scholarly journals Effects of virtual reality on social participation after stroke: a systematic review

2020 ◽  
pp. 1-6
Author(s):  
Letícia Costa Queiroz ◽  
Kênia Kiefer Parreiras de Menezes ◽  
Patrick Roberto Avelino
Keyword(s):  
Systematic Review ◽  
Virtual Reality ◽  
Social Participation ◽  
Experimental Studies ◽  
Control Group ◽  
Permanent Disability ◽  
Unified Health System ◽  
The Social ◽  
Local Supply

Background: The cerebrovascular accident (CVA), or stroke, is characterized as a vascular injury occurring in the nervous tissue, in which there is interruption in the blood flow with consequent loss of the local supply of nutrients and oxygen, leading to tissue death. According to data from the Unified Health System and other studies, the CVA represents the greatest cause of death and permanent disability in Brazil. Objectives: The objective of this study was to perform a systematic review of the literature, searching for evidence of the effects of the use of the rehabilitation based on virtual reality to help recover the social participation of hemiparetic subjects after stroke. Methods: Searches were conducted on Medline, CINAHL, Web of Science, LILACS and PEDro databases, without restriction regarding the language and publication year of the study. The articles were evaluated by title, abstract and full text and, finally, selected in relation to the eligibility by two independent authors. The methodological quality of the included experimental studies was evaluated according to the PEDro scale. Results: Among the 11 articles included in the present review, only 4 demonstrated significant effects of virtual reality training on social participation/quality of life of hemiparetic subjects, when compared to the control group. Conclusion: The studies analyzed show that although there seems to be benefits of using virtual reality in global aspects of hemiparetic patient recovery, such as in motor function, the results are still not consistent regarding the social participation.

scholarly journals Virtual reality in assessment and treatment of schizophrenia: a systematic review

2015 ◽  
Vol 64 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Mônica Macedo ◽  
António Marques ◽  
Cristina Queirós
Keyword(s):  
Systematic Review ◽  
Virtual Reality ◽  
Software Maintenance ◽  
Social Inclusion ◽  
Experimental Studies ◽  
Participation Rate ◽  
The Social ◽  
Assessment And Treatment ◽  
Business Source Premier ◽  
Academic Search

Objective To conduct a systematic review about the use of virtual reality (VR) for evaluation, treatment and/or rehabilitation of patients with schizophrenia, focused on: areas, fields and objectives; methodological issues; features of the VR used; viability and efficiency of this resource. Methods Searches were performed about schizophrenia and virtual reality in PsycINFO, Academic Search Complete, MEDLINE Complete, CINAHL with Full Text, Web of Science and Business Source Premier databases, using the following keywords: [“schizophrenia”] AND [“virtual reality” OR “serious game”] AND [“treatment” OR “therapy” OR “rehabilitation”]. The search was carried out between November 2013 and June 2014 without using any search limiters. Results A total of 101 papers were identified, and after the application of exclusion criteria, 33 papers remained. The studies analysed focused on the use of VR for the evaluation of cognitive, social, perceptual and sensory skills, and the vast majority were experimental studies, with virtual reality specifically created for them. All the reviewed papers point towards a reliable and safe use of VR for evaluating and treating cognitive and social deficits in patients with schizophrenia, with different results in terms of generalisation, motivation, assertiveness and task participation rate. Some problems were highlighted, such as its high cost and a constant need for software maintenance. Conclusion The studies show that using the virtual reality may streamline traditional evaluation/rehabilitation programmes, allowing to enhance the results achieved, both in the cognitive and in the social field, helping for the legitimisation of this population’s psycho-social inclusion.

Epistemic and relational conflicts in sharing identical vs. complementary information during cooperative learning

2002 ◽  
Vol 61 (3) ◽  
pp. 139-151 ◽  
Author(s):  
Céline Darnon ◽  
Céline Buchs ◽  
Fabrizio Butera
Keyword(s):  
Cooperative Learning ◽  
Social Comparison ◽  
Positive Relationship ◽  
Learning Task ◽  
Control Group ◽  
Complementary Information ◽  
Relational Conflict ◽  
The Social ◽  
The University

