The method of the exophthalmos value predicted calculation when planning the orbital decompression procedure in patients with endocrine ophthalmopathy

BACKGROUND: The most effective method of surgical treatment of lipogenic and mixed forms of edematous exophthalmos is currently the internal orbital decompression. During this surgical procedure, the excessive pathologically altered adipose tissue is removed from the external and the internal surgical spaces of the orbit. Many scientists are developing methods for calculating the volume of orbital fat, but the question on developing a method for predicted exophthalmos after internal orbital decompression, which could be used without attracting additional equipment and software, is easy to learn and does not require a long calculation time, remains actual. This method has to take into account the individual features of the patients orbital structure and be used for calculations in the bilateral proptosis correction. AIM: To develop and evaluate the effectiveness of a new method for calculating the eyeball position after orbital decompression. MATERIALS AND METHODS: 64 patients (126 orbits) with lipogenic and mixed forms of endocrine ophthalmopathy were examined. All patients underwent internal orbital decompression, during which the orbital fat was removed, the volume of which was calculated according to the developed original method. Patients underwent ophthalmological examination and MSCT before surgery and 6 months after it. . RESULTS: As a result of orbital decompression in the examined group, a decrease in proptosis was observed in all patients, and the exophthalmos calculated by the method corresponded to the eyeball position in patients in 6 months after surgery. The level of statistical significance of the planned postoperative eyeball position in relation to the actual postoperative exophthalmos calculated according to the Students t-test was 0.98 (p 0.05), that is, it can be argued that the groups do not differ, and no statistically significant differences were found. CONCLUSIONS: The developed method for calculating the estimated postoperative exophthalmos is effective without using additional software. This technique allows you to achieve a symmetrical eyeball position in the postoperative period and to reduce the risk of complications.

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Orbital Decompression for Endocrine Ophthalmopathy: The Endonasal Approach

American Journal of Rhinology ◽

10.2500/105065894781874430 ◽

1994 ◽

Vol 8 (3) ◽

pp. 123-128 ◽

Cited By ~ 4

Author(s):

Wolf J. Mann ◽

G. Kahaly ◽

W. Lieb ◽

Ronald G. Amedee

Keyword(s):

Visual Acuity ◽

Training Program ◽

Complication Rate ◽

Present Series ◽

Orbital Decompression ◽

Endonasal Approach ◽

Muscle Training ◽

Orbital Fat ◽

Lamina Papyracea ◽

Endocrine Ophthalmopathy

A surgical endonasal procedure is described to perform orbital decompression in patients suffering from ophthalmopathy in Grave's disease. The decompression technique employs removal of the lamina papyracea as an exclusive modality or in conjunction with a transmaxillary or lateral decompression approach. This present series contain 23 patients who underwent decompression over a 3-year period and were followed for at least 6 months postoperative. The results of decompression were assessed by measuring reduction in proptosis and visual acuity. All patients demonstrated improved visual acuity. Measuring retroplacement of the globe, the endonasal approach proved to equal the results obtained after a combined transantral-endonasal approach. Orbital fat was removed depending on the degree of proptosis. The complication rate was low, and establishment of an ocular muscle training program proved helpful.

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Etiology, clinical presentation, laboratory diagnostics, pathogenesis of impetigo and treatment methods

Terapevt (General Physician) ◽

10.33920/med-12-2003-07 ◽

2020 ◽

pp. 64-70

Author(s):

Anastasiya Laknitskaya

Keyword(s):

Streptococcus Pyogenes ◽

Skin Diseases ◽

Group A Streptococcus ◽

Antibiotic Sensitivity ◽

Antioxidant Defense System ◽

Laboratory Diagnostics ◽

Treatment Methods ◽

Group A ◽

The Individual

Currently, one of the priority medical and social problems is the optimization of treatment methods for pyoderma associated with Streptococcus pyogenes — group A streptococcus (GAS). To date, the proportion of pyoderma, the etiological factor of which is Streptococcus pyogenes, is about 6 % of all skin diseases and is in the range from 17.9 to 43.9 % of all dermatoses. Role of the bacterial factor in the development of streptococcal pyoderma is obvious. Traditional treatment complex includes antibacterial drugs selected individually, taking into account the antibiotic sensitivity of pathognomonic bacteria, and it is not always effective. Currently implemented immunocorrection methods often do not take into account specific immunological features of the disease, the individual, and the fact that the skin performs the function of not only a mechanical barrier, but it is also an immunocompetent organ. Such an approach makes it necessary to conduct additional studies clarifying the role of factors of innate and adaptive immunity, intercellular mediators and antioxidant defense system, that allow to optimize the treatment of this pathology.

