scholarly journals Influence of heliogeophysical factors on the minute blood volume in hypertensive patients with different temperament

2018 ◽  
Vol 20 (1) ◽  
pp. 35-37
Author(s):  
G A Usenko ◽  
D V Vasendin ◽  
A G Usenko ◽  
N A Schakirova ◽  
L I Makarova ◽  
...  
Keyword(s):  
Blood Flow ◽  
Solar Activity ◽  
Atmospheric Pressure ◽  
Meteorological Factors ◽  
Minute Volume ◽  
Healthy Individuals ◽  
Oxygen Utilization ◽  
Correlation Relationship ◽  
Physiological Processes ◽  
Heliogeophysical Factors

Correlation between the annual average values of minute volume of blood flow in healthy men with different psychosomatic status, suffering from arterial hypertension, and Solar activity from 1995 to 2015 was investigated. Variations of γ-background during the study period did not exceed the limits of normal regional values (7-9 µr/h). However, the analysis of solar activity dynamics represented periodic increase and a momentary increase by the 2005-2006. With the increase in solar activity and γ-ray background a significant reduction of oxygen utilization coefficient by tissues of healthy individuals and patients with different temperament was noted. The increase in solar activity was followed by an increase in ambient temperature and atmospheric pressure. The study showed a significant increase in minute volume of blood flow in the groups of healthy individuals and patients in the same years as the increase in solar activity and γ-background environment. There has been established a significant correlation relationship between indicators of solar activity, meteorological factors and minute volume of blood flow that indicates on the possibility of combined effects of the studied environmental factors to affect the course of physiological processes in organism of both healthy and hypertension person. Overall, it was reflected in the increase of functional activity of the cardiovascular system (by minute volume of blood flow).

scholarly journals STUDY OF THE RELATIONSHIP BETWEEN HELIOGEOPHYSICAL FACTORS AND THE COURSE OF CERTAIN PHYSIOLOGICAL PROCESSES IN INDIVIDUALS WITH DIFFERENT PSYCHOSOMATIC STATUS AS A COMPONENT OF PSYCHOLOGICAL SUPPORT

2020 ◽  
Vol 1 ◽  
pp. 121-125
Author(s):  
Gennady A. Usenko ◽  
Dmitry V. Vasendin ◽  
Valery I. Tatarenko ◽  
Anatoly A. Chernov
Keyword(s):  
Blood Flow ◽  
Solar Activity ◽  
Minute Volume ◽  
The Body ◽  
Oxygen Utilization ◽  
Physiological Processes ◽  
Heliogeophysical Factors ◽  
The Relationship ◽  
Adaptive Reaction ◽  
Socio Economic Factors

Тhe purpose of the study: to establish a correlation between the average annual values of the minute volume of blood flow in hypertensive men with different temperaments and high anxiety and solar activity. There were 848 patients with arterial hypertension and 422 healthy individuals. All of them were determined by temperament and anxiety, and the minute volume of blood flow. To compare the calculated method for determining the minute volume of blood flow with the hardware method, the authors measured the minute volume of blood flow in patients using tetrapolar rheography on a 6-NEG device connected with a computer and compared it with the value of the minute volume of blood flow determined by calculation. Data on the dynamics of solar activity in wolf numbers and radio emission at a wavelength of 10.5 cm were obtained from the West-Siberian Department for Hydrometeorology and Environmental Monitoring. During the period of increased solar activity, the body was affected by a complex of factors, including socio-economic factors, together with ionizing radiation of the environment; contribute to a decrease in the coefficient of oxygen utilization by tissues, which caused the development of an adaptive reaction, part of which was an increase in the minute volume of blood flow. A significant correlation was established between solar activity indicators, meteorological factors, and minute blood flow volume, which indicates the possibility of a combined effect of the studied factors on increasing the functional activity of the cardiovascular system.

scholarly journals Correlation between heliogeophysical factors and osmotic pressure of blood plasma in patients with arterial hypertension with different temperament

2018 ◽  
Vol 20 (3) ◽  
pp. 37-40
Author(s):  
G A Usenko ◽  
D V Vasendin ◽  
A G Usenko ◽  
N A Shakirova
Keyword(s):  
Solar Activity ◽  
Blood Plasma ◽  
Osmotic Pressure ◽  
Vascular Resistance ◽  
Atmospheric Pressure ◽  
Peripheral Vascular Resistance ◽  
Peripheral Vascular ◽  
Correlation Relationship ◽  
Total Peripheral Vascular Resistance ◽  
Heliogeophysical Factors