When interacting on a learning task, which is typical of several academic situations, individuals may experience two different motives: Understanding the problem, or showing their competences. When a conflict (confrontation of divergent propositions) emerges from this interaction, it can be solved either in an epistemic way (focused on the task) or in a relational way (focused on the social comparison of competences). The latter is believed to be detrimental for learning. Moreover, research on cooperative learning shows that when they share identical information, partners are led to compare to each other, and are less encouraged to cooperate than when they share complementary information. An epistemic vs. relational conflict vs. no conflict was provoked in dyads composed by a participant and a confederate, working either on identical or on complementary information (N = 122). Results showed that, if relational and epistemic conflicts both entailed more perceived interactions and divergence than the control group, only relational conflict entailed more perceived comparison activities and a less positive relationship than the control group. Epistemic conflict resulted in a more positive perceived relationship than the control group. As far as performance is concerned, relational conflict led to a worse learning than epistemic conflict, and - after a delay - than the control group. An interaction between the two variables on delayed performance showed that epistemic and relational conflicts were different only when working with complementary information. This study shows the importance of the quality of relationship when sharing information during cooperative learning, a crucial factor to be taken into account when planning educational settings at the university.

scholarly journals Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Gabriela Elis Wachholz ◽  
Julia do Amaral Gomes ◽  
Juliano André Boquett ◽  
Fernanda Sales Luiz Vianna ◽  
Lavínia Schuler-Faccini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Zika Virus ◽  
Methodological Quality ◽  
Molecular Mechanisms ◽  
Grey Literature ◽  
Standard Form ◽  
Teratogenic Effect ◽  
Control Group

Abstract Background Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the methodological quality of these studies, as well as to demonstrate which genes and which molecular pathways are affected by ZIKV in different animal models. Methods This search will be performed in four databases: PubMed/MEDLINE, EMBASE, Web of Science, and Scopus, as well as in the grey literature. The studies selection process will be reported through the PRISMA Statement diagram model. All studies describing the molecular mechanisms possibly involved in the development of malformations caused by embryonic/fetal ZIKV exposure in animal models with an appropriate control group and methodology will be included (including, for instance, randomized and non-randomized studies). All animals used as experimental models for ZIKV teratogenesis may be included as long as exposure to the virus occurred during the embryonic/fetal period. From the selected studies, data will be extracted using a previously prepared standard form. Bias risk evaluation will be conducted following the SYRCLE’s Risk of Bias tool. All data obtained will be tabulated and organized by outcomes (morphological and molecular). Discussion With the proposed systematic review, we expect to present results about the methodological quality of the published studies with animal models that investigated the molecular mechanisms involved in the teratogenic effect of ZIKV, as well as to show the studies with greater reliability. Systematic review registration PROSPERO CRD42019157316

Mesenchymal Stem Cell Therapy for Acetaminophen-Related Liver Injury: A Systematic Review and Meta-Analysis of Experimental Studies in Vivo

2021 ◽  
Vol 16 ◽  
Author(s):  
Li Wang ◽  
Yiwen Zhang ◽  
Jiajun Zhong ◽  
Yuan Zhang ◽  
Shuisheng Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Liver Injury ◽  
Mesenchymal Stem Cell ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Small Sample ◽  
Control Group

Objective: The efficacy of mesenchymal stem cell (MSC) therapy in acetaminophen-induced liver injury has been investigated in animal experiments, but individual studies with a small sample size cannot be used to draw a clear conclusion. Therefore, we conducted a systematic review and meta-analysis of preclinical studies to explore the potential of using MSCs in acetaminophen-induced liver injury. Methods: Eight databases were searched for studies reporting the effects of MSCs on acetaminophen hepatoxicity. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used. SYRCLE’s risk of bias tool for animal studies was applied to assess the methodological quality. A meta-analysis was performed by using RevMan 5.4 and STATA/SE 16.0 software. Results: Eleven studies involving 159 animals were included according to PRISMA statement guidelines. Significant associations were found for MSCs with the levels of alanine transaminase (ALT) (standardized mean difference (SMD) − 2.58, p < 0.0001), aspartate aminotransferase (AST) (SMD − 1.75, p = 0.001), glutathione (GSH) (SMD 3.7, p < 0.0001), superoxide dismutase (SOD) (SMD 1.86, p = 0.022), interleukin 10 (IL-10) (SMD 5.14, p = 0.0002) and tumor necrosis factor-α (TNF-α) (SMD − 4.48, p = 0.011) compared with those in the control group. The subgroup analysis showed that the tissue source of MSCs significantly affected the therapeutic efficacy (p < 0.05). Conclusion: Our meta-analysis results demonstrate that MSCs could be a potential treatment for acetaminophen-related liver injury.

scholarly journals Impact of eating disorders on paid or unpaid work participation and performance: a systematic review and meta-analysis protocol

2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Fatima Safi ◽  
Anna M. Aniserowicz ◽  
Heather Colquhoun ◽  
Jill Stier ◽  
Behdin Nowrouzi-Kia
Keyword(s):  
Systematic Review ◽  
Eating Disorders ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Work Participation ◽  
Unpaid Work ◽  
Cochrane Library ◽  
And Performance ◽  
The Impact

