scholarly journals Comparative evaluation of research methods for patients with gastric ulcer

2021 ◽  
Vol 32 (2-3) ◽  
pp. 162-165
Author(s):  
E. V. Bantin
Keyword(s):  
Gastric Ulcer ◽  
Research Methods ◽  
Comparative Evaluation ◽  
Working Time ◽  
Practical Work ◽  
Significant Part ◽  
Gastric Diseases

It can be said without exaggeration that gastric diseases in our country and in the Union have occupied a particularly prominent place among other diseases in recent years. Each internist, and partly a surgeon, in his daily practical work has to devote a significant part of his working time to the analysis of patients with various gastric diseases.

scholarly journals Histopathological Evaluation of Gastro Protective Effect of Trigonella Foenum Graecum Seed (Methi) and omeprazole in Experimentally Induced Gastric Ulcer in Rats

2020 ◽  
Vol 28 (1) ◽  
pp. 67-75
Author(s):  
Rumana Afroz ◽  
Md Ismail Khan ◽  
Kazi Afzalur Rahman ◽  
Mahbuba Jahan Lotus ◽  
Mir muhammad Shoyeb Shahabuddin ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Developed Countries ◽  
Histopathological Analysis ◽  
Peptic Ulcers ◽  
Gastric Diseases ◽  
Major Drawback ◽  
Medical College ◽  
Trigonella Foenum Graecum

Context: Peptic ulcer is a common disorder of the stomach and duodenum. Bangladesh is a developing country with a very high point prevalence of duodenal ulcer disease (11.9%) and a H. pylori prevalence of more than 90% in asymptomatic adults and 80% in children at the age of 5 years. The multifactorial pathogenesis of peptic ulcers is secretion of gastric acid. The main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole). However, nowadays, gastric ulcer therapy faces a major drawback because most of the drugs currently available in the market show limited efficacy against gastric diseases and are often associated with severe side effects. Thus, there is an urgent need to identify more effective and safe antiulcer agents. In this context, the use of medicinal plants for the prevention and treatment of different pathologies is in continuous expansion worldwide. From the ancient time, various plants were used in traditional medicine with reputation as efficacious remedies. The list of plant derived modern medicine is very long now. About 33% of the drugs produced in the developed countries are derived from plants. Trigonella foenum-graecum (Fenugreek, Methi) is one of them used in many parts of world. Preliminary study on animal showed that Trigonella foenum-graecum seed has significant gastro-protective effect. A study was carried out to demonstrate the gastro-protective effect of aqueous extract and ethanolic extract of Trigonella foenum-graecum seed (Fenugreek, Methi) and omeprazole on ethanol induced gastric ulcer in experimental rats. Material and Methods: The present study was performed on 24 (twenty four) rats which were divided randomly into 4 groups each having 6 rats in the Pharmacology Department of Dhaka Medical college, Dhaka. 1 ml of absolute ethanol (5ml/kg body wt.) was orally administered to all groups by gastric intubations to induce gastric ulcer in all groups except normal control. Omeprazole suspension (20mg/kg body wt) was used as synthetic anti ulcer drug in study. Aqueous and ethanolic extract of Trigonella foenum-graecum seed(500mg/kg body wt) were used respectively orally. Histopathological analysis was carried out to evaluate the gastroprotective activity of aqueous and ethanolic extract of Trigonella foenum-graecum seed and omeprazole on ethanol induced gastric ulcer in experimental rats. Result: Pretreatment with aqueous and ethanolic extract of Trigonella foenum-graecum seed (500mg/kg/body wt) showed very significant prevention in ethanol induced gastric ulcer. Results of the study showed that in case of ethanol treated rats gross examination showed a large amount of haemorrhagic lesions confined mostly in the gastric corpus. Histologically lesion involved about two-third of the mucosa layer and exfoliation of the mucosal cells was detected. Meanwhile, red blood cells were present in the gastric mucosa and edematous submucosa was discovered. However aqueous and ethanolic extract of Trigonella foenum-graecum seed significantly reduced the haemorrhagic lesions, tissue proliferation, infiltration of cells and sloughing induced by ethanol. This prevention was statistically very significant (P<0.001). Conclusion: The aqueous and ethanol extracts of Trigonella foenum-graecum seed and omeprazole possess gastro protective properties. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 67-75

