scholarly journals The frequency of postpartum hemorrhage in women with different somatotypes

2019 ◽  
Vol 10 (1) ◽  
pp. 37-41
Author(s):  
Sergey N. Gaidukov ◽  
Kristina G. Tomaeva ◽  
Elena N. Komissarova
Keyword(s):  
Postpartum Hemorrhage ◽  
Preventive Measures ◽  
Risk Group ◽  
First Trimester ◽  
High Accuracy ◽  
High Risk Group ◽  
Body Type ◽  
Effective Implementation ◽  
Postpartum Bleeding ◽  
First Trimester Of Pregnancy

The aim of the study was to study the frequency of postpartum hemorrhage in women with different somatotypes and to develop a method for predicting the risk of this pathology. Materials and methods. 390 women were examined, 110 were mаcrosomatotype, 173 – mesosomatotype, and 107 – microsomatotype. Somatometry was performed according to R.N. Dorokhov for women in early pregnancy (before 9-10 weeks of gestation). Results. It was found that postpartum hemorrhage was significantly more prevalent among the women of macro-and microsomatic body type compared with women with mesosomatotypes (p < 0.05). In the course of multiple regression analysis, we obtained a regression equation (formula) for predictive models, which predicts the development of postpartum hemorrhage in women of different somatotypes. The calculations according to the presented formula, allows to predict with high accuracy the prognosis of postpartum bleeding, and also allows to form among patients a high-risk group for the development of this disease in the first trimester of pregnancy when the pregnant woman is registered in the women’s consultation, long before delivery, which will contribute to more effective implementation of therapeutic and preventive measures to prevent the development of postpartum bleeding.

scholarly journals A model for predicting the risk of preeclampsia in women with different somatotypes

2020 ◽  
Vol 68 (6) ◽  
pp. 65-72
Author(s):  
Kristina G. Tomayeva ◽  
Sergey N. Gaydukov
Keyword(s):  
Risk Groups ◽  
First Trimester ◽  
High Accuracy ◽  
Podocyte Injury ◽  
Spectrophotometric Methods ◽  
Effective Implementation ◽  
Expectant Mothers ◽  
Therapeutic Measures ◽  
First Trimester Of Pregnancy ◽  
Risk Of Preeclampsia

Hypothesis/aims of study. Preeclampsia is a serious pregnancy-specific multi-organ disease of complex etiology. It affects 36% of expectant mothers worldwide and it persists as a leading cause of maternal and fetal morbidity and mortality. This study aimed at analyzing the frequency of preeclampsia in women with different somatotypes and at developing a prediction model to determine the risk of this disease. Study design, materials and methods. 390 women were examined, of whom 110 were of the macrosomatic type, 173 of the mesosomatic type, and 107 of the microsomatic type. Somatometry was performed according to R.N. Dorokhov in women in early pregnancy (before 910 weeks of gestation). The urinary excretion of markers for podocyte injury (nephrin, podocalyxin, and VEGF) was measured using ELISA spectrophotometric methods. Results. Preeclampsia has been found to be significantly more prevalent among the representatives of the macrosomatic type, compared to women of the meso- and microsomatic types. Urine nephrin, podocalyxin and VEGF levels were significantly higher in women of the macrosomatic type, as compared to those of the meso- and microsomatic types. Using multiple regression analysis, we obtained the regression equation (formula), which predicts the development of preeclampsia in women of different somatotypes. Conclusion. Carrying out calculations according to the presented formula allows predicting the occurrence of preeclampsia with high accuracy, as well as forming high-risk groups among patients already in the first trimester of pregnancy when a pregnant woman is registered in the womens consultation, long before the disease develops. This will contribute to more effective implementation of therapeutic measures to prevent the development of this complication.

scholarly journals Cohort profile: targeted antenatal screening for haemoglobinopathies in Basel

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e035735
Author(s):  
Gabriela Amstad Bencaiova ◽  
Franziska Geissler ◽  
Irene Hoesli
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Risk Group ◽  
Iron Status ◽  
First Trimester ◽  
High Risk Group ◽  
University Hospital ◽  
Pregnancy Cohort ◽  
Haemoglobin Variant ◽  
Adverse Pregnancy

