The structure of the thymus and mesenteric lymph nodes of newborn rats as a result of the prenatal influence of ethanol

2015 ◽  
Vol 6 (4) ◽  
pp. 51-55 ◽  
Author(s):  
Petr Vladimirovich Pugach ◽  
Sergey Vladimirovich Kruglov ◽  
Natalia Rafailovna Karelina ◽  
Dmitriy Vitalievich Breusenko ◽  
Stepan Yurevich Bazhin ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Morphological Changes ◽  
Alcohol Intoxication ◽  
Sole Source ◽  
Structural Features ◽  
Lymphoid Cells ◽  
Newborn Rats ◽  
Mesenteric Lymph Nodes ◽  
White Rats ◽  
Mesenteric Lymph

The present study was undertaken to examine the structural features of the thymus and cranial mesenteric lymph nodes of newborn rats that have occurred as a result of antenatal alcohol intoxication. We used a set of morphometric, anatomical and histological methods. A study of the cranial mesenteric lymph nodes performed on 45 newborn rats born to 18 female mongrel white rats seven months of age. The studies were conducted in compliance with the order of the Ministry of Health of the USSR N 755 from 12.08.1977 and the order of the Ministry of Higher and Secondary Special Education of the USSR from 13.11.1984, "On the rules of work with experimental animals". Females, on which was received investigated offspring exposed to 15 % ethanol as the sole source of fluid for 1 week, one and three months before pregnancy, during pregnancy and after its completion. It is shown that depending on the duration of pregravid exposure to ethanol occur progredient changes in the structure of the thymus and cranial mesenteric lymph nodes. In the thymus, as well as in the lymph nodes, decreases the number of lymphoid cells and stromal elements content increases. In lymph nodes there are significant changes in the structure of the sinus system. The severity of the identified morphological changes due to the duration of the effects of alcohol on the system "mother-placenta-fetus”.

The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles

2014 ◽  
Author(s):  
Olga V. Zlobina ◽  
Svetlana S. Pakhomy ◽  
Alla B. Bucharskaya ◽  
Irina O. Bugaeva ◽  
Galina N. Maslyakova ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Lymph Nodes ◽  
Morphological Changes ◽  
Peroral Administration ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals Electron microscopic changes of lymph nodes during correction of sodium glutamate action by melatonin

2020 ◽  
Vol 26 (1) ◽  
pp. 59-64 ◽  
Author(s):  
T.V. Harapko
Keyword(s):  
Lymph Nodes ◽  
Monosodium Glutamate ◽  
Reproductive Age ◽  
Female Rats ◽  
Mesenteric Lymph Nodes ◽  
Electron Microscopic ◽  
Male And Female ◽  
White Rats ◽  
Mesenteric Lymph ◽  
Male And Female Rats

The effect of monosodium glutamate on lymphoid organs remains insufficiently studied. Also, no less relevant is the issue of correction of changes caused by the action of monosodium glutamate. The aim of the study was to study the electron microscopic changes in the parenchyma of the lymph nodes of rats under the action of monosodium glutamate for six weeks and during correction with melatonin. The experimental study was performed on 66 white male and female rats of reproductive age. The structure of mesenteric lymph nodes of white rats under the conditions of physiological norm at the electron microscopic level was studied in 10 intact animals. Experimental animals were divided into 4 groups, each with 10 animals. The control was 16 white rats, which instead of a high-calorie diet (HCD) received a standard diet of vivarium. HCD was achieved by adding to the diet of monosodium glutamate at a dose of 0.07 g/kg body weight of rats. The dose of melatonin was 10 mg/kg body weight of rats, administered orally daily at the same time in the afternoon. The electron microscopic structure of the mesenteric lymph nodes of male and female rats of reproductive age of the intact and control groups corresponds to the species norm. The study showed that monosodium glutamate causes changes in the parenchyma of the lymph nodes as in alimentary obesity. After six weeks of HCD, the number of apoptically altered lymphocytes increases. That part of lymphocytes, which has no signs of karyorrhexis or karyolysis, has a karyolemma with deep intussusception, the cytoplasm is enlightened, the tubules of the granular endoplasmic reticulum in cells with signs of edema, dilated, mitochondrial ridges swollen, damaged. There are profound destructive changes in the cellular composition of the organ and violations at the level of all parts of the vascular bed. After six weeks of melatonin correction, the number of macrophages and plasma cells decreased, in some lymphocytes the nucleolus is not clearly expressed, the karyolemma is uneven, the cytoplasm is enlightened, the number of osmophilic (fatty) inclusions decreases both in the intercellular space and in the cytoplasm of the cell. Therefore, the introduction of melatonin led to a significant restoration of the structural organization, and hence the function of this organ.

scholarly journals Fulminant Liver Failure with Necrotizing Foci in the Liver, Spleen and Lymph Nodes in Celiac Disease Due to Malignant Lymphoma

1996 ◽  
Vol 10 (4) ◽  
pp. 225-229 ◽  
Author(s):  
Hugh James Freeman
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Lymph Nodes ◽  
Liver Failure ◽  
Cell Receptor ◽  
Lymphoid Cells ◽  
Mesenteric Lymph Nodes ◽  
Rare Type ◽  
Mesenteric Lymph ◽  
Spleen And Lymph Nodes

A 65-year-old female with celiac disease developed cholestatic jaundice and fatal liver failure. Investigations revealed widespread necrotic foci in the liver, spleen and mesenteric lymph nodes, changes reminiscent of the mesenteric lymph node cavitation syndrome, which is known to complicate celiac disease. In addition, malignant lymphoid cells were present infiltrating hepatic sinusoids, lymph nodes and spleen. These features are typical of hepatosplenic lymphoma, a rare type of peripheral T cell lymphoma with T cell receptor rearrangement. Lymphorecticular malignancy complicating celiac disease may present with fulminant liver disease.

scholarly journals CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Emma C. Mackley ◽  
Stephanie Houston ◽  
Clare L. Marriott ◽  
Emily E. Halford ◽  
Beth Lucas ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Lymphoid Cells ◽  
Intestinal Cells ◽  
Lymphoid Tissues ◽  
Mesenteric Lymph Nodes ◽  
Cell Responses ◽  
Mesenteric Lymph ◽  
Peripheral Lymph ◽  
Group 3 ◽  
Draining Lymph Nodes

Abstract Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

Protoplasmic fragments in haematopoietic tissues and analysis of intranuclear vesicles in lymph node blast cells of the rabbit

1970 ◽  
Vol 48 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Jean E. Mills Westermann ◽  
Jessica L. G. Shelley ◽  
Vibeke E. Engelbert
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Formation ◽  
Lymphoid Cells ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Blood Smears ◽  
Blast Cells

Vesicles and cytoplasmic fragments are found in greatest numbers in the lymph node and spleen and least commonly in the thymus and bone narrow in the rabbit. Vesicles appear to originate by the extrusion of intranuclear and intracytoplasmic vesicles mostly from cells of the lymphoid series. Cytoplasmic fragments formed by the pinching off of cytoplasmic buds of blast and lymphoid cells may be either round, oval, or irregular in shape. Vesicles and cytoplasmic fragments are absent from blood smears and extremely difficult to recognize in sections or in areas of imprints where the cells are closely applied one to another. About one-third of all round to oval "naked" blast cells in imprints of mesenteric lymph nodes contain vesicles ranging to 7 μ in diameter although most are about 1 μ in diameter. Large "naked" nuclei contain more vesicles than expected although the size of the nucleus does not affect the size of the vesicles present. We suggest that chromatin from "naked" nuclei and smaller free chromatin masses may become transferred to free vesicles and this process may function in new cell formation.

Identification of Group 2 Innate Lymphoid Cells in Mouse Lung, Liver, Small Intestine, Bone Marrow, and Mediastinal and Mesenteric Lymph Nodes

2019 ◽  
Vol 125 (1) ◽  
pp. e73 ◽  
Author(s):  
Mónica Romera‐Hernández ◽  
Laura Mathä ◽  
Catherine A. Steer ◽  
Maryam Ghaedi ◽  
Fumio Takei
Keyword(s):  
Bone Marrow ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Mouse Lung ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Group 2

In vitrotapeworm extract-induced proliferative responses of gut-associated lymphoid cells fromHymenolepis diminutainfected mice

1983 ◽  
Vol 57 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Dale D. Isaak
Keyword(s):  
Lymph Nodes ◽  
Immune Cells ◽  
Culture System ◽  
Lymphoid Cells ◽  
Hymenolepis Diminuta ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

AbstractThe development of lymphoid cells reactive to tapeworm-associated antigens during the course ofHymenolepis diminutarejection from mice was studied using anin vitrotapeworm extract (TWE)-induced cell proliferation culture system. Mice infected with three cysticercoids on day 0 developed three adult worms by day 7 but worms were rejected by day 21 post-infection. Concomitant with worm rejection was the development of TWE-sensitized lymphoid cells which responded by proliferation when stimulatedin vitrowith TWE. Sensitized cells were detected in gut-associated mesenteric lymph nodes but were not detected in spleen, axillary lymph nodes, or peyer's patches of infected mice, or in lymphoid organs of non-infected mice. These studies suggest that rejection ofH. diminutafrom mice is associated with the activities of gut-associated, tapeworm antigen-sensitized immune cells localized in the mesenteric lymph nodes.

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