scholarly journals Steinach. Ueber die centripetale Erregungsleitung im Bereiche des Spinalganglions. (On the centripetal conduction of excitation along the dorsal nodes). - Arch of Pfluger. Bd. 78, p. 291

2020 ◽  
Vol VIII (2) ◽  
pp. 181-185
Author(s):  
D. Polumordvinov
Keyword(s):  
Spinal Cord ◽  
Spinal Nerve ◽  
Nerve Cells ◽  
Point Of View ◽  
Nerve System ◽  
Conduction Of Excitation

According to the generally accepted view, sensory excitation in the spinal nerve system reaches the spinal cord through the nerve cells of the dorsal nodes, which from this point of view with full right can be attributed to the category of sensitive nerve cells. Working in the early 90s on the issue of negative fluctuations, Steinach came across a fact that remained completely inexplicable for him until the last day.

scholarly journals OTAK DAN AKAL DALAM AYAT-AYAT NEUROSAINS

2018 ◽  
Vol 18 (1) ◽  
pp. 115-140
Author(s):  
Fu`ad Arif Noor
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Molecular Biology ◽  
Spinal Nerve ◽  
Nerve Cells ◽  
Genetic Studies ◽  
The Past ◽  
Reasonable Use ◽  
Brain And Spinal Cord ◽  
The Brain

Neuroscience, are simply the science devoted to learning Neoron(nerve cells). Nerve cells make up the nervous system, both thecentral nervous system (brain and spinal cord) and the peripheralnerves (31 pairs and 12 pairs of spinal nerve head). A nerve cellitself is not the smallest unit away from the nerve cell, the smallestunit of nerve cells (neurons) are the synapses ie the meeting point oftwo nerve cells move and pass the information (neurotransmitters).At the level of molecular biology, the smallest unit is like genes(genetic studies). Generally, the neuroscientist focused on nervecells in the brain. In the Qur'an sense has a glorious position. It wasevident the word "reasonable" in the Qur'an is mentioned insignificant amounts. The word "reasonable" in the Qur'an is called49 times. All in the form mudhari deed '(a verb that indicates thecurrent and future), but one that is shaped madhi verb (a verb thatindicates the past).Although the Qur'an does not mention the "sense" in its form as' acertain part of the human self '(سفنلا ىف لاقتسم ارهوج), which becamethe source of the birth of any acts rationally, but the Qur'anmentions "reasonable" in its meaning as' activities reasonable use'(لقعتلا ةيلمع), the appeal that invites use of reason as the path to truth(لقعتلا), thinking (ركفتلا), watching (رظنلا), to understand and learn(هقفتلا), take the wisdom and lessons from each incident (رابتعلاا) andetc.

Immunocytochemical methodology for the localization of neuronal antigens at the ultrastructural level

1990 ◽  
Vol 48 (3) ◽  
pp. 876-877
Author(s):  
Jorge Pecci Saavedra ◽  
Mark Connaughton ◽  
Juan José López ◽  
Alicia Brusco
Keyword(s):  
Spinal Cord ◽  
Substantia Nigra ◽  
Polyclonal Antibodies ◽  
Ultrastructural Level ◽  
Point Of View ◽  
Nerve Tissue ◽  
Tissue Fixation ◽  
Optimal Conditions ◽  
Interpeduncular Nucleus ◽  
Technical Point

The use of antibodies as labels for the localization of specific molecules in the nervous systan has been extensively applied in recent years. Both monoand polyclonal antibodies or antisera have been employed. The knowledge of the organization of neuronal connectivities, gliovascular relationships, glioneuronal relationships and other features of nerve tissue has greatly increased.A number of areas of the nervous systan have been analyzed in our laboratory, including the nuclei of the raphe system, the reticular formation, interpeduncular nucleus, substantia nigra, caudate nucleus, putamen, pallidum, spinal cord, pineal gland and others.From a technical point of view, a number of variables needed to be taken into account in order to obtain reliable and reproducible results. The design of the optimal conditions of tissue fixation, embedding, sectioning, dilution of antibodies, and adaptation of Sternberger PAP technique were sane of the parameters taken into account to optimize the results. It is critical that each step of the technique be defined for each particular case.

