Comparison of CPP-ACP, Tri-Calcium Phosphate and Hydroxyapatite on Remineralization of Artificial Caries Like Lesions on Primary Enamel -An in vitro Study

2016 ◽  
Vol 40 (5) ◽  
pp. 404-409 ◽  
Author(s):  
Meghna Bajaj ◽  
P Poornima ◽  
S Praveen ◽  
NB Nagaveni ◽  
KB Roopa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Polarized Light ◽  
In Vitro Study ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Before And After ◽  
Group B ◽  
Group D

Objectives: To compare CPP-ACP, Tri-calcium phosphate and Hydroxyapatite on remineralization of artificial caries like lesions on primary enamel. Study design: Ten extracted Primary molars coated with nail varnish, leaving a window of 2×4 mm on buccal and lingual surface were immersed in demineralizing solution for 96 hours and sectioned longitudinally to obtain 40 sections (4 sections per tooth) and were randomly divided into 4 groups (A to D) n=10; Group A: negative control, Group B: CPP-ACP, Group C: Tri-calcium phosphate, Group D: Hydroxyapatite. Sections were subjected to pH cycling for 10 days and were evaluated by polarized light microscope before and after treatment. Results: Intra group comparison of demineralization and remineralization was done by paired t-test. One way ANOVA was used for multiple group comparisons followed by post HOC TUKEY'S Test for group wise comparisons. Remineralization was found more with Group D followed by Group B, C and A. Conclusion: Hydroxyapatite showed better remineralization when compared to CPP-ACP and Tri-calcium phosphate.

EVALUATION OF THE EFFECT OF FERROUS SULFATE ON ENAMEL DEMINERALIZATION OF HUMAN DECIDUOUS TEETH: AN IN VITRO STUDY

2017 ◽  
Vol 8 (3) ◽  
pp. 83-89
Author(s):  
Johnny Holanda De Gauw ◽  
Lara Maria Melo Costa ◽  
Rodrigo Neves Silva ◽  
Natanael Barbosa Santos ◽  
Maria Dânia Holanda Tenorio
Keyword(s):  
Ferrous Sulfate ◽  
Polarized Light ◽  
In Vitro Study ◽  
Deciduous Teeth ◽  
Control Group ◽  
Group A ◽  
Ph Cycling ◽  
Group B ◽  
Group D

Objective: This study aimed to evaluate the effect of ferrous sulfate (FS) on demineralized and non-demineralized human deciduous teeth. Additionally, it was evaluated the penetration extent of FS and its remineralizing effect on the enamel of deciduous teeth using Polarized Light Microscopy (PLM). Method: The sample comprised 44 human deciduous teeth. The 44 crowns were divided randomly into four groups: group A (FS after demineralization), group B (FS without demineralization), group C (only demineralization), and group D (control group). FS at 0.45 mol/L-1 was used daily (15 days) and demineralization was done by pH cycling (7 days). Then, three longitudinal slices of the crowns were photographed using PLM. The degree of penetration of the lesion or stain was measured in micrometers, as well as the distance between the external enamel surface and the core of lesion. Results: Group A showed a dark stain on the outer surface of enamel larger than the group B. It is suggested, a remineralizing effect when comparing groups, A and C. The mean depth and standard deviation for groups A, B, and C were 4.27µm (±1.49), 3.72 µm (±1.68) and 5.00 µm (±1.84), respectively. No dark stains were observed in group D. Conclusion: FS stained the demineralized and non-demineralized human deciduous teeth. However, dark stains in the non-demineralized teeth were smaller or absent, than in the demineralized teeth. Therefore, FS may have a protective effect against demineralization.

scholarly journals Zeolite as a Bone Bio-Modifier Carrier: An In-Vitro Study

2019 ◽  
Vol 9 (1) ◽  
pp. 126
Author(s):  
Mobina Mousavi ◽  
Azadeh Esmaeil Nejad ◽  
Erfan Shamsoddin ◽  
Mohammad Mehdi Golabgiran ◽  
Behzad Houshmand
Keyword(s):  
In Vitro Study ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Alizarin Red ◽  
Group A ◽  
Group B ◽  
And Function ◽  
Group D

