scholarly journals Cure tactics of patients with infertility on suspicion to external genital endometriosis

2021 ◽  
Vol 51 (3) ◽  
pp. 15-18
Author(s):  
V. I. Kulakov ◽  
J. V. Bespalova ◽  
N. I. Volkov
Keyword(s):  
Infertility Treatment ◽  
Female Patients ◽  
Clinical Observations

The role of laparoscopy in diagnostics of the outside genital endometriosis at infertility is indicated on the base of 548 clinical observations. It was made an assessment concerning dependences on clinical appearing the outside genital endometriosis in respect of the grade of process extension. The article contains the algorithm of female patients with infertility treatment on suspicion to the outside genital endometriosis.

Psychological sequelae of infertility treatment: The role of gender and sex-role identification

1991 ◽  
Vol 33 (9) ◽  
pp. 1071-1080 ◽  
Author(s):  
Barbara J. Berg ◽  
John F. Wilson ◽  
Paul J. Weingartner
Keyword(s):  
Sex Role ◽  
Infertility Treatment ◽  
Psychological Sequelae ◽  
Role Identification

scholarly journals BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Andrew S McNeal ◽  
Rachel L Belote ◽  
Hanlin Zeng ◽  
Marcus Urquijo ◽  
Kendra Barker ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Genome Duplication ◽  
Melanocytic Nevus ◽  
Healthy Human ◽  
Melanocytic Nevi ◽  
Clinical Observations ◽  
Human Melanocytes ◽  
Reciprocal Expression ◽  
Benign Melanocytic Nevi

Benign melanocytic nevi frequently emerge when an acquired BRAFV600E mutation triggers unchecked proliferation and subsequent arrest in melanocytes. Recent observations have challenged the role of oncogene-induced senescence in melanocytic nevus formation, necessitating investigations into alternative mechanisms for the establishment and maintenance of proliferation arrest in nevi. We compared the transcriptomes of melanocytes from healthy human skin, nevi, and melanomas arising from nevi and identified a set of microRNAs as highly expressed nevus-enriched transcripts. Two of these microRNAs—MIR211-5p and MIR328-3p—induced mitotic failure, genome duplication, and proliferation arrest in human melanocytes through convergent targeting of AURKB. We demonstrate that BRAFV600E induces a similar proliferation arrest in primary human melanocytes that is both reversible and conditional. Specifically, BRAFV600E expression stimulates either arrest or proliferation depending on the differentiation state of the melanocyte. We report genome duplication in human melanocytic nevi, reciprocal expression of AURKB and microRNAs in nevi and melanomas, and rescue of arrested human nevus cells with AURKB expression. Taken together, our data describe an alternative molecular mechanism for melanocytic nevus formation that is congruent with both experimental and clinical observations.

scholarly journals Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

Bone Research ◽  
2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Charles Hwang ◽  
Simone Marini ◽  
Amanda K. Huber ◽  
David M. Stepien ◽  
Michael Sorkin ◽  
...  
Keyword(s):  
Heterotopic Ossification ◽  
Bone Development ◽  
Surgical Excision ◽  
Vascular Endothelial ◽  
Operative Blood Loss ◽  
Native Bone ◽  
Clinical Observations ◽  
Ectopic Bone ◽  
Endothelial Growth Factor

AbstractHeterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.

scholarly journals Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 224 ◽  
Author(s):  
Sara Lega ◽  
Samuele Naviglio ◽  
Stefano Volpi ◽  
Alberto Tommasini
Keyword(s):  
Severe Disease ◽  
Host Immune System ◽  
Great Effort ◽  
Clinical Observations ◽  
Current State ◽  
Key Factor ◽  
Pharmacologic Treatments ◽  
Immunomodulating Drugs ◽  
Insight Into

As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.

Natriuretic peptides in hormonal regulation of hypoxia responses

2009 ◽  
Vol 296 (2) ◽  
pp. R257-R264 ◽  
Author(s):  
Olli Arjamaa ◽  
Mikko Nikinmaa
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Hormonal Regulation ◽  
Aquatic Organisms ◽  
Future Studies ◽  
Hypoxic Conditions ◽  
Clinical Observations ◽  
Terrestrial Environments ◽  
The Relationship

The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e.g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.

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