PurposeThe pregnancy cohort was established to examine the prevalence and variety of haemoglobinopathies in a high-risk group of pregnant women.ParticipantsThe pregnancy cohort is located in the Department of Obstetrics and Antenatal Care, University Hospital of Basel. The pregnant women were recruited in the first trimester between June 2015 and May 2019. Family origin questionnaires were used to screen pregnant women for the risk of a haemoglobin variant. Based on the questionnaire, pregnant women were divided into two groups: women with a high risk and women with a low risk of a haemoglobin variant. In women with a high risk, red blood cell indices, iron status and chromatography were conducted.Findings to date1785 pregnant women were recruited. Out of the 1785 women, 929 were identified as a part of the high-risk group. Due to the missing data of 74 pregnant women with a high risk, the final analysis was conducted in the remaining 855 women. The prevalence of haemoglobinopathies in the high-risk group was 14.5% (124/855).Future plansThis cohort will be used to: (1) implement the screening in prenatal care in Basel; (2) recommend the screening among pregnant women with a high risk of a haemoglobin variant in Switzerland; (3) improve prenatal and neonatal care in patients with a haemoglobin variant; (4) examine adverse pregnancy outcomes in women with a haemoglobin variant and (5) reduce maternal and neonatal morbidity and mortality in the future.Trial registration numberClinicalTrials.gov Registry (NCT04029142).

Prediction of placental insufficiency in pregnant women with different somatotypes

2020 ◽  
Vol 69 (4) ◽  
pp. 23-28
Author(s):  
Kristina G. Tomayeva
Keyword(s):  
Pregnant Women ◽  
Preventive Measures ◽  
Risk Groups ◽  
Serum Levels ◽  
Placental Insufficiency ◽  
Fetal Growth Retardation ◽  
Fetal Hypoxia ◽  
Body Type ◽  
Effective Implementation ◽  
Placental Dysfunction

Hypothesis/aims of study. Poor placental vascularization can lead to placental insufficiency, due to which the metabolism of nutrients and microelements between the maternal and fetal blood circulations subsequently decreases. Due to poor perfusion of placental vessels, placental dysfunction occurs. Chronic fetal hypoxia causes fetal growth retardation. The aim of this study was to assess the frequency of placental insufficiency in women with different somatotypes and to develop a model for predicting the risk of this pathology. Study design, materials and methods. A total of 390 women were examined, of whom 110 were macrosomatic, 173 mesosomatic, and 107 microsomatic. Somatometry was performed according to R.N. Dorokhov for women in the early stages of pregnancy (up to 9-10 weeks). Placental insufficiency markers (VEGF, PlGF, IL-6, and endocan-1) were determined spectrophotometrically in blood serum at the gestational age of 1213 and 2223 weeks using ELISA methods. Results. Placental insufficiency was significantly more prevalent among the women of the macro- and microsomatic body type compared with those of mesosomatotypes (p 0.05). In pregnant women with subsequent placental insufficiency, VEGF and PlGF serum levels at 1213 weeks were lower, when compared to those in patients who did not develop pathology (p 0.05), and the levels of serum endocan-1 and IL-6 were higher in comparison with those in individuals who did not develop pathology (p 0.05). Using multiple regression analysis, we obtained the regression equation (formula), which predicts the development of placental insufficiency in women of different somatotypes. Conclusion. The resulting formula allows us to accurately predict the development of placental insufficiency and to form high-risk groups among women for the development of this disease. This will contribute to the effective implementation of therapeutic and preventive measures to avert the development of this pathology.

scholarly journals Ultrasound elastography capabilities in studying uterine cerviх state in pregnant women of high-risk group in the first trimester of pregnancy

2016 ◽  
Vol 97 (4) ◽  
pp. 656-661
Author(s):  
M G Tukhbatullin ◽  
K V Yanakova
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Chromosomal Abnormality ◽  
Chromosomal Abnormalities ◽  
Ultrasound Examination ◽  
Risk Group ◽  
First Trimester ◽  
High Risk Group ◽  
Control Group ◽  
Significant Difference

Aim. To study capabilities of quantitative elastographic study to assess the elasticity of the uterine cervix in women with a fetal chromosomal abnormality in the first trimester of pregnancy.Methods. 230 pregnant women of high-risk group at 11-13.6 weeks of pregnancy (parietal-coccygeal length 45-84 mm) were included in this study. The first group consisted of 213 women without fetal pathology. The second group included 17 women, in whose fetuses different chromosomal abnormalities were detected. In ultrasound examination of pregnant women in the I trimester of pregnancy, in addition to standard methods of examination, quantitative cervical elastography was performed.Results. According to results of quantitative elastography in 14 (82.35%) out of 17 pregnant women (second group) one or another degree of the cervical tissue softening was found, and 3 (17.64%) pregnant women with fetal chromosomal pathology had stiff cervix (all 3 cases with Down syndrome). In the control group in 10 (4.7%) of 213 pregnant women relatively soft cervix was identified, and in 203 (95.3%) women cervical density was higher than the myometrial density. A statistically significant difference between the indices of SWE-Ratio in groups was revealed. Quantitative elastography, as a diagnostic test predicting the risk of miscarriage due to chromosomal abnormalities, has a high sensitivity (84.38%) and even higher specificity (95.26%) of negative predictive value 97.57%.Conclusion. Quantitative elastography reveals a significant decrease in the cervical elasticity (softening) in pregnant women with fetal chromosomal abnormality in the I trimester of pregnancy, which allows us to recommend this method of ultrasound examination as an additional marker for early diagnosis of miscarriage due to fetal chromosomal abnormality.

