scholarly journals Application possibilities of biguanides for fibrocystic breast disease in women of reproductive age

2019 ◽  
Vol 68 (3) ◽  
pp. 35-40 ◽  
Author(s):  
Ekaterina V. Musina ◽  
Igor Yu. Kogan
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Breast Disease ◽  
Breast Ultrasound ◽  
Reproductive Age ◽  
Childbearing Age ◽  
Actual Problem ◽  
Female Population ◽  
Fibrocystic Mastopathy ◽  
Fibrocystic Breast Disease

Hypothesis/aims of study. The ongoing global problem of health care and medical science is an associated increase in the frequency of endocrine and metabolic diseases and cancer, including in women of childbearing age. Thus, the frequency of diabetes in the population has been growing rapidly for many years. Similar trends were observed in the dynamics of the frequency of cancer pathology, especially of breast cancer, which is one of the leading places in the structure of the cancer incidence in the female population. It is known that diabetes and related insulin resistance have a very negative effect on the female reproductive function, leading to hyperplastic processes of the mammary glands. The least studied problem so far is understanding the mechanisms of development, timely diagnosis, prevention, and treatment of fibrocystic mastopathy, the proliferative forms of which underlie malignant tumors, while its atypical variations are regarded as a precancerous condition. It is likely that the pathogenesis of hyperplastic processes in the mammary gland and the risk of neoplastic transformation in disorders of carbohydrate metabolism may have special factors. The actual problem is the development of a method for pathogenetically substantiated correction of fibrocystic breast disease. This is essential for the development of pharmacological strategies for secondary prevention of breast cancer and, in this regard, it is of great interest to study application possibilities of biguanides. The purpose of the present study was to conduct a comparative assessment of the effectiveness of metformin therapy in fibrocystic mastopathy patients with and without insulin resistance. Study design, materials, and methods. The study involved 120 women, aged 18 to 40 years inclusive, with clinical and / or ultrasound signs of fibrocystic breast disease. According to the results of calculating HOMA index, patients were divided into two groups: the first group comprised 66 patients with insulin resistance (HOMA > 2.5) and the second group consisted of 54 patients with no insulin resistance (HOMA < 2.5). Assessment of mastalgia was performed using the Visual Analogue Scale. Breast ultrasound examination was performed on days 5 to 7 of the menstrual cycle. For the purpose of quantitative image analysis of the breast parenchyma, the following parameters were evaluated: a) thickness of the parenchyma (fibroglandular zone); b) diameter of the milk ducts; c) echogenicity. All patients received metformin at a dose of 1500 mg per day. Dynamic control of the clinical picture of the disease, as well as of mammographic breast parenchymal pattern, was performed after 3 and 6 months from the start of therapy. Results and conclusion. After 6 months of therapy, there was a decrease in the frequency of mastalgia, and significant changes in breast ultrasound picture were observed. The data obtained on the positive effect of metformin on clinical mastitis and structural changes in the mammary parenchyma in patients with mastopathy allow considering such an approach as a promising therapeutic strategy in this pathological association.

scholarly journals Factors influencing breast cancer screening practices among women of reproductive age in South Kayonza District, Rwanda

2021 ◽  
Vol 31 (3) ◽  
pp. 251-257
Author(s):  
Pierre Céléstin Igiraneza ◽  
Lilian A. Omondi ◽  
Bellancille Nikuze ◽  
Marie Goretti Uwayezu ◽  
Margaret Fitch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Screening ◽  
Breast Ultrasound ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Cancer Risk Factors ◽  
Screening Practices ◽  
Factors Influencing