Background: Zeolite is a microporous aluminosilicate compound which has been successfully used in tissue engineering. The effects of Zeolite on the morphology and functions of pre-osteoblastic MG-63 cells as new bone enhancer material is still unclear. Methods: In this vitro experimental study, MTT and Alizarin red staining test were performed on six groups of MG-63 cells which differed in Zeolite (Z) concentration and the presence or absence of Alloplast extract (A). Group A: 0.1μg/mL Z+A, Group B: 0.1μg/mL Z without A, Group C: 0.2μg/mL Z+A, Group D: 0.2μg/mL Z without A, Group E: 0.3μg/mL Z+A, Group F: 0.3μg/mL Z without A. There were also three control groups as positive control, negative control, and Alloplast control based on each related test. The data were analyzed by SPSS 20 via one-way ANOVA and Welch test. (P<0.05). Results: At 24 hours, results showed that solutions with 0.1μg/mL, 0.2μg/mL, and 0.3μg/mL Zeolite with or without Alloplast had significantly higher proliferation rates than positive control (distilled water) groups without Alloplast (p<0.001). At 72hours time point, the results showed significantly higher proliferation rates in the solutions with 0.1μg/mL, 0.2μg/mL, and 0.3μg/mL Zeolite with or without Alloplast compared to the positive control group without Alloplast (p<0.001). Conclusions: Zeolite can increase proliferation of MG-63 cells without presence of Alloplast; It seems that combination of Zeolite with Alloplast maybe enhancing proliferation and function of MG-63 cells.

scholarly journals Effects of Additional Use of Bioactive Glasses or a Hydroxyapatite Toothpaste on Remineralization of Artificial Lesions in vitro

2020 ◽  
Vol 54 (4) ◽  
pp. 336-342
Author(s):  
Philipp Körner ◽  
Jana A Schleich ◽  
Daniel B. Wiedemeier ◽  
Thomas Attin ◽  
Florian J. Wegehaupt
Keyword(s):  
Bioactive Glass ◽  
Artificial Saliva ◽  
Test Group ◽  
In Vitro Study ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Bioactive Glasses ◽  
Initial Caries

<b><i>Objectives:</i></b> This in vitro study aimed to evaluate and compare the effect of two different bioactive glasses, a hydroxyapatite-containing, fluoride-free toothpaste (HTP) and a fluoride toothpaste (FTP) on the remineralization behavior of initial caries lesions. <b><i>Materials and Methods:</i></b> A total of 100 bovine enamel samples were randomly allocated to five groups of 20 samples each: NC = negative control group (artificial saliva); HTP = HTP group (Karex); FTP = FTP group (Elmex caries protection, 1,400 ppm); FTP + BG<sub>nano</sub> = FTP followed by Actimins bioactive glass; FTP + BG<sub>amorph</sub> = FTP followed by Schott bioactive glass. Radiographic documentation (advanced transversal microradiography; aTMR) was applied before and after all samples were exposed to a demineralizing gel for 10 days. Over a period of 28 days, samples were covered twice a day (every 12 h) with a toothpaste slurry of the respective test group or with artificial saliva in NC for 60 s and brushed with 15 brushing strokes. Samples in FTP + BG<sub>nano</sub> and FTP + BG<sub>amorph</sub> were additionally treated with the respective bioactive glass slurry for 30 s after brushing with the FTP. In the meantime, all samples were stored in artificial saliva. After 28 days, the structure of all samples was assessed again using aTMR and compared to the values measured after demineralization. The statistical evaluation of the integrated mineral loss was performed using Kruskal-Wallis test followed by a post hoc Conover test. <b><i>Results:</i></b> The FTP revealed the significantly highest increase of mineral content while the HTP showed the significantly lowest remineralization. Compared to artificial saliva, the use of the HTP or the combined application of FTP followed by bioactive glasses (FTP + BG<sub>nano</sub> and FTP + BG<sub>amorph</sub>) showed no significant remineralization. <b><i>Conclusion:</i></b> Under remineralizing in vitro conditions, brushing with 1,400 ppm FTP induced significantly more remineralization compared to storage in artificial saliva. The additional administration of both bioactive glasses as well as the substitutional brushing with an HTP resulted in significantly less remineralization compared to brushing with 1,400 ppm FTP.

scholarly journals A Preliminary Research Study on the Cytotoxicity of Expired and Non-expired Composite Resins: In Vitro Study

