scholarly journals Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 224 ◽  
Author(s):  
Sara Lega ◽  
Samuele Naviglio ◽  
Stefano Volpi ◽  
Alberto Tommasini
Keyword(s):  
Severe Disease ◽  
Host Immune System ◽  
Great Effort ◽  
Clinical Observations ◽  
Current State ◽  
Key Factor ◽  
Pharmacologic Treatments ◽  
Immunomodulating Drugs ◽  
Insight Into

As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great effort is being made to understand the disease pathogenesis and host factors that predispose to disease progression in an attempt to find a window of opportunity for intervention. In addition to the direct cytopathic effect of the virus, the host hyper-inflammatory response has emerged as a key factor in determining disease severity and mortality. Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. So far, Covid-19 management remains mainly supportive. However, many researches are underway to clarify the role of antiviral and immunomodulating drugs in changing morbidity and mortality in patients who become severely ill. This review summarizes the current state of knowledge on the interaction between SARS-CoV-2 and the host immune system and discusses recent findings on proposed pharmacologic treatments.

Emerging Role of Technology in Health Education for Youth

2016 ◽  
pp. 1447-1464
Author(s):  
Amir Manzoor
Keyword(s):  
Health Education ◽  
Young People ◽  
Technology Use ◽  
Youth Of Color ◽  
Current State ◽  
Use Of Technology ◽  
Usage Patterns ◽  
Health Related ◽  
Insight Into

The Information Technology (IT) produces significant impact on the emotional and social health of young people. It is obvious that IT is playing an increasingly important part in people's lives. This chapter reviews the current state of youth health and the role of digital landscapes in health education of youth. The chapter also provides insight into how youth, particularly youth of color, use technology to learn, communicate, and discuss various health-related issues. Specific technology needs and usage patterns are identified and success of various initiatives of use of technology for health educations is assessed. Various implications and recommendations are provided for optimizing technology use in young people health education.

scholarly journals Formation of Information Culture of Students as an Integral Component of Educational Activity

2020 ◽  
Vol 6 (7) ◽  
pp. 336-342
Author(s):  
E. Nurkulova ◽  
M. Nurkulova
Keyword(s):  
Knowledge Society ◽  
Educational Activity ◽  
University Libraries ◽  
Information Culture ◽  
Important Place ◽  
Current State ◽  
Key Factor ◽  
Concept Of Information ◽  
Education Of Students

In the modern developing knowledge society, the role and importance of information is expanding more and more, information is becoming a key factor in the development of human civilization. Under these conditions, an important place in the structure of the personality belongs to its information culture, which involves the possession of information sources, the ability to search for it and its active use in life processes. An important role in the mastery of information culture by young people belongs to universities and university libraries. The article shows the relevance of the problem, the importance of these factors in the formation of the information culture of young generations during the period of higher education, when the formation of the entire culture of the personality as a whole is in progress. The content of the concept of information culture is revealed, the current state of the formation of information culture in universities of Kyrgyzstan is briefly characterized, the role of university libraries in the education of students’ information culture is determined.

scholarly journals A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

2016 ◽  
Vol 10 (1) ◽  
pp. 129-140 ◽  
Author(s):  
Brad A. Goupil ◽  
Christopher N. Mores
Keyword(s):  
Clinical Research ◽  
Chikungunya Virus ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Western Hemisphere ◽  
Joint Disease ◽  
Chikv Infection ◽  
Initial Infection ◽  
Current State

Background:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection.Objective:The purpose of this review is to evaluate the literature and summarize the current state of knowledge regarding CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe disease, treatment, and pathogenesis in human patients. Additionally, recommendations are presented regarding avenues for clinical research to help further elucidate the pathogenesis of joint disease associated with CHIKV infection.Conclusion:While there is an association between initial CHIKV infection and acute disease, a causal relationship with development of chronic arthralgia has not been established at this time. Potential causes of chronic CHIKV-induced arthritis have been postulated, including viral persistence, induction of autoimmune disease, and exacerbation of pre-existing joint disease. While there are numerous reports of chronic CHIKV-associated arthralgia and/or arthritis, there is currently no evidence of a definitive link between initial infection and development of chronic disease. Additional, prospective clinical research on CHIKV-associated disease is necessary to further determine the potential role of virus and development of chronic joint disease.