The relation between heliogeophysical factors and the osmotic pressure of blood plasma in patients with arterial hypertension with different temperaments is analyzed. It is found that with increasing solar activity (Wolf numbers and radio flux wavelength 10,7 cm), is closely related increase in atmospheric pressure, air temperature and γ-background (within normal limits) in the workplace examinees. It was revealed that in choleric and sanguine patients there is a reliable high inverse correlation relationship between heliogeophysical, meteorological factors and total peripheral vascular resistance, while the phlegmatic and melancholic - the average direct and direct high correlation relationship. Antihypertensive therapy with diuretics with increased solar activity, combined with an increase in the atmospheric pressure, γ-background and the air temperature in the workplace, due a decrease in total peripheral vascular resistance at the choleric and sanguine and increase in total peripheral vascular resistance in healthy individuals and phlegmatic patients and melancholic. The presence of significant and reverse correlation relationship between the total peripheral vascular resistance and osmotic pressure of blood plasma in choleric and sanguine and significant, but a direct correlation - the phlegmatic and melancholic indicates the inclusion of an adaptive process various physiological mechanisms, which determines the need to consider the temperament at solar biospheric relations bonds.

scholarly journals CONSUMPTION AND USE OF OXYGEN BY THE BODY OF PERSONS WITH CARDIOVASCULAR PATHOLOGY WITH CHANGES IN GEOMAGNETIC ACTIVITY

2021 ◽  
Vol 3 (1) ◽  
pp. 323-330
Author(s):  
Gennady A. Usenko ◽  
Dmitry V. Vasendin
Keyword(s):  
Solar Activity ◽  
Radio Emission ◽  
Arterial Hypertension ◽  
Air Temperature ◽  
Atmospheric Pressure ◽  
The Body ◽  
Emission Flux ◽  
Oxygen Utilization ◽  
Gamma Background ◽  
The One

The aim of the study was to identify and evaluate the relationship between the indicators of solar activity, the content of magnesium in the blood and the level of oxygen utilization by tissues in men with different temperaments and anxiety, suffering from arterial hypertension. During the period of the study from 1995 to 2015, sick and healthy men were divided into equal groups with a predominance of choleric, sanguine, phlegmatic and melancholic temperament with high and low anxiety. The average annual values of the Wolf numbers, the radio emission of the Sun at a wavelength of 10,7 cm, atmospheric pressure, gamma background and air temperature were taken into account, and the content of magnesium and hemoglobin in the blood serum was determined. The oxygen concentration was determined by the calculated method. A statistically significant direct correlation has been established between the increase in solar activity (Wolf numbers, radio emission flux at a wavelength of 10.7 cm), on the one hand, and atmospheric pressure, air temperature, and the gamma background of the environment, on the other. Under the same environmental conditions, the content of magnesium in the blood and the level of oxygen utilization by the body tissues of patients with arterial hypertension decreased in the temperamental range from high- and low-anxiety sympathotonics (choleric and sanguine) to parasympathotonics (high- and low-anxiety phlegmatic and melancholic). During the study period, a statistically significant relationship was established between an increase in solar activity (Wolf numbers, radio emission flux), atmospheric pressure, air temperature, and gamma background, on the one hand, and a decrease in the content of magnesium in the blood, as well as the level of oxygen utilization by tissues in healthy high- and low-anxiety individuals and patients with arterial hypertension, regardless of temperament.

Dopamine-1 receptor stimulation impairs intestinal oxygen utilization during critical hypoperfusion

2003 ◽  
Vol 284 (2) ◽  
pp. H668-H675 ◽  
Author(s):  
Jorge A. Guzman ◽  
Ariosto E. Rosado ◽  
James A. Kruse
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Control Group ◽  
Oxygen Utilization ◽  
Hemorrhage Control ◽  
Receptor Stimulation ◽  
Anesthetized Dogs ◽  
Group 2 ◽  
Increased Susceptibility ◽  
Group 1