2020 ◽  
pp. 227-238
Author(s):  
Magrur Kazak DDS, PhD ◽  
Nazmiye Donmez DDS, PhD ◽  
Fatemeh Bahadori PhD ◽  
Vildan Betul Yenigun PhD ◽  
Abdurrahim Kocyigit MD, PhD
Keyword(s):  
Cell Viability ◽  
Composite Resin ◽  
In Vitro Study ◽  
Negative Control Group ◽  
Negative Control ◽  
Composite Resins ◽  
Control Group ◽  
Significant Difference ◽  
Preliminary Research

Objective: Studies have focused on use of non-expired composites. Unfortunately some clinicians still use expired composite resins without considering their effects. The objective of this in vitro preliminary research was to investigate cytotoxicity of expired(6-months) and non-expired composite resins. Materials and methods: Expired (E) and non-expired (NE) samples of one bulk-fill (Tetric N-Ceram Bulk-fill [TNB], Ivoclar Vivadent), two nano-hybrid (Tetric N-Ceram [TN], Ivoclar Vivadent; Clearfil Majesty ES-2 [CM], Kuraray) composite resins were tested on L929 fibroblast cells. Medium covering cells was removed then plastic rings (2-mm height) were filled with non-polymerized composite resins, placed in direct contact with cells and polymerized with LED light curing unit (LCU). Three samples were prepared for each group. After polymerization, removed medium was added to the cells. Cells that were left without medium (WOM) and cells that were exposed to LCU were used as positive control groups. Cells without any treatment were used as negative control group (C). Cells were incubated with tested materials for 7-days to evaluate cytotoxicity. Cell viability was calculated by sulforhodamine B test as a percentage (%). One-way ANOVA and post-hoc Tukey tests were used for statistical analyses (p<0.05). Results: Comparison between E and NE groups of same composite resins did not result in statistically significant differences (p>0.05), except between TN NE and TN E (p<0.05). TN E group was significantly more cytotoxic than TN NE group. When NE composite resin groups were compared to each other, statistically significant difference was only obtained between TNB NE and TN NE (p<0.05). Among all tested groups, TN NE group showed the least cytotoxic profile. No statistically significant differences were determined when E composite resin groups were compared to each other (p>0.05). All experimental groups compared with C group showed statistically significant cytotoxicity (p<0.05). A statistically significant difference existed between LCU and C groups (p<0.05). Conclusions: In clinical practice, expired composite resins should never be used. Although a correlation was found between expiration dates of nano-hybrid composite resins and cell viability, opposite data were obtained for bulk-fill composite resin. Researches are still required to evaluate biocompatibility of bulk-fill composite resins at various thicknesses with current LCUs.

scholarly journals The Effect and Mechanism of Vascular Endothelial Growth Fac-tor (VEGF) on Tumor Angiogenesis in Gallbladder Carcinoma

2019 ◽  
Author(s):  
Dongqing XU ◽  
Jianwen Jianwen LI ◽  
Fangfang JIANG ◽  
Kaishuang CAI ◽  
Guangxue REN
Keyword(s):  
Gallbladder Carcinoma ◽  
Tumor Angiogenesis ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Vascular Endothelial ◽  
Blank Group ◽  
Group B ◽  
Group D ◽  
Inhibition Group

Background: To investigate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis in gallbladder carcinoma. Methods: Fifty one patients with gallbladder carcinoma were enrolled as observation group. Thirty healthy people were included as control group. Chemically synthesized siRNA sequences targeting VEGF was transfected with VEGF-siRNA. A blank group (group B), a negative control group (transfected with independent sequence, group C), and an inhibition group (transfected with VEGF siRNA, group D) were established. Physiological saline was set as group A. The expression of VEGF was detected by qRT-PCR. The expression of VEGF protein was detected by Western blot. MVD was used to measure microvessel density. CCK-8, Transwell and flow cytometry were used to detect cell proliferation, invasion and apoptosis. Results: The tumor volume of nude mice and VEGF mRNA expression in group D was significantly smaller than that in group B and C (P<0.05). The MVD density in group B and C was significantly higher than that in group D (P<0.01). The proliferation of cells was detected from the 3rd day, and the proliferation of cells in the blank and negative control groups was faster than that of the inhibition group (P<0.05). The apoptosis rate of the blank group and the negative control group was lower than that of the inhibition group (P<0.001). Conclusion: VEGF is highly expressed in serum of patients with cholangiocarcinoma, it promotes angiogenesis, proliferation and invasion of gallbladder cancer cells, and inhibits apoptosis of tumor cells.