Introduction: Breast cancer in Rwanda is a major concern for women’s health, as most breast cancer diagnoses are made at an advanced stage. Yet, diagnosis can be done early with breast cancer screening practices. Aim: To assess factors influencing breast cancer screening practices among women of reproductive age in South Kayonza District of Rwanda. Methodology: A quantitative survey was conducted with 246 women between 16 and 49 years of age from four health centres in South Kayonza District. A structured, pretested, and self-administered questionnaire was used to assess the influence of knowledge, health facilities, and socioeconomic and cultural factors on breast screening practices among women in South Kayonza. Result: Among all respondents, 55.5% had moderate knowledge about breast cancer risk factors and 60.2% also had moderate knowledge on the influence of breast cancer screening. While 28% were knowledgeable about Breast Self-Examination (BSE), 16.4% were knowledgeable about Clinical Breast Examination (CBE) and breast ultrasound. Responses about the practice of breast screening in the last two years showed 72% of respondents had never practiced BSE and 81.3% had not used CBE or breast ultrasound scan. The main source of information about breast cancer screening was the radio, used by 30.4% of respondents. Significant relationships were found between age and marital status with breast cancer screening practices. Conclusion: This study revealed low levels of knowledge about breast cancer, breast cancer screening, and practice regarding breast cancer screening. There is a need to promote awareness of breast cancer and create a program, which can influence breast cancer screening knowledge and practice to ultimately improve health among women in south Kayonza.

The relationship of osteoporosis with severity of pain dirung the treatment of breast cancer patients of childbearing age

2016 ◽  
Vol 21 (3) ◽  
pp. 122-125
Author(s):  
Nataliya. Yu Tretyakova ◽  
E. V Kotljarov
Keyword(s):  
Breast Cancer ◽  
Hormone Therapy ◽  
Cancer Patients ◽  
Comparison Group ◽  
Specific Treatment ◽  
Reproductive Age ◽  
Breast Cancer Patients ◽  
Childbearing Age ◽  
Relationship Of ◽  
The Relationship

Aim. The analysis of the relationship of osteoporosis with severity of pain and the improvement of the diagnosis of osteoporosis in breast cancer (BC) patients of the reproductive age. Methods. There were examined 60 women, including 30 BC patients at the age from 30 to 50 years and 30 women of similar age as comparison group. The examination included a blood test for osteocalcin, calcitonin, alkaline phosphatase, parathyroid hormone, thyroid stimulating hormone, calcium and phosphorus. The degree ofpain in BC patients was evaluated according to the McGill Pain Questionnaire and classification of pain. Osteodensitometry was made in all BC patients and cases from the comparison group. These 30 BC patients were examined prior to the appointment of specific treatment and a half year after the performed treatment Results. In the analysis of 30 breast cancer patients of childbearing age in 26 patients the onset of artificial menopause occurred. Pain syndrome prior to the treatment of the underlying disease was determined in 20% of cases. 6 months after treatment of BC pain breast cancer was detected in 70% of patients. Artificial menopause is associated with the delivery of chemotherapy and shutdown of ovarian function. Hormone therapy with tamoxifen was prescribed to 16 BC patients, 5 of them were transferred to second-line hormone therapy due to side effects of antiestrogens. At that the menopause is the basic condition for the appointment of aromatase inhibitors. In the examination of the whole group ofpatients in 63,3% of cases were revealed to have osteopenia and osteoporosis. Conclusion The prevalence rate of osteoporosis in BC patients of reproductive age is directly related to the performed specific treatment when the appointment of the therapy of osteoporosis it is necessary in complex treatment of cancer patients for the its prevention

Impact of Symptom and Social Support on Fertility Intention in Reproductive-Age Women With Breast Cancer

2018 ◽  
Vol 29 (6) ◽  
pp. 411-418
Author(s):  
Sheng-Miauh Huang ◽  
Ling-Ming Tseng ◽  
Jerry Cheng-Yen Lai ◽  
Yi-Fang Tsai ◽  
Pei-Ju Lien ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Social Support ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Instrumental Support ◽  
Fertility Intention ◽  
Childbearing Age ◽  
Cross Sectional ◽  
Related Data ◽  
Reproductive Age Women

