Sign up

Export Citation Format

Share Document