scholarly journals Diffusion of calcium hydroxide through dentinal tubules of retreated root canals: An in vitro study

2018 ◽  
Vol 12 (03) ◽  
pp. 386-392 ◽  
Author(s):  
Mohammed Mustafa ◽  
Wafa Hassan Alaajam ◽  
Ahmed Abdul Azeim ◽  
Najla Aedh Alfayi ◽  
Rahaif Misfer Alqobty ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Normal Saline ◽  
Root Canal ◽  
In Vitro Study ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Group I ◽  
Group Ii

ABSTRACTObjective: Studies about the dispersion of hydroxyl ions through dentin of endodontically retreated teeth are scarce. The present study aims at examining the diffusion of calcium hydroxide in vitro by recording the pH changes of retreated root canal using two types of calcium hydroxide preparations. Materials and Methods: A total of 45 recently extracted single-rooted mandibular first premolars were collected and cleaned from calculus and remains of periodontal tissue. The teeth so collected were stored in thymol 10% solution till use. During collection, teeth with cracks, open apices, and restorations were excluded. Root canal preparations were performed using Protaper rotary system files, till #F3 file. All canals were obturated using cold lateral condensation and zinc oxide-based sealer. After 7 days, all gutta-percha were removed and the canals were irrigated with normal saline. The teeth were then randomly distributed into three groups. Canals in Group I were kept empty without any dressing to serve as a negative control group, Canals in Group II were filled with a freshly prepared mixture of calcium hydroxide powder with normal saline solution, and Group III was filled with Metapex. Periodically, the calcium hydroxide material was removed and the pH was measured using pH meter at 7, 10, 14, and 30 days. Results: The pH values of Group II and III ranged between 9.2 and 11.2. This was found to be highly significant against the negative control group. After 7 and 10 days, freshly mixed Ca(OH)2 showed the higher pH than the creamy Metapex, and statistically the difference was highly significant after 10 days (P<0.001). After 14 days, Metapex group pH was higher than freshly mixed Ca(OH)2, but it was not statistically significant as they reached nearly the same pH after 30 days (P>0.05). Conclusion: All Ca(OH)2 preparations had high pH around the roots after 7 and 10 days. Metapex continued to have higher pH after 14 days.

scholarly journals Potential anti-tumor activites of extract from fresh leaves of the male papaya (Carica papaya L.) collected in Ha Tinh province

2020 ◽  
Vol 18 (1) ◽  
pp. 127-134
Author(s):  
Tran Phuong Trinh ◽  
Phan Bao Linh ◽  
Pham Thi Tam
Keyword(s):  
Carica Papaya ◽  
In Vitro Study ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Hek 293 ◽  
Extraction Solvent ◽  
Positive Effects ◽  
Ic50 Values

Nowadays, the percentage of people with cancer is increasing. There are many methods used to treat cancer such as surgery, chemotherapy, the radiation, etc. In addition, the use of medicinal plants, natural products, is also popularly applied for cancer patients. Using 90% ethanol as the extraction solvent, we produced 4 kinds of concentrated extracts from dried flowers, dried leaves, fresh flowers, fresh leaves of male papaya (Carica papaya Linn). In vitro study, the extracts of dried flowers, fresh flowers did not effect on MCF7, A549, HT 29, Huh 7R, HEK 293 and LLC cancer cell lines. The extracts of dried leaves and fresh leaves presented cytotoxic effects with IC50 values ranging from 1.88 to 13.64 mg/mL. Meanwhile, activities of the extract of fresh leaves was 4-6 times stronger than that of the extract of dried leaves's. Based on evaluation of the IL2 and IL6 production capability of macrophage, we found that the extract of fresh leaves strongly inhibited the IL-6 production at 4 mg/mL (50.56%) and 0.8 mg/mL (23.79%) in comparison with the negative control (P<0.05) while it did not show the ability to induce IL-2 in the same studied concentrations. Using tumor bearing mice as model for studying the antitumor activities of extract of fresh leaves at the dose of 3 mL/kg/day and 6 mL/kg/day, we identified the positive effects of the higher dose treatment. The results showed that the extract of fresh leaves at the dose of 6 mL/kg/day could inhibit 33.44% the tumors’ sizes on day 28 (P<0.05); tumor's weigh decreased to 9.84 against 13.76 g of the negative control; the WBC parameter reduced from 41.65x106/mL to 19.1x106/mL (P<0.05), AST decreased from 1441.6 U/L to 1038.97 U/L (P<0.01), and creatinin decreased from 26.37 µmol/L to 20.63 µmol/L compared with the negative control group (P<0.05). These promising results are the scientific evidences for applying this extract in cancer treatment in the future.