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The Influence of the Physiotherapeutic Program on Selected Static and Dynamic Foot Indicators and the Balance of Elderly Women Depending on the Ground Stability

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094660 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4660

Author(s):

Joanna Matla ◽

Katarzyna Filar-Mierzwa ◽

Anna Ścisłowska-Czarnecka ◽

Agnieszka Jankowicz-Szymańska ◽

Aneta Bac

Keyword(s):

Elderly Women ◽

Statistical Significance ◽

Exercise Program ◽

Control Group ◽

Balance Assessment ◽

Motor Functions ◽

Static Test ◽

Group A ◽

Group B ◽

The Impact

Seniors are a constantly growing group of people in many societies. It is necessary to develop physiotherapeutic programs to improve their mobility. The aim of this study was to assess the impact of the physiotherapeutic program conducted unstable ground on selected indicators of motor functions of elderly women. Sixty women (60–80 years) participated in the research. Group A (N = 20) underwent a 12-week physiotherapeutic program on stable ground, group B (N = 20) followed an exercise program on unstable ground, and group C (N = 20) (control group) had no therapeutic intervention. The effects of the therapy were assessed by using a FreeMed platform (foot load analysis) and a Biosway balance system. The results were compared using ANOVA (the one-way analysis), the Kruskal–Wallis test and also the post hoc tests (Tukey’s test and the multiple comparison test). In group A, a statistically significant change was observed in the static test and balance assessment, in group B this was observed in the static and dynamic foot tests and balance assessment, in group C, no statistical significance was achieved. The authors’ physiotherapeutic program had a statistically significant effect on changes in the balance and selected indicators of the motor functions of the examined people. Comparing the results before and after the therapy more improvement changes were noted in women training on an unstable ground compared to women training on a stable ground.

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Marginal Integrity of CAD/CAM Ceramic Crowns Using Two Different Finish Line Designs

Medical Principles and Practice ◽

10.1159/000516833 ◽

2021 ◽

Author(s):

Jaber Hussain Akbar ◽

Ridwaan Omar ◽

Yacoub Al Tarakmah

Keyword(s):

Dental Treatment ◽

Statistical Significance ◽

United States Public Health ◽

Finish Line ◽

Marginal Integrity ◽

Computer Aided ◽

Cad Cam ◽

Group A ◽

Group B ◽

Line Design

Statement of problem- Research on evaluation of crowns made by the latest CAD/CAM systems for their marginal adaptation is scarce. Purpose- The purpose of this in vitro study was to evaluate the marginal integrity of crowns fabricated by the latest Chairside Economical Restorations of Esthetic Ceramic (CEREC) system using two different finish line preparation designs: Chamfer and Shoulder. Material and methods- Typhodont teeth were equally divided into two groups, group A and B. The teeth were prepared for full coverage crowns with a shoulder (group A) and chamfer finish line design (group B). An experienced prosthodontist prepared all crown preparations. Evaluation of six sites per sample was completed by two calibrated, experienced prosthodontists using the modified United States Public Health Services (USPHS) criteria. The descriptive statistics and Z-test were used to evaluate the results. Results- A total of 180 teeth were included in the study (90 teeth in each group). Only two crowns in group A and one crown in group B were clinically unacceptable. There was no statistical significance (p=0.282) between the two groups regarding finish-line design. Conclusions- CEREC system provides clinically acceptable crowns and can safely be utilized in dental treatment. Therefore, Contemporary Dental Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) restorations should be considered as a safe treatment modality by dental professionals.

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The Subjective Present and Its Modulation in Clinical Contexts

Timing & Time Perception ◽

10.1163/22134468-00002013 ◽

2013 ◽

Vol 1 (2) ◽

pp. 239-259 ◽

Cited By ~ 7

Author(s):

Wolfgang Tschacher ◽

Fabian Ramseyer ◽

Claudia Bergomi

Keyword(s):

