scholarly journals The incidence of alleles and genotypes of polymorphic genes leptin G(-2548) A, adiponectin G(276) T and receptor adiponectin A(+219) T in patients with psoriasis alimentary obesity

2019 ◽  
Vol 21 (2) ◽  
pp. 24-27
Author(s):  
I V Rychkova ◽  
O A Pritulo ◽  
K D Malyi

Investigated prevalence of alleles and genotypes G(-2548)A (rs7799039) gene leptin and G(276)T (rs1501299) of the adiponectin and A(+219)T (rs11061971) adiponectin receptor 2 in patients with psoriasis with abdominal obesity. The frequency of the allele A of the promoter region of the G(-2548) A polypeptide leptin gene in 99/226 (43,8%) patients with a body mass index ≥30 kg / m2 was found to be higher than in69/228 (30,3% ) patients with a body mass index

2017 ◽  
Vol 27 (1) ◽  
pp. 56 ◽  
Author(s):  
Willian R. Tebar ◽  
Luiz Carlos M. Vanderlei ◽  
Catarina C. Scarabotollo ◽  
Edner F. Zanuto ◽  
Bruna T. C. Saraiva ◽  
...  

Objectives: The aim of this study was to determine the prevalence of abdominal obesity and its associated factors among adolescents, independent of confounders. Method: A sample of 14–17-year-old individuals (n=1.231), who were students from Londrina/PR-Brazil public schools, was studied. A questionnaire about physical activity, sedentary behaviour and socioeconomic conditions was applied. Anthropometry was composed of body weight (kg), height (m), body mass index (BMI=kg/m²) and waist circumference (cm). The association of abdominal obesity and independent variables was assessed using the chi-square test and the magnitude of associations was verified using Binary Logistic Regression in an unadjusted model and adjusted for confounders (gender, age, socioeconomic status, physical activity and sedentary behaviour). The confidence interval and statistical significance were set at 95% and 5%, respectively, using SPSS v15.0. Results: The abdominal obesity prevalence was 17.5% (CI = 15.4%–19.6%), and was higher in boys than in girls. Adolescents with abdominal obesity had higher values of body weight, height, body mass index and sedentary behaviour compared to eutrophic individuals. Being male increased the risk of abdominal obesity by 36% in adolescents. This risk was two times higher in those with high levels of sedentary behaviour. Conclusion: Abdominal obesity was significantly associated with gender and high levels of sedentary behaviour, regardless of confounding factors. Lifestyle habits are important modifiable risk factors that can effectively contribute to the reduction of obesity from an early age.


2019 ◽  
Vol 37 (11) ◽  
pp. 2393-2400 ◽  
Author(s):  
Jin Bong Choi ◽  
Jung Ho Kim ◽  
Sung-Hoo Hong ◽  
Kyung-Do Han ◽  
U-Syn Ha

2002 ◽  
Vol 87 (8) ◽  
pp. 3984-3988 ◽  
Author(s):  
Valentina Vicennati ◽  
Luana Ceroni ◽  
Lorenza Gagliardi ◽  
Alessandra Gambineri ◽  
Renato Pasquali

Subjects with abdominal obesity are characterized by hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. Food intake, particularly at noon, is a well-known inducer of HPA axis activation. Whether obese subjects present an abnormal response to meals containing different macronutrient proportions is at present unknown. Therefore, this study was carried out to investigate the effect of a high-lipid/protein meal (HLP-meal) and a high-carbohydrate meal (HCHO-meal) on the HPA axis activity in women with different obesity phenotypes. Nondepressed, noncomplicated obese (body mass index greater than 28 kg/m2) women with abdominal (A-BFD) (n = 10) and peripheral body fat distribution (P-BFD) (n = 9) and a group of 11 normal-weight controls were investigated in the follicular phase of the menstrual cycle. They were randomly given an 800-kcal HCHO-meal (containing 89% carbohydrates, 11% proteins, 0% lipids), and an 800-kcal HLP-meal (containing 53% lipids, 43% proteins, 4% carbohydrates), which were eaten within 15 min at noon, with an interval of 2 d between each meal. Blood samples for ACTH, cortisol, glucose, and insulin were obtained at 15-min intervals before and after each meal. Baseline hormone and glucose concentrations in the three groups were similar. After the HLP-meal, ACTH tended to similarly but insignificantly increase in all groups, whereas cortisol increased significantly (P < 0.05) in the P-BFD group and insignificantly in the other groups. Conversely, both ACTH and cortisol significantly (P < 0.05) increased only in the A-BFD group, without any significant changes in both controls and P-BFD women. The analysis of the interaction between meals and groups clearly indicated that the cortisol response to the HLP-meal and the HCHO-meal was significantly different (P < 0.025) between the two obese groups, the A-BFD group being characterized by a significantly lower response to the HLP-meal and a significantly higher response to the HCHO-meal, compared with the P-BFD group. Considering all groups together and after adjusting for body mass index, a highly significant relationship was found between cortisol-area under the curve and ACTH-area under the curve after each meal test. However, no relationships were found between changes in ACTH and cortisol and those of glucose, insulin, and the glucose:insulin ratio after each meal. Therefore, our data demonstrate that the response of the HPA axis to meals containing different macronutrient proportions may depend on the pattern of body fat distribution. We also suggest that the activation of the HPA axis following the ingestion of large amounts of carbohydrates may have some pathophysiological relevance, specifically in women with the abdominal obesity phenotype.


