The contribution of N.F. Filatov the national pediatrics (to the 170 anniversary from the birthday of N.F. Filatov) (1847-1902)

2017 ◽  
Vol 8 (5) ◽  
pp. 117-120
Author(s):  
Temuri Sh. Morgoshiia

It was noted that during 25 years of scientific and teaching activity N.F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including “a Short textbook of pediatric diseases” (1893), aged 12 editions, and “Clinical lectures” (1900). His monograph “Lectures on acute infectious diseases” (1885) through 4 editions, “Semiotics and diagnosis of childhood diseases” (1890) – 9 editions, it is translated into German, Czech, Italian, Hungarian and French. In the monographs and manuals N.F. Filatov studied many of pokoleniya-pediatricians. He described the infectious disease named Filatov scarlatinal rubella. She was later described by the British physician Duxom; one of the presently used names of the disease – a disease Filatov-Dukes. In the first edition of "Lectures on infectious diseases" N.F. Filatov described is not known until the time of infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic glands. The disease is now often called a disease Filatov. In 1895 N.F. Filatov, described an important diagnostic sign of measles is the appearance of catarrhal period of illness 1-2 days before appearance of rash spot grayish-white lesions on the mucosa of lips and cheeks. As was established later, this sign was first described by A.P. Belsky in 1890, then regardless of him F. Filatov, and in 1896 Koplik. In the literature, this symptom is known as spots Belsky-Filatova-Koplik. N.F. Filatov described the pathogenesis of some forms of edema syndrome in children, published works on prolonged afebrile forms of the flu. N.F. Filatov developed a clinical-physiological direction in Pediatrics. He created a large school of domestic pediatricians. Among his students were V.I. Molchanov and G.N. Speransky.

Author(s):  
T. Sh. Morgoshiia

The article contains the main milestones of life and career of professor Filatov. It was noted that during 25 years of scientific and teaching activity N.F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including “a Short textbook of pediatric diseases” (1893), aged 12 editions, and “Clinical lectures” (1900). His monograph “Lectures on acute infectious diseases” (1885) through 4 editions, “Semiotics and diagnosis of childhood diseases” (1890) - 9 editions, it is translated into German, Czech, Italian, Hungarian and French. In the monographs and manuals N.F. Filatov studied many of pokoleniya-pediatricians. He described the infectious disease named Filatov scarlatinal rubella. She was later described by the British physician Duxom; one of the presently used names of the disease - a disease Filatov-Dukes. In the first edition of “Lectures on infectious diseases” N.F. Filatov described is not known until the time of infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic glands. The disease is now often called a disease Filatov. In 1895 N. F. Filatov, described an important diagnostic sign of measles is the appearance of catarrhal period of illness 1 - 2 days before appearance of rash spot grayish-white lesions on the mucosa of lips and cheeks. As was established later, this sign was first described by A.P. Belsky in 1890, then regardless of him. F. Filatov, and in 1896 Aplicom. In the literature, this symptom is known as spots Belsky-Filatova-Koplik. N.F. Filatov described the pathogenesis of some forms of edema syndrome in children, published works on prolonged afebrile forms of the flu. N. F. Filatov developed a clinical-physiological direction in Pediatrics. He created a large school of domestic pediatricians. Among his students were V.I. Molchanov and G.N. Speransky.


Author(s):  
T. Sh. Morgoshiia

The article contains the main milestones of life and career of professor Filatov. It was noted that during 25 years of scientific and teaching activity N.F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including “a Short textbook of pediatric diseases” (1893), aged 12 editions, and “Clinical lectures” (1900). His monograph “Lectures on acute infectious diseases” (1885) through 4 editions, “Semiotics and diagnosis of childhood diseases” (1890) - 9 editions, it is translated into German, Czech, Italian, Hungarian and French. In the monographs and manuals N.F. Filatov studied many of pokoleniya-pediatricians. He described the infectious disease named Filatov scarlatinal rubella. She was later described by the British physician Duxom; one of the presently used names of the disease - a disease Filatov-Dukes. In the first edition of “Lectures on infectious diseases” N.F. Filatov described is not known until the time of infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic glands. The disease is now often called a disease Filatov. In 1895 N. F. Filatov, described an important diagnostic sign of measles is the appearance of catarrhal period of illness 1 - 2 days before appearance of rash spot grayish-white lesions on the mucosa of lips and cheeks. As was established later, this sign was first described by A.P. Belsky in 1890, then regardless of him. F. Filatov, and in 1896 Aplicom. In the literature, this symptom is known as spots Belsky-Filatova-Koplik. N.F. Filatov described the pathogenesis of some forms of edema syndrome in children, published works on prolonged afebrile forms of the flu. N. F. Filatov developed a clinical-physiological direction in Pediatrics. He created a large school of domestic pediatricians. Among his students were V.I. Molchanov and G.N. Speransky.