Effects of a dopamine-1 (DA-1) receptor agonist on systemic and intestinal oxygen delivery (D˙o 2)-uptake relationships were studied in anesthetized dogs during sequential hemorrhage. Control ( group 1) and experimental animals ( group 2) were treated similarly except for the addition of fenoldopam (1.0 μg · kg−1 · min−1) in group 2. Both groups had comparable systemic criticalD˙o 2(D˙o 2crit), but animals in group 2 had a higher gut D˙o 2crit(1.12 ± 1.13 vs. 0.80 ± 0.09 ml · kg−1 · min−1, P < 0.05). At the mucosal level, a clear biphasic delivery-uptake relationship was not observed in group 1; thus oxygen consumption by the mucosa may be supply dependent under physiological conditions. Group 2 demonstrated higher peak mucosal blood flow and lack of supply dependency at higher mucosalD˙o 2 levels. Fenoldopam resulted in a more conspicuous biphasic relationship at the mucosa and a rightward shift of overall splanchnic D˙o 2crit despite increased splanchnic blood flow. These findings suggest that DA-1 receptor stimulation results in increased gut perfusion heterogeneity and maldistribution of perfusion, resulting in increased susceptibility to ischemia.

Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow, and oxygen utilization in humans

1977 ◽  
Vol 46 (4) ◽  
pp. 446-453 ◽  
Author(s):  
Robert L. Grubb ◽  
Marcus E. Raichle ◽  
John O. Eichling ◽  
Mokhtar H. Gado
Keyword(s):  
Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Blood Volume ◽  
Cerebral Vasospasm ◽  
Cerebral Blood Volume ◽  
Neurological Deficits ◽  
Regional Cerebral Blood ◽  
Oxygen Utilization ◽  
Ruptured Intracranial Aneurysm ◽  
Regional Cerebral Blood Volume

✓ Forty-five studies of regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), and regional cerebral oxygen utilization (rCMRO2) were performed in 30 patients undergoing diagnostic cerebral angiography for evaluation of a subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Tracer methods employing radioactive oxygen-15 were used to measure rCBV, rCBF, and rCMRO2. The patient studies were divided into groups based on their neurological status and the presence or absence of cerebral vasospasm. Subarachnoid hemorrhage, with and without vasospasm, produced significant decreases in CBF and CMRO2. In general, patients with more severe neurological deficits, and patients with more severe degrees of vasospasm, had a more marked depression of CBF and CMRO2. The most striking finding was a significant (p < 0.001) increase in CBV (to 58% above normal) in patients with severe neurological deficits associated with severe cerebral vasospasm. This large increase suggests that cerebral vasospasm consists of constriction of the large, radiographically visible extraparenchymal vessels accompanied by a massive dilation of intraparenchymal vessels.

scholarly journals SARS-CoV-2 and the Weather: Correlation between COVID-19 and Meteorological Variables in 3 Cities in Mexico

2021 ◽  
pp. 74-91
Author(s):  
Hermes Ulises Ramirez-Sanchez ◽  
Alma Delia Ortiz-Bañuelos ◽  
Aida Lucia Fajardo-Montiel
Keyword(s):  
Wind Speed ◽  
Atmospheric Pressure ◽  
Ecological Study ◽  
Metropolitan Areas ◽  
Meteorological Factors ◽  
Correlation Coefficients ◽  
Weather Conditions ◽  
Dew Point ◽  
Meteorological Variables ◽  
Infected Person

Meteorological factors such as temperature, humidity, atmospheric pressure, wind speed and direction are associated with the dispersion of the SARS-CoV-2 virus through aerosols, particles <5μm are suspended in the air being infective at least three hours and dispersing from eight to ten meters. It has been shown that a 10-minute conversation, an infected person produces up to 6000 aerosol particles, which remain in the air from minutes to hours, depending on the prevailing weather conditions. Objective: To establish the correlation between meteorological variables, confirmed cases and deaths from COVID-19 in the 3 most important cities of Mexico. Methodology: A retrospective ecological study was conducted to evaluate the correlation of meteorological factors with COVID-19 cases and deaths in three Mexican cities. Results: The correlations between health and meteorological variables show that in the CDMX the meteorological variables that best correlate with the health variables are Temperature (T), Dew Point (DP), Wind speed (WS), Atmospheric Pressure (AP) and Relative Humidity (RH) in that order. In the ZMG are T, WS, RH, DP and AP; and in the ZMM are RH, WS, DP, T and AP. Conclusions In the 3 Metropolitan Areas showed that the meteorological factors that best correlate with the confirmed cases and deaths from COVID-19 are the T, RH; however, the correlation coefficients are low, so their association with health variables is less than other factors such as social distancing, hand washing, use of antibacterial gel and use of masks.

