Predictive value of glucose tolerance test

1982 ◽  
Vol 63 (1) ◽  
pp. 18-19
Author(s):  
V. G. Baranov
Keyword(s):  
Glucose Tolerance ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Time Intervals ◽  
Glucose Content ◽  
Glucose Loading ◽  
Normal Glucose ◽  
Risk Zones ◽  
Long Term Observation

Abstract. A retrospective analysis of the long-term observation of the dynamics of normal glucose tolerance in 564 women was carried out. Re-examination revealed violations of tolerance in 33.8% (of doubtful type in 25.7% and of diabetic type in 8.1%). An unfavorable prognostic value of the blood glucose content after glucose loading was established after 1 hour - from 7.8 mmol / L and more and after 2 hours - from 6.1 mmol / L or more. It is proposed to consider these levels as the limit of normoglycemia at the indicated time intervals when conducting a test for glucose tolerance. Glycemia from 7.8 to 9.9 mmol / L 1 hour after glucose loading and from 6.1 to 7.2 mmol / L after 2 hours are regarded by the authors as risk zones for diabetes mellitus.

scholarly journals Postloading insulinemia is independently associated with arterial stiffness in young Japanese persons

2021 ◽  
Author(s):  
Norimitsu Murai ◽  
Naoko Saito ◽  
Sayuri Nii ◽  
Yuto Nishikawa ◽  
Asami Suzuki ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Glucose Tolerance ◽  
Area Under The Curve ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Immunoreactive Insulin ◽  
Oral Glucose ◽  
Glucose Loading ◽  
Before And After ◽  
Normal Glucose

AbstractAssociations of arterial stiffness with glucose, insulin, and proinsulin dynamics during the oral glucose tolerance test (OGTT) remain under debate. The aim of this study was to investigate whether plasma glucose (PG), insulin, and proinsulin (Pro) contribute to arterial stiffness, measured by pulse wave velocity (PWV), in young Japanese persons. PG, immunoreactive insulin (IRI), and Pro levels were determined in 1193 young Japanese subjects (<40 years of age) with normal glucose tolerance or nondiabetic hyperglycemia before and at 30, 60, and 120 min during a 75-g OGTT. Participants were divided into two groups according to the median PWV. Background factors, PG, IRI, and Pro levels during the OGTT, and insulin sensitivity (SI) indices in each group were compared. Several multiple regression analysis models were used to evaluate factors contributing to PWV. All IRI and Pro levels before and after glucose loading and the area under the curve (AUC) values for IRI and Pro increased with higher PWV. 1/HOMA-IR and ISI-Matsuda as measures of SI decreased with higher PWV. The IRI AUC and Pro level before glucose loading (Pro0) were independently associated with PWV, in addition to male sex, heart rate, and mean blood pressure. The IRI AUC had a stronger relationship with PWV than Pro0. The IRI AUC had an independent relationship with PWV, whereas both SI indices did not. Postloading insulinemia, but not reduced SI, was independently associated with arterial stiffness in young Japanese persons.

PLASMA CORTICOSTEROID, PLASMA INSULIN AND BLOOD SUGAR OF NORMAL FASTING AND DIABETIC SUBJECTS WITH OR WITHOUT HYPERCORTICISM

1968 ◽  
Vol 58 (4) ◽  
pp. 643-654 ◽  
Author(s):  
Vivian Harding Asfeldt ◽  
Kai R. Jørgensen
Keyword(s):  
Glucose Tolerance ◽  
Blood Sugar ◽  
Plasma Insulin ◽  
Insulin Response ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Acth Stimulation ◽  
Normal Glucose ◽  
Plasma Insulin Response

ABSTRACT Transient, maximum stimulation with β1–24 corticotrophin has been carried out in nine normal fasting subjects, in two fasting diabetics without hypercorticism and in three fasting diabetics with hypercorticism. Fluorimetric determinations of corticosteroids and determinations of immunological detectable insulin in plasma and blood sugar were made during stimulation. No significant variation in the blood sugar or the plasma insulin during transient, maximum ACTH stimulation was found either in normal fasting subjects or in fasting diabetics with or without hypercorticism. Moreover, in two diabetics with hypercorticism the plasma insulin response was measured during an oral glucose tolerance test. After treatment for approximately seven months with glucocorticosteroids, a reduced glucose tolerance and an increased plasma insulin response were found in one of these two patients. Four and a half months after the termination of steroid treatment, normal glucose tolerance and normal insulin responses were observed. In one patient, after several years of hypercorticism, a reduced glucose tolerance and a markedly reduced plasma insulin response were found.

scholarly journals Inflammatory mediators in morbidly obese subjects: associations with glucose abnormalities and changes after oral glucose

2009 ◽  
Vol 161 (3) ◽  
pp. 451-458 ◽  
Author(s):  
Dag Hofsø ◽  
Thor Ueland ◽  
Helle Hager ◽  
Trond Jenssen ◽  
Jens Bollerslev ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Inflammatory Mediators ◽  
Interleukin 1 ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Normal Weight ◽  
Morbidly Obese ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Normal Glucose