Perceptual Grouping ◽

Statistical Significance ◽

Temporal Distribution ◽

Future Research ◽

Implicit Processes ◽

The Social ◽

Gestalt Perception ◽

Psychotherapeutic Techniques ◽

The Mean ◽

The Individual

Time is a basic dimension in psychology, underlying behavior and experience. Timing and time perception constitute implicit processes that are often inaccessible to the individual person. Research in this field has shown that timing is involved in many areas of clinical significance. In the projects presented here, we combine timing with seemingly different fields of research, such as psychopathology, perceptual grouping, and embodied cognition. Focusing on the time scale of the subjective present, we report findings from three different clinical studies: (1) We studied perceived causality in schizophrenia patients, finding that perceptual grouping (‘binding’, ‘Gestalt formation’), which leads to visual causality perceptions, did not distinguish between patients and healthy controls. Patients however did integrate context (provided by the temporal distribution of auditory context stimuli) less into perceptions, in significant contrast to controls. This is consistent with reports of higher inaccuracy in schizophrenia patients’ temporal processing. (2) In a project on auditory Gestalt perception we investigated auditory perceptual grouping in schizophrenia patients. The mean dwell time was positively related to how much patients were prone to auditory hallucinations. Dwell times of auditory Gestalts may be regarded as operationalizations of the subjective present; findings thus suggested that patients with hallucinations had a shorter present. (3) The movement correlations of interacting individuals were used to study the non-verbal synchrony between therapist and patient in psychotherapy sessions. We operationalized the duration of an embodied ‘social present’ by the statistical significance of such associations, finding a window of roughly 5.7 seconds in conversing dyads. We discuss that temporal scales of nowness may be modifiable, e.g., by mindfulness. This yields promising goals for future research on timing in the clinical context: psychotherapeutic techniques may alter binding processes, hence the subjective present of individuals, and may affect the social present in therapeutic interactions.

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Anisotropy of the galaxy cluster X-ray luminosity–temperature relation

Astronomy and Astrophysics ◽

10.1051/0004-6361/201731222 ◽

2018 ◽

Vol 611 ◽

pp. A50 ◽

Cited By ~ 5

Author(s):

Konstantinos Migkas ◽

Thomas H. Reiprich

Keyword(s):

Galaxy Clusters ◽

Statistical Significance ◽

Cosmological Parameters ◽

Galaxy Cluster ◽

Luminosity Distance ◽

Temperature Relation ◽

X Ray ◽

Two Samples ◽

The Galaxy ◽

Group A

We introduce a new test to study the cosmological principle with galaxy clusters. Galaxy clusters exhibit a tight correlation between the luminosity and temperature of the X-ray-emitting intracluster medium. While the luminosity measurement depends on cosmological parameters through the luminosity distance, the temperature determination is cosmology-independent. We exploit this property to test the isotropy of the luminosity distance over the full extragalactic sky, through the normalization a of the LX–T scaling relation and the cosmological parameters Ωm and H0. To this end, we use two almost independent galaxy cluster samples: the ASCA Cluster Catalog (ACC) and the XMM Cluster Survey (XCS-DR1). Interestingly enough, these two samples appear to have the same pattern for a with respect to the Galactic longitude. More specifically, we identify one sky region within l ~ (−15°, 90°) (Group A) that shares very different best-fit values for the normalization of the LX–T relation for both ACC and XCS-DR1 samples. We use the Bootstrap and Jackknife methods to assess the statistical significance of these results. We find the deviation of Group A, compared to the rest of the sky in terms of a, to be ~2.7σ for ACC and ~3.1σ for XCS-DR1. This tension is not significantly relieved after excluding possible outliers and is not attributed to different redshift (z), temperature (T), or distributions of observable uncertainties. Moreover, a redshift conversion to the cosmic microwave background (CMB) frame does not have an important impact on our results. Using also the HIFLUGCS sample, we show that a possible excess of cool-core clusters in this region, is not able to explain the obtained deviations. Furthermore, we tested for a dependence of the results on supercluster environment, where the fraction of disturbed clusters might be enhanced, possibly affecting the LX–T relation. We indeed find a trend in the XCS-DR1 sample for supercluster members to be underluminous compared to field clusters. However, the fraction of supercluster members is similar in the different sky regions, so this cannot explain the observed differences, either. Constraining Ωm and H0 via the redshift evolution of LX–T and the luminosity distance via the flux–luminosity conversion, we obtain approximately the same deviation amplitudes as for a. It is interesting that the general observed behavior of Ωm for the sky regions that coincide with the CMB dipole is similar to what was found with other cosmological probes such as supernovae Ia. The reason for this behavior remains to be identified.

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Stability in Waking-Sleep States in Neonates as a Predictor of Long-Term Neurologic Outcome

PEDIATRICS ◽

10.1542/peds.76.1.52 ◽

1985 ◽

Vol 76 (1) ◽

pp. 52-63

Author(s):

Cesare T. Lombroso ◽

Yoichi Matsumiya

Keyword(s):

Statistical Significance ◽

Observation Time ◽

Long Term Outcomes ◽

Newborn Period ◽

Waking And Sleep ◽

Total Observation Time ◽

Total Observation ◽

The Individual

Thirty-three full-term neonates were ranked blindly on a scale ranging from the least to the highest "risk" for future neurologic complications on the basis of available perinatal biographies, tests, and examinations performed during the newborn period. Four prolonged polygraphic-behavioral recordings were obtained one week apart beginning at ten days after birth. Five waking and sleep states were scored in each session as percentages of total observation time, giving a total of 20 scores for each baby to be subjected to analysis of variance. These measures also provided individual profile consistency or variability in maintaining waking-sleep states over the selected period of postnatal time. The whole cohort, except three infants who could not be followed adequately, was then reexamined periodically over a period ranging from 3 to 4 years (±6 months) for neurologic and developmental assessments. Except for two scores that produced a low level of statistical significance (P < .05), the other 18 scores were found to be not associated with long-term outcomes. Even the first two scores were not satisfactory discriminators for the outcome of the individual babies. However, when coefficients of concordance (W) were computed from each individual baby profile, significant statistics (P < .001) emerged to indicate good correlations between high or low W values in the newborn period and long-term outcomes. All 17 newborns who had W scores greater than 0.9 were found to be normal at follow-up regardless of the poor ranking given several of them during the newborn period. Among the 13 newborns who had W scores less than 0.9, 11 had a poor clinical outcome at follow-up, though several had been ranked initially as falling within the least "risk" group.