scholarly journals Combination of Areca catechu , Sauropus androgynous , and Mineral Block is Effective to control Nematode in Goats

2017 ◽  
Vol 2 (2) ◽  
pp. 34-38
Author(s):  
Henni Vanda ◽  
Muhammad Hambal ◽  
Farida Athailah ◽  
Mustafa Sabri
Keyword(s):  
Anthelmintic Activity ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Intestinal Nematode ◽  
Areca Catechu ◽  
Group A ◽  
Overall Performance ◽  
Group B ◽  
Group D

A study has been conducted to investigate the effect of two local herbs in Indonesia; Areca catechu nut and Sauropus androgynous leaf, combined with mineral block to treat gastro intestinal nematode in goats. A.catechu is well known to have anthelmintic property due to its alkaloid and tannin content, and S.androgynus also contains tannin, alkaloid and steroid that will enhance the anthelmintic property of those herbals.  As many as 80 goats had been divided into 4 groups; 20 were treated with albendazole (Group A), 20 were given A.catechu and S.androgynus (Group B), 20 were given combination of A.catechu, S.androgynus, and mineral block (Group C), and 20 as negative control (Group D). The result revealed that herbal treatment showed significantly effective toward nematodes in gastro intestinal, demonstrated by declining egg worm of Group B and C. Body weight improvement and overall performance in Group C was higher compared to other groups. However, goats treated with albendazole showed slightly better results in the decreasing amount of egg worms found after treatment. Nevertheless, A.catechu and S.androgynus are potential anthelmintic herbal; combination with mineral block will enhance the anthelmintic activity. Therefore they are good options for treating helminthiasis in livestock.   

scholarly journals Development of caries adjacent to composite restorations after exposure to dentifrices with different fluoride concentrations

2015 ◽  
Vol 44 (2) ◽  
pp. 113-117
Author(s):  
Dayse Andrade Romão ◽  
Guilherme José Pimentel Lopes de Oliveira ◽  
José Ivo Limeira dos Reis ◽  
Lucineide de Melo Santos
Keyword(s):  
Resin Composite ◽  
Fluoride Concentration ◽  
Polarized Light ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Lesion Length ◽  
Treatment Groups ◽  
Group B

Objective To evaluate the development of recurrent caries after exposure to fluoride dentifrices with different concentrations. Material and method: 48 samples of bovine incisors (4x4mm2) were exposed to pH cycling for 7 days before the preparation of the cavities (2mm deep). The samples were restored with a microhybrid resin composite. Then, the samples were exposed to thermal cycling (350 cycles) and they were randomly allocated into 4 treatment groups (n = 12): Group A - non-fluoridated dentifrice (negative control); Group B - 500 ppm dentifrice; Group C - 750 ppm dentifrice; group D - 1100 ppm dentifrice (positive control). The samples were treated with solutions of each dentifrice (9.6 ml water/1.6 g dentifrice) for 60 seconds and then were immersed in demineralizing (3 h) and remineralizing (2 h) solutions 3 times a day. Next, the samples were immersed in a remineralizing solution for 18 hours. Then, the blocks were sectioned for examination of the length of the outer caries lesion, using polarized light microscopy. The ANOVA parametric test complemented by the Tukey test with a confidence level of 95%, were used in the statistical analysis. Result: A smaller lesion length was observed in the group treated with the fluoride concentration of 1100 ppm F, but there were no differences between toothpastes with fluoride concentrations of 500 and 750 ppm F. Conclusion: The use of fluoride dentifrices (1100 ppm) reduces the development of caries adjacent to dental restorations.