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

The Neurosurgical Point of View on Spinal Cord Tumors

1998 ◽  
Vol 11 (3) ◽  
pp. 271-273
Author(s):  
R.M. Villani ◽  
O. De Divitiis
Keyword(s):  
Spinal Cord ◽  
Point Of View ◽  
Spinal Cord Tumors

scholarly journals Croonian lecture.— The mammalian spinal cord as an organ of reflex action

1897 ◽  
Vol 61 (369-377) ◽  
pp. 220-221 ◽  
Keyword(s):  
Spinal Cord ◽  
Spinal Nerve ◽  
Spinal Reflex ◽  
Reflex Action

The channels of connection between spinal nerve-centres. Long spinal reflex paths and short spinal reflex paths. The First Law of Pflüger: examples of it and exceptions to it; relation between it and microscopical features of the cord.

scholarly journals Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain

2021 ◽  
Vol 17 ◽  
pp. 174480692110033
Author(s):  
Travis Okerman ◽  
Taylor Jurgenson ◽  
Madelyn Moore ◽  
Amanda H Klein
Keyword(s):  
Spinal Cord ◽  
Sciatic Nerve ◽  
Signaling Pathway ◽  
Intracellular Signaling ◽  
Morphine Tolerance ◽  
Spinal Nerve ◽  
Intracellular Signaling Pathway ◽  
Spinal Cord Dorsal ◽  
Phosphoinositide 3 Kinase ◽  
Induced Tolerance

Research presented here sought to determine if opioid induced tolerance is linked to activity changes within the PI3Kγ-AKT-cGMP-JNK intracellular signaling pathway in spinal cord or peripheral nervous systems. Morphine or saline injections were given subcutaneously twice a day for five days (15 mg/kg) to male C57Bl/6 mice. A separate cohort of mice received spinal nerve ligation (SNL) one week prior to the start of morphine tolerance. Afterwards, spinal cord, dorsal root ganglia, and sciatic nerves were isolated for quantifying total and phosphorylated- JNK levels, cGMP, and gene expression analysis of Pik3cg, Akt1, Pten, and nNos1. This pathway was downregulated in the spinal cord with increased expression in the sciatic nerve of morphine tolerant and morphine tolerant mice after SNL. We also observed a significant increase in phosphorylated- JNK levels in the sciatic nerve of morphine tolerant mice with SNL. Pharmacological inhibition of PI3K or JNK, using thalidomide, quercetin, or SP600125, attenuated the development of morphine tolerance in mice with SNL as measured by thermal paw withdrawal. Overall, the PI3K/AKT intracellular signaling pathway is a potential target for reducing the development of morphine tolerance in the peripheral nervous system. Continued research into this pathway will contribute to the development of new analgesic drug therapies.

scholarly journals TWIK-Related Spinal Cord K+Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation

2015 ◽  
Vol 56 (5) ◽  
pp. 1307 ◽  
Author(s):  
Hee Youn Hwang ◽  
Enji Zhang ◽  
Sangil Park ◽  
Woosuk Chung ◽  
Sunyeul Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
K Channel ◽  
Spinal Dorsal ◽  
Channel Expression

scholarly journals A Contribution to the Morbid Anatomy and the Pathology of General Paralysis of the Insane

1900 ◽  
Vol 46 (195) ◽  
pp. 688-711
Author(s):  
David Orr ◽  
Thomas Philip Cowen
Keyword(s):  
Spinal Cord ◽  
Nerve Cells ◽  
General Paralysis ◽  
Preliminary Communication ◽  
Morbid Anatomy

At the last February meeting of the Manchester Pathological Society we made a preliminary communication upon this subject, limited to a description of the changes found in the cortical nerve-cells and the descending degenerations in the spinal cord. Since then we have examined a much larger number of cases, and can therefore give a fuller description, with observations upon other points in the morbid anatomy of general paralysis of the insane.

scholarly journals Systemic Administration of Fibroblast Growth Factor 21 Improves the Recovery of Spinal Cord Injury (SCI) in Rats and Attenuates SCI-Induced Autophagy

2021 ◽  
Vol 11 ◽  
Author(s):  
Sipin Zhu ◽  
Yibo Ying ◽  
Lin Ye ◽  
Weiyang Ying ◽  
Jiahui Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Functional Recovery ◽  
Nerve Cells ◽  
Systemic Administration ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Cord Injury

Protecting the death of nerve cells is an essential tactic for spinal cord injury (SCI) repair. Recent studies show that nerve growth factors can reduce the death of nerve cells and promote the healing of nerve injury. To investigate the conducive effect of fibroblast growth factor 21 (FGF21) on SCI repair. FGF21 proteins were systemically delivered into rat model of SCI via tail vein injection. We found that administration of FGF21 significantly promoted the functional recovery of SCI as assessed by BBB scale and inclined plane test, and attenuated cell death in the injured area by histopathological examination with Nissl staining. This was accompanied with increased expression of NeuN, GAP43 and NF200, and deceased expression of GFAP. Interestingly, FGF21 was found to attenuate the elevated expression level of the autophagy marker LC3-II (microtubules associated protein 1 light chain 3-II) induced by SCI in a dose-dependent manner. These data show that FGF21 promotes the functional recovery of SCI via restraining injury-induced cell autophagy, suggesting that systemic administration of FGF21 could have a therapeutic potential for SCI repair.

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