This study describes the fertility intention and explores factors related to fertility intention in reproductive-age women with breast cancer in Taiwan. In this cross-sectional study, women of childbearing age who had been diagnosed with breast cancer completed a face-to-face survey that included demographic, disease, and symptom-related data, and social support and fertility intention information. The mean fertility intention score among the 223 participants was “medium” ( M ± SD = 41.18 ± 12.62). Higher symptom severity, especially for distress, was related to lower fertility intention. Instrumental support from families and friends was positively associated with fertility intention score. Younger women had better fertility intention scores than older women. The Sobel test showed that age mediated menopause and fertility intention. The findings offer the evidence of the needs to control symptoms and provide sufficient instrumental support regarding fertility after completing chemotherapy.

scholarly journals The effect of Metformin on fibrocystic breast disease in women with insulin resistance

2018 ◽  
Vol 14 (3) ◽  
pp. 19-24
Author(s):  
E. V. Musina ◽  
I. Y. Kogan
Keyword(s):  
Insulin Resistance ◽  
Mammary Gland ◽  
Structural Changes ◽  
Clinical Course ◽  
Dynamic Control ◽  
Breast Disease ◽  
Mammary Glands ◽  
Positive Influence ◽  
Treatment And Prevention ◽  
Fibrocystic Breast Disease

A little studied question is the development mechanism, timely diagnostics, treatment and prevention of the fibrocystic breast disease at patients with insulin resistance. One of the possible perspective directions of pathogenetic impact on tissues of a mammary gland at the mastopathy associated with a giperinsulinemiya and insulin resistance is use of metformin. Now clinical trials on use of metformin at cancer of mammary glands continue. Data on use of medicines of this group at patients with fibrocystic breast disease in domestic and foreign literature are absent.Objective:assessment of influence of metformin on clinical displays of fibrocystic breast disease and ultrasonic characteristics of a parenchyma of mammary glands at patients with insulin resistance.Materials and methods.As therapy of fibrocystic breast disease patients received metformin in a dose of 1500 mg a day. Dynamic control of a clinical picture of a disease and ultrasonic indicators of a parenchyma of a mammary gland carried out in 3 and 6 months from the beginning of therapy.Results and conclusion.In 6 months of therapy there was a reliable decrease in frequency of a mastalgiya, change of an ultorasound picture of mammary glands: echogenicity of a parenchyma of mammary glands – became sredeny in 95,9% of cases, there was a reliable reduction of thickness of a parenchyma of mammary glands (from 15.5 mm to 10. 5 mm) and diameter of lacteal channels (from 1.7 mm to 0.9 mm). The obtained data on positive influence of metformin on the clinical course of mastopathy and structural changes of a parenchyma of mammary glands at patients with fibrocystic breast disease and insulin resistance allow to consider similar approach as the perspective direction of pathogenetic influence at such pathological association.

Clinical Examination as a Screening Method for Breast Cancer

1982 ◽  
Vol 27 (2) ◽  
pp. 152-153 ◽  
Author(s):  
Greg McLatchie ◽  
Colin McArdle ◽  
Thomas Menzies
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Clinical Examination ◽  
Screening Method ◽  
Age Groups ◽  
Breast Disease ◽  
Female Population ◽  
Economical Method ◽  
Patients With Cancer ◽  
Screening Clinic

A five-year experience of a breast cancer screening clinic in a Scottish urban area is reported. During this period 28 per cent of the female population aged 25 to 70 years was screened by clinical examination alone. The pick-up rate for cancers was 7.8 per 1,000 ‘well’ women examined, and 21 per cent of all patients with cancer were under 40 years old. Clinical examination is an effective and economical method of screening for breast cancer. The establishment of similar clinics to detect breast disease in women of all age groups is recommended.