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Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

Molecules ◽

10.3390/molecules23123109 ◽

2018 ◽

Vol 23 (12) ◽

pp. 3109 ◽

Cited By ~ 3

Author(s):

Andres Bernal-Ballen ◽

Jorge Lopez-Garcia ◽

Martha-Andrea Merchan-Merchan ◽

Marian Lehocky

Keyword(s):

Antibacterial Activity ◽

Polyvinyl Alcohol ◽

Statistical Significance ◽

Antibacterial Properties ◽

Intermolecular Forces ◽

Polymeric System ◽

Bacterial Strains ◽

Natural Polymers ◽

The Matrix ◽

The Individual

Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

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Averaging and integral manifolds

Bulletin of the Australian Mathematical Society ◽

10.1017/s0004972700041812 ◽

1970 ◽

Vol 2 (2) ◽

pp. 197-222 ◽

Cited By ~ 16

Author(s):

W. A. Coppel ◽

K. J. Palmer

Keyword(s):

Autonomous System ◽

Method Of Characteristics ◽

Integral Manifold ◽

Artificial Viscosity ◽

Original Method ◽

Method Of Averaging ◽

System Of Differential Equations ◽

Viscosity Term ◽

Integral Manifolds ◽

The Individual

An integral manifold for a system of differential equations is a manifold such that any solution of the equations which has a point on it is entirely contained on it. The method of averaging establishes the existence of such a manifold for a system which is a perturbation of an autonomous system with a periodic orbit. The existence of the manifold is established here under more general hypotheses, namely for perturbations which are ‘integrally small’. The method differs from the original method of Bogolyubov and Mitropolskii and operates directly with the individual solutions. This is made possibly by the use of an appropriate norm, and is equivalent to solving the partial differential equation which occurs in work by Moser and Sacker by the method of characteristics rather than by the introduction of an artificial viscosity term. Moreover, detailed smoothness properties of the manifold are obtained. For periodic perturbations the integral manifold is a torus and these smoothness properties are just sufficient to permit the application of Denjoy's theorem.

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A cross-sectional study of the use and effectiveness of the Individual Development Plan among doctoral students

F1000Research ◽

10.12688/f1000research.15154.2 ◽

2018 ◽

Vol 7 ◽

pp. 722 ◽

Cited By ~ 4

Author(s):

Nathan L. Vanderford ◽

Teresa M. Evans ◽

L. Todd Weiss ◽

Lindsay Bira ◽

Jazmin Beltran-Gastelum

Keyword(s):

Career Development ◽

Doctoral Students ◽

Online Survey ◽

Career Planning ◽

Statistical Significance ◽

Development Plan ◽

Individual Development ◽

Negative Consequences ◽

Cross Sectional ◽

The Individual

Background: The Individual Development Plan (IDP) was introduced as a tool to aid in career planning for doctoral trainees. Despite the National Institutes of Health and academic institutions creating policies that mandate the use of IDPs, little information exists regarding the use and effectiveness of the career planning tool. Methods: We conducted a multi-institutional, online survey to measure IDP use and effectiveness. The survey was distributed to potential respondents via social media and direct email. IDP survey questions were formatted using a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). For data analysis purposes, responses were grouped into two categories (agree versus does not agree/disagree). The data were summarized as one-way frequencies and the Pearson chi-square test was used to determine the statistical significance of univariate associations between the survey variables and an outcome measure of the effectiveness of the IDP. Results: Among all respondents, fifty-three percent reported that they are required to complete an IDP while thirty-three percent reported that the tool is helpful to their career development. Further, our data suggests that the IDP is most effective when doctoral students complete the tool with faculty mentors with whom they have a positive relationship. Respondents who are confident about their career plans and who take advantage of career development resources at their institution are also more likely to perceive that the IDP is useful for their career development. Conclusion: Given the nuanced use and effectiveness of the IDP, we call for additional research to characterize the overall use and effectiveness of the IDP and to determine whether there are unintended negative consequences created through the use of the tool. Furthermore, we recommend an enhancement of career development infrastructure that would include mentorship training for faculty in order to provide substantially more career planning support to trainees.

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