Abstract P141: GYY4137, a H 2 S Donor, Normalizes miR-132 Targeted Sirt1 and Ace2 Expression to Improve Kidney Function in Hypertension

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Gregory Weber ◽  
Sathnur Pushpakumar ◽  
Utpal Sen
Keyword(s):  
Blood Flow ◽  
Kidney Function ◽  
Expression Patterns ◽  
Sirtuin 1 ◽  
Ang Ii ◽  
Cellular Processes ◽  
Physiological Processes ◽  
Epigenetic Gene Silencing ◽  
Increased Blood Flow

MicroRNAs regulate several physiological processes and are implicated in various pathologies, including hypertension. Previous work indicates miR-132 targets Sirtuin 1 (Sirt1), a histone deacetylase and regulator of epigenetic gene silencing in various cellular processes. Sirt1 is expressed in the kidney; however, its role in hypertensive kidney and whether it is regulated by physiological gaseous molecules, such as hydrogen sulfide (H 2 S), is not known. In this study, we sought to determine the role of miR-132 in regulating Sirt1, Ace2 and At1 in hypertensive kidney and whether H 2 S donor, GYY4137 (GYY), could reverse these effects and mitigates renal dysfunction. Wild-type mice were treated without or with Ang-II (1000 ng/Kg/Min) and GYY (133 μM) for 4 weeks. Quantitative PCR, Western blot, and immunofluorescence assays were performed. Increased expression levels of miR-132 in hypertensive mice (3.79 fold vs control) were reduced in mice receiving GYY treatment (2.43 fold vs control). Sirt1 expression was reduced (-1.15 fold) in Ang-II mice but was upregulated in GYY (1.25 fold) and Ang-II+GYY (1.9 fold) groups. A similar effect was seen with Sirt1 protein where the expression was increased in animals treated with GYY and Ang-II+GYY (1.16, 1.03 respectively) compared to Ang-II (0.47). Ace2 in Ang-II+GYY (0.45) was increased compared to Ang-II (0.17), while At1 was reduced (0.46) compared to Ang-II (0.86). Immunofluorescence showed decreased signal of Sirt1 in the glomerulus in Ang-II mice and increased At1 in the blood vessels surrounding the glomerulus, leading to constriction of renal artery, decreased blood flow, and kidney dysfunction. These effects were alleviated in mice treated with GYY. Our data suggests that upregulation of miR-132 in hypertensive kidney decreases Sirt1 and Ace2 expression, leading to increased Ang-II signaling through the At1 receptor and GYY supplementation reverses these expression patterns, leading to increased blood flow and kidney function.

Effect of hypothermia on myocardial metabolism

1965 ◽  
Vol 208 (6) ◽  
pp. 1253-1258 ◽  
Author(s):  
Clem Russ ◽  
John C. Lee
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Myocardial Metabolism ◽  
Mechanical Efficiency ◽  
Substrate Utilization ◽  
Nonesterified Fatty Acid ◽  
Sodium Pentobarbital ◽  
Oxygen Utilization ◽  
Reduced Body ◽  
Carbohydrate Levels

Effect of hypothermia of 25 C for 24 hr was determined on myocardial metabolism and efficiency in dogs fasted for approximately 15 hr and anesthetized with sodium pentobarbital. Coronary blood flow, cardiac output, myocardial oxygen and substrate utilization, and mechanical efficiency of the heart were determined at normal and reduced body temperatures. Prolonged reduction of myocardial temperature with concomitant reduction in coronary blood flow led to diminished oxygen and substrate utilization. Myocardial glycolysis began after 12 hr of cooling when pyruvate utilization stopped in negative balance. After 24 hr the heart stopped utilizing carbohydrates with negative arteriovenous differences for these substrates (in the presence of normal arterial carbohydrate levels), but continued to utilize nonesterified fatty acid. The coefficient of oxygen utilization for the heart increased following 24 hr of cooling, suggesting a relative state of myocardial hypoxia. The appearance of hypoxia and glycolysis during the late hours of cooling suggests that the limit of tolerance of the heart to cooling was near.

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