scholarly journals THICKNESS OF subcutaneous AND preperitoneal fat: ASSESSMENT AND IMPORTANCE OF THE PARAMETER IN PREGNANT WOMEN WITH COMPONENTS OF METABOLIC SYNDROME

2018 ◽  
pp. 39-43
Author(s):  
O. N. Kononova ◽  
A. M. Pristrom ◽  
N. V. Nikolayeva ◽  
O. V. Zotova ◽  
A. V. Korotayev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Pregnant Women ◽  
Metabolic Disorders ◽  
Risk Group ◽  
First Trimester ◽  
Reproductive Age ◽  
Cardiovascular Risks ◽  
Lipid Exchange ◽  
Reproductive Losses ◽  
First Trimester Of Pregnancy

Objective: to assess results of ultrasonography of the thickness of subcutaneous and preperitoneal fat in women with components of metabolic syndrome in the first trimester of pregnancy (n = 143). Material and methods. Anthropometrical parameters, indicators of carbohydrate and lipid exchange have been investigated. The thickness of subcutaneous and preperitoneal fat has been studied. Results. It has been found that increased thickness of subcutaneous and preperitoneal fat is observed in pregnant women with both metabolic syndrome and risk factors for development of metabolic syndrome. Women of reproductive age with obesity make a risk group of development of metabolic disorders in the gestational period. Conclusion. To prevent metabolic disorders and reproductive losses, it is necessary to take measures to reduce overweight in women before pregnancy. Prevalence and importance of obesity and metabolic syndrome in female patients of reproductive age necessitate further comprehensive and thorough investigation of pathogenetic mechanisms of its development aimed at decrease of cardiovascular risks in future.

Сhorionic bump: analysis of 16 cases and literature review

2018 ◽  
Author(s):  
N.A. Altynnik, M.V. Medvedev, Å.G. Voytuk
Keyword(s):  
Prenatal Diagnosis ◽  
High Risk ◽  
Literature Review ◽  
Risk Group ◽  
First Trimester ◽  
High Risk Group ◽  
Prenatal Ultrasound ◽  
Ultrasound Diagnosis ◽  
Threatened Miscarriage ◽  
Dynamic Ultrasound

Sixteen cases of prenatal ultrasound diagnosis of chorionic bump at 6–29 weeks of gestation, as well as an analysis of the literature covering 97 cases of prenatal diagnosis of chorionic bump is presented. All cases of chorionic bump was isolated. In 14 (87.5 %) cases the outcome of pregnancy was favourable, in 2 (12.5 %) cases were poor outcome. Сhorionic bump on first-trimester sonography is not necessarily associated with a guarded prognosis, but it condition is recommended to assign the patient to the high-risk group of a threatened miscarriage and ensure careful dynamic ultrasound observation.

scholarly journals PREVENTION OF PREECLAMPSIA IN WOMEN WITH MULTIPLE PREGNANCY AFTER ASSISTED REPRODUCTION

2020 ◽  
Vol 73 (3) ◽  
pp. 494-497
Author(s):  
Tamara G. Romanenko ◽  
Olha M. Sulimenko
Keyword(s):  
Pregnant Women ◽  
Biochemical Markers ◽  
Preventive Measures ◽  
Risk Group ◽  
Plasma Concentrations ◽  
Multiple Pregnancy ◽  
Perinatal Outcomes ◽  
High Risk Group ◽  
Prospective Analysis ◽  
Second Trimester