2009 ◽  
Vol 65A (4) ◽  
pp. 377-381 ◽  
Author(s):  
R. E. Hubbard ◽  
I. A. Lang ◽  
D. J. Llewellyn ◽  
K. Rockwood

2010 ◽  
Vol 38 (5) ◽  
pp. 1308-1314 ◽  
Author(s):  
Jean-Baptiste M. Paolini ◽  
Julien Mancini ◽  
Michèle Genestal ◽  
Hélène Gonzalez ◽  
Rachel Eshima McKay ◽  
...  

2014 ◽  
Vol 2 (1) ◽  
pp. 48
Author(s):  
Nenni Septyaningrum ◽  
Santi Martini

ABSTRACTThe increasing prevalence of overweight and obesity is associated with the increasing incident of type 2 diabetes mellitus. Obesity, especially abdominal obesity is an important risk factor for the onset of diabetes. The objective of this study was to determine the relationship between body mass index, waist circumference and waist hip ratio with blood glucose level. The study design was cross-sectional. The study population was elderly posyandu member aged 45 to 70 years in Menur clinic work area who were registered in elderly posyandu activities in May 2013. The numbers of sample were 60 respondents who drawn by simple random sampling method. The variabels of this study were the characteristics of respondent, body mass index, waist  circumference,  waist hip ratio and fasting blood glucose level. The study showed that respondents classified as overweight (38%), obesity (33, 3%), abdominal obesity based on waist circumference  (77.8%), abdominal obesity based on waist hip ratio (81,7 %) and blood glucose level more than 125 mg/dl (8.3%). Pearson correlation test showed that there was relationship between body mass index with blood sugar levels (p=0,007; r=0,345), between waist circumference with blood sugar levels (p=0,001; r=0,424) and  between waist hip ratio with blood sugar levels (p =0,002; r=0,392). Waist circumference as the strongest factor related to blood glucose level. Waist circumference measurement should be done in elderly posyandu activities to detect high-risk individuals with diabetes. Keywords: Diabetes, body mass index, waist circumference, waist hip ratio,                     blood glucose level


Author(s):  
E. I. Nikishina ◽  
V. B. Nikishina ◽  
E. A. Petrash

The relevance of the study is conditioned by the need to study the way of eating as a method of correct in geating disorders in adolescents.Objective. To evaluate the correction potential of the nutrition method in adolescents with eating disorders by alimentary obesity type. Characteristic of children and research methods. At the first stage of the study the research sampling was based on the criteria for body mass index assessing in adolescents. The total size of the research sample was 69 adolescents aged13–16 years with alimentary obesity. The group was equalized by gender. At the second stage, the adolescents were surveyed to assess the rules for the use and content of food consumed, including energy value. At the third stage, all patients were divided into three research groups, two groups had a separate program for the correction of eating disorders, taking in to account the measured parameters.Results. The study confirmed the effectiveness of the nutritional disorders method by changing the eating rules and using object-mediated consumption of food (using cutlery – forks, knives, sticks). At the same time, the content, volume and frequency of food intake were preserved. The average weight loss with an indirect way of eating was up to 2 kg per week. In addition, they recorded a decrease in body mass index. The time of food intake significantly increased, which affects the control of the amount of food consumed, transferring eating actions from an involuntary level with a lack of fixation on taste sensations to an arbitrary one.Conclusion. The technique is recommended for use as part of the eating disorders correction, since it can be easily integrated into any methodological complex and has no contraindications.


2019 ◽  
Vol 26 (12) ◽  
pp. 1326-1334 ◽  
Author(s):  
Maira A Ortiz-Pinto ◽  
Honorato Ortiz-Marrón ◽  
Isabel Ferriz-Vidal ◽  
María V Martínez-Rubio ◽  
María Esteban-Vasallo ◽  
...  

Objectives To evaluate the association of general and abdominal obesity with high blood pressure in young children. Methods A longitudinal study including 1796 participants from the Madrid region (Spain) with baseline at age 4 years and a follow-up 2 years later. Blood pressure, body mass index and waist circumference were measured during a physical examination. We evaluated the association between obesity at baseline and weight changes between the ages of 4 and 6 years and high blood pressure. Data were analysed using linear and logistic regressions adjusted for covariates. Results Obese 4 year olds (general or abdominal obesity) experienced an average 4–5 mmHg increase in systolic blood pressure and a 2.5–3 mmHg increase in diastolic blood pressure by the age of 6 years. Compared to children maintaining a non-excess weight (based on body mass index) during follow-up incident and persistent cases of excess weight (overweight or obesity) had an odds ratio (OR) for high blood pressure of 2.49 (95% confidence interval (CI) 1.50–4.13) and OR 2.54 (95% CI 1.27–5.07), respectively. Regarding abdominal obesity we estimated OR 2.81 (95% CI 0.98–8.02) for incident cases and OR 3.42 (95% CI 1.38–8.49) for persistent cases. Similar estimates for the waist–height ratio were observed. Individuals who experienced remission to non-excess weight did not have an increased risk of high blood pressure. Conclusions We observed an increased risk for high blood pressure among 4-year-olds who presented with persistent or incident cases of excess weight (body mass index) or abdominal obesity after 2 years of follow-up. Children with excess weight or obesity at baseline who remitted to non-excess weight did not exhibit an increased risk of high blood pressure.


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