Who am I? (Personal name as a tool for self-identification of Russianspeaking bilingual children)

2021 ◽  
Vol 82 (2) ◽  
pp. 66-75
Author(s):  
A. V. Zelenin ◽  
N. L. Ivanova
Keyword(s):  
Pilot Study ◽  
Research Methods ◽  
Significant Part ◽  
Bilingual Children ◽  
Case Study Method ◽  
Electronic Survey ◽  
Identification Processes

This article presents the results of a sociolinguistic electronic survey conducted in 2017–2019 in Finland. The purpose was to reveal the attitude of children towards their names in bilingual and polylingual families living in Finland. The questionnaire was answered by 19 children (4 interviews was taken additionally) aged from 10 to 16 years old (born between 2002–2010). The research methods were: the method of sociolinguistic questionnaire, focused interviews, the method of verification, the case study method. As a result, socio-psychological motives determining the orientation of variants of children’s names both at the culture of their parents (family) and the Finnish society. The novelty of the pilot study is an analysis of bilingual children’s reflections on their personal name as a significant part in self-identification processes.

scholarly journals Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil

2000 ◽  
Vol 192 (11) ◽  
pp. 1601-1610 ◽  
Author(s):  
Keiji Ogura ◽  
Shin Maeda ◽  
Masafumi Nakao ◽  
Takeshi Watanabe ◽  
Mayumi Tada ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Secretion System ◽  
Mongolian Gerbils ◽  
Wild Type ◽  
Gastric Diseases ◽  
Type Iv ◽  
H Pylori ◽  
Isogenic Mutants

Helicobacter pylori infection induces various gastroduodenal diseases. We examined the role of two genes, vacA and cagE, in the gastric pathogenesis induced by H. pylori using a long-term (62 wk) animal model. Reportedly, both genes are associated with the virulence of H. pylori: vacA encodes vacuolating cytotoxin, and cagE, with other genes in the cag pathogenicity islands, encodes a type IV secretion system. Mongolian gerbils were challenged in this study by a wild-type TN2 strain and its isogenic mutants of cagE or vacA. The wild-type and vacA mutants induced severe gastritis, whereas cagE mutants induced far milder changes. Gastric ulcer was induced at the highest rate (22/23) by the wild-type TN2, followed by the vacA mutant (19/28). No ulcer was found in the gerbils infected with the cagE mutant (0/27) or in controls (0/27). Intestinal metaplasia was also found in the gerbils infected with the wild-type (14/23) or vacA mutant (15/28). Gastric cancer developed in one gerbil with wild-type infection and in one with vacA mutant infection. In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role.

scholarly journals WORKS OF THE FAMOUS CENTRAL ASIAN SCIENTIST ABU ALI IBN SINA IN THE FIELD OF PHYSICS

2021 ◽  
Vol 5 (1) ◽  
pp. 2-17
Author(s):  
Malokhat Akhadovna Vakhobova ◽  
◽  
Munira Ibragimovna Akhrorova
Keyword(s):  
Research Methods ◽  
Physical Science ◽  
Historical Data ◽  
Manufacturing Sector ◽  
Practical Work ◽  
Natural Phenomena ◽  
Ibn Sina ◽  
Central Asian ◽  
Heavy Loads ◽  
Solid Bodies

Introduction. This article examines the scientific and practical work of the sultan of the science of medicine Abu Ali ibn Sina in the field of physics. In the rare masterpieces created by Ibn Sina, his ideas about the structure of mater, the laws of dynamics, natural phenomena, the eye and vision, the historical data in the correspondence of Ibn Sina and Beruni were studied to explain the essence of the content of physics. Research methods. The actual task of physical science is the movement of bodies under the influence of the same force placed on bodies of different masses, their interaction, the laws of inertia, the lifting of heavy loads to the top, the splitting of solid bodies, the expansion and contraction of bodies from heat to cold, the application of the laws of refraction and return in the field of technology and in the field of the manufacturing sector. Results and discussions.

scholarly journals Personal anxiety and its manifestation in young teenagers.