ObjectiveTo explore inflammatory mediators in morbidly obese (MO) subjects with various categories of glucose tolerance and to study the changes in these mediators after an oral glucose load.DesignCross-sectional and experimental study.MethodsA total of 144 MO subjects were classified into three categories: normal glucose tolerance (NGT); pre-diabetes; and new onset diabetes mellitus (NODM) were included, as were 27 normal weight normoglycemic controls. Serum osteoprotegerin (OPG), visfatin, leptin, adiponectin, interleukin-1 receptor antagonist (IL-1Ra), and C-reactive protein (CRP) were analyzed during an oral glucose tolerance test (OGTT).ResultsFasting levels of leptin and IL-1Ra were consistently higher in obese persons (P<0.001 and P<0.05). MO subjects with NGT had higher CRP levels (P<0.001) and lower adiponectin levels (P<0.05) compared to controls. Yet when compared with MO subjects with NODM, those with NGT had lower CRP levels and higher adiponectin levels (both P<0.05). Baseline OPG and visfatin levels did not differ between the groups (P=0.326 and P=0.198). During OGTT, OPG levels decreased (P<0.001) and visfatin levels increased transiently (P=0.018). The response in OPG and visfatin did not differ between the groups (P=0.690 and P=0.170). There were minor changes in adiponectin and leptin levels.ConclusionsMorbid obesity and glucose intolerance were associated with lower adiponectin levels and higher CRP levels, thus supporting a relationship between obesity, glucose homeostasis, and inflammation. Oral glucose suppressed OPG levels and transiently enhanced visfatin levels independent of obesity and glucose tolerance status, indicating that glucose may be involved in the acute regulation of these proteins.

Insulin resistance and cardiovascular risk factors in women with PCOS who have normal glucose tolerance test

2012 ◽  
Vol 29 (2) ◽  
pp. 148-151 ◽  
Author(s):  
Ismail Cem Yildir ◽  
Faruk Kutluturk ◽  
Turker Tasliyurt ◽  
Berna Murat Yelken ◽  
Berat Acu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Glucose Tolerance ◽  
Cardiovascular Risk Factors ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Normal Glucose

scholarly journals Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men

2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
Guang Yin ◽  
Keizo Ohnaka ◽  
Makiko Morita ◽  
Shinji Tabata ◽  
Osamu Tajima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Alcohol Consumption ◽  
Glucose Tolerance ◽  
Positive Association ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Normal Glucose ◽  
Glucose Tolerance Status

This study investigated the association of ADH1B (rs1229984) and ALDH2 (rs671) polymorphisms with glucose tolerance status, as determined by a 75-g oral glucose tolerance test, and effect modification of these polymorphisms on the association between alcohol consumption and glucose intolerance in male officials of the Self-Defense Forces. The study subjects included 1520 men with normal glucose tolerance, 553 with prediabetic condition (impaired fasting glucose and impaired glucose tolerance), and 235 men with type 2 diabetes. There was an evident interaction between alcohol consumption and ADH1B polymorphism in relation to type 2 diabetes (interaction P=.03). The ALDH2487Lys allele was associated with a decreased prevalence odds of type 2 diabetes regardless of alcohol consumption. In conclusion, the ADH1B polymorphism modified the association between alcohol consumption and type 2 diabetes. A positive association between alcohol consumption and type 2 diabetes was confounded by ALDH2 polymorphism.

scholarly journals Association between a biomarker of glucose spikes, 1,5-anhydroglucitol, and cancer mortality

2020 ◽  
Vol 8 (1) ◽  
pp. e001607
Author(s):  
Sakurako Kira ◽  
Chikako Ito ◽  
Rumi Fujikawa ◽  
Munechika Misumi
Keyword(s):  
Glucose Tolerance ◽  
Cancer Mortality ◽  
Cox Regression ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Quartile Group ◽  
Normal Glucose ◽  
Design And Methods ◽  
Risk Of Cancer

Introduction1,5-Anhydroglucitol (1,5-AG) is a biomarker of glucose spikes. To evaluate the effect of acute glucose excursions on cancer death, we clarified the association between 1,5-AG and cancer mortality among Japanese individuals with normal glucose tolerance.Research design and methodsWe measured 1,5-AG in 6783 (2842 men, 3941 women) individuals with normal fasting and 2-hour plasma glucose who received a 75 g oral glucose tolerance test between 1994 and 2012. They were followed for mortality until August 2013. A systematic review of death certificates was used to confirm the cause of death. We divided the participants into four groups according to the quartile of 1,5-AG level at registration. We used Cox regression to clarify the association between 1,5-AG levels and cancer mortality with multivariate adjustment for possible confounders.ResultsDuring the follow-up period (median, 10.0 years), 140 men and 109 women died of cancer. The HR for cancer mortality of the lowest quartile group was higher than that of the highest quartile group in men (HR, 2.62; 95% CI, 1.60 to 4.41) and in women (HR, 1.47; 95% CI, 0.88 to 2.47). These associations were not attenuated with further adjustment for HbA1c.Conclusions1,5-AG was associated with high risk of cancer mortality in Japanese men after adjustment for HbA1c.

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