The aim: To reduce the frequency and severity of preeclampsia, to improve obstetrical and perinatal outcomes in women with multiple pregnancy after assisted reproduction by the development and implementation of the preventive algorithm with biochemical markers of endothelial dysfunction prospective analysis. Materials and methods: Clinical and laboratory prospective analysis of 54 cases of twins in women, treated from infertility with assisted reproductive technologies (ART), using the method of intracytoplasmic sperm injection (ICSI) and frozen embryos transfer, have been made. It was proven, that women with multiple pregnancy are always in a high risk group of placental dysfunction (PD) and preeclampsia (PE). Depending on the treatment algorithm and preventive measures, 2 groups of patients were formed. Group I included 29 pregnant women with twins, managed in accordance with developed recommendations. We didn’t find evidence-based European guidelines, that would recommend routine prescription of progesterone to improve chorion invasion and further placentation in such group of patients, but in order to prevent endothelial dysfunction and to decrease the incidence and severity of preeclampsia, placental abnormalities and intrauterine growth restriction (IUGR), we proposed the following algorithm: – micronized progesterone 200 mg vaginally (PV), as soon as pregnancy was diagnosed by positive hCG-test, till 16 weeks of pregnancy, angioprotector diosmin 600 mg once daily orally (PO), 2 courses: from 8 till 12 and from 16 till 20 weeks of gestation, antiaggregant – acetylsalicylic acid 150 mg from 12 till 36 weeks of gestation. Group II included 25 pregnant women with twins after the same ART procedures, who have not received above mentioned treatment. Plasma concentrations of PlGF, sFlt-1 and the ratio of sFlt-1/PlGF in the second trimester were investigated in both groups of women in order to assess the effectiveness of proposed preventive measures. Results: Usage of preventive algorithm has shown the reduction of PE incidences in 26%, PD in 28.1%, IUGR in 35%, prematurity by 23% and fetal distress in 18%, that led to improvement of obstetrical and perinatal outcomes in I group of women with multiple pregnancies after ART-treated infertility, compared with group II (p<0.05). The evaluation of PlGF, sFlt-1 plasma concentrations and the ratio of sFlt-1/PlGF in the second trimester of pregnancy reflected the effectiveness of our method in women with twins after ART. The level of PlGF in the study group was higher (186.5 ± 12 vs 154.2 ± 10.7; p<0.05), and the level of sFlt-1 was lower (1523.1 ± 40.3 vs 1835.3 ± 33.6; p <0.05). Results of sFlt-1/PlGF ratio analysis in the I group also showed effectiveness of the method proposed (20.3 ± 3.1 vs 28.1 ± 2.2; p<0.05). Conclusions: The observed results suggest, that pregnant women with twins after ART-treated infertility are in a high-risk group of PE, PD and IUGR of one or both fetuses. Implementation of the proposed preventive algorithm allows to reduce the incidence of PE, obstetrical and perinatal complications in this group of patients, and can be widely used in clinical practice. Evaluation and prospective assessment of biochemical markers, such as PlGF, sFlt-1 and sFlt-1/PIGF ratio, in the second trimester of pregnancy in the target groups may likely predict the development of PE and its severity.

Weight-for-Height as a Measure of Nutritional Status in Filipino Pregnant Women

1988 ◽  
Vol 2 (2) ◽  
pp. 96-104 ◽  
Author(s):  
JA Magbitang ◽  
JBM Tangco ◽  
EO de laCruz ◽  
EG Flores ◽  
FE Guanlao
Keyword(s):  
At Risk ◽  
Pregnant Women ◽  
Low Birthweight ◽  
Preventive Measures ◽  
First Trimester ◽  
Risk Indicator ◽  
Low Birth Weight Babies ◽  
First Trimester Of Pregnancy ◽  
The Subject ◽  
Potential Use

A weight-for-height table by week of pregnancy for Filipinos was developed and its potential use in identifying mothers at risk of delivering low birth-weight babies was tested. The table derived from the weight-for-height table for adult Filipinos developed by de Leon et al assumed the following: 1). Average increase in weight during pregnancy is 20% of pre-pregnant weight, with an increase of 1.7% of pre-pregnant weight in the first trimester of pregnancy and the remaining 18.3% increase achieved during the second and third trimesters. 2). The pre-pregnant weight of the subject equals the standard reference for her height. The derived table was subsequently tested on existing data on 158 urban and rural pregnant women sampled by Magbitang et al2and Baltazar et al.3Results showed that pregnant women whose weight at first visit was below 95% of the proposed standard had twice as much risk of delivering low birthweight babies than those whose weights were greater than or equal to 95% of the proposed standard. The table can be used by barangay level workers as a risk indicator for screening mothers at risk of delivering low birthweight babies so that appropriate and timely preventive measures can be taken.

scholarly journals Features Of The Anamnesis Of Women With The Threat Of Miscarriage And Their Role In Determining The Risk Group

2020 ◽  
Vol 2 (09) ◽  
pp. 32-34
Author(s):  
Solieva N.K. ◽  
Negmatullaeva M.N ◽  
Sultonova N. A
Keyword(s):  
Clinical Symptoms ◽  
Risk Group ◽  
First Trimester ◽  
Control Group ◽  
Biological Factors ◽  
Lower Abdomen ◽  
Case Histories ◽  
Perinatal Center ◽  
First Trimester Of Pregnancy

Determine the role of studying socio-biological factors and obstetric-gynecological history in predicting and early diagnosis of the threat of termination in the first trimester of pregnancy. We analyzed 210 case histories of patients who were treated in the gynecological department of the Perinatal Center in Bukhara and were observed in antenatal clinics No. 6 and No. 11 of the same city for the period of 2019. All pregnant women were divided into two groups. The main I-group consisted of 110 women, whose pregnancies with the threat of termination with clinical symptoms - pain in the lower abdomen with the onset of the 1st trimester at gestation periods from 5 to 12 weeks. The control group included 100 patients with the physiological course of pregnancy II – group.

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