2021 ◽  
Vol 4 (1) ◽  
pp. 134-142
Author(s):  
Nina V. Skrynnikova ◽  
Keyword(s):  
Theoretical Analysis ◽  
Research Methods ◽  
Early Adolescence ◽  
Social Situation ◽  
Practical Work ◽  
Scientific Schools ◽  
The Social ◽  
Deductive Method ◽  
Personal Anxiety ◽  
The Subject

This article gives the concept of anxiety and disturbance as an object of research in various psychological scientific schools, as well as the characteristics of personal anxiety in early adolescence, which are directly related to the social situation of development and the leading activity of this age period. It also highlights the main caus-es of personal anxiety in early adolescence. The object of the research is anxiety and disturbance. The subject is personal anxiety in early adolescence. The aim of the study is to identify and characterize the features of personal anxiety in early adolescence. The following research methods were used: theoretical analysis of literature and sources, hypothetical-deductive method, modeling method. The results obtained are the basis for further empirical and practical work in this area.

Aquaporin 3 Expression Pattern in Gastric Diseases and its significance

2020 ◽  
Author(s):  
Heng Li ◽  
Xudong Dai ◽  
Jin Dou ◽  
Hualin Xu ◽  
Qi Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Ulcer ◽  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
Treatment Strategy ◽  
Gastric Carcinogenesis ◽  
Gastric Erosion ◽  
Gastric Diseases ◽  
Aquaporin 3 ◽  
Gastric Intestinal Metaplasia

Abstract Background Aquaporin 3(AQP3) has been implicated in gastric intestinal metaplasia and gastric cancer, and considered as a biomarker to improve treatment strategy. Accumulating evidence suggests that AQP3 is involved in the gastric carcinogenesis and the disease progression. However, whether AQP3 is involved in the transformation from gastritis to gastric cancer remain elusive. In this study, we intended to realized the expression pattern and its significance of AQP3 in different gastric diseases. Methods A total of 101 patients diagnosed with gastric diseases were included in the study. A gastric tissue biopsy was taken from the gastric antrum during endoscopic examination. Expression of AQP3 protein is determined by immunohistochemistry using polyclonal rabbit anti-AQP3 antibody. Percentage of positive cells and staining intensity were counted and measured. Results The frequency of AQP3 positivity was similar between the disease types of chronic gastritis, gastric ulcer, gastric erosion, and atrophic gastritis, whereas the frequency of AQP3 positivity was significantly higher in patients with gastric intestinal metaplasia、gastric dysplasia 、gastric polyps and intestinal-type gastric adenocarcinoma than that in patients with gastritis, gastric ulcer, gastric erosion, or atrophic gastritis(p<0.0001, p=0.001, p=0.006, p=0.0009, respectively), especially in the patients with hyperplastic polyps (p<0.0001). Conclusion The frequency of AQP3 positivity was significantly higher in patients with gastric intestinal metaplasia, gastric dysplasia, and gastric adenocarcinoma, and the frequency between them was similar, suggesting that AQP3 expression is peaked at the stage of gastric intestinal metaplasia, which further confirmed that gastric intestinal metaplasia is a pivotal progression in gastric carcinogenesis pathologically. Interestingly, it is the first time to report AQP3 positive expression in patients with gastric polyps. In short, AQP3 is involved in the progression from gastritis to gastric adenocarcinoma, and might be a potential biomarker to improve the treatment strategy of gastric cancer.

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