Abstract Background Eating disorders (ED) can reduce quality of life by limiting participation and performance in social and occupational roles, including paid or unpaid work. The association between ED pathologies and work participation and performance must be well understood to strengthen vocational rehabilitation programmes and prevent occupational disruptions in the ED population. The aims of this study are: (1) to examine the degree of association between ED pathologies and work participation and performance in 15-year-olds and older; (2) to highlight the specific ED symptoms that are most correlated with changes in work performance and participation; (3) to compile the most common metrics and assessments used to measure work participation and performance with ED. Methods Medline, Embase, CINAHL, Web of Science, PsycINFO, and Cochrane Library will be searched for observational and experimental studies that meet the following criteria: (1) a clinical sample of typical or atypical ED; (2) paid or unpaid employment or training; (3) an association between ED pathologies and work participation or performance. Unpublished data will also be examined. Title and abstract, and full-text screening will be conducted in duplicate. Risk of bias and quality of evidence assessments will be completed. A random-effect meta-analysis will be performed. Discussion This synthesis can clarify knowledge and gaps around the impact of ED on work functioning, thereby allowing better evaluation, improvements and development of current workplace assessments, interventions, and policies. Trial registration The registration number for this systematic review on PROSPERO is CRD42021255055.

The quality of pork when included in the diet of the drug Permaite

2021 ◽  
pp. 3-11
Author(s):  
N. I. Kulmakova ◽  
L. B. Leontiev
Keyword(s):  
Dry Matter ◽  
Silicon Oxide ◽  
Experimental Studies ◽  
Live Weight ◽  
Biologically Active ◽  
Potassium Oxide ◽  
Control Group ◽  
Chuvash Republic ◽  
On Farm

It is well known that the growth rate of an animal depends on the level of feeding. However, the diets used in farms do not always meet the body’s needs for biologically active substances. In recent years numerous studies have been conducted to study the eff ect of natural and synthetic complex biologically active drugs on the productivity, metabolism of pigs and the quality of the products obtained. The imbalance or lack of certain nutrients in the diet reduces the productivity of animals, reduces the conversion of feed. The purpose of our research was to study the effect of the drug Permaite included in the diet of pigs on some indicators of the quality and safety of pork. Permaite is a standardized zeolite-containing trepel of the Chuvash Republic. Its chemical composition is (%): silicon oxide – 64,39, iron oxide – 3,25. aluminum oxide – 8,42, titanium oxide – 0,45, calcium oxide – 7,74, calcium carbonate – 14,7, magnesium oxide – 1,71, potassium oxide – 1,81, sodium oxide – 0,03, phosphorus pentoxide – 0,20 and other impurities – 11,9. Experimental studies have been conducted on 2 groups of pigs on rearing and subsequent fattening. Pigs of the experimental group have been received the main diet with the inclusion of the drug Permaite at a dose of 3 % to the dry matter of the main diet in the form of a fraction of 0,1–0,3 mm. The drug has been prescribed once a day in a mixture with compound feed for 60 days. The control group of pigs during this period was on farm diet without the inclusion of the drug. Upon reaching the live weight of 100–110 kg the pigs have been sent for slaughter. The results of the research allow us to conclude that the inclusion of the drug Permaite in the dose of 3 % to the dry matter of the main diet provides the increase in the nutritional, biological, energy value, technological properties and safety of pork.

Postoperative Prophylactic Antibiotics Reduce Surgical Site Infection Rates after Ventral Hernia Repair: A Systematic Review

2019 ◽  
Vol 85 (11) ◽  
pp. 1228-1233
Author(s):  
Pablo A. Baltodano ◽  
Anmol Chattha ◽  
Philip K. Johnson ◽  
Justin Kittredge ◽  
Joseph A. Ricci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hernia Repair ◽  
Ventral Hernia ◽  
Ventral Hernia Repair ◽  
Prophylactic Antibiotics ◽  
Control Group ◽  
Infection Rates ◽  
The Impact ◽  
Independent Assessment

SSIs after ventral hernia repair (VHR) represent a significant complication. The impact of postoperative prophylactic antibiotics on the SSI rates after VHRs is unclear. A systematic review of PubMed and Web of Science databases from inception through March 2016 investigating the effect of postoperative prophylactic antibiotics after VHRs was performed. Strict inclusion and exclusion criteria were implemented, and the methodological quality of the included studies was assessed. After systematic independent assessment of 216 citations, four studies, involving 344 patients, met the inclusion criteria. Among the included studies, 164 patients received >24 hours of postoperative prophylactic antibiotics, whereas 180 patients were controls. The overall incidence of SSI among patients receiving postoperative antibiotics was 14.6 per cent (95% confidence interval [CI], 9.9 to 20.9) which compares favorably with the control group: 35.5 per cent (95% CI, 28.9 to 42.7) (odds ratio: 0.3, 95% CI: 0.2 to 0.5, P < 0.01). Among patient's receiving postoperative antibiotics, the pooled average duration of postoperative antibiotic treatment was 6.2 ± 0.4 days. Based on the available evidence, the use of postoperative prophylactic antibiotics seems to be associated with lower SSI rates after VHRs. Future prospective randomized controlled trials should be conducted to further confirm the efficacy of this prophylactic intervention.