Author(s):  
T. Sh. Morgoshiia

It was noted that during 25 years of scientific and teaching activity N. F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including «A short textbook of pediatric diseases» (1893), that was published in 12 editions, and «Clinical lectures» (1900). His monograph «Lectures on acute infectious diseases» (1885) was published in 4 editions, «Semiotics and diagnosis of childhood diseases» (1890) – 9 editions, it istranslated into German, Czech, Italian, Hungarian and French. Many generations of pediatricians have studied on N.F. Filatov’s monographs and manuals. He described the infectious disease named Filatov scarlatinal rubella. Later it was described by the British physician Dukes; one of the presently used names of the disease is Filatov-Dukes disease. In the first edition of «Lectures on infectious diseases» N. F. Filatov described not known until that time infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic nodes. The disease is now often called the Filatov’s disease. In 1895 N. F. Filatov, described an important diagnostic sign of measles – the appearance in the catarrhal period of illness of grayish-white lesions on the mucose membrane of lips and cheeks 1–2 days prior to the appearance of rash. As was established later, this sign was first described by A. P. Belsky in 1890, then, independently, by N.F. Filatov, and in 1896 by Koplik. In the literature, this symptom is known as Belsky-Filatov-Koplik spots. N.F. Filatov described the pathogenesis of some forms of oedema syndrome in children, published works on prolonged afebrile forms of the flu. N.F. Filatov was developing a clinical-physiological direction in Pediatrics. He created a large school of native pediatricians. Among his students were famous pediatricians V.I. Molchanov and G.N. Speransky.


2003 ◽  
Vol 1 (3) ◽  
Author(s):  
Ramon Shaban ◽  
Debra Creedy ◽  
Michele Clark

Introduction Paramedics and other emergency health workers are exposed to infectious disease particularly when undertaking exposure-prone procedures as a component of their everyday practice. This study examined paramedic knowledge of infectious disease aetiology and transmission in the pre-hospital care environment. Methods A mail survey of paramedics from an Australian ambulance service (n=2274) was conducted. Results With a response rate of 55.3% (1258/2274), the study demonstrated that paramedic knowledge of infectious disease aetiology and modes of transmission was poor. Of the 25 infectious diseases included in the survey, only three aetiological agents were correctly identified by at least 80% of respondents. The most accurate responses for aetiology of individual infectious diseases were for HIV/AIDS (91.4%), influenza (87.4%), and hepatitis B (85.7%). Poorest results were observed for pertussis, infectious mononucleosis, leprosy, dengue fever, Japanese B encephalitis and vancomycin resistant enterococcus (VRE), all with less than half the sample providing a correct response. Modes of transmission of significant infectious diseases were also assessed. Most accurate responses were found for HIV/AIDS (85.8%), salmonella (81.9%) and influenza (80.1%). Poorest results were observed for infectious mononucleosis, diphtheria, shigella, Japanese B encephalitis, vancomycin resistant enterococcus, meningococcal meningitis, rubella and infectious mononucleosis, with less than a third of the sample providing a correct response. Conclusion Results suggest that knowledge of aetiology and transmission of infectious disease is generally poor amongst paramedics. A comprehensive in-service education infection control programs for paramedics with emphasis on infectious disease aetiology and transmission is recommended.