Polycystic Ovary Syndrome and Fibrocystic Breast Disease: An Updated Review

2021 ◽  
Vol 53 (04) ◽  
pp. 219-224
Author(s):  
Michał Kunicki ◽  
Roman Smolarczyk
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Benign Breast Disease ◽  
Polycystic Ovary ◽  
Large Population ◽  
Breast Disease ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Fibrocystic Breast Disease ◽  
Clear Association ◽  
The Relationship

AbstractPolycystic ovary syndrome (PCOS) is the most common hormonal disorder in women of reproductive age. There is no clear association between PCOS and benign breast disease (BBD). The latter is a frequent benign disorder, affecting women between 20 and 50 years of age. To date, the classification remains controversial, and the risk of developing breast cancer that is associated with these changes is different depending on the histopathological findings. The most frequent changes are breast cysts, which are noted in up to 50% of patients older than 30 years of age. This up-to-date review presents the relationship between PCOS and BBD. In conclusion, there is no clear association between benign breast disease and PCOS. Further studies on a large population with prospectively collected data using updated PCOS criteria are necessary.

scholarly journals Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread

2014 ◽  
Vol 4 (1) ◽  
pp. 4-11
Author(s):  
Mirsad Dorić ◽  
Suada Kuskunović-Vlahovljak ◽  
Svjetlana Radović ◽  
Ajna Hukić ◽  
Mirsad Babić ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Histological Grade ◽  
Lymphatic Vessels ◽  
Lymphatic Endothelial Cell ◽  
Breast Disease ◽  
Invasive Breast Carcinoma ◽  
Endothelial Cell Proliferation ◽  
Fibrocystic Breast Disease

Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study was to investigate the existence of lymphangiogenesis in invasive breast carcinoma: by measuring the lymphatic vessels density (LVD) and lymphatic endothelial cell proliferation (LECP) and their correlation with various prognostic parameters in breast cancer, including lymphovascular invasion (LVI).Methods: Lymphatic vessels density was investigated in 75 specimens of invasive breast carcinoma by immunostaining for D2-40 using the Chalkley counting method. Endothelial proliferation in lymphatic vessels was analyzed by dual-color immunohistochemistry with D2-40 and Ki-67.Results: Decrease of intra and peritumoral LVD in invasive breast carcinoma compared to fibrocystic breast disease was detected (p=0.002). Lymphatic endothelial cell proliferation was significantly higher in invasive breast cancer (p=0.008) than in the fibrocystic breast disease. LECP showed a correlation with histological grade of the tumor (p=0.05). Involvement of axillary lymph nodes with metastatic tissue was in strong correlation only with existence of lymphatic vascular invasion (p=0.0001).Conclusion: These results suggest that development of breast cancer promotes proliferation of lymphatic endothelial cells whose level correlates with histological grade of tumor, but in a scope that is insufficient to follow growth of tumor tissue that invades them and destruct them. This might explain the decrease of lymphatic vessels density.

scholarly journals Breast Reduction for Fibrocystic Breast Disease: a case report

2018 ◽  
Vol 7 (2) ◽  
pp. 42-44
Author(s):  
Taslima Sultana ◽  
Maruf Alam ◽  
Shakhawat Hossain
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Connective Tissue ◽  
Breast Reduction ◽  
Breast Disease ◽  
Breast Diseases ◽  
Fibrocystic Disease ◽  
Breast Reduction Surgery ◽  
Fibrocystic Breast Disease ◽  
Clinical Correlate

The pathophysiology of fibrocystic breast disease is determined by estrogen predominance that results in hyper proliferation of connective tissue (fibrosis), the risk of breast cancer is increased twofold to fourfold in these patients. The clinical correlate of fibrocystic disease is reflected by breast and axillary pain or tenderness. The disease progresses with advancing premenopausal age and is most pronounced in women during their 40s. We present a case of 23 years old lady who completely get rid of her symptoms from heavy breast with diagnosed fibrocystic changes immediately after breast reduction surgery. Breast reduction can be a treatment option for fibrocystic breast diseases which are not responding to medical treatment. CBMJ 2018 July: Vol. 07 No. 02 P: 42-44

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