scholarly journals Games Centered Approaches in Teaching Children & Adolescents: Systematic Review of Associated Student Outcomes

2015 ◽  
Vol 34 (1) ◽  
pp. 36-58 ◽  
Author(s):  
Andrew Miller
Keyword(s):  
Systematic Review ◽  
Decision Making ◽  
Student Outcomes ◽  
Procedural Knowledge ◽  
Experimental Studies ◽  
Weight Of Evidence ◽  
Control Group ◽  
Play Skills ◽  
Game Play ◽  
Level Of Evidence

The purpose of this systematic review was to investigate the weight of scientific evidence regarding student outcomes (physical, cognitive and affective) of a Game Centered Approach (GCA) when the quality of a study was taken into account in the interpretation of collective findings. A systematic search of five electronic databases (Sports Discuss, ERIC, A+ Education, PsychInfo and PROQUEST Education) was conducted from their year of inception to 30 January 2014. Included studies were longitudinal or experimental/quasi-experimental studies involving children or adolescents that quantitatively assessed (using repeat measures and/or comparison with a control group) the effects upon student outcomes when an intervention involved the use of a GCA. The search identified 15 articles examining the effects of GCA on student outcomes that met the criteria for inclusion. The weight of evidence provided by the included studies identified an association between a GCA and the outcomes of declarative knowledge, support during game play and affective outcomes of perceived competence, interest/enjoyment and effort/importance. Development of technical skill, procedural knowledge and game play skills of decision making and skill execution are not supported by the level of evidence currently provided. Intervention volume appears to have a large effect on the development of game based decision making and skill execution, with a positive association between these outcomes and use of GCA interventions greater than eight hours in volume. More longitudinal and intervention research examining the use of a GCA and potential psychological, physiological and behavioral outcomes in children and adolescents is recommended.

scholarly journals Hyperthermic intraperitoneal chemotherapy with cisplatin and mitomycin C for colorectal cancer peritoneal metastases: A systematic review of the literature

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Amandine Pinto ◽  
Marc Pocard
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Mitomycin C ◽  
Intraperitoneal Chemotherapy ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Experimental Studies ◽  
Hematological Toxicity ◽  
Control Group ◽  
High Dose ◽  
Phase 2 Trial

AbstractBackgroundThe randomized trial PRODIGE 7 failed to show the benefit of oxaliplatin hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal peritoneal metastasis treatment (CR PM). This systematic review focuses on the association of cisplatin (CDDP) with mitomycin C (MMC) in HIPEC in CR PM.ContentExperimental studies demonstrated that hyperthermia, in addition to CDDP ± MMC treatment, gradually improved the cytotoxic effect by increasing early apoptosis, eATP interaction, intracellular CDDP concentration (by 20%) and p73 expression. Recent studies with highly selected patients reported unusual prolonged survival with a median overall survival (OS) of approximately 60 months, with a HIPEC combination of CDDP (25 mg/m2/L) plus MMC (3.3 mg/m2/L) at a temperature of 41.5–42.5 °C for 60–90 min. Major complications occurred in less than 30% of patients with limited hematological toxicity (less than 15%). In addition, in a phase 2 trial, an adjuvant HIPEC benefit was demonstrated in colorectal cancer patients with high risk for peritoneal failure (5-year OS: 81.3% vs. 70% for the HIPEC group vs. the control group, respectively, p=0.047). After a recurrence, an iterative procedure permitted similar recurrence-free disease (13 vs. 13.7 months) with an acceptable morbidity (18.7% of severe complications).Summary and outlookThe combination of CDDP and MMC seems to be an interesting protocol as an alternative to high-dose and short-term oxaliplatin.

Quality of reporting of experimental studies in medical education: a systematic review

2007 ◽  
Vol 41 (8) ◽  
pp. 737-745 ◽  
Author(s):  
David A Cook ◽  
Thomas J Beckman ◽  
Georges Bordage
Keyword(s):  
Systematic Review ◽  
Medical Education ◽  
Experimental Studies ◽  
Quality Of Reporting
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