scholarly journals GAMBARAN HISTOPATOLOGIK LAMBUNG TIKUS WISTAR YANG DIBERIKAN BUAH PEPAYA SEBELUM INDUKSI ASPIRIN

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Vallery Jerry Nanlohy
Keyword(s):  
Wistar Rats ◽  
Qualitative Change ◽  
Negative Control Group ◽  
Negative Control ◽  
Lower Degree ◽  
Control Group ◽  
Treatment Groups ◽  
Acute Gastritis ◽  
Group B ◽  
Group D

Abstract: Aspirin contains acetyl salicylic acid which can cause qualitative change on the gastric mucosa. The active ingredients of papaya can increase immunity and protect the stomach from the use of aspirin and steroid. Objective: To reveal the histophatological features of the stomach of Wistar rats administered with papaya juice before aspirin induction. Method: This experimental research employed 20 wistar rats which were divided into the negative control group (A) and treatment groups. All rats were fed with regular or standard pellets for 10 days. Treatment groups were classified into four groups; rats were given papaya juice of 0.8 cc/day (group B), rats were administered aspirin of 30 mg/day (group C), rats were given papaya juice 0.8 cc/day before induced with aspirin (group D), and rats were given papaya juice 2.4 cc/day before induced with aspirin of 30 mg/day (group E). On the eleventh day, the rats were terminated to isolate the stomach followed by macroscopic and microscopic examinations. Results: It was found that the microscopic features were normal in negative control group and group B. In group C, histological examination showed acute gastritis, i.e.,inflammatory cells, edema mucosa and capillary dilatation. Rats in group D and E showed lower degree of acute gastritis compared with group C. Conclusions: Administration of papaya juice for 10 days before aspirin  is given may reduce the signs of acute gastritis as demonstrated by histopathological features of the stomach of wistar rats. Administration of papaya juice of 2.4 cc/day result in lower degree of gastritis compared with recommended dose of papaya juice (0.8 cc/day). Keywords: Aspirin, papaya, stomach.   Abstrak: Aspirin mengandung asam asetil salisilat  yang dapat menimbulkan perubahan kualitatif mukus lambung. Bahan aktif buah pepaya dapat meningkatkan kekebalan dan melindungi lambung dari penggunaan obat aspirin dan steroid. Tujuan: Untuk mengetahui gambaran histopatologik lambung tikus wistar yang diberikan jus buah pepaya sebelum induksi aspirin. Metode: Penelitian eksperimental ini menggunakan 20 ekor tikus wistar yang dibagi dalam kelompok kontrol negatif (A) dan kelompok perlakuan yang diberikan diet pellet standar selama 10 hari. Kelompok perlakuan dibagi dalam empat kelompok, yaitu  kelompok  yang diberikan jus pepaya 0,8 cc/hari (B), kelompok  yang diberikan aspirin 30 mg/hari (C),  kelompok  yang diberikan jus pepaya 0,8 cc/hari sebelum diinduksi aspirin (D), dan kelompok  yang diberikan jus pepaya 2,4 cc/ hari sebelum diinduksi aspirin 30 mg/hari (E). Pada hari ke-11 Tikus wistar diterminasi  untuk diambil lambungnya yang kemudian diamati secara makroskopik dan mikroskopik. Hasil: Penelitian ini menunjukkan gambaran mikroskopik yang normal pada kelompok kontrol negatif dan perlakuan B. Pada kelompok perlakuan C menunjukkan gambaran histologik gastritis akut, yaitu sel-sel radang, edema mukosa, dan pelebaran kapiler. Pada kelompok perlakuan D dan E menunjukkan gambaran histologi gastritis akut yang lebih ringan dibandingkan dengan kelompok perlakuan C. Simpulan: Pemberian jus buah pepaya sebelum pemberian aspirin selama 10 hari dapat mengurangi tanda-tanda gastritis akut yang terlihat pada gambaran histopatologik lambung tikus wistar. Pemberian jus buah pepaya sebanyak 2,4 cc/hari menghasilkan gambaran gastritis  yang lebih ringan dibandingkan dengan pemberian dosis anjuran (0,8 cc/hari) jus buah pepaya. Kata Kunci: Aspirin, pepaya, lambung.

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