THE ART AND SCIENCE OF SOFTWARE ARCHITECTURE

2007 ◽  
Vol 16 (03n04) ◽  
pp. 439-466 ◽  
Author(s):  
ALAN W. BROWN ◽  
JOHN A. McDERMID
Keyword(s):  
Software Architecture ◽  
Theory And Practice ◽  
Critical Systems ◽  
Art And Science ◽  
Research Activities ◽  
Current State ◽  
Key Factor ◽  
Operational Systems ◽  
Architectural Research

Experience in all aspects of software engineering has confirmed the pivotal role of focusing on architectural concerns in the development of complex software-intensive systems. Consequently, the past 20 years has seen significant investments in the theory and practice of software architecture. However, architectural deficiencies are frequently cited as a key factor in the shortcomings and failures that lead to unpredictable delivery of complex operational systems. Here, we consider the art and science of software architecture: we explore the current state of software architecture, identify key architectural trends, and directions in academia and industry, and highlight some of the architectural research challenges which need to be addressed. The paper proposes a detailed agenda of research activities to be carried out by a partnership between academia and industry. While challenges exist in many domains, for this paper we draw examples from one area of particular concern: safety-critical systems.

scholarly journals Rediscovering Psilocybin as an Antidepressive Treatment Strategy

2021 ◽  
Vol 14 (10) ◽  
pp. 985
Author(s):  
Rene Zeiss ◽  
Maximilian Gahr ◽  
Heiko Graf
Keyword(s):  
Psychiatric Treatment ◽  
Therapeutic Potential ◽  
Future Research ◽  
Current State ◽  
Controversial Topic ◽  
State Of Research ◽  
Antidepressive Treatment ◽  
High Treatment ◽  
Insight Into

There has recently been a renewal of interest in psychedelic research on the use of psilocybin in psychiatric treatment and, in particular, for the treatment of major depressive disorder (MDD). Several state-of-the-art studies have provided new insight into the mechanisms of action of psilocybin and its therapeutic potential. Nevertheless, many questions remain unanswered. With this review, we provide an overview of the current state of research on the potential mechanisms of psilocybin, its antidepressant potential, and the associated risks and adverse effects, to provide an update on a controversial topic discussed in psychopharmacology. A database search was conducted in Medline including articles on psilocybin over the period of the last 20 years. Despite the promising progress in understanding the mechanisms of psilocybin, the exact antidepressive mechanism and the role of the psychedelic experience remain elusive. The studies included in this review found high treatment effect sizes for psilocybin as an antidepressant. However, the results must be regarded as preliminary due to several limitations. Although the current studies observed no severe adverse events, several questions regarding safety and utility remain and must be subject of future research.

scholarly journals Mucus Is a Key Factor in Neisseria meningitidis Commensalism

mSphere ◽  
2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Melanie M. Callaghan ◽  
Joseph P. Dillard
Keyword(s):  
Neisseria Meningitidis ◽  
Human Infection ◽  
Content Type ◽  
Host Interactions ◽  
Air Interface ◽  
Culture Model ◽  
Key Factor ◽  
Tissue Culture Model ◽  
Insight Into

ABSTRACT The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of Neisseria meningitidis and the human nasopharynx. Using an air interface tissue culture model of a polarized, mucus-secreting epithelium, Audry et al. demonstrate that N. meningitidis bacteria do not commonly invade epithelial cells. Rather, they are trapped in the mucus layer, where they are protected from dessication. In this model, meningicocci fail to elicit a pro-inflammatory immune response and show growth effects in response to another nasopharyngeal colonizer, Streptococcus mitis. These findings prompt new questions about pathobiont behaviors, the role of mucus in bacterium-host interactions, and modeling human infection.

scholarly journals Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators

2020 ◽  
Author(s):  
Benjamin Schwarz ◽  
Lokesh Sharma ◽  
Lydia Roberts ◽  
Xiaohua Peng ◽  
Santos Bermejo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Severe Disease ◽  
Severe Infection ◽  
Factors Associated ◽  
Immune Mediators ◽  
Mechanistic Insight ◽  
Immune Balance ◽  
Diabetes And Obesity ◽  
Insight Into

The COVID-19 pandemic has affected more than 10 million people worldwide with mortality exceeding half a million patients. Risk factors associated with severe disease and mortality include advanced age,hypertension, diabetes, and obesity. Clear mechanistic understanding of how these comorbidities converge to enable severe infection is lacking. Notably each of these risk factors pathologically disrupts the lipidome and this disruption may be a unifying feature of severe COVID-19. Here we provide the first in depth interrogation of lipidomic changes, including structural-lipids as well as the eicosanoids and docosanoids lipid mediators (LMs), that mark COVID-19 disease severity. Our data reveal that progression from moderate to severe disease is marked by a loss of specific immune regulatory LMs and increased pro-inflammatory species. Given the important immune regulatory role of LMs, these data provide mechanistic insight into the immune balance in COVID-19 and potential targets for therapy with currently approved pharmaceuticals.

Ambulatory Monitoring of Daily Voice Use

2011 ◽  
Vol 21 (2) ◽  
pp. 56-61 ◽  
Author(s):  
Robert E. Hillman ◽  
Daryush D. Mehta
Keyword(s):  
State Of The Art ◽  
Ambulatory Monitoring ◽  
Vocal Behavior ◽  
Future Directions ◽  
Vocal Function ◽  
Current State ◽  
Voice Use ◽  
Insight Into

Many common voice disorders are chronic or recurring conditions likely to result from faulty and/or abusive patterns of vocal behavior. Such behaviorally based disorders can be difficult to assess accurately in the clinical setting and potentially could be much better characterized by long-term ambulatory monitoring of vocal function as individuals engage in their typical daily activities. Ambulatory monitoring also could provide new insight into the actual role of voice use in common disorders and missing quantitative data on what constitutes normal levels of daily voice use for different groups of individuals, activities, and occupations. This report describes the motivation, previous development efforts, current state-of-the-art technology, and future directions in ambulatory monitoring of voice use.

Emerging Role of Technology in Health Education for Youth

2016 ◽  
pp. 374-390 ◽  
Author(s):  
Amir Manzoor
Keyword(s):  
Health Education ◽  
Young People ◽  
Technology Use ◽  
Youth Of Color ◽  
Current State ◽  
Use Of Technology ◽  
Usage Patterns ◽  
Health Related ◽  
Insight Into

The Information Technology (IT) produces significant impact on the emotional and social health of young people. It is obvious that IT is playing an increasingly important part in people's lives. This chapter reviews the current state of youth health and the role of digital landscapes in health education of youth. The chapter also provides insight into how youth, particularly youth of color, use technology to learn, communicate, and discuss various health-related issues. Specific technology needs and usage patterns are identified and success of various initiatives of use of technology for health educations is assessed. Various implications and recommendations are provided for optimizing technology use in young people health education.

scholarly journals APPLICATION OF SYSTEM ARCHETYPES IN PRACTICE: AN UNDERUTILISED PATHWAY TO BETTER MANAGERIAL PERFORMANCE

2016 ◽  
Vol 17 (6) ◽  
pp. 1081-1096 ◽  
Author(s):  
Vladimír BUREŠ ◽  
Fridrich RACZ
Keyword(s):  
Qualitative Research ◽  
Final Section ◽  
Business Environment ◽  
Organisational Performance ◽  
Managerial Performance ◽  
Current State ◽  
High Level ◽  
System Archetypes ◽  
Insight Into

Current dynamic business environment forces managers to apply various tools in order to improve organisational performance and effectiveness. System archetypes enable to cope with complexity and make appropriate decisions. This study is theoretically grounded in the field of economic cybernetics and system archetype analysis. It applies qualitative research on the sample of 54 managers with the high level of seniority. The aim is to reveal whether system archetypes are effectively used in practice. Two hypotheses focused on both knowledge about and application of system archetypes are tested. The results prove that there are inconsistencies tied to forms of system archetypes insight and knowledge. Moreover, there is an inadequate level of attention identified in investigated organisations. Results imply various potential research pathways that are outlined in the final section of the paper. Hence, the manuscript offers a unique insight into the current state of practical system archetypes utilisation and contributes to the explanation of the role of system archetypes in the economic cybernetics framework.

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