Author(s):  
Cécile Viboud ◽  
Hélène Broutin ◽  
Gerardo Chowell

Disentangling the spatial-temporal dynamics of infectious disease transmission is important to address issues of disease persistence, epidemic growth and optimal control. In this chapter, we review key concepts relating to the spatial-temporal dynamics of infectious diseases in meta-populations, whereby geographically separate subpopulations are connected by migration or mobility rates. We review the dynamics of colonization, persistence and extinction of emerging and recurrent pathogens in meta-populations; the role of demographic and environmental factors; and geographic heterogeneity in epidemic growth rate. We illustrate theoretical concepts by reviewing the spatial dynamics of childhood diseases and other acute infections in low- and middle-income countries, and provide a detailed description of the spatial-temporal dynamics of the 2014–16 Ebola epidemic in West Africa. We further discuss how increased availability of empirical data and recent methodological developments provide a deeper mechanistic understanding of transmission processes in space and time, and make recommendations for future work.


2009 ◽  
Vol 22 (2) ◽  
pp. 370-385 ◽  
Author(s):  
Jenefer M. Blackwell ◽  
Sarra E. Jamieson ◽  
David Burgner

SUMMARY Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as major genes that determine susceptibility to infectious disease? This review looks afresh at the evidence supporting a role for classical HLA loci in susceptibility to infectious disease, examines the limitations of data reported to date, and discusses current advances in methodology and technology that will potentially lead to greater understanding of their role in infectious diseases in the future.


2021 ◽  
pp. 074873042098732
Author(s):  
N. Kronfeld-Schor ◽  
T. J. Stevenson ◽  
S. Nickbakhsh ◽  
E. S. Schernhammer ◽  
X. C. Dopico ◽  
...  

Not 1 year has passed since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Since its emergence, great uncertainty has surrounded the potential for COVID-19 to establish as a seasonally recurrent disease. Many infectious diseases, including endemic human coronaviruses, vary across the year. They show a wide range of seasonal waveforms, timing (phase), and amplitudes, which differ depending on the geographical region. Drivers of such patterns are predominantly studied from an epidemiological perspective with a focus on weather and behavior, but complementary insights emerge from physiological studies of seasonality in animals, including humans. Thus, we take a multidisciplinary approach to integrate knowledge from usually distinct fields. First, we review epidemiological evidence of environmental and behavioral drivers of infectious disease seasonality. Subsequently, we take a chronobiological perspective and discuss within-host changes that may affect susceptibility, morbidity, and mortality from infectious diseases. Based on photoperiodic, circannual, and comparative human data, we not only identify promising future avenues but also highlight the need for further studies in animal models. Our preliminary assessment is that host immune seasonality warrants evaluation alongside weather and human behavior as factors that may contribute to COVID-19 seasonality, and that the relative importance of these drivers requires further investigation. A major challenge to predicting seasonality of infectious diseases are rapid, human-induced changes in the hitherto predictable seasonality of our planet, whose influence we review in a final outlook section. We conclude that a proactive multidisciplinary approach is warranted to predict, mitigate, and prevent seasonal infectious diseases in our complex, changing human-earth system.


2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Hyeonji Kim ◽  
Junyoung Kwon ◽  
Yeong-Jin Choi ◽  
Jinah Jang ◽  
...  

AbstractRapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.


PEDIATRICS ◽  
1980 ◽  
Vol 66 (3) ◽  
pp. 458-461
Author(s):  
Thomas H. Weller

For this address at the opening session of the First Mexican National Congress of Infectious Diseases in Children (ler, Congreso National de Infectologia Pediatrica), I have chosen as my title "Contemporary Plagues and Social Progress." While in medicine the term plague usually refers to diseases caused by Pasteurella pestis, the word has broader meanings and usages. It describes that which smites or troubles, can refer to an afflictive evil or anything troublesome or vexatious, or can be applied to any malignant disease, especially those that are contagious. It can be used as an expression of annoyance, as a mild oath, or with the implication of harassment. Thus, today we are concerned with the plague of plagues, the afflictive evils of the cumulative insults of infectious disease. Additionally, we might be tempted to cast a plague on the system of medical education and on the political process that neither conveys the continuing importance of infectious diseases nor funds the mechanisms for their containment. Or, should the shoe be on the other foot? Should not society cast a plague on us? As experts in the field of infectious disease, have we not failed to publicize that, on a global basis, the combination of diarrheal disease and malnutrition is the leading cause of death in infants and children? Has not our successful use of antibiotics induced unjustified public complacency regarding the problems of infectious disease? Why have our low-keyed reports of resistant typhoid bacilli, or pneumococci or of gonococci failed to dispel the prevalent mystique that science has controlled infectious agents, leaving cancer and heart disease in the public eye as the major